Exostosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A hyperostosis that involves formation of new bone on the surface of preexisting bone. (Human Disease Ontology, DOID_203)
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Genes

211 genes co-occuring with the disease Exostosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
EXT2 exostosin glycosyltransferase 2 3.833
EXT1 exostosin glycosyltransferase 1 3.825
EXTL1 exostosin-like glycosyltransferase 1 2.747
EXTL2 exostosin-like glycosyltransferase 2 2.73
EXTL3 exostosin-like glycosyltransferase 3 2.604
ACAN aggrecan 2.418
IHH indian hedgehog 2.358
MMP13 matrix metallopeptidase 13 2.243
COL2A1 collagen, type II, alpha 1 2.178
GDF5 growth differentiation factor 5 2.117
BMP2 bone morphogenetic protein 2 2.085
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 2.076
SOST sclerostin 2.064
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.032
HSPG2 heparan sulfate proteoglycan 2 2.009
FAM20B family with sequence similarity 20, member B 1.985
RUNX2 runt-related transcription factor 2 1.959
PTHLH parathyroid hormone-like hormone 1.952
BGLAP bone gamma-carboxyglutamate (gla) protein 1.947
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.932
CRP C-reactive protein, pentraxin-related 1.921
TGFB1 transforming growth factor, beta 1 1.917
SOX9 SRY (sex determining region Y)-box 9 1.912
PTH parathyroid hormone 1.905
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.877
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.848
IGF1 insulin-like growth factor 1 (somatomedin C) 1.845
MMP3 matrix metallopeptidase 3 1.822
ACVR1 activin A receptor, type I 1.818
IL1B interleukin 1, beta 1.81
FGF18 fibroblast growth factor 18 1.809
PHEX phosphate regulating endopeptidase homolog, X-linked 1.803
XYLT1 xylosyltransferase I 1.8
TNF tumor necrosis factor 1.793
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 1.791
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 1.784
IRS4 insulin receptor substrate 4 1.769
FGF9 fibroblast growth factor 9 1.737
FGF7 fibroblast growth factor 7 1.736
PRG4 proteoglycan 4 1.719
IL6 interleukin 6 1.719
SP7 Sp7 transcription factor 1.718
FGF8 fibroblast growth factor 8 (androgen-induced) 1.712
FGF16 fibroblast growth factor 16 1.697
FGF6 fibroblast growth factor 6 1.697
FGF5 fibroblast growth factor 5 1.696
FGF22 fibroblast growth factor 22 1.692
FGF17 fibroblast growth factor 17 1.692
FGF3 fibroblast growth factor 3 1.69
FGF10 fibroblast growth factor 10 1.689
SULF1 sulfatase 1 1.689
FGF20 fibroblast growth factor 20 1.688
FGF4 fibroblast growth factor 4 1.686
B3GAT3 beta-1,3-glucuronyltransferase 3 1.673
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.673
COMP cartilage oligomeric matrix protein 1.666
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.648
ACP5 acid phosphatase 5, tartrate resistant 1.632
FGF23 fibroblast growth factor 23 1.622
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.62
COL10A1 collagen, type X, alpha 1 1.593
UXS1 UDP-glucuronate decarboxylase 1 1.587
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.585
PTH1R parathyroid hormone 1 receptor 1.584
ANKH ANKH inorganic pyrophosphate transport regulator 1.583
TRPS1 trichorhinophalangeal syndrome I 1.578
BMP4 bone morphogenetic protein 4 1.566
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.56
FGFR3 fibroblast growth factor receptor 3 1.558
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 1.551
SULF2 sulfatase 2 1.54
RARG retinoic acid receptor, gamma 1.531
ASPN asporin 1.528
IL1A interleukin 1, alpha 1.517
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 1.511
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 1.506
COL1A1 collagen, type I, alpha 1 1.496
LRP5 low density lipoprotein receptor-related protein 5 1.493
COL12A1 collagen, type XII, alpha 1 1.491
BMP6 bone morphogenetic protein 6 1.487
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 1.483
CTSK cathepsin K 1.481
GPC1 glypican 1 1.455
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 1.454
FGF2 fibroblast growth factor 2 (basic) 1.451
XYLT2 xylosyltransferase II 1.444
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.434
HPSE heparanase 1.432
COL1A2 collagen, type I, alpha 2 1.426
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 1.419
ALPL alkaline phosphatase, liver/bone/kidney 1.418
IL17A interleukin 17A 1.417
COL9A1 collagen, type IX, alpha 1 1.415
BMP7 bone morphogenetic protein 7 1.408
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 1.395
NOG noggin 1.395
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.39
BMP5 bone morphogenetic protein 5 1.387
FRZB frizzled-related protein 1.376
CCDC91 coiled-coil domain containing 91 1.375
CHSY1 chondroitin sulfate synthase 1 1.373
SPP1 secreted phosphoprotein 1 1.372
COL11A2 collagen, type XI, alpha 2 1.372
LEP leptin 1.364
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.363
IBSP integrin-binding sialoprotein 1.36
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 1.351
SDC2 syndecan 2 1.35
FGF13 fibroblast growth factor 13 1.349
CLCN7 chloride channel, voltage-sensitive 7 1.342
LEMD3 LEM domain containing 3 1.339
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 1.329
DCN decorin 1.328
GPC4 glypican 4 1.323
INS insulin 1.321
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.32
BGN biglycan 1.306
SDC3 syndecan 3 1.304
TGFB3 transforming growth factor, beta 3 1.298
SOX5 SRY (sex determining region Y)-box 5 1.294
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 1.293
BTBD8 BTB (POZ) domain containing 8 1.29
SDC4 syndecan 4 1.285
ALB albumin 1.279
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 1.268
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 1.268
MMP1 matrix metallopeptidase 1 1.268
GLCE glucuronic acid epimerase 1.25
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.249
ALX4 ALX homeobox 4 1.241
FGFR1 fibroblast growth factor receptor 1 1.235
DSPP dentin sialophosphoprotein 1.22
CD44 CD44 molecule (Indian blood group) 1.22
ALLC allantoicase 1.211
FN1 fibronectin 1 1.208
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.204
MKX mohawk homeobox 1.203
COL11A1 collagen, type XI, alpha 1 1.202
CHRD chordin 1.2
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 1.2
SCX scleraxis basic helix-loop-helix transcription factor 1.194
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.181
COL9A2 collagen, type IX, alpha 2 1.18
MMP2 matrix metallopeptidase 2 1.177
MMP9 matrix metallopeptidase 9 1.175
FAM20A family with sequence similarity 20, member A 1.175
TAC1 tachykinin, precursor 1 1.174
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 1.168
CHPF2 chondroitin polymerizing factor 2 1.161
RSPO2 R-spondin 2 1.159
SRGN serglycin 1.152
WNT10B wingless-type MMTV integration site family, member 10B 1.14
FMOD fibromodulin 1.139
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.135
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.131
PXDNL peroxidasin-like 1.118
PXDN peroxidasin 1.117
ACR acrosin 1.116
SHH sonic hedgehog 1.115
HAPLN1 hyaluronan and proteoglycan link protein 1 1.115
CCN6 cellular communication network factor 6 1.113
USHBP1 Usher syndrome 1C binding protein 1 1.11
HGD homogentisate 1,2-dioxygenase 1.107
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 1.105
CHPF chondroitin polymerizing factor 1.104
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 1.102
ELN elastin 1.101
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 1.099
TP53 tumor protein p53 1.098
SMAD3 SMAD family member 3 1.096
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.092
FOS FBJ murine osteosarcoma viral oncogene homolog 1.089
WNT16 wingless-type MMTV integration site family, member 16 1.085
GDF6 growth differentiation factor 6 1.079
FLYWCH1 FLYWCH-type zinc finger 1 1.07
BMP3 bone morphogenetic protein 3 1.066
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 1.066
GREM2 gremlin 2, DAN family BMP antagonist 1.063
MTMR12 myotubularin related protein 12 1.058
SLC10A7 solute carrier family 10, member 7 1.053
ACTB actin, beta 1.052
TIMP1 TIMP metallopeptidase inhibitor 1 1.052
WNT5A wingless-type MMTV integration site family, member 5A 1.051
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 1.047
COL9A3 collagen, type IX, alpha 3 1.045
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 1.045
COL6A1 collagen, type VI, alpha 1 1.043
DMP1 dentin matrix acidic phosphoprotein 1 1.042
ARSB arylsulfatase B 1.04
DOK4 docking protein 4 1.038
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.036
GDF2 growth differentiation factor 2 1.036
LRP6 low density lipoprotein receptor-related protein 6 1.034
CXCL8 chemokine (C-X-C motif) ligand 8 1.033
LRRTM4 leucine rich repeat transmembrane neuronal 4 1.033
AGRN agrin 1.031
MATN1 matrilin 1, cartilage matrix protein 1.029
DLX3 distal-less homeobox 3 1.027
ENG endoglin 1.027
IL10 interleukin 10 1.025
OSTM1 osteopetrosis associated transmembrane protein 1 1.021
THY1 Thy-1 cell surface antigen 1.021
SDC1 syndecan 1 1.02
JUN jun proto-oncogene 1.018
HIP1 huntingtin interacting protein 1 1.016
PRRX1 paired related homeobox 1 1.011
NGF nerve growth factor (beta polypeptide) 1.01
GPC3 glypican 3 1.005
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.004
PHOSPHO1 phosphatase, orphan 1 1.003
TGFBR3 transforming growth factor, beta receptor III 1.002