FADD Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description Fas (TNFRSF6)-associated via death domain|The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8772)
External Link http://www.ncbi.nlm.nih.gov/gene/8772
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Genes

90 interacting proteins for FADD from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
AURKA aurora kinase A
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMX BMX non-receptor tyrosine kinase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
CLIP3 CAP-GLY domain containing linker protein 3
CLTC clathrin, heavy chain (Hc)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CSNK1A1 casein kinase 1, alpha 1
CUL3 cullin 3
DAP3 death associated protein 3
DAPK1 death-associated protein kinase 1
DAXX death-domain associated protein
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DEDD death effector domain containing
EDA2R ectodysplasin A2 receptor
EDAR ectodysplasin A receptor
EZR ezrin
FAF1 Fas (TNFRSF6) associated factor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
HIPK3 homeodomain interacting protein kinase 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK1 interleukin-1 receptor-associated kinase 1
IRF7 interferon regulatory factor 7
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MADD MAP-kinase activating death domain
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MAVS mitochondrial antiviral signaling protein
MBD4 methyl-CpG binding domain protein 4
MKRN1 makorin ring finger protein 1
MOB4 MOB family member 4, phocein
MSN moesin
MYD88 myeloid differentiation primary response 88
NACA nascent polypeptide-associated complex alpha subunit
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRF1 nuclear respiratory factor 1
OTUD7B OTU deubiquitinase 7B
PARK7 parkinson protein 7
PEA15 phosphoprotein enriched in astrocytes 15
PLK1 polo-like kinase 1
PRKCZ protein kinase C, zeta
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RALBP1 ralA binding protein 1
RALGDS ral guanine nucleotide dissociation stimulator
RAP1A RAP1A, member of RAS oncogene family
RDX radixin
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
RYBP RING1 and YY1 binding protein
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPOP speckle-type POZ protein
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SUMO1 small ubiquitin-like modifier 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRIM21 tripartite motif containing 21
UBC ubiquitin C
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO5 exportin 5
YES1 YES proto-oncogene 1, Src family tyrosine kinase