F2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description coagulation factor II (thrombin)|Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 2147)
External Link http://www.ncbi.nlm.nih.gov/gene/2147
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228 interacting proteins for F2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
A2M alpha-2-macroglobulin
AANAT aralkylamine N-acetyltransferase
ADRA1B adrenoceptor alpha 1B
AGA aspartylglucosaminidase
AHSG alpha-2-HS-glycoprotein
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
AMPD3 adenosine monophosphate deaminase 3
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APCS amyloid P component, serum
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOM apolipoprotein M
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATM ATM serine/threonine kinase
BBC3 BCL2 binding component 3
C1QBP complement component 1, q subcomponent binding protein
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
C6 complement component 6
C9 complement component 9
CABLES1 Cdk5 and Abl enzyme substrate 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMTA1 calmodulin binding transcription activator 1
CD5L CD5 molecule-like
CDC45 cell division cycle 45
CDCP1 CUB domain containing protein 1
CEP44 centrosomal protein 44kDa
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CHKB choline kinase beta
CLCA2 chloride channel accessory 2
CLU clusterin
CNOT1 CCR4-NOT transcription complex, subunit 1
COL6A6 collagen, type VI, alpha 6
CP ceruloplasmin (ferroxidase)
CPB2 carboxypeptidase B2 (plasma)
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CROT carnitine O-octanoyltransferase
CST3 cystatin C
CTAGE5 CTAGE family, member 5
DCC DCC netrin 1 receptor
DCD dermcidin
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT3 DNA-damage-inducible transcript 3
DERL1 derlin 1
DGKG diacylglycerol kinase, gamma 90kDa
DICER1 dicer 1, ribonuclease type III
DMD dystrophin
DNA2 DNA replication helicase/nuclease 2
DUOX1 dual oxidase 1
EPYC epiphycan
EXOC6 exocyst complex component 6
F10 coagulation factor X
F11 coagulation factor XI
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FAM71E2 family with sequence similarity 71, member E2
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
FURIN furin (paired basic amino acid cleaving enzyme)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GC group-specific component (vitamin D binding protein)
GCC2 GRIP and coiled-coil domain containing 2
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GFAP glial fibrillary acidic protein
GGCX gamma-glutamyl carboxylase
GJC2 gap junction protein, gamma 2, 47kDa
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP1BB glycoprotein Ib (platelet), beta polypeptide
GP5 glycoprotein V (platelet)
GP9 glycoprotein IX (platelet)
GRAP2 GRB2-related adaptor protein 2
GSN gelsolin
HBA2 hemoglobin, alpha 2
HGFAC HGF activator
HP haptoglobin
HPR haptoglobin-related protein
HPX hemopexin
HRG histidine-rich glycoprotein
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGKC immunoglobulin kappa constant
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLL5 immunoglobulin lambda-like polypeptide 5
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JARID2 jumonji, AT rich interactive domain 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0232 KIAA0232
KIAA0753 KIAA0753
KIAA1551 KIAA1551
KIRREL kin of IRRE like (Drosophila)
KLC1 kinesin light chain 1
KLK3 kallikrein-related peptidase 3
KNG1 kininogen 1
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT9 keratin 9, type I
LAT linker for activation of T cells
LBP lipopolysaccharide binding protein
LDB3 LIM domain binding 3
LUM lumican
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK3 myosin light chain kinase 3
NCOA3 nuclear receptor coactivator 3
NLRC4 NLR family, CARD domain containing 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
OBSL1 obscurin-like 1
OPTN optineurin
OR2T6 olfactory receptor, family 2, subfamily T, member 6
OR3A2 olfactory receptor, family 3, subfamily A, member 2
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene)
ORM2 orosomucoid 2
PALB2 partner and localizer of BRCA2
PCDH1 protocadherin 1
PCED1B PC-esterase domain containing 1B
PDE4B phosphodiesterase 4B, cAMP-specific
PDZRN4 PDZ domain containing ring finger 4
PEG3 paternally expressed 3
PF4V1 platelet factor 4 variant 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PLA2G4F phospholipase A2, group IVF
PLAG1 pleiomorphic adenoma gene 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLG plasminogen
PON1 paraoxonase 1
PON3 paraoxonase 3
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PROS1 protein S (alpha)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRSS1 protease, serine, 1 (trypsin 1)
PRSS3 protease, serine, 3
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RANBP2 RAN binding protein 2
RANBP3 RAN binding protein 3
RLF rearranged L-myc fusion
RYR2 ryanodine receptor 2 (cardiac)
SAA2 serum amyloid A2
SAA4 serum amyloid A4, constitutive
SACS sacsin molecular chaperone
SCAF1 SR-related CTD-associated factor 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SETX senataxin
SGOL2 shugoshin-like 2 (S. pombe)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHBG sex hormone-binding globulin
SLA2 Src-like-adaptor 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SORBS3 sorbin and SH3 domain containing 3
SPAST spastin
SPATA31A7 SPATA31 subfamily A, member 7
SPP1 secreted phosphoprotein 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
THBD thrombomodulin
THBS1 thrombospondin 1
THRAP3 thyroid hormone receptor associated protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN2 talin 2
TRAPPC11 trafficking protein particle complex 11
TRIM33 tripartite motif containing 33
TSC22D1 TSC22 domain family, member 1
TTN titin
TTPAL tocopherol (alpha) transfer protein-like
TTR transthyretin
UBE2L3 ubiquitin-conjugating enzyme E2L 3
VTN vitronectin
VWF von Willebrand factor
ZNF232 zinc finger protein 232
ZNF292 zinc finger protein 292
ZYX zyxin