| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | coagulation factor XII (Hageman factor)|This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2161) |
| External Link | https://ncbi.nlm.nih.gov/gene/2161 |
| Similar Terms | |
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499 genes differentially expressed following the F12 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 0.0302005 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.0201641 |
| MT1E | metallothionein 1E | 0.0154266 |
| MT1X | metallothionein 1X | 0.0154249 |
| MT1H | metallothionein 1H | 0.0150177 |
| ADI1 | acireductone dioxygenase 1 | 0.0149327 |
| XIC | X chromosome inactivation center | 0.0147591 |
| MT1G | metallothionein 1G | 0.0142174 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0134911 |
| MT1HL1 | metallothionein 1H-like 1 | 0.0125834 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0123805 |
| GPX2 | glutathione peroxidase 2 | 0.0122717 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0120308 |
| MEF2C | myocyte enhancer factor 2C | 0.0118132 |
| FCGBP | Fc fragment of IgG binding protein | 0.0117628 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.010945 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0107509 |
| MT2A | metallothionein 2A | 0.0103817 |
| C1QB | complement component 1, q subcomponent, B chain | 0.0103735 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0103252 |
| STAP2 | signal transducing adaptor family member 2 | 0.0101226 |
| MT1F | metallothionein 1F | 0.00997424 |
| CFH | complement factor H | 0.00988821 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.00957702 |
| IL32 | interleukin 32 | 0.00951862 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00925443 |
| MT1M | metallothionein 1M | 0.00913748 |
| CCN2 | cellular communication network factor 2 | 0.00904902 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00899185 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.00889584 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00880189 |
| RASA4 | RAS p21 protein activator 4 | 0.00871417 |
| FOXO1 | forkhead box O1 | 0.00857127 |
| LAMC2 | laminin, gamma 2 | 0.0085288 |
| ITK | IL2-inducible T-cell kinase | 0.00845956 |
| BMP2 | bone morphogenetic protein 2 | 0.00834186 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00829672 |
| PLAU | plasminogen activator, urokinase | 0.00828106 |
| SLAMF7 | SLAM family member 7 | 0.0081582 |
| AIM2 | absent in melanoma 2 | 0.0081321 |
| CTSS | cathepsin S | 0.00811915 |
| IFRD2 | interferon-related developmental regulator 2 | 0.00810104 |
| PLS1 | plastin 1 | 0.00808346 |
| ALB | albumin | 0.00808115 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0080204 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00796977 |
| FABP1 | fatty acid binding protein 1, liver | 0.00794245 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | 0.00791049 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00783265 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00783005 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | 0.00781263 |
| GIMAP6 | GTPase, IMAP family member 6 | 0.00775059 |
| CD4 | CD4 molecule | 0.00770643 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.00769043 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | 0.00768253 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00765101 |
| GIMAP4 | GTPase, IMAP family member 4 | 0.00763815 |
| UFM1 | ubiquitin-fold modifier 1 | 0.0076148 |
| PRKCA | protein kinase C, alpha | 0.00761271 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 0.00754709 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.00749812 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | 0.00749075 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00738996 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.00735912 |
| RND3 | Rho family GTPase 3 | 0.00727022 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00726639 |
| CYRIA | CYFIP related Rac1 interactor A | 0.00724481 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00719297 |
| GIMAP5 | GTPase, IMAP family member 5 | 0.00718744 |
| CTSB | cathepsin B | 0.0071865 |
| RTN1 | reticulon 1 | 0.00713926 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.00710039 |
| CD38 | CD38 molecule | 0.00708672 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00703509 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.00701624 |
| RUNX1 | runt-related transcription factor 1 | 0.00699129 |
| CD53 | CD53 molecule | 0.00697634 |
| GOLGA8A | golgin A8 family, member A | 0.00697313 |
| RXYLT1 | ribitol xylosyltransferase 1 | 0.00696348 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00695643 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.00694061 |
| GPR171 | G protein-coupled receptor 171 | 0.00693516 |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.0069284 |
| PRDX4 | peroxiredoxin 4 | 0.00692562 |
| FYB1 | FYN binding protein 1 | 0.0069234 |
| CCNA2 | cyclin A2 | 0.00692169 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.00692015 |
| SLC35D1 | solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 | 0.0068872 |
| IMPA1 | inositol(myo)-1(or 4)-monophosphatase 1 | 0.00683635 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.0068331 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | 0.00682189 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 0.00681559 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00677807 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00676739 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.00675785 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.00674996 |
| IL6R | interleukin 6 receptor | 0.00673289 |
| CTSE | cathepsin E | 0.00673258 |
| CA2 | carbonic anhydrase II | 0.00673244 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | 0.00671173 |
| SMAD3 | SMAD family member 3 | 0.00666062 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00663624 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00655212 |
| PLAUR | plasminogen activator, urokinase receptor | 0.00651815 |
| NUDC | nudC nuclear distribution protein | 0.0065118 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00646878 |
| KRT15 | keratin 15, type I | 0.00646228 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 0.00644435 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00641954 |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.00641185 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 0.00639213 |
| RGS13 | regulator of G-protein signaling 13 | 0.00637374 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00636235 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00636143 |
| ARL14 | ADP-ribosylation factor-like 14 | 0.00632683 |
| PCDH9 | protocadherin 9 | 0.00629522 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.00627433 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00626928 |
| EIF6 | eukaryotic translation initiation factor 6 | 0.00625245 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00622182 |
| NKX2-1 | NK2 homeobox 1 | 0.00621125 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00620822 |
| ELMO1 | engulfment and cell motility 1 | 0.00620719 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | 0.00620295 |
| CES1 | carboxylesterase 1 | 0.00615884 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00615408 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.00611529 |
| XAF1 | XIAP associated factor 1 | 0.00611308 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.0061026 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.00605597 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.00604926 |
| AOX1 | aldehyde oxidase 1 | 0.0060087 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.00597272 |
| PPA1 | pyrophosphatase (inorganic) 1 | 0.00597026 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | 0.00595935 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00595477 |
| SCPEP1 | serine carboxypeptidase 1 | 0.00593985 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.00593245 |
| LAMB3 | laminin, beta 3 | 0.00593217 |
| GSDMB | gasdermin B | 0.00592912 |
| SIK1 | salt-inducible kinase 1 | 0.00592869 |
| CYP2C18 | cytochrome P450, family 2, subfamily C, polypeptide 18 | 0.00592259 |
| ALDOB | aldolase B, fructose-bisphosphate | 0.00591074 |
| MXRA7 | matrix-remodelling associated 7 | 0.00589591 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.00588146 |
| PER3 | period circadian clock 3 | 0.00584228 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00583629 |
| APLNR | apelin receptor | 0.00581864 |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.00580466 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.00579747 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | 0.00579478 |
| SDC4 | syndecan 4 | 0.0057819 |
| KIF13B | kinesin family member 13B | 0.00578142 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.00577269 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | 0.00574061 |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.00571285 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00569587 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.0056949 |
| CD163 | CD163 molecule | 0.00569321 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.0056924 |
| NLGN4X | neuroligin 4, X-linked | 0.00569072 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 0.00568614 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00566793 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00566731 |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | 0.00566145 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.00565607 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0056408 |
| TNC | tenascin C | 0.00564001 |
| ATP5F1D | ATP synthase F1 subunit delta | 0.00563641 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.00563618 |
| DSG3 | desmoglein 3 | 0.00560212 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.00557738 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00557518 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.00555554 |
| MUC13 | mucin 13, cell surface associated | 0.00554862 |
| ESR1 | estrogen receptor 1 | 0.00554715 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.00554584 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.00553655 |
| NR1I2 | nuclear receptor subfamily 1, group I, member 2 | 0.0055236 |
| SLCO2B1 | solute carrier organic anion transporter family, member 2B1 | 0.0054975 |
| IL16 | interleukin 16 | 0.00548573 |
| OPTN | optineurin | 0.00548335 |
| GOLGA8H | golgin A8 family, member H | 0.00547588 |
| PLPP2 | phospholipid phosphatase 2 | 0.00546932 |
| PLXNA1 | plexin A1 | 0.00546721 |
| TSPAN8 | tetraspanin 8 | 0.00546042 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00545938 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.00545265 |
| KCNQ1 | potassium channel, voltage gated KQT-like subfamily Q, member 1 | 0.00544397 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00544131 |
| VILL | villin-like | 0.00543241 |
| TXLNA | taxilin alpha | 0.0054257 |
| MED1 | mediator complex subunit 1 | 0.00540892 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 0.00540737 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.00540415 |
| GUCY2C | guanylate cyclase 2C | 0.00539841 |
| DOCK9 | dedicator of cytokinesis 9 | 0.00538429 |
| CCR2 | chemokine (C-C motif) receptor 2 | 0.0053585 |
| SLC35E3 | solute carrier family 35, member E3 | 0.00534685 |
| EPS8L3 | EPS8-like 3 | 0.00533888 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00533482 |
| EPHA2 | EPH receptor A2 | 0.00532889 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.00532596 |
| TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | 0.00532193 |
| CCNL2 | cyclin L2 | 0.00531649 |
| IL2RG | interleukin 2 receptor, gamma | 0.00531493 |
| SLAMF8 | SLAM family member 8 | 0.00529483 |
| P2RY13 | purinergic receptor P2Y, G-protein coupled, 13 | 0.00529402 |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.00528059 |
| ANGPTL4 | angiopoietin-like 4 | 0.00527854 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0052714 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | 0.00526867 |
| ABHD2 | abhydrolase domain containing 2 | 0.00525932 |
| TDO2 | tryptophan 2,3-dioxygenase | 0.00525818 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00524103 |
| FBL | fibrillarin | 0.00523001 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | 0.00522884 |
| FKBP5 | FK506 binding protein 5 | 0.00522432 |
| COQ8A | coenzyme Q8A | 0.00519481 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 0.00519328 |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 0.00518684 |
| SRM | spermidine synthase | 0.00518524 |
| RGS5 | regulator of G-protein signaling 5 | 0.00515793 |
| PAPOLG | poly(A) polymerase gamma | 0.00515041 |
| FZD6 | frizzled class receptor 6 | 0.00514536 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | 0.00514035 |
| CXXC1 | CXXC finger protein 1 | 0.00514016 |
| TXNL4A | thioredoxin-like 4A | 0.00513445 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0051231 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | 0.00512222 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00512158 |
| PER2 | period circadian clock 2 | 0.0051194 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00511341 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00511178 |
| DMD | dystrophin | 0.00510644 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 0.00510616 |
| PLK1 | polo-like kinase 1 | 0.00510038 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.00508679 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 0.00508239 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00507791 |
| C2 | complement component 2 | 0.00506943 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.00506896 |
| NEK3 | NIMA-related kinase 3 | 0.00505286 |
| CYB561 | cytochrome b561 | 0.00504828 |
| TSPO | translocator protein (18kDa) | 0.00502891 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.0050249 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.00502466 |
| ADRA2A | adrenoceptor alpha 2A | 0.0050181 |
| HECA | headcase homolog (Drosophila) | 0.00501646 |
| LYZ | lysozyme | 0.0050152 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0172011 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.0150135 |
| PRR7 | proline rich 7 (synaptic) | -0.0138241 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0130609 |
| MMP7 | matrix metallopeptidase 7 | -0.0124389 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0119057 |
| ABHD4 | abhydrolase domain containing 4 | -0.0117168 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0116661 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.0111718 |
| MAP7 | microtubule-associated protein 7 | -0.0107751 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0107494 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.0105362 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.0103541 |
| MEIS1 | Meis homeobox 1 | -0.0103419 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0102742 |
| RAPSN | receptor-associated protein of the synapse | -0.0101321 |
| LTF | lactotransferrin | -0.0101189 |
| SYT1 | synaptotagmin I | -0.00986532 |
| BEX1 | brain expressed, X-linked 1 | -0.00953438 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00926558 |
| FLNA | filamin A, alpha | -0.00926033 |
| G6PD | glucose-6-phosphate dehydrogenase | -0.00925613 |
| PLAT | plasminogen activator, tissue | -0.00886861 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00853995 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00845872 |
| LXN | latexin | -0.00832184 |
| CCNB2 | cyclin B2 | -0.00831801 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00828769 |
| STC2 | stanniocalcin 2 | -0.00815833 |
| FOXC1 | forkhead box C1 | -0.00811617 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00810118 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.0080766 |
| DSP | desmoplakin | -0.00798255 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00789122 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00787828 |
| GPC3 | glypican 3 | -0.00786486 |
| NXN | nucleoredoxin | -0.00784971 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00784078 |
| CD99 | CD99 molecule | -0.00783698 |
| PLIN2 | perilipin 2 | -0.00782942 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00782417 |
| S100A4 | S100 calcium binding protein A4 | -0.00782064 |
| AHSP | alpha hemoglobin stabilizing protein | -0.00779414 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | -0.0077725 |
| HAT1 | histone acetyltransferase 1 | -0.00773133 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00771019 |
| WASF1 | WAS protein family, member 1 | -0.00769977 |
| S100A8 | S100 calcium binding protein A8 | -0.00769848 |
| CTSZ | cathepsin Z | -0.00760999 |
| WBP5 | WW domain binding protein 5 | -0.00759484 |
| CST6 | cystatin E/M | -0.00756266 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -0.00749835 |
| MEIS2 | Meis homeobox 2 | -0.00746344 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0074304 |
| TSPAN6 | tetraspanin 6 | -0.00742323 |
| DUSP2 | dual specificity phosphatase 2 | -0.00742177 |
| ANXA3 | annexin A3 | -0.00741186 |
| KRT19 | keratin 19, type I | -0.00740962 |
| STK10 | serine/threonine kinase 10 | -0.00740566 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.00738762 |
| WLS | wntless Wnt ligand secretion mediator | -0.00737404 |
| MREG | melanoregulin | -0.00732211 |
| TRIB3 | tribbles pseudokinase 3 | -0.00730893 |
| MORF4L1 | mortality factor 4 like 1 | -0.00729726 |
| FGR | FGR proto-oncogene, Src family tyrosine kinase | -0.00728997 |
| WDR61 | WD repeat domain 61 | -0.00728853 |
| S100A7 | S100 calcium binding protein A7 | -0.00727145 |
| CD83 | CD83 molecule | -0.00725244 |
| KIF20A | kinesin family member 20A | -0.00724683 |
| HOXA10 | homeobox A10 | -0.00723449 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00717634 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00716288 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00709353 |
| MSMO1 | methylsterol monooxygenase 1 | -0.00705261 |
| ABHD6 | abhydrolase domain containing 6 | -0.00704759 |
| HBD | hemoglobin, delta | -0.00702967 |
| SLC25A46 | solute carrier family 25, member 46 | -0.00699164 |
| FOXF1 | forkhead box F1 | -0.00698839 |
| DLD | dihydrolipoamide dehydrogenase | -0.00694661 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00689364 |
| WASHC4 | WASH complex subunit 4 | -0.00688616 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.00688043 |
| PRKCB | protein kinase C, beta | -0.0068668 |
| FASN | fatty acid synthase | -0.00686257 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00682968 |
| MPO | myeloperoxidase | -0.00682354 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.00681253 |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | -0.0067987 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00679779 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.00679401 |
| NKX3-1 | NK3 homeobox 1 | -0.00678053 |
| ACTN1 | actinin, alpha 1 | -0.00674062 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.00671775 |
| KIF1A | kinesin family member 1A | -0.00668946 |
| MMP11 | matrix metallopeptidase 11 | -0.00664894 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00664559 |
| S100A9 | S100 calcium binding protein A9 | -0.00664168 |
| LRRC17 | leucine rich repeat containing 17 | -0.00661373 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0066108 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | -0.00660886 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.00655463 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00654502 |
| MATN2 | matrilin 2 | -0.00654038 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.00651991 |
| EMP2 | epithelial membrane protein 2 | -0.00649515 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00649285 |
| TYROBP | TYRO protein tyrosine kinase binding protein | -0.00648203 |
| USP3 | ubiquitin specific peptidase 3 | -0.00648011 |
| REEP1 | receptor accessory protein 1 | -0.00647401 |
| COLEC12 | collectin sub-family member 12 | -0.00645252 |
| CALD1 | caldesmon 1 | -0.00643515 |
| C5ORF28 | chromosome 5 open reading frame 28 | -0.00643451 |
| PSPH | phosphoserine phosphatase | -0.00639548 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | -0.00639517 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00638802 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00637885 |
| ENDOD1 | endonuclease domain containing 1 | -0.00636517 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.00635414 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00634134 |
| DHCR7 | 7-dehydrocholesterol reductase | -0.00634052 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00630266 |
| LRRC1 | leucine rich repeat containing 1 | -0.00629618 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00629254 |
| SRGN | serglycin | -0.00626283 |
| LPXN | leupaxin | -0.00624398 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00624 |
| ESM1 | endothelial cell-specific molecule 1 | -0.00623273 |
| CHMP4A | charged multivesicular body protein 4A | -0.00617841 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00617672 |
| CPE | carboxypeptidase E | -0.00617174 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.00617113 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.00614305 |
| MAPT | microtubule-associated protein tau | -0.00612136 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00611992 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.00607591 |
| CLEC11A | C-type lectin domain family 11, member A | -0.00606249 |
| COL1A2 | collagen, type I, alpha 2 | -0.00605553 |
| KLHL23 | kelch-like family member 23 | -0.00605098 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -0.00602203 |
| PCLAF | PCNA clamp associated factor | -0.00598648 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00596383 |
| FADS1 | fatty acid desaturase 1 | -0.00594596 |
| GAL | galanin/GMAP prepropeptide | -0.00591513 |
| RAB38 | RAB38, member RAS oncogene family | -0.00591283 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00589656 |
| TLR4 | toll-like receptor 4 | -0.00586677 |
| PAPSS1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | -0.00585698 |
| JADE3 | jade family PHD finger 3 | -0.00585469 |
| KAZN | kazrin, periplakin interacting protein | -0.00585021 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00584241 |
| NELL1 | NEL-like 1 (chicken) | -0.00582795 |
| WWC1 | WW and C2 domain containing 1 | -0.0058222 |
| HPCAL1 | hippocalcin-like 1 | -0.00581209 |
| KCNG1 | potassium channel, voltage gated modifier subfamily G, member 1 | -0.00581108 |
| PLA2G12A | phospholipase A2, group XIIA | -0.00580597 |
| TRAF5 | TNF receptor-associated factor 5 | -0.00578343 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.0057741 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.00575985 |
| L1CAM | L1 cell adhesion molecule | -0.00575933 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -0.00574927 |
| AMD1 | adenosylmethionine decarboxylase 1 | -0.00574573 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00574232 |
| TMED7 | transmembrane emp24 protein transport domain containing 7 | -0.0057102 |
| ANXA6 | annexin A6 | -0.00570295 |
| VANGL1 | VANGL planar cell polarity protein 1 | -0.0057017 |
| FOLR1 | folate receptor 1 (adult) | -0.00570021 |
| CD69 | CD69 molecule | -0.00568976 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.00567493 |
| NEK2 | NIMA-related kinase 2 | -0.00567262 |
| MEA1 | male-enhanced antigen 1 | -0.00567202 |
| NPTX1 | neuronal pentraxin I | -0.00565576 |
| HOXA11 | homeobox A11 | -0.00565295 |
| NPR3 | natriuretic peptide receptor 3 | -0.0056466 |
| COMMD8 | COMM domain containing 8 | -0.00561425 |
| CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | -0.00561321 |
| PCP4 | Purkinje cell protein 4 | -0.00561174 |
| RGCC | regulator of cell cycle | -0.00561163 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.00559229 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | -0.00557961 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.00557764 |
| NPTN | neuroplastin | -0.00557377 |
| TGM2 | transglutaminase 2 | -0.00556367 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.00555364 |
| PDE9A | phosphodiesterase 9A | -0.00553717 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 | -0.00551503 |
| MOAP1 | modulator of apoptosis 1 | -0.00549611 |
| UBE2N | ubiquitin-conjugating enzyme E2N | -0.00549607 |
| COL3A1 | collagen, type III, alpha 1 | -0.00548826 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.00548806 |
| MAGEB2 | melanoma antigen family B2 | -0.00548539 |
| HPN | hepsin | -0.00548119 |
| C1ORF115 | chromosome 1 open reading frame 115 | -0.00547553 |
| FOXF2 | forkhead box F2 | -0.00546684 |
| FAF2 | Fas associated factor family member 2 | -0.00545673 |
| ORC4 | origin recognition complex, subunit 4 | -0.00545598 |
| MAPK1 | mitogen-activated protein kinase 1 | -0.00540195 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | -0.00538215 |
| SQLE | squalene epoxidase | -0.00537927 |
| HOPX | HOP homeobox | -0.00535813 |
| RND1 | Rho family GTPase 1 | -0.005348 |
| DMBT1 | deleted in malignant brain tumors 1 | -0.0053156 |
| PCNA | proliferating cell nuclear antigen | -0.00528127 |
| STX3 | syntaxin 3 | -0.00524154 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | -0.00523788 |
| GCA | grancalcin, EF-hand calcium binding protein | -0.00520953 |
| MNDA | myeloid cell nuclear differentiation antigen | -0.00520715 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00520064 |
| SC5D | sterol-C5-desaturase | -0.0052003 |
| F12 | coagulation factor XII (Hageman factor) | -0.00519354 |
| TPM4 | tropomyosin 4 | -0.00518929 |
| EXPH5 | exophilin 5 | -0.00518685 |
| GDF15 | growth differentiation factor 15 | -0.00518086 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00518041 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.00518033 |
| PDCD10 | programmed cell death 10 | -0.00517556 |
| HIRA | histone cell cycle regulator | -0.00517137 |
| KLK5 | kallikrein-related peptidase 5 | -0.00517066 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.0051645 |
| CD52 | CD52 molecule | -0.00515541 |
| ELN | elastin | -0.00515232 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00514653 |
| LYPD1 | LY6/PLAUR domain containing 1 | -0.00513263 |
| NVL | nuclear VCP-like | -0.00511659 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.00511616 |
| THAP10 | THAP domain containing 10 | -0.00511614 |
| PENK | proenkephalin | -0.00510013 |
| TAOK3 | TAO kinase 3 | -0.00508173 |
| TUBA3D | tubulin, alpha 3d | -0.00507899 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00507487 |
| LCN2 | lipocalin 2 | -0.00506971 |
| KLK6 | kallikrein-related peptidase 6 | -0.00506818 |
| CD9 | CD9 molecule | -0.00506729 |
| LAMB1 | laminin, beta 1 | -0.00506658 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00506418 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00506394 |
| FZD2 | frizzled class receptor 2 | -0.00506162 |
| TRIM16 | tripartite motif containing 16 | -0.0050563 |
| TEX30 | testis expressed 30 | -0.00505409 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -0.00504665 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | -0.00504524 |
| MSMB | microseminoprotein, beta- | -0.00504063 |
| LOX | lysyl oxidase | -0.00502912 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | -0.00501707 |
| PLSCR4 | phospholipid scramblase 4 | -0.00500512 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00500425 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.00500336 |
| UBA3 | ubiquitin-like modifier activating enzyme 3 | -0.00500118 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.00499943 |
| KLF10 | Kruppel-like factor 10 | -0.00499668 |
