FAS Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description Fas cell surface death receptor|The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 355)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_TNFRSF6
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Genes

169 co-expressed genes for FAS from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAM20 ADAM metallopeptidase domain 20
ADAMTSL3 ADAMTS-like 3
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AOC4P amine oxidase, copper containing 4, pseudogene
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP7 aquaporin 7
ARL3 ADP-ribosylation factor-like 3
ASB4 ankyrin repeat and SOCS box containing 4
ATF2 activating transcription factor 2
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN3 ataxin 3
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMP10 bone morphogenetic protein 10
BRD4 bromodomain containing 4
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CADM4 cell adhesion molecule 4
CALN1 calneuron 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCL16 chemokine (C-C motif) ligand 16
CCR3 chemokine (C-C motif) receptor 3
CD8A CD8a molecule
CDC73 cell division cycle 73
CELA2B chymotrypsin-like elastase family, member 2B
CEP162 centrosomal protein 162kDa
CFH complement factor H
COL19A1 collagen, type XIX, alpha 1
COL8A1 collagen, type VIII, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPB2 carboxypeptidase B2 (plasma)
CRHR1 corticotropin releasing hormone receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DKFZP434C153 DKFZP434C153 protein
DMD dystrophin
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EPHB2 EPH receptor B2
ERCC4 excision repair cross-complementation group 4
EXOC4 exocyst complex component 4
F2RL3 coagulation factor II (thrombin) receptor-like 3
FAM13A family with sequence similarity 13, member A
FAM153B family with sequence similarity 153, member B
FAS Fas cell surface death receptor
FBXL4 F-box and leucine-rich repeat protein 4
FGF18 fibroblast growth factor 18
FGF2 fibroblast growth factor 2 (basic)
FLRT2 fibronectin leucine rich transmembrane protein 2
FNTB farnesyltransferase, CAAX box, beta
FOSL1 FOS-like antigen 1
FSHR follicle stimulating hormone receptor
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD5 frizzled class receptor 5
GCA grancalcin, EF-hand calcium binding protein
GCM1 glial cells missing homolog 1 (Drosophila)
GJB5 gap junction protein, beta 5, 31.1kDa
GLRA3 glycine receptor, alpha 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR171 G protein-coupled receptor 171
GPR18 G protein-coupled receptor 18
GPR19 G protein-coupled receptor 19
GRIK1 glutamate receptor, ionotropic, kainate 1
GUCY2F guanylate cyclase 2F, retinal
HCG8 HLA complex group 8
HCRTR2 hypocretin (orexin) receptor 2
HIST1H3E histone cluster 1, H3e
HNF1A HNF1 homeobox A
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNA10 interferon, alpha 10
IGKV7-3 immunoglobulin kappa variable 7-3 (pseudogene)
IL11RA interleukin 11 receptor, alpha
IL16 interleukin 16
IL5 interleukin 5
IPO9 importin 9
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
JRKL JRK-like
KDR kinase insert domain receptor
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KRT2 keratin 2, type II
KRT34 keratin 34, type I
LDB3 LIM domain binding 3
LECT2 leukocyte cell-derived chemotaxin 2
LGI1 leucine-rich, glioma inactivated 1
LOR loricrin
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC48 leucine rich repeat containing 48
MAGEA8 melanoma antigen family A8
MAGEA9 melanoma antigen family A9
MAP2 microtubule-associated protein 2
MC5R melanocortin 5 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MSL3 male-specific lethal 3 homolog (Drosophila)
NHEJ1 nonhomologous end-joining factor 1
NOS2 nitric oxide synthase 2, inducible
NPFF neuropeptide FF-amide peptide precursor
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTNG2 netrin G2
OCM oncomodulin
OPCML opioid binding protein/cell adhesion molecule-like
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PCM1 pericentriolar material 1
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PGM3 phosphoglucomutase 3
PHF10 PHD finger protein 10
PHLDB1 pleckstrin homology-like domain, family B, member 1
PHOX2B paired-like homeobox 2b
POU6F1 POU class 6 homeobox 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PSG1 pregnancy specific beta-1-glycoprotein 1
PTPRB protein tyrosine phosphatase, receptor type, B
PVR poliovirus receptor
R3HCC1L R3H domain and coiled-coil containing 1-like
RAD51D RAD51 paralog D
RB1CC1 RB1-inducible coiled-coil 1
RORB RAR-related orphan receptor B
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RREB1 ras responsive element binding protein 1
RUNX2 runt-related transcription factor 2
RXRG retinoid X receptor, gamma
S100A5 S100 calcium binding protein A5
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SGPL1 sphingosine-1-phosphate lyase 1
SIM2 single-minded family bHLH transcription factor 2
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SOAT2 sterol O-acyltransferase 2
SPA17 sperm autoantigenic protein 17
SPAG11B sperm associated antigen 11B
SPATA2 spermatogenesis associated 2
STAC SH3 and cysteine rich domain
SULT4A1 sulfotransferase family 4A, member 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
T T, brachyury homolog (mouse)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBX19 T-box 19
TENM4 teneurin transmembrane protein 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM26 transmembrane protein 26
TPD52 tumor protein D52
TSSK2 testis-specific serine kinase 2
TTTY1 testis-specific transcript, Y-linked 1 (non-protein coding)
VSTM4 V-set and transmembrane domain containing 4
WBP4 WW domain binding protein 4
ZBTB14 zinc finger and BTB domain containing 14
ZBTB40 zinc finger and BTB domain containing 40
ZNF134 zinc finger protein 134
ZNF141 zinc finger protein 141
ZNF157 zinc finger protein 157
ZNF200 zinc finger protein 200
ZNF202 zinc finger protein 202
ZNF266 zinc finger protein 266
ZSCAN26 zinc finger and SCAN domain containing 26