| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Everolimus perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Everolimus_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.355631 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.19274 |
| HMGA2 | high mobility group AT-hook 2 | 0.0924101 |
| YAP1 | Yes-associated protein 1 | 0.0718435 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0713952 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0612337 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0576074 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.057562 |
| VMP1 | vacuole membrane protein 1 | 0.0553659 |
| RPS12 | ribosomal protein S12 | 0.0551644 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0542972 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0495827 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0465625 |
| IPO7 | importin 7 | 0.0456097 |
| PDGFC | platelet derived growth factor C | 0.0449529 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0443563 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0434529 |
| AREG | amphiregulin | 0.0430332 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0426542 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0423475 |
| RPS7 | ribosomal protein S7 | 0.0412733 |
| WWOX | WW domain containing oxidoreductase | 0.0396092 |
| LDHA | lactate dehydrogenase A | 0.0378672 |
| EPHA6 | EPH receptor A6 | 0.0376563 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0368414 |
| NEGR1 | neuronal growth regulator 1 | 0.0366347 |
| RPS2 | ribosomal protein S2 | 0.0343825 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0342862 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0339925 |
| TPM3 | tropomyosin 3 | 0.0331311 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0329996 |
| MKI67 | marker of proliferation Ki-67 | 0.0324651 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0310287 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0310223 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0308032 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0305268 |
| RPS8 | ribosomal protein S8 | 0.0300426 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0298146 |
| BRD2 | bromodomain containing 2 | 0.0293425 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0284893 |
| VIM | vimentin | 0.0283515 |
| HDAC9 | histone deacetylase 9 | 0.0281213 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0280363 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0267888 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0265866 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0261514 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0259532 |
| RRM2 | ribonucleotide reductase M2 | 0.0258753 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0257558 |
| ZNF638 | zinc finger protein 638 | 0.0255267 |
| INTS6 | integrator complex subunit 6 | 0.0254377 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0253023 |
| ATP11A | ATPase, class VI, type 11A | 0.0247944 |
| PEG10 | paternally expressed 10 | 0.0246477 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0244875 |
| ENO1 | enolase 1, (alpha) | 0.0244288 |
| RPS3 | ribosomal protein S3 | 0.0237373 |
| SON | SON DNA binding protein | 0.0231842 |
| RPL37A | ribosomal protein L37a | 0.023044 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.0228839 |
| PTMS | parathymosin | 0.0227689 |
| SKIL | SKI-like proto-oncogene | 0.0226772 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0226097 |
| FTL | ferritin, light polypeptide | 0.0226063 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0222228 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0220324 |
| EGR1 | early growth response 1 | 0.0217627 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0214851 |
| ADIPOR2 | adiponectin receptor 2 | 0.0211502 |
| TBK1 | TANK-binding kinase 1 | 0.0210046 |
| RPS17 | ribosomal protein S17 | 0.0209673 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0209282 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.020681 |
| LEMD3 | LEM domain containing 3 | 0.0205786 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.020548 |
| INTS4 | integrator complex subunit 4 | 0.0204949 |
| USP47 | ubiquitin specific peptidase 47 | 0.020394 |
| NRXN3 | neurexin 3 | 0.020325 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0202298 |
| CALR | calreticulin | 0.0201622 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0201101 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0199767 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0199616 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0198744 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0198244 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0196925 |
| CIP2A | cellular inhibitor of PP2A | 0.0196782 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 0.0196082 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0195565 |
| ETNK1 | ethanolamine kinase 1 | 0.0195255 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0194855 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0194808 |
| CACYBP | calcyclin binding protein | 0.0192278 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0190575 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0190006 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.0189198 |
| EFNA5 | ephrin-A5 | 0.0187087 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0187049 |
| HELLS | helicase, lymphoid-specific | 0.0186835 |
| TMSB10 | thymosin beta 10 | 0.0185817 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.313898 |
| NLGN1 | neuroligin 1 | -0.143883 |
| ACTG1 | actin gamma 1 | -0.114538 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.101653 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.101071 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0909391 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0894384 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0840978 |
| RPL35A | ribosomal protein L35a | -0.077379 |
| CLDN1 | claudin 1 | -0.0730867 |
| AHNAK | AHNAK nucleoprotein | -0.0718618 |
| LMO7 | LIM domain 7 | -0.0626274 |
| PTMA | prothymosin, alpha | -0.0617248 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0578574 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0527976 |
| RASAL2 | RAS protein activator like 2 | -0.0499894 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.04957 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0492634 |
| H1-0 | H1.0 linker histone | -0.0481386 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0480835 |
| UBC | ubiquitin C | -0.0469705 |
| NF1 | neurofibromin 1 | -0.0454268 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.04534 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0443853 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0439922 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0433382 |
| TMEM123 | transmembrane protein 123 | -0.0429383 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0418952 |
| RBMX | RNA binding motif protein, X-linked | -0.0418248 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0414662 |
| S100A10 | S100 calcium binding protein A10 | -0.0413799 |
| ZNF804A | zinc finger protein 804A | -0.0405154 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0404291 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0401128 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0391048 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0387228 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.038665 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0385063 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0380499 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0380207 |
| GCG | glucagon | -0.0359809 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0354933 |
| CXADR | coxsackie virus and adenovirus receptor | -0.035422 |
| RPL8 | ribosomal protein L8 | -0.0353855 |
| S100A6 | S100 calcium binding protein A6 | -0.035316 |
| HMGA1 | high mobility group AT-hook 1 | -0.0352843 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.034596 |
| PGK1 | phosphoglycerate kinase 1 | -0.0340486 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.03404 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0331064 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.032923 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0324245 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0322344 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0318161 |
| DST | dystonin | -0.0316233 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0314596 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0310224 |
| YBX3 | Y box binding protein 3 | -0.0305525 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0304517 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0299686 |
| RPL34 | ribosomal protein L34 | -0.0299651 |
| TUBB | tubulin, beta class I | -0.0297202 |
| CCND1 | cyclin D1 | -0.0296512 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.029492 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0293566 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0292384 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0292336 |
| NHSL1 | NHS-like 1 | -0.029164 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0288353 |
| CDK12 | cyclin-dependent kinase 12 | -0.028381 |
| DIAPH2 | diaphanous-related formin 2 | -0.0283268 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0279238 |
| TMEM131 | transmembrane protein 131 | -0.0277688 |
| HLA-A | major histocompatibility complex, class I, A | -0.0275947 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0274329 |
| TXNRD1 | thioredoxin reductase 1 | -0.0270768 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0269445 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0262319 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0251707 |
| NABP1 | nucleic acid binding protein 1 | -0.0248245 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0247924 |
| DEK | DEK proto-oncogene | -0.0246775 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.024674 |
| NAV3 | neuron navigator 3 | -0.0241978 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0241483 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0238269 |
| ACLY | ATP citrate lyase | -0.0236191 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0235916 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0235661 |
| CDK17 | cyclin-dependent kinase 17 | -0.0235252 |
| RPL38 | ribosomal protein L38 | -0.0234778 |
| ZNF292 | zinc finger protein 292 | -0.0234603 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0234273 |
| CCNI | cyclin I | -0.0232792 |
| RBM39 | RNA binding motif protein 39 | -0.0231898 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.023188 |
| PCDH7 | protocadherin 7 | -0.0230112 |
| RPS21 | ribosomal protein S21 | -0.0229988 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0229182 |
| MGAT4C | MGAT4 family, member C | -0.0226192 |
