Everolimus_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Everolimus perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Everolimus_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.393838
SVIL supervillin 0.145741
ENO1 enolase 1, (alpha) 0.144225
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.124276
IGF2 insulin-like growth factor 2 0.120281
SAMD4A sterile alpha motif domain containing 4A 0.0985359
FAM107B family with sequence similarity 107, member B 0.0856625
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0827487
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.081885
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0795358
CRY1 cryptochrome circadian clock 1 0.0679044
DSPP dentin sialophosphoprotein 0.0672543
PDLIM5 PDZ and LIM domain 5 0.0638354
PAWR PRKC, apoptosis, WT1, regulator 0.0578367
EXT1 exostosin glycosyltransferase 1 0.0545025
ITGAV integrin, alpha V 0.0533725
LDHA lactate dehydrogenase A 0.0529345
MBNL2 muscleblind-like splicing regulator 2 0.0512601
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0478311
FTH1 ferritin, heavy polypeptide 1 0.0438892
CCL20 chemokine (C-C motif) ligand 20 0.0432737
KYNU kynureninase 0.0431925
FRMD5 FERM domain containing 5 0.0426125
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0419671
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.041964
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0417062
TF transferrin 0.0413409
FOXP1 forkhead box P1 0.0402498
CPE carboxypeptidase E 0.0402228
RPS7 ribosomal protein S7 0.0395837
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0392613
RPS12 ribosomal protein S12 0.0388913
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0379564
MYO1E myosin IE 0.037855
SIK3 SIK family kinase 3 0.0371237
MBNL1 muscleblind-like splicing regulator 1 0.0367681
IGFBP1 insulin-like growth factor binding protein 1 0.0365362
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0362636
KLF6 Kruppel-like factor 6 0.0361528
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0347808
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0338651
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0338212
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0337958
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0337231
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0334421
KIF21A kinesin family member 21A 0.0328748
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0325234
DSTN destrin (actin depolymerizing factor) 0.0321656
FAT1 FAT atypical cadherin 1 0.0320888
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0317956
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0313778
LIMS1 LIM and senescent cell antigen-like domains 1 0.0307221
ENAH enabled homolog (Drosophila) 0.0300031
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0298593
DLC1 DLC1 Rho GTPase activating protein 0.0296104
KALRN kalirin, RhoGEF kinase 0.0293087
JMJD1C jumonji domain containing 1C 0.0289013
NSUN6 NOP2/Sun domain family, member 6 0.0287234
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0287164
NKD1 naked cuticle homolog 1 (Drosophila) 0.0286447
GK glycerol kinase 0.0284001
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0282886
VCL vinculin 0.0281345
AFF1 AF4/FMR2 family, member 1 0.0281064
SOX9 SRY (sex determining region Y)-box 9 0.0280923
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0277423
DOCK4 dedicator of cytokinesis 4 0.0276812
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0275787
RAI14 retinoic acid induced 14 0.0272426
KIF1B kinesin family member 1B 0.0271891
GRB10 growth factor receptor-bound protein 10 0.0260798
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0260384
RAB10 RAB10, member RAS oncogene family 0.0257539
DNAH17 dynein, axonemal, heavy chain 17 0.0252334
RASA2 RAS p21 protein activator 2 0.0250675
RNASEH2A ribonuclease H2, subunit A 0.0248113
VMP1 vacuole membrane protein 1 0.0246184
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0245882
TCIM transcriptional and immune response regulator 0.0242165
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0240912
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.02401
FOXO1 forkhead box O1 0.0239478
PER2 period circadian clock 2 0.0237027
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0236952
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0236898
FNBP1L formin binding protein 1-like 0.0235573
FAM13A family with sequence similarity 13, member A 0.0233369
MALRD1 MAM and LDL receptor class A domain containing 1 0.0233077
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0232695
CLIC4 chloride intracellular channel 4 0.0231957
FAM135A family with sequence similarity 135, member A 0.0229521
ASXL1 additional sex combs like transcriptional regulator 1 0.0229095
DUSP16 dual specificity phosphatase 16 0.0228975
SKIL SKI-like proto-oncogene 0.0227765
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0226231
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0225184
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0224986
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0224851
DNAH5 dynein, axonemal, heavy chain 5 0.0223469
TRIO trio Rho guanine nucleotide exchange factor 0.0221854

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.188776
APOA2 apolipoprotein A-II -0.149054
AKAP12 A kinase (PRKA) anchor protein 12 -0.143482
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113655
APOB apolipoprotein B -0.106905
C3 complement component 3 -0.0850174
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0796793
RPS6 ribosomal protein S6 -0.0736884
CP ceruloplasmin (ferroxidase) -0.0682839
SLC38A2 solute carrier family 38, member 2 -0.0644777
RBM39 RNA binding motif protein 39 -0.0637337
RPS19 ribosomal protein S19 -0.0601366
GMDS GDP-mannose 4,6-dehydratase -0.05873
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0572402
FN1 fibronectin 1 -0.0561579
RPL11 ribosomal protein L11 -0.0558761
MT2A metallothionein 2A -0.052697
FNDC3B fibronectin type III domain containing 3B -0.0514629
SDC4 syndecan 4 -0.0511583
H1-0 H1.0 linker histone -0.0506829
RPL35A ribosomal protein L35a -0.050605
RPL34 ribosomal protein L34 -0.0494213
ELL2 elongation factor, RNA polymerase II, 2 -0.0476514
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0470187
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0455101
AMBP alpha-1-microglobulin/bikunin precursor -0.0454374
A2M alpha-2-macroglobulin -0.0451151
ASPH aspartate beta-hydroxylase -0.0434945
HMGA1 high mobility group AT-hook 1 -0.0430327
GPC3 glypican 3 -0.0393338
APOE apolipoprotein E -0.0392955
EML4 echinoderm microtubule associated protein like 4 -0.0388184
KDM3A lysine (K)-specific demethylase 3A -0.038247
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0377254
PCBP2 poly(rC) binding protein 2 -0.0373934
RPS5 ribosomal protein S5 -0.0373731
NDRG1 N-myc downstream regulated 1 -0.0362022
RPS29 ribosomal protein S29 -0.0359496
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.035634
RPS11 ribosomal protein S11 -0.0349954
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0349374
RPS10 ribosomal protein S10 -0.0345252
ITGA1 integrin, alpha 1 -0.0344118
TM4SF1 transmembrane 4 L six family member 1 -0.0340533
FLNB filamin B, beta -0.0335869
P4HB prolyl 4-hydroxylase, beta polypeptide -0.033235
RPS21 ribosomal protein S21 -0.0332256
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0332247
RRBP1 ribosome binding protein 1 -0.0321926
CCNL1 cyclin L1 -0.0321683
BRD4 bromodomain containing 4 -0.0321664
TPT1 tumor protein, translationally-controlled 1 -0.0320916
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0320789
NPAS2 neuronal PAS domain protein 2 -0.0320117
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0319055
ICAM1 intercellular adhesion molecule 1 -0.0314677
FMNL2 formin-like 2 -0.0314475
UBC ubiquitin C -0.0312208
LRMDA leucine rich melanocyte differentiation associated -0.0310478
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0307976
CANX calnexin -0.0307349
EIF1 eukaryotic translation initiation factor 1 -0.0306853
RPS23 ribosomal protein S23 -0.030528
RPS13 ribosomal protein S13 -0.030339
TMEM123 transmembrane protein 123 -0.0296489
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0293666
KDM7A lysine (K)-specific demethylase 7A -0.029095
LOC112694756 uncharaterized LOC112694756 -0.029062
UGP2 UDP-glucose pyrophosphorylase 2 -0.0290095
PGK1 phosphoglycerate kinase 1 -0.0286416
FBF1 Fas (TNFRSF6) binding factor 1 -0.0282894
LYZ lysozyme -0.028158
NCOR1 nuclear receptor corepressor 1 -0.028025
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0279217
SOD2 superoxide dismutase 2, mitochondrial -0.0279063
MYL12B myosin, light chain 12B, regulatory -0.0276697
ZMYND8 zinc finger, MYND-type containing 8 -0.0276369
RPL32 ribosomal protein L32 -0.0276088
RPL8 ribosomal protein L8 -0.0276043
RPL38 ribosomal protein L38 -0.0273894
TRIM26 tripartite motif containing 26 -0.0270387
UBXN4 UBX domain protein 4 -0.0267346
ACTG1 actin gamma 1 -0.0266189
MT1X metallothionein 1X -0.0263895
NPR2 natriuretic peptide receptor 2 -0.0263193
RSL1D1 ribosomal L1 domain containing 1 -0.0261631
GPC6 glypican 6 -0.0261264
GSE1 Gse1 coiled-coil protein -0.0260145
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0260026
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0259109
RSRC2 arginine/serine-rich coiled-coil 2 -0.0256593
RPL19 ribosomal protein L19 -0.0256519
EPAS1 endothelial PAS domain protein 1 -0.0253918
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0251376
PTMA prothymosin, alpha -0.0250743
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.0249648
WSB1 WD repeat and SOCS box containing 1 -0.0247478
TM9SF3 transmembrane 9 superfamily member 3 -0.0245441
SP3 Sp3 transcription factor -0.0244895
RPL4 ribosomal protein L4 -0.0243667