| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | Fas cell surface death receptor|The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 355) |
| External Link | https://ncbi.nlm.nih.gov/gene/355 |
| Similar Terms | |
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498 genes differentially expressed following the FAS gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0090874 |
| MAGEA3 | melanoma antigen family A3 | 0.00899612 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.00876348 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00783774 |
| DSP | desmoplakin | 0.00701408 |
| IPO13 | importin 13 | 0.00673834 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00645484 |
| POSTN | periostin, osteoblast specific factor | 0.00640109 |
| CCN3 | cellular communication network factor 3 | 0.00632385 |
| CYB561 | cytochrome b561 | 0.00624003 |
| MAGEA12 | melanoma antigen family A12 | 0.00598676 |
| NPY | neuropeptide Y | 0.00595316 |
| S100A9 | S100 calcium binding protein A9 | 0.00588911 |
| BEX1 | brain expressed, X-linked 1 | 0.00580469 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00565536 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | 0.0056082 |
| S100A7 | S100 calcium binding protein A7 | 0.00558536 |
| LRRC8D | leucine rich repeat containing 8 family, member D | 0.00547621 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00545181 |
| VCAN | versican | 0.0054065 |
| ZNF91 | zinc finger protein 91 | 0.00530919 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00518306 |
| RGS4 | regulator of G-protein signaling 4 | 0.00511037 |
| PERP | PERP, TP53 apoptosis effector | 0.00504516 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.00501423 |
| LTF | lactotransferrin | 0.00497539 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00496442 |
| CD320 | CD320 molecule | 0.00494019 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00491996 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 0.00489949 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00486834 |
| C3 | complement component 3 | 0.00485495 |
| CLEC7A | C-type lectin domain family 7, member A | 0.00482656 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.00481896 |
| TRIB3 | tribbles pseudokinase 3 | 0.00480667 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00478582 |
| TOX3 | TOX high mobility group box family member 3 | 0.00475636 |
| S100A8 | S100 calcium binding protein A8 | 0.0047391 |
| NTS | neurotensin | 0.0047321 |
| GAS1 | growth arrest-specific 1 | 0.00472443 |
| OPHN1 | oligophrenin 1 | 0.00471987 |
| KYNU | kynureninase | 0.00465134 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00462964 |
| TFF1 | trefoil factor 1 | 0.00456476 |
| THBS1 | thrombospondin 1 | 0.00452341 |
| SCD5 | stearoyl-CoA desaturase 5 | 0.00451057 |
| TDO2 | tryptophan 2,3-dioxygenase | 0.00446028 |
| MAP7 | microtubule-associated protein 7 | 0.00445144 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 0.0044393 |
| NNMT | nicotinamide N-methyltransferase | 0.00441135 |
| PRTN3 | proteinase 3 | 0.00440982 |
| DIPK1A | divergent protein kinase domain 1A | 0.00439329 |
| COG7 | component of oligomeric golgi complex 7 | 0.00438266 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00436571 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00436269 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 0.00436238 |
| TAGLN | transgelin | 0.00436047 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 0.00434688 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.00433122 |
| PCP4 | Purkinje cell protein 4 | 0.00432988 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.00432569 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.00429867 |
| HOXB2 | homeobox B2 | 0.00424011 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00423615 |
| GPC1 | glypican 1 | 0.00422787 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.0042128 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.00420588 |
| PLPP2 | phospholipid phosphatase 2 | 0.00419806 |
| EREG | epiregulin | 0.0041785 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.0041742 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00416907 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00412444 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.00412362 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.00410449 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00407258 |
| SLC12A8 | solute carrier family 12, member 8 | 0.00406713 |
| PYCARD | PYD and CARD domain containing | 0.00406224 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00405411 |
| FGB | fibrinogen beta chain | 0.00398349 |
| IFRD2 | interferon-related developmental regulator 2 | 0.003975 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.00396813 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0039656 |
| PLP1 | proteolipid protein 1 | 0.0039606 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 0.00394538 |
| HMG20B | high mobility group 20B | 0.00393664 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.00393076 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00392037 |
| LRP2 | low density lipoprotein receptor-related protein 2 | 0.00386945 |
| SVIL | supervillin | 0.00386534 |
| MYO6 | myosin VI | 0.00385938 |
| WASHC4 | WASH complex subunit 4 | 0.00384223 |
| MYLK | myosin light chain kinase | 0.00384172 |
| DCT | dopachrome tautomerase | 0.00384141 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.00383032 |
| SMAGP | small cell adhesion glycoprotein | 0.00382595 |
| KRT6A | keratin 6A, type II | 0.00382248 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00382001 |
| ESR1 | estrogen receptor 1 | 0.00381876 |
| CARS2 | cysteinyl-tRNA synthetase 2, mitochondrial (putative) | 0.00381553 |
| CD52 | CD52 molecule | 0.00377315 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.00377277 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.00375485 |
| EGF | epidermal growth factor | 0.00373125 |
| S100A12 | S100 calcium binding protein A12 | 0.00371355 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.00370785 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.00370659 |
| ZNF331 | zinc finger protein 331 | 0.00370317 |
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 0.00368654 |
| LEFTY1 | left-right determination factor 1 | 0.00366743 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00366644 |
| CNPY3 | canopy FGF signaling regulator 3 | 0.00365564 |
| MOCOS | molybdenum cofactor sulfurase | 0.00364987 |
| TBC1D4 | TBC1 domain family, member 4 | 0.00362704 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00361183 |
| ALB | albumin | 0.00360561 |
| PEG10 | paternally expressed 10 | 0.00360431 |
| F12 | coagulation factor XII (Hageman factor) | 0.0035749 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00356567 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.00356183 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.0035588 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.00355458 |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial | 0.00354446 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00354412 |
| RAB3B | RAB3B, member RAS oncogene family | 0.00353946 |
| CNTNAP2 | contactin associated protein-like 2 | 0.00353036 |
| KIF1B | kinesin family member 1B | 0.00352486 |
| CAPN1 | calpain 1, (mu/I) large subunit | 0.0035225 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.00351498 |
| ESRP2 | epithelial splicing regulatory protein 2 | 0.00351089 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | 0.00347141 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 0.00346326 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00345211 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.00344737 |
| RPA3 | replication protein A3, 14kDa | 0.003444 |
| NCK1 | NCK adaptor protein 1 | 0.00344307 |
| PXDN | peroxidasin | 0.00343983 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00342738 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 0.00342653 |
| APOA2 | apolipoprotein A-II | 0.00342541 |
| TCL1A | T-cell leukemia/lymphoma 1A | 0.00339936 |
| MAMLD1 | mastermind-like domain containing 1 | 0.003396 |
| COL5A1 | collagen, type V, alpha 1 | 0.00339458 |
| RRAGA | Ras-related GTP binding A | 0.00339455 |
| L1CAM | L1 cell adhesion molecule | 0.00339351 |
| PRR7 | proline rich 7 (synaptic) | 0.00338771 |
| TBC1D16 | TBC1 domain family, member 16 | 0.00337987 |
| PROM1 | prominin 1 | 0.00337276 |
| ADGRE1 | adhesion G protein-coupled receptor E1 | 0.00337276 |
| EML3 | echinoderm microtubule associated protein like 3 | 0.0033723 |
| FBN2 | fibrillin 2 | 0.00334946 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00334675 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00334655 |
| BSCL2 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | 0.00334323 |
| TMEM223 | transmembrane protein 223 | 0.00334012 |
| TNPO2 | transportin 2 | 0.00333486 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.00333474 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.0033332 |
| VSNL1 | visinin-like 1 | 0.00332324 |
| IRS2 | insulin receptor substrate 2 | 0.00332193 |
| CHGB | chromogranin B | 0.0033106 |
| HSD3B2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 0.00330015 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00330012 |
| HOXC6 | homeobox C6 | 0.00329888 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | 0.00329413 |
| KRT81 | keratin 81, type II | 0.00329378 |
| AMPD1 | adenosine monophosphate deaminase 1 | 0.00329281 |
| TSPO | translocator protein (18kDa) | 0.00327973 |
| CYC1 | cytochrome c-1 | 0.00327677 |
| MMP8 | matrix metallopeptidase 8 | 0.0032703 |
| LOX | lysyl oxidase | 0.0032639 |
| TARP | TCR gamma alternate reading frame protein | 0.00326272 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | 0.003261 |
| ZNF264 | zinc finger protein 264 | 0.00325873 |
| MTF2 | metal response element binding transcription factor 2 | 0.00324678 |
| LOXL2 | lysyl oxidase-like 2 | 0.00324468 |
| NPR3 | natriuretic peptide receptor 3 | 0.00323805 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 0.00323343 |
| THBS2 | thrombospondin 2 | 0.00323303 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.00322883 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | 0.00322759 |
| FPGS | folylpolyglutamate synthase | 0.00322516 |
| RTN1 | reticulon 1 | 0.00322054 |
| TBC1D8B | TBC1 domain family, member 8B (with GRAM domain) | 0.00322009 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.00321471 |
| C11ORF71 | chromosome 11 open reading frame 71 | 0.00321458 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | 0.00320885 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.00320604 |
| MEIS2 | Meis homeobox 2 | 0.0032023 |
| LIG1 | ligase I, DNA, ATP-dependent | 0.00319922 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00319263 |
| TMEM14A | transmembrane protein 14A | 0.00318167 |
| TNC | tenascin C | 0.00318015 |
| UBE3C | ubiquitin protein ligase E3C | 0.00316504 |
| TWIST1 | twist family bHLH transcription factor 1 | 0.00316447 |
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 0.00316174 |
| DERL1 | derlin 1 | 0.00315282 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0031316 |
| ANXA3 | annexin A3 | 0.0031289 |
| DNASE1L1 | deoxyribonuclease I-like 1 | 0.00312772 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.00312598 |
| NEBL | nebulette | 0.00312404 |
| PFN2 | profilin 2 | 0.00312344 |
| AKAP1 | A kinase (PRKA) anchor protein 1 | 0.00312204 |
| LIN28A | lin-28 homolog A (C. elegans) | 0.0031199 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.00311528 |
| CES1 | carboxylesterase 1 | 0.00311111 |
| ERLIN2 | ER lipid raft associated 2 | 0.00310849 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 0.00310477 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00310024 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00309821 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.00309751 |
| KRT10 | keratin 10, type I | 0.00308686 |
| PCNT | pericentrin | 0.00308338 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.00308105 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00307627 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.00306685 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | 0.00306615 |
| IRF5 | interferon regulatory factor 5 | 0.00306482 |
| IL7R | interleukin 7 receptor | 0.00306432 |
| SLC44A4 | solute carrier family 44, member 4 | 0.00305984 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00305974 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.00305656 |
| SELL | selectin L | 0.00305653 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.00305639 |
| CSTA | cystatin A (stefin A) | 0.0030562 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.00303447 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.00303042 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00302906 |
| AIM2 | absent in melanoma 2 | 0.00302374 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00302334 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00301527 |
| CD177 | CD177 molecule | 0.00300746 |
| CLGN | calmegin | 0.00300033 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00299764 |
| EVI2A | ecotropic viral integration site 2A | 0.00299334 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00299266 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00298273 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00298019 |
| SF3B3 | splicing factor 3b, subunit 3, 130kDa | 0.00297125 |
| VLDLR | very low density lipoprotein receptor | 0.00295711 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0029488 |
| CALD1 | caldesmon 1 | 0.00294477 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.0029421 |
| RAB31 | RAB31, member RAS oncogene family | 0.00292948 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.00292876 |
| GSTA4 | glutathione S-transferase alpha 4 | 0.00292749 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.00292447 |
| PLIN1 | perilipin 1 | 0.00292118 |
| RELN | reelin | 0.00292061 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MGLL | monoglyceride lipase | -0.00847593 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00829675 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00745257 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00744845 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.00691165 |
| CFH | complement factor H | -0.0068776 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00678596 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.00666225 |
| PWP1 | PWP1 homolog (S. cerevisiae) | -0.00657317 |
| TMEM100 | transmembrane protein 100 | -0.00653767 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | -0.00626312 |
| DMBT1 | deleted in malignant brain tumors 1 | -0.0060299 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0059948 |
| RBM34 | RNA binding motif protein 34 | -0.00599192 |
| MECOM | MDS1 and EVI1 complex locus | -0.00593696 |
| FAM107A | family with sequence similarity 107, member A | -0.00577045 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00573816 |
| VWF | von Willebrand factor | -0.00572858 |
| FAIM | Fas apoptotic inhibitory molecule | -0.00559965 |
| MAOB | monoamine oxidase B | -0.00559599 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00547158 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00544594 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00542749 |
| ADIRF | adipogenesis regulatory factor | -0.00537231 |
| DNM1L | dynamin 1-like | -0.00524973 |
| NDNF | neuron-derived neurotrophic factor | -0.00521648 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00521598 |
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | -0.00512241 |
| CA2 | carbonic anhydrase II | -0.00506852 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.00505556 |
| EZR | ezrin | -0.00505398 |
| MMP7 | matrix metallopeptidase 7 | -0.00496841 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.00496147 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.00496121 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.00486997 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00486639 |
| GLUL | glutamate-ammonia ligase | -0.00486536 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00485728 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00484511 |
| HBB | hemoglobin, beta | -0.00483881 |
| SERTAD2 | SERTA domain containing 2 | -0.00483757 |
| RGCC | regulator of cell cycle | -0.00480444 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00479194 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00476591 |
| PDLIM1 | PDZ and LIM domain 1 | -0.00476217 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.00474865 |
| TSPAN8 | tetraspanin 8 | -0.00473899 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00473689 |
| SPARCL1 | SPARC-like 1 (hevin) | -0.00472526 |
| OGN | osteoglycin | -0.00471745 |
| DUSP6 | dual specificity phosphatase 6 | -0.00470493 |
| ASS1 | argininosuccinate synthase 1 | -0.00470118 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00466072 |
| PLPP3 | phospholipid phosphatase 3 | -0.00462714 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | -0.0045783 |
| KIAA0040 | KIAA0040 | -0.0045687 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | -0.00454776 |
| GEM | GTP binding protein overexpressed in skeletal muscle | -0.00452885 |
| PTHLH | parathyroid hormone-like hormone | -0.0045204 |
| LIMA1 | LIM domain and actin binding 1 | -0.00448348 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00446047 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | -0.0044472 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -0.00444674 |
| PLTP | phospholipid transfer protein | -0.00444546 |
| LAMA2 | laminin, alpha 2 | -0.00444442 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | -0.00444132 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | -0.00440592 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.00438848 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00438202 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | -0.00436574 |
| EDN3 | endothelin 3 | -0.00434168 |
| SFTPC | surfactant protein C | -0.00432373 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.00432162 |
| CTSE | cathepsin E | -0.00431562 |
| MX1 | MX dynamin-like GTPase 1 | -0.00428794 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00427634 |
| DEFB1 | defensin, beta 1 | -0.00427607 |
| MT1M | metallothionein 1M | -0.00426285 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.00426162 |
| CADM1 | cell adhesion molecule 1 | -0.0042611 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00424969 |
| CERK | ceramide kinase | -0.0042323 |
| DESI1 | desumoylating isopeptidase 1 | -0.00423133 |
| PALLD | palladin, cytoskeletal associated protein | -0.00422431 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00421334 |
| AUTS2 | autism susceptibility candidate 2 | -0.00419263 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.00417441 |
| FRY | furry homolog (Drosophila) | -0.00417198 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00415469 |
| HOPX | HOP homeobox | -0.00414094 |
| BPGM | 2,3-bisphosphoglycerate mutase | -0.00412002 |
| ELN | elastin | -0.00411619 |
| OSR2 | odd-skipped related transciption factor 2 | -0.00411555 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.00411277 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00411262 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00410274 |
| CLU | clusterin | -0.00405965 |
| CTSW | cathepsin W | -0.00400827 |
| C4BPA | complement component 4 binding protein, alpha | -0.003991 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00397843 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.00396058 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00395172 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00395085 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.00394091 |
| GPX3 | glutathione peroxidase 3 | -0.00393702 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0039087 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.00390578 |
| TSPAN13 | tetraspanin 13 | -0.00390043 |
| RGS13 | regulator of G-protein signaling 13 | -0.00390026 |
| BTG3 | BTG family, member 3 | -0.00389875 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0038909 |
| P2RY14 | purinergic receptor P2Y, G-protein coupled, 14 | -0.00388804 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | -0.0038837 |
| SUSD6 | sushi domain containing 6 | -0.00387372 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.0038716 |
| ATXN1 | ataxin 1 | -0.00385935 |
| ANGPT2 | angiopoietin 2 | -0.00384597 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00384123 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.00383834 |
| NRIP3 | nuclear receptor interacting protein 3 | -0.00380051 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | -0.00379703 |
| PXDC1 | PX domain containing 1 | -0.00379526 |
| GATA2 | GATA binding protein 2 | -0.00379036 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.00378434 |
| ZNF165 | zinc finger protein 165 | -0.00377995 |
| OGA | O-GlcNAcase | -0.00377491 |
| NRN1 | neuritin 1 | -0.00376013 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.0037581 |
| KRT23 | keratin 23, type I | -0.00375469 |
| ATF4 | activating transcription factor 4 | -0.0037481 |
| WAPL | WAPL cohesin release factor | -0.00374729 |
| METTL7A | methyltransferase like 7A | -0.00373245 |
| QPRT | quinolinate phosphoribosyltransferase | -0.00373199 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00372774 |
| EMX2 | empty spiracles homeobox 2 | -0.00371764 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.003709 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.00370722 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00370048 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.00369396 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00369226 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | -0.00369022 |
| SFTPB | surfactant protein B | -0.003673 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | -0.00366737 |
| CAPG | capping protein (actin filament), gelsolin-like | -0.00365348 |
| FCGRT | Fc fragment of IgG, receptor, transporter, alpha | -0.0036418 |
| GRAMD2B | GRAM domain containing 2B | -0.00363097 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00360592 |
| SELE | selectin E | -0.00360152 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | -0.00359809 |
| SNAP23 | synaptosomal-associated protein, 23kDa | -0.00358599 |
| LAMP1 | lysosomal-associated membrane protein 1 | -0.00358424 |
| CH25H | cholesterol 25-hydroxylase | -0.00357902 |
| ANOS1 | anosmin 1 | -0.0035768 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -0.00356655 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.00356395 |
| LPIN2 | lipin 2 | -0.00355836 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00355184 |
| IL1B | interleukin 1, beta | -0.00354603 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.00353561 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.0035319 |
| REG3A | regenerating islet-derived 3 alpha | -0.00352941 |
| HMOX1 | heme oxygenase 1 | -0.00352054 |
| ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 | -0.00351999 |
| RPS26 | ribosomal protein S26 | -0.00351782 |
| KAT2B | K(lysine) acetyltransferase 2B | -0.00350664 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00350501 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00349742 |
| NDP | Norrie disease (pseudoglioma) | -0.00349575 |
| PQBP1 | polyglutamine binding protein 1 | -0.00349566 |
| MPZL2 | myelin protein zero-like 2 | -0.00348265 |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 | -0.00347924 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | -0.00346594 |
| CPNE1 | copine I | -0.00346269 |
| FOXF1 | forkhead box F1 | -0.00344825 |
| KATNA1 | katanin p60 (ATPase containing) subunit A 1 | -0.00344672 |
| TM6SF1 | transmembrane 6 superfamily member 1 | -0.00344293 |
| GPC3 | glypican 3 | -0.00343036 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00342869 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00342826 |
| RNASET2 | ribonuclease T2 | -0.00342691 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.00342324 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00341542 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00340281 |
| PGF | placental growth factor | -0.00339812 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00339094 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00338163 |
| RPL36AL | ribosomal protein L36a-like | -0.00337956 |
| TBX2 | T-box 2 | -0.00337366 |
| MMRN1 | multimerin 1 | -0.00337084 |
| SMAD7 | SMAD family member 7 | -0.00337038 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.00336613 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00336191 |
| FABP1 | fatty acid binding protein 1, liver | -0.00335758 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.00334671 |
| LZTFL1 | leucine zipper transcription factor-like 1 | -0.00334457 |
| TRIM8 | tripartite motif containing 8 | -0.00334233 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.00333716 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | -0.003333 |
| TSPAN12 | tetraspanin 12 | -0.00333156 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | -0.00332616 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00332615 |
| IL1R1 | interleukin 1 receptor, type I | -0.00332406 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.0033142 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.00331006 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.0033012 |
| MMP10 | matrix metallopeptidase 10 | -0.00329933 |
| AQP4 | aquaporin 4 | -0.00329848 |
| DHRS11 | dehydrogenase/reductase (SDR family) member 11 | -0.00329833 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00329607 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00328135 |
| DOCK4 | dedicator of cytokinesis 4 | -0.00328079 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00327689 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | -0.00326946 |
| SARS1 | seryl-tRNA synthetase 1 | -0.00326223 |
| SOCS1 | suppressor of cytokine signaling 1 | -0.00324736 |
| C1R | complement component 1, r subcomponent | -0.00324327 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -0.00323926 |
| XK | X-linked Kx blood group | -0.00323086 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.00322231 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | -0.0032158 |
| RGS2 | regulator of G-protein signaling 2 | -0.0032017 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00319561 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00318257 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00316935 |
| ODAM | odontogenic, ameloblast asssociated | -0.00316766 |
| C1QB | complement component 1, q subcomponent, B chain | -0.0031672 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00316705 |
| RNF167 | ring finger protein 167 | -0.00316239 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00315495 |
| SOBP | sine oculis binding protein homolog (Drosophila) | -0.00315306 |
| HEPH | hephaestin | -0.00314587 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | -0.00314505 |
| PSPC1 | paraspeckle component 1 | -0.00314387 |
| C1ORF54 | chromosome 1 open reading frame 54 | -0.00314332 |
| KIAA0355 | KIAA0355 | -0.00314246 |
| CLDN5 | claudin 5 | -0.00313814 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.00313587 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.00312424 |
| ATF5 | activating transcription factor 5 | -0.00312343 |
| RUBCN | rubicon autophagy regulator | -0.00311702 |
| WDR45 | WD repeat domain 45 | -0.00311697 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.00311582 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | -0.00310457 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | -0.00310259 |
| STON1 | stonin 1 | -0.0031 |
| IFI44 | interferon-induced protein 44 | -0.00309717 |
| CRTAC1 | cartilage acidic protein 1 | -0.00309691 |
| OCRL | oculocerebrorenal syndrome of Lowe | -0.00309619 |
| CCL4 | chemokine (C-C motif) ligand 4 | -0.00309465 |
