FADD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Fas (TNFRSF6)-associated via death domain|The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8772)
Similar Terms
Downloads & Tools

Genes

293 genes differentially expressed following the FADD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.80302
GLYAT glycine-N-acyltransferase 2.80302
PNMA5 paraneoplastic Ma antigen family member 5 2.80302
TM4SF20 transmembrane 4 L six family member 20 2.80302
RRAD Ras-related associated with diabetes 2.80302
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.80302
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.80302
MTTP microsomal triglyceride transfer protein 2.80302
FETUB fetuin B 2.80302
PRSS41 protease, serine, 41 2.80302
GLUD2 glutamate dehydrogenase 2 2.80302
CTRL chymotrypsin-like 2.80302
ACTG2 actin, gamma 2, smooth muscle, enteric 2.80302
HEATR9 HEAT repeat containing 9 2.80302
OR4F17 olfactory receptor, family 4, subfamily F, member 17 2.80302
PTX3 pentraxin 3, long 2.80302
CELF6 CUGBP, Elav-like family member 6 2.80302
IL22RA1 interleukin 22 receptor, alpha 1 2.80302
MAGEA2 melanoma antigen family A2 2.80302
PLCH2 phospholipase C, eta 2 2.80302
ASB17 ankyrin repeat and SOCS box containing 17 2.80302
RSPO1 R-spondin 1 2.80302
DOK2 docking protein 2, 56kDa 2.80302
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.80302
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.80302
BFSP2 beaded filament structural protein 2, phakinin 2.80302
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.80302
PRDM12 PR domain containing 12 2.80302
GALR3 galanin receptor 3 2.80302
GRP gastrin-releasing peptide 2.80302
RGPD4 RANBP2-like and GRIP domain containing 4 2.80302
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.80302
NEU4 sialidase 4 2.80302
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.80302
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.80302
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.80302
ANKRD34A ankyrin repeat domain 34A 2.80302
CA9 carbonic anhydrase IX 2.80302
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.80302
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.80302
SPACA3 sperm acrosome associated 3 2.80302
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.80302
LRTM3 leucine rich repeat transmembrane protein 3 2.80302
CAVIN2 caveolae associated protein 2 2.80302
SAPCD1 suppressor APC domain containing 1 2.80302
CMA1 chymase 1, mast cell 2.80302
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.80302
SRGN serglycin 2.80302
NUP37 nucleoporin 37kDa 2.80302
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.80302
ASIC3 acid sensing (proton gated) ion channel 3 2.80302
STING1 stimulator of interferon response cGAMP interactor 1 2.80302
FAM237B family with sequence similarity 237 member B 2.80302
SPATA31H1 SPATA31 subfamily H member 1 2.80302
FAM240C family with sequence similarity 240 member C 2.80302
NOTCH2NLB notch 2 N-terminal like B 2.80302
PRRT1B proline rich transmembrane protein 1B 2.80302
ACP4 acid phosphatase 4 2.80302
DNAAF6 dynein axonemal assembly factor 6 2.80302
MEIOSIN meiosis initiator 2.80302
P3R3URF PIK3R3 upstream open reading frame 2.80302
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.80302
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.80302
CELA2A chymotrypsin-like elastase family, member 2A 2.80302
DTHD1 death domain containing 1 2.80302
ACTL10 actin-like 10 2.80302
TBX20 T-box 20 2.80302
TBX21 T-box 21 2.80302
RAET1G retinoic acid early transcript 1G 2.80302
KLHL35 kelch-like family member 35 2.80302
CD93 CD93 molecule 2.80302
MYBPHL myosin binding protein H-like 2.80302
PTPRC protein tyrosine phosphatase, receptor type, C 2.80302
EDAR ectodysplasin A receptor 2.80302
CDSN corneodesmosin 2.80302
MIA melanoma inhibitory activity 2.80302
GDF10 growth differentiation factor 10 2.80302
TLR7 toll-like receptor 7 2.80302
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.80302
LDHAL6B lactate dehydrogenase A-like 6B 2.80302
IDO2 indoleamine 2,3-dioxygenase 2 2.80302
MEOX1 mesenchyme homeobox 1 2.80302
PARP3 poly (ADP-ribose) polymerase family, member 3 2.80302
HIC1 hypermethylated in cancer 1 2.80302
ITGAD integrin, alpha D 2.80302
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.80302
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.80302
SPATA4 spermatogenesis associated 4 2.80302
PLET1 placenta expressed transcript 1 2.80302
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.80302
GLOD5 glyoxalase domain containing 5 2.80302
CYSLTR1 cysteinyl leukotriene receptor 1 2.80302
CLRN2 clarin 2 2.80302
EFCAB9 EF-hand calcium binding domain 9 2.80302
CLEC4G C-type lectin domain family 4, member G 2.80302
CST9 cystatin 9 (testatin) 2.80302
CST1 cystatin SN 2.80302
CSTA cystatin A (stefin A) 2.80302
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.80302
DYDC1 DPY30 domain containing 1 2.80302
CT55 cancer/testis antigen 55 2.80302
CLIC5 chloride intracellular channel 5 2.80302
EVPLL envoplakin-like 2.80302
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.80302
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.80302
GOLGA8R golgin A8 family, member R 2.80302
GOLGA8N golgin A8 family, member N 2.80302
SRRD SRR1 domain containing 2.80302
LMX1B LIM homeobox transcription factor 1, beta 2.80302
MGP matrix Gla protein 2.80302
PHGR1 proline/histidine/glycine-rich 1 2.80302
QRFP pyroglutamylated RFamide peptide 2.80302
IBSP integrin-binding sialoprotein 2.80302
PRH2 proline-rich protein HaeIII subfamily 2 2.80302
MAGED4B melanoma antigen family D4B 2.80302
GFRAL GDNF family receptor alpha like 2.80302
MORN5 MORN repeat containing 5 2.80302
PTHLH parathyroid hormone-like hormone 2.80302
UTS2B urotensin 2B 2.80302
TEX12 testis expressed 12 2.80302
ANKRD20A1 ankyrin repeat domain 20 family, member A1 2.80302
TRIM29 tripartite motif containing 29 2.80302
NPR3 natriuretic peptide receptor 3 2.80302
APOA5 apolipoprotein A-V 2.80302
LRRC74B leucine rich repeat containing 74B 2.80302
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.80302
ZPLD1 zona pellucida-like domain containing 1 2.80302
AQP1 aquaporin 1 (Colton blood group) 2.80302
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.80302
DUOXA1 dual oxidase maturation factor 1 2.80302
RGS4 regulator of G-protein signaling 4 2.80302
WFDC10A WAP four-disulfide core domain 10A 2.80302
NRGN neurogranin (protein kinase C substrate, RC3) 2.80302
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.80302
ADAM29 ADAM metallopeptidase domain 29 2.80302
POTEI POTE ankyrin domain family, member I 2.80302
GREM1 gremlin 1, DAN family BMP antagonist 2.80302
ACKR2 atypical chemokine receptor 2 2.80302
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.80302
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.80302
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.80302
CD34 CD34 molecule 2.80302
TECRL trans-2,3-enoyl-CoA reductase-like 2.80302
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.80302
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.80302
WBP2NL WBP2 N-terminal like 2.7389
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2.66943
MED13L mediator complex subunit 13-like 2.66592
TRIM39 tripartite motif containing 39 2.66592
NICOL1 NELL2 interacting cell ontogeny regulator 1 2.62852
PARP14 poly (ADP-ribose) polymerase family, member 14 2.62706
MON2 MON2 homolog (S. cerevisiae) 2.62706
TMEM238 transmembrane protein 238 2.59743
SECISBP2 SECIS binding protein 2 2.56417
PAX6 paired box 6 2.49084
RPS8 ribosomal protein S8 2.47097
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 2.3831
CA11 carbonic anhydrase XI 2.38075
ZXDB zinc finger, X-linked, duplicated B 2.3722
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta 2.37062
IFFO1 intermediate filament family orphan 1 2.36884
EDNRB endothelin receptor type B 2.35904
SNTG2 syntrophin, gamma 2 2.35777
OIP5 Opa interacting protein 5 2.34885
CERS6 ceramide synthase 6 2.31004
STAMBP STAM binding protein 2.30359
PWWP3A PWWP domain containing 3A, DNA repair factor 2.3035
MRFAP1L1 Morf4 family associated protein 1-like 1 2.24445
TARBP2 TAR (HIV-1) RNA binding protein 2 2.22932
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 2.22122
SPA17 sperm autoantigenic protein 17 2.21434
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 2.16464
ZNF546 zinc finger protein 546 2.14056
SEC61B Sec61 beta subunit 2.12854
STARD3NL STARD3 N-terminal like 2.12564
DPEP3 dipeptidase 3 2.12511
PKDCC protein kinase domain containing, cytoplasmic 2.10694
RNPS1 RNA binding protein S1, serine-rich domain 2.10638
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.10452
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 2.10034
LIG1 ligase I, DNA, ATP-dependent 2.0873
OSBPL5 oxysterol binding protein-like 5 2.07596
RPL22 ribosomal protein L22 2.07087
RPS16 ribosomal protein S16 2.06805
CEP95 centrosomal protein 95kDa 2.05966
GLUL glutamate-ammonia ligase 2.04932
SCART1 scavenger receptor protein family member 2.04165
SPIN1 spindlin 1 2.03209
ITM2B integral membrane protein 2B 2.01824
RBM22 RNA binding motif protein 22 2.01824
CFL2 cofilin 2 (muscle) 2.00124

decreased expression

Symbol Name Standardized Value
SPATC1 spermatogenesis and centriole associated 1 -2.80302
ZNHIT2 zinc finger, HIT-type containing 2 -2.80302
FAM131B family with sequence similarity 131, member B -2.80302
ZNF230 zinc finger protein 230 -2.80302
SMAD2 SMAD family member 2 -2.80302
IGIP IgA-inducing protein -2.80302
LARP1B La ribonucleoprotein domain family, member 1B -2.80302
CNTNAP3 contactin associated protein-like 3 -2.80302
RAB8A RAB8A, member RAS oncogene family -2.80302
FOXJ1 forkhead box J1 -2.80302
SCARA3 scavenger receptor class A, member 3 -2.80302
ZHX3 zinc fingers and homeoboxes 3 -2.80302
DIO2 deiodinase, iodothyronine, type II -2.77665
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.67455
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.66943
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.62706
TMEM217 transmembrane protein 217 -2.62706
SFXN3 sideroflexin 3 -2.62706
LKAAEAR1 LKAAEAR motif containing 1 -2.62706
OC90 otoconin 90 -2.62706
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.62706
TDRD1 tudor domain containing 1 -2.62706
SLC9C2 solute carrier family 9, member C2 (putative) -2.62706
VCX variable charge, X-linked -2.62706
HCST hematopoietic cell signal transducer -2.62706
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.62706
SNAI2 snail family zinc finger 2 -2.62706
RUMY2 RUMY family member 2 -2.62706
HES3 hes family bHLH transcription factor 3 -2.62706
SLC22A14 solute carrier family 22, member 14 -2.62706
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.62706
CFAP206 cilia and flagella associated protein 206 -2.62706
TAFA3 TAFA chemokine like family member 3 -2.62706
FOXN4 forkhead box N4 -2.62706
MROH5 maestro heat-like repeat family member 5 -2.62706
MTMR11 myotubularin related protein 11 -2.62706
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -2.62706
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.62706
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.62706
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.62706
CKM creatine kinase, muscle -2.62706
GCOM1 GRINL1A complex locus 1 -2.62706
AXDND1 axonemal dynein light chain domain containing 1 -2.62706
TMIE transmembrane inner ear -2.62706
CD177 CD177 molecule -2.62706
RNF170 ring finger protein 170 -2.61608
PCDHGB6 protocadherin gamma subfamily B, 6 -2.59743
RASD2 RASD family, member 2 -2.59743
RASAL2 RAS protein activator like 2 -2.59743
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.59743
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -2.585
ZFYVE19 zinc finger, FYVE domain containing 19 -2.58376
SCML1 sex comb on midleg-like 1 (Drosophila) -2.54999
TTC5 tetratricopeptide repeat domain 5 -2.54927
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.54588
UBE2K ubiquitin-conjugating enzyme E2K -2.51614
UGDH UDP-glucose 6-dehydrogenase -2.51226
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -2.49172
DNAH10 dynein, axonemal, heavy chain 10 -2.3734
IGSF6 immunoglobulin superfamily, member 6 -2.3734
ABI3 ABI family, member 3 -2.3734
EPPK1 epiplakin 1 -2.36884
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.34545
SIRAL1 SIR2 antiphage like 1 -2.34139
TRIML2 tripartite motif family-like 2 -2.33485
CA4 carbonic anhydrase IV -2.3035
CEBPZOS CEBPZ opposite strand -2.30161
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.27044
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.26614
CD52 CD52 molecule -2.26614
GPR68 G protein-coupled receptor 68 -2.26614
QRFPR pyroglutamylated RFamide peptide receptor -2.26074
EVI5 ecotropic viral integration site 5 -2.24871
TOM1L1 target of myb1 (chicken)-like 1 -2.22163
USP3 ubiquitin specific peptidase 3 -2.21416
BAK1 BCL2-antagonist/killer 1 -2.20518
TRIM38 tripartite motif containing 38 -2.19963
SFXN1 sideroflexin 1 -2.1765
SORBS2 sorbin and SH3 domain containing 2 -2.17368
OFD1 oral-facial-digital syndrome 1 -2.16449
SOBP sine oculis binding protein homolog (Drosophila) -2.15477
SRSF11 serine/arginine-rich splicing factor 11 -2.15362
WDR89 WD repeat domain 89 -2.13216
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 -2.13216
TRMT10B tRNA methyltransferase 10 homolog B (S. cerevisiae) -2.12738
MMP3 matrix metallopeptidase 3 -2.11223
KTN1 kinectin 1 (kinesin receptor) -2.09367
CYB5R2 cytochrome b5 reductase 2 -2.09294
TECPR1 tectonin beta-propeller repeat containing 1 -2.08893
KMT5C lysine methyltransferase 5C -2.07739
INO80D INO80 complex subunit D -2.07098
ARMCX3 armadillo repeat containing, X-linked 3 -2.06996
LIMS1 LIM and senescent cell antigen-like domains 1 -2.06566
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.04892
NPW neuropeptide W -2.04892
MED10 mediator complex subunit 10 -2.03667
SPEN spen family transcriptional repressor -2.03209
SLC16A14 solute carrier family 16, member 14 -2.024
GEMIN4 gem (nuclear organelle) associated protein 4 -2.02091
RBMS1 RNA binding motif, single stranded interacting protein 1 -2.01946
WNK1 WNK lysine deficient protein kinase 1 -2.01824
COL1A1 collagen, type I, alpha 1 -2.00899