Everolimus_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Everolimus perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Everolimus_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.156574
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.153902
VCAN versican 0.12938
LDHA lactate dehydrogenase A 0.108486
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.105856
FTH1 ferritin, heavy polypeptide 1 0.087786
RPS12 ribosomal protein S12 0.0872492
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0831018
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.077197
MT2A metallothionein 2A 0.0714269
STC1 stanniocalcin 1 0.0691293
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0659398
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0655478
ENO1 enolase 1, (alpha) 0.0650077
HMGA2 high mobility group AT-hook 2 0.0627284
TRIO trio Rho guanine nucleotide exchange factor 0.0623208
GLIS3 GLIS family zinc finger 3 0.060173
NAV2 neuron navigator 2 0.0575797
EEF2 eukaryotic translation elongation factor 2 0.0566051
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0555036
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0540894
ZSWIM6 zinc finger, SWIM-type containing 6 0.0498218
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0491387
SOX9 SRY (sex determining region Y)-box 9 0.0483738
RUNX1 runt-related transcription factor 1 0.0476328
COL6A3 collagen, type VI, alpha 3 0.0445232
CD44 CD44 molecule (Indian blood group) 0.0443023
SQSTM1 sequestosome 1 0.043389
RPS2 ribosomal protein S2 0.0427264
TENT5A terminal nucleotidyltransferase 5A 0.0419264
APLP2 amyloid beta (A4) precursor-like protein 2 0.0416537
ZMIZ1 zinc finger, MIZ-type containing 1 0.040723
ZBTB38 zinc finger and BTB domain containing 38 0.0405735
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0404794
INTS6 integrator complex subunit 6 0.0400534
SPTBN1 spectrin, beta, non-erythrocytic 1 0.039489
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0391956
ASPH aspartate beta-hydroxylase 0.039142
HLA-E major histocompatibility complex, class I, E 0.0388609
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0369936
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0369684
VEGFA vascular endothelial growth factor A 0.0359361
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0358927
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0356581
SYNJ2 synaptojanin 2 0.034273
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0342621
PRELID2 PRELI domain containing 2 0.033862
B2M beta-2-microglobulin 0.0337703
RPS3 ribosomal protein S3 0.0337402
LOC102724023 ES1 protein homolog, mitochondrial 0.0326804
MBNL1 muscleblind-like splicing regulator 1 0.0316674
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0316522
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0303617
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0299178
MYO10 myosin X 0.0298912
VMP1 vacuole membrane protein 1 0.0298722
BACE2 beta-site APP-cleaving enzyme 2 0.0298418
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0297157
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0294827
IRAK2 interleukin-1 receptor-associated kinase 2 0.0294155
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0290371
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0289583
RPS17 ribosomal protein S17 0.0289054
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0288271
JMJD1C jumonji domain containing 1C 0.0287872
MACF1 microtubule-actin crosslinking factor 1 0.0287444
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0283975
WEE1 WEE1 G2 checkpoint kinase 0.0282152
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.028141
EGR1 early growth response 1 0.0280942
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0278833
SMAD3 SMAD family member 3 0.0276066
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0275308
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0273289
RPS7 ribosomal protein S7 0.0272495
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0270139
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0266921
TPM3 tropomyosin 3 0.0266642
ZNF608 zinc finger protein 608 0.0265397
BRD2 bromodomain containing 2 0.0263238
FBXL7 F-box and leucine-rich repeat protein 7 0.025904
ANO6 anoctamin 6 0.0258985
FMNL2 formin-like 2 0.0256758
TLE4 transducin-like enhancer of split 4 0.0252693
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0248418
FLNA filamin A, alpha 0.0246044
ANGPTL4 angiopoietin-like 4 0.0242457
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0241264
MMP2 matrix metallopeptidase 2 0.0240383
BIRC3 baculoviral IAP repeat containing 3 0.0240218
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0239681
SEPTIN9 septin 9 0.0239347
SVIL supervillin 0.0237711
EFNA5 ephrin-A5 0.0231703
PDIA3 protein disulfide isomerase family A, member 3 0.0230083
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0228797
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0228687
CD59 CD59 molecule, complement regulatory protein 0.0227306
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0227211
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0226386

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201523
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.173847
FN1 fibronectin 1 -0.136671
IER3 immediate early response 3 -0.116696
NAMPT nicotinamide phosphoribosyltransferase -0.113591
IGFBP3 insulin-like growth factor binding protein 3 -0.112142
HLA-B major histocompatibility complex, class I, B -0.106568
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0983147
PTMA prothymosin, alpha -0.0948541
RPL35A ribosomal protein L35a -0.0839635
ACTG1 actin gamma 1 -0.082191
TPT1 tumor protein, translationally-controlled 1 -0.0804048
ZMYND8 zinc finger, MYND-type containing 8 -0.0780704
FRMD4A FERM domain containing 4A -0.0737662
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0717632
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0688699
TMSB10 thymosin beta 10 -0.0681621
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0679089
UBC ubiquitin C -0.0663214
EIF1 eukaryotic translation initiation factor 1 -0.0654034
AHNAK AHNAK nucleoprotein -0.0653194
SLC38A2 solute carrier family 38, member 2 -0.064873
COL1A1 collagen, type I, alpha 1 -0.0592331
PGK1 phosphoglycerate kinase 1 -0.0572873
RBM39 RNA binding motif protein 39 -0.0572561
KDM3A lysine (K)-specific demethylase 3A -0.0560726
CANX calnexin -0.0531957
RTN4 reticulon 4 -0.0517834
VCL vinculin -0.0509131
SOD2 superoxide dismutase 2, mitochondrial -0.0477809
ELL2 elongation factor, RNA polymerase II, 2 -0.0472136
TPM4 tropomyosin 4 -0.0467126
RRBP1 ribosome binding protein 1 -0.0461916
WSB1 WD repeat and SOCS box containing 1 -0.0457414
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0443929
RPS6 ribosomal protein S6 -0.0436767
BTG1 B-cell translocation gene 1, anti-proliferative -0.0436702
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0435237
DEK DEK proto-oncogene -0.0428321
SBF2 SET binding factor 2 -0.0415499
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0414624
GNAS GNAS complex locus -0.0409655
UGCG UDP-glucose ceramide glucosyltransferase -0.0404003
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0398504
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0384903
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0384896
EXT1 exostosin glycosyltransferase 1 -0.0382182
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0378445
TMSB4X thymosin beta 4, X-linked -0.0373502
MAP4 microtubule-associated protein 4 -0.0371867
CTSD cathepsin D -0.0369016
FBXO32 F-box protein 32 -0.0365357
TXNRD1 thioredoxin reductase 1 -0.0362249
TUBB tubulin, beta class I -0.0355004
RAI14 retinoic acid induced 14 -0.0341286
CD63 CD63 molecule -0.0335778
NPEPPS aminopeptidase puromycin sensitive -0.0335348
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0325653
RPS24 ribosomal protein S24 -0.0320956
TMEM263 transmembrane protein 263 -0.0320039
RPL34 ribosomal protein L34 -0.0318449
KLHL24 kelch-like family member 24 -0.0316758
MARCHF6 membrane associated ring-CH-type finger 6 -0.031181
RPS23 ribosomal protein S23 -0.031042
RPL38 ribosomal protein L38 -0.0309384
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0303264
RPS19 ribosomal protein S19 -0.0299999
GOLGA4 golgin A4 -0.029774
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0296662
WTAP Wilms tumor 1 associated protein -0.029493
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0293476
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0288617
CUL4B cullin 4B -0.0285056
KLHL5 kelch-like family member 5 -0.0279228
CD2AP CD2-associated protein -0.0276975
PALLD palladin, cytoskeletal associated protein -0.0275951
FBXO11 F-box protein 11 -0.0274285
QKI QKI, KH domain containing, RNA binding -0.0272826
RSF1 remodeling and spacing factor 1 -0.0271576
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0271558
RPS11 ribosomal protein S11 -0.0271541
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0269168
TMEM41B transmembrane protein 41B -0.0267619
DLG1 discs, large homolog 1 (Drosophila) -0.0267019
CADM1 cell adhesion molecule 1 -0.0263068
OPTN optineurin -0.0261517
RPS21 ribosomal protein S21 -0.0260038
HDLBP high density lipoprotein binding protein -0.0258054
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0254289
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0253736
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0251709
LMAN1 lectin, mannose-binding, 1 -0.0251176
SLC38A1 solute carrier family 38, member 1 -0.0250823
TMEM123 transmembrane protein 123 -0.0249443
CTSB cathepsin B -0.0248574
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0248408
SEC31A SEC31 homolog A (S. cerevisiae) -0.024668
AFF4 AF4/FMR2 family, member 4 -0.0244956
ARF4 ADP-ribosylation factor 4 -0.0242993
CALD1 caldesmon 1 -0.0241137