Exophthalmos Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit. (Human Disease Ontology, DOID_9370)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D005094
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Genes

130 genes/proteins associated with the disease Exophthalmos from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
VCAM1 vascular cell adhesion molecule 1 1.45352
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.38469
CLU clusterin 1.37217
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.33966
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.33405
BDNF brain-derived neurotrophic factor 1.32251
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.31506
VEGFA vascular endothelial growth factor A 1.31387
IFNG interferon, gamma 1.28765
TMED9 transmembrane emp24 protein transport domain containing 9 1.28333
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.26329
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.25432
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.24718
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.24056
CTSB cathepsin B 1.24056
CAT catalase 1.22821
NOS1 nitric oxide synthase 1 (neuronal) 1.21468
BCL2L1 BCL2-like 1 1.20064
CSNK2A1 casein kinase 2, alpha 1 polypeptide 1.18948
ICAM1 intercellular adhesion molecule 1 1.18882
TIAM2 T-cell lymphoma invasion and metastasis 2 1.18685
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.17366
FHL2 four and a half LIM domains 2 1.17202
HSPA1A heat shock 70kDa protein 1A 1.16533
PER1 period circadian clock 1 1.16137
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.15593
EGF epidermal growth factor 1.15425
LITAF lipopolysaccharide-induced TNF factor 1.15391
IL6 interleukin 6 1.15324
GAL galanin/GMAP prepropeptide 1.15022
CEP83 centrosomal protein 83kDa 1.14336
SH3GL1 SH3-domain GRB2-like 1 1.14268
JUN jun proto-oncogene 1.13895
CCND1 cyclin D1 1.13552
TMPRSS4 transmembrane protease, serine 4 1.1294
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.12461
CBLN1 cerebellin 1 precursor 1.12254
DAZAP1 DAZ associated protein 1 1.12151
GSK3B glycogen synthase kinase 3 beta 1.1198
GHR growth hormone receptor 1.11741
HSF1 heat shock transcription factor 1 1.11707
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 1.11501
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.11046
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.11011
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 1.10872
FLNB filamin B, beta 1.10872
FOXO1 forkhead box O1 1.10872
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.10388
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.10104
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.10104
FOS FBJ murine osteosarcoma viral oncogene homolog 1.09892
ADAT2 adenosine deaminase, tRNA-specific 2 1.09716
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 1.09716
KCNT1 potassium channel, sodium activated subfamily T, member 1 1.09716
CCL2 chemokine (C-C motif) ligand 2 1.09436
FGFR1 fibroblast growth factor receptor 1 1.09366
LDB2 LIM domain binding 2 1.0919
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.09154
CXCL8 chemokine (C-X-C motif) ligand 8 1.09119
EGR2 early growth response 2 1.08442
ADORA1 adenosine A1 receptor 1.08372
PDGFA platelet-derived growth factor alpha polypeptide 1.08196
SERTAD4 SERTA domain containing 4 1.08196
SEPT8 septin 8 1.08196
MARK1 MAP/microtubule affinity-regulating kinase 1 1.08126
ZNF207 zinc finger protein 207 1.08126
JUND jun D proto-oncogene 1.07875
CES2 carboxylesterase 2 1.0784
PBX3 pre-B-cell leukemia homeobox 3 1.07625
SART1 squamous cell carcinoma antigen recognized by T cells 1.07625
VIMP VCP-interacting membrane selenoprotein 1.07163
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 1.07163
ATE1 arginyltransferase 1 1.07163
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 1.07163
IL1A interleukin 1, alpha 1.07163
RAB3A RAB3A, member RAS oncogene family 1.06808
BBC3 BCL2 binding component 3 1.06479
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 1.0637
CYBA cytochrome b-245, alpha polypeptide 1.06333
MAP1A microtubule-associated protein 1A 1.06225
CHUK conserved helix-loop-helix ubiquitous kinase 1.06152
APOB apolipoprotein B 1.06008
QPRT quinolinate phosphoribosyltransferase 1.05972
GFM1 G elongation factor, mitochondrial 1 1.05864
RDH10 retinol dehydrogenase 10 (all-trans) 1.05793
EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.05793
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.05721
HMOX1 heme oxygenase 1 1.05721
ACSL1 acyl-CoA synthetase long-chain family member 1 1.05648
DDIT3 DNA-damage-inducible transcript 3 1.05648
PLLP plasmolipin 1.05423
BMP2K BMP2 inducible kinase 1.05349
ART3 ADP-ribosyltransferase 3 1.05015
SAR1A secretion associated, Ras related GTPase 1A 1.04941
HOMER2 homer scaffolding protein 2 1.04941
PHLDB1 pleckstrin homology-like domain, family B, member 1 1.04611
CLK4 CDC-like kinase 4 1.04501
SATB1 SATB homeobox 1 1.04126
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 1.04126
CNR1 cannabinoid receptor 1 (brain) 1.04051
TNF tumor necrosis factor 1.04014
SGK1 serum/glucocorticoid regulated kinase 1 1.03864
CRYAB crystallin, alpha B 1.03864
UBTF upstream binding transcription factor, RNA polymerase I 1.03715
SPRED1 sprouty-related, EVH1 domain containing 1 1.03715
XBP1 X-box binding protein 1 1.0353
KLF7 Kruppel-like factor 7 (ubiquitous) 1.03419
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.03345
KIF3A kinesin family member 3A 1.03345
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.03084
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 1.03046
ATF4 activating transcription factor 4 1.03009
GLRX3 glutaredoxin 3 1.02971
TUBA8 tubulin, alpha 8 1.02971
CD44 CD44 molecule (Indian blood group) 1.02522
ADAM19 ADAM metallopeptidase domain 19 1.02262
CPNE8 copine VIII 1.02262
CXXC5 CXXC finger protein 5 1.02262
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.02262
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.01966
PLEC plectin 1.01852
HINT1 histidine triad nucleotide binding protein 1 1.01625
DDAH2 dimethylarginine dimethylaminohydrolase 2 1.01625
AACS acetoacetyl-CoA synthetase 1.01549
TARS threonyl-tRNA synthetase 1.01549
COX7B cytochrome c oxidase subunit VIIb 1.01549
CLTB clathrin, light chain B 1.01549
SLK STE20-like kinase 1.01549
CARHSP1 calcium regulated heat stable protein 1, 24kDa 1.01324
GFAP glial fibrillary acidic protein 1.01174