FAS Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description Fas cell surface death receptor|The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 355)
External Link http://www.ncbi.nlm.nih.gov/gene/355
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95 interacting proteins for FAS from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APAF1 apoptotic peptidase activating factor 1
APOA5 apolipoprotein A-V
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAG6 BCL2-associated athanogene 6
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMX BMX non-receptor tyrosine kinase
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BTK Bruton agammaglobulinemia tyrosine kinase
C14ORF1 chromosome 14 open reading frame 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCND3 cyclin D3
CD47 CD47 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
CLTC clathrin, heavy chain (Hc)
CRMP1 collapsin response mediator protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAXX death-domain associated protein
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGFR epidermal growth factor receptor
EZR ezrin
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FAF2 Fas associated factor family member 2
FAIM2 Fas apoptotic inhibitory molecule 2
FASLG Fas ligand (TNF superfamily, member 6)
FBF1 Fas (TNFRSF6) binding factor 1
FEM1B fem-1 homolog b (C. elegans)
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
HIPK3 homeodomain interacting protein kinase 3
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KRIT1 KRIT1, ankyrin repeat containing
LCK LCK proto-oncogene, Src family tyrosine kinase
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MBD4 methyl-CpG binding domain protein 4
MET MET proto-oncogene, receptor tyrosine kinase
MSN moesin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
ONECUT1 one cut homeobox 1
PDCD6 programmed cell death 6
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PML promyelocytic leukemia
PRAM1 PML-RARA regulated adaptor molecule 1
PRKCA protein kinase C, alpha
PTBP1 polypyrimidine tract binding protein 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAP1A RAP1A, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RDX radixin
RHOA ras homolog family member A
RIF1 replication timing regulatory factor 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUMO1 small ubiquitin-like modifier 1
TCAP titin-cap
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMX1 thioredoxin-related transmembrane protein 1
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TP63 tumor protein p63
TRADD TNFRSF1A-associated via death domain
TRAF3 TNF receptor-associated factor 3
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBA7 ubiquitin-like modifier activating enzyme 7
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBQLN1 ubiquilin 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase