Everolimus_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Everolimus perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Everolimus_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.15397
ENO1 enolase 1, (alpha) 0.130936
CADM1 cell adhesion molecule 1 0.106791
COL6A3 collagen, type VI, alpha 3 0.10574
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104414
LDHA lactate dehydrogenase A 0.101695
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.100813
NDRG1 N-myc downstream regulated 1 0.0990515
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0966413
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0926176
FTH1 ferritin, heavy polypeptide 1 0.088781
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0850526
TRIO trio Rho guanine nucleotide exchange factor 0.0796242
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0795283
FNDC3B fibronectin type III domain containing 3B 0.0788933
CALR calreticulin 0.07554
VIM vimentin 0.0742045
VCAN versican 0.0732351
HILPDA hypoxia inducible lipid droplet-associated 0.0731943
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0704293
TIMP3 TIMP metallopeptidase inhibitor 3 0.0677428
VEGFA vascular endothelial growth factor A 0.0636305
HYOU1 hypoxia up-regulated 1 0.0591707
MBNL1 muscleblind-like splicing regulator 1 0.0586917
JARID2 jumonji, AT rich interactive domain 2 0.058354
ALCAM activated leukocyte cell adhesion molecule 0.0572602
FBN1 fibrillin 1 0.0555243
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0546889
MYO10 myosin X 0.0503357
RUNX1 runt-related transcription factor 1 0.0484038
PDIA3 protein disulfide isomerase family A, member 3 0.0482459
PSD3 pleckstrin and Sec7 domain containing 3 0.0449211
P4HB prolyl 4-hydroxylase, beta polypeptide 0.044259
CDH13 cadherin 13 0.0439467
CA12 carbonic anhydrase XII 0.0431979
SQSTM1 sequestosome 1 0.0387082
SP100 SP100 nuclear antigen 0.0385937
MAP1B microtubule-associated protein 1B 0.0383662
GOLGB1 golgin B1 0.0368964
DSTN destrin (actin depolymerizing factor) 0.0362486
IFI6 interferon, alpha-inducible protein 6 0.0358017
ZSWIM6 zinc finger, SWIM-type containing 6 0.0356324
LOX lysyl oxidase 0.0354818
LOC102724023 ES1 protein homolog, mitochondrial 0.0354813
SOD2 superoxide dismutase 2, mitochondrial 0.0354524
IGFBP7 insulin-like growth factor binding protein 7 0.0352356
IQGAP1 IQ motif containing GTPase activating protein 1 0.0333488
COL6A2 collagen, type VI, alpha 2 0.0331651
MT2A metallothionein 2A 0.0328683
DDIT4 DNA-damage-inducible transcript 4 0.0326406
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0322713
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.03222
ZBTB20 zinc finger and BTB domain containing 20 0.0319964
FGFR1 fibroblast growth factor receptor 1 0.0317499
MRTFA myocardin related transcription factor A 0.0316638
PDIA6 protein disulfide isomerase family A, member 6 0.0313481
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0312906
INHBA inhibin, beta A 0.0312044
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0306399
FAM107B family with sequence similarity 107, member B 0.0305608
STC2 stanniocalcin 2 0.0305375
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0303748
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0300904
KMT2C lysine (K)-specific methyltransferase 2C 0.0298322
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0296915
ESYT2 extended synaptotagmin-like protein 2 0.029133
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286719
EGFR epidermal growth factor receptor 0.0285629
DPYSL2 dihydropyrimidinase-like 2 0.0283892
LIMS1 LIM and senescent cell antigen-like domains 1 0.0282216
HIPK2 homeodomain interacting protein kinase 2 0.0282069
TPBG trophoblast glycoprotein 0.0281583
PITPNB phosphatidylinositol transfer protein, beta 0.0278992
CSNK1A1 casein kinase 1, alpha 1 0.0276586
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0275796
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0273945
CHD1 chromodomain helicase DNA binding protein 1 0.0272922
TCEA1 transcription elongation factor A (SII), 1 0.0272826
NFE2L1 nuclear factor, erythroid 2-like 1 0.0266749
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0263077
TTC3 tetratricopeptide repeat domain 3 0.0260727
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0258526
HDAC9 histone deacetylase 9 0.0258354
ELL2 elongation factor, RNA polymerase II, 2 0.0256779
CSDE1 cold shock domain containing E1, RNA-binding 0.0256767
BACE2 beta-site APP-cleaving enzyme 2 0.0256277
GPBP1 GC-rich promoter binding protein 1 0.0251712
RLF rearranged L-myc fusion 0.0247709
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0243931
KMT2E lysine (K)-specific methyltransferase 2E 0.0241046
PKM pyruvate kinase, muscle 0.0240075
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0240024
RYBP RING1 and YY1 binding protein 0.0237267
ARRDC3 arrestin domain containing 3 0.0236546
FAM13A family with sequence similarity 13, member A 0.0234775
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0232942
CLU clusterin 0.0231108
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0228616
ZMIZ1 zinc finger, MIZ-type containing 1 0.0227044
KIF1B kinesin family member 1B 0.022657

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.438469
FN1 fibronectin 1 -0.280968
COL1A1 collagen, type I, alpha 1 -0.173683
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104543
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0919834
TM4SF1 transmembrane 4 L six family member 1 -0.0781845
RPL35A ribosomal protein L35a -0.0697842
IER3 immediate early response 3 -0.0483748
PTMA prothymosin, alpha -0.0441915
LOXL2 lysyl oxidase-like 2 -0.0401255
ACTG1 actin gamma 1 -0.0393717
F3 coagulation factor III (thromboplastin, tissue factor) -0.0359757
TMSB4X thymosin beta 4, X-linked -0.0345943
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0325522
RPL34 ribosomal protein L34 -0.0319202
SMAD3 SMAD family member 3 -0.0318604
TPT1 tumor protein, translationally-controlled 1 -0.0317567
EIF1 eukaryotic translation initiation factor 1 -0.030499
RPS11 ribosomal protein S11 -0.0267243
RPS27A ribosomal protein S27a -0.0261236
HAS2 hyaluronan synthase 2 -0.0251859
ICAM1 intercellular adhesion molecule 1 -0.0250829
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0248461
RPLP2 ribosomal protein, large, P2 -0.0248435
NAMPT nicotinamide phosphoribosyltransferase -0.0240846
UBC ubiquitin C -0.0239405
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0236167
RPL38 ribosomal protein L38 -0.0235963
CANX calnexin -0.0232308
RPS21 ribosomal protein S21 -0.0226322
RPS19 ribosomal protein S19 -0.0224919
CD63 CD63 molecule -0.0222161
HLA-B major histocompatibility complex, class I, B -0.0215686
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.021109
RPS29 ribosomal protein S29 -0.0209742
MTSS1 metastasis suppressor 1 -0.0208509
AHNAK AHNAK nucleoprotein -0.0207173
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0204939
EEF2 eukaryotic translation elongation factor 2 -0.0203557
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0203461
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0202413
SRGN serglycin -0.0195721
PLAUR plasminogen activator, urokinase receptor -0.0193691
MAML2 mastermind-like 2 (Drosophila) -0.019149
LMAN1 lectin, mannose-binding, 1 -0.019098
RPL11 ribosomal protein L11 -0.018599
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0179305
NPC1 Niemann-Pick disease, type C1 -0.0179243
RPS23 ribosomal protein S23 -0.017681
TUBB tubulin, beta class I -0.0175879
DPYSL3 dihydropyrimidinase-like 3 -0.0175868
PDE4D phosphodiesterase 4D, cAMP-specific -0.0174363
TAPBP TAP binding protein (tapasin) -0.0174281
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0173756
DEK DEK proto-oncogene -0.0172298
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0171584
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0169682
GPC6 glypican 6 -0.0169275
ACTN4 actinin, alpha 4 -0.0167823
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0165607
VCL vinculin -0.0165342
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0164176
FLNB filamin B, beta -0.0163065
COL3A1 collagen, type III, alpha 1 -0.0161983
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0160361
RPS6 ribosomal protein S6 -0.0159551
ZMYND8 zinc finger, MYND-type containing 8 -0.015861
ANXA5 annexin A5 -0.0158319
LTBP1 latent transforming growth factor beta binding protein 1 -0.0158101
ASPH aspartate beta-hydroxylase -0.0158026
SBF2 SET binding factor 2 -0.0157173
COL5A2 collagen, type V, alpha 2 -0.0155893
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0155234
COL7A1 collagen, type VII, alpha 1 -0.0155063
FSTL1 follistatin-like 1 -0.0154408
TUBB6 tubulin, beta 6 class V -0.0152963
CTSD cathepsin D -0.0151942
SH3GLB1 SH3-domain GRB2-like endophilin B1 -0.0151308
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0149961
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0149884
AKAP12 A kinase (PRKA) anchor protein 12 -0.0149749
WASHC5 WASH complex subunit 5 -0.0147554
CALM3 calmodulin 3 (phosphorylase kinase, delta) -0.0147503
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0145706
CD2AP CD2-associated protein -0.0144439
RPS13 ribosomal protein S13 -0.0144124
TUBA1C tubulin, alpha 1c -0.0142901
RBM39 RNA binding motif protein 39 -0.0142503
SAR1A secretion associated, Ras related GTPase 1A -0.0138977
IL1B interleukin 1, beta -0.0137894
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0135166
RPS5 ribosomal protein S5 -0.0134008
THY1 Thy-1 cell surface antigen -0.0133701
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0133575
RAI14 retinoic acid induced 14 -0.0133352
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.013304
H3-3B H3.3 histone B -0.0132767
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0132672
FBXL2 F-box and leucine-rich repeat protein 2 -0.0131152
APOL2 apolipoprotein L, 2 -0.0130965