FASTKD2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description FAST kinase domains 2|This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 22868)
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Genes

350 genes differentially expressed following the FASTKD2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.78688
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.78688
MYOCOS myocilin opposite strand 3.78688
TICAM1 toll-like receptor adaptor molecule 1 3.78688
IP6K3 inositol hexakisphosphate kinase 3 3.78688
RIPK4 receptor-interacting serine-threonine kinase 4 3.78688
GPR52 G protein-coupled receptor 52 3.78688
SPATA22 spermatogenesis associated 22 3.78688
PLA2G4E phospholipase A2, group IVE 3.78688
CPZ carboxypeptidase Z 3.78688
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.78688
TNIP3 TNFAIP3 interacting protein 3 3.78688
SERF1A small EDRK-rich factor 1A (telomeric) 3.78688
PADI6 peptidyl arginine deiminase, type VI 3.78688
SAMD15 sterile alpha motif domain containing 15 3.78688
UBA7 ubiquitin-like modifier activating enzyme 7 3.78688
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.78688
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.78688
NPBWR1 neuropeptides B/W receptor 1 3.78688
ZNF831 zinc finger protein 831 3.78688
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.78688
HLA-DMB major histocompatibility complex, class II, DM beta 3.78688
MLANA melan-A 3.78688
MEIS1 Meis homeobox 1 3.78688
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.76406
OR5B12 olfactory receptor, family 5, subfamily B, member 12 3.76406
HEATR9 HEAT repeat containing 9 3.76406
PGAM4 phosphoglycerate mutase family member 4 3.76406
WDR87 WD repeat domain 87 3.76406
ACTL8 actin-like 8 3.76406
RLBP1 retinaldehyde binding protein 1 3.76406
ATP13A5 ATPase type 13A5 3.76406
SIX3 SIX homeobox 3 3.76406
CST11 cystatin 11 3.76406
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.76406
PLEK pleckstrin 3.76406
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.76406
USP26 ubiquitin specific peptidase 26 3.76406
HES5 hes family bHLH transcription factor 5 3.76406
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.76406
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.76406
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.76406
GIMAP4 GTPase, IMAP family member 4 3.76406
CXCL2 chemokine (C-X-C motif) ligand 2 3.76406
GADL1 glutamate decarboxylase-like 1 3.76406
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 3.76406
NCF4 neutrophil cytosolic factor 4, 40kDa 3.76406
ARRDC5 arrestin domain containing 5 3.76406
FOLR2 folate receptor 2 (fetal) 3.76406
APOA2 apolipoprotein A-II 3.76406
GJB3 gap junction protein, beta 3, 31kDa 3.76406
HORMAD1 HORMA domain containing 1 3.76406
DDO D-aspartate oxidase 3.76406
AFM afamin 3.76406
PAX3 paired box 3 3.76406
CLEC19A C-type lectin domain family 19, member A 3.76406
SLC25A41 solute carrier family 25, member 41 3.76406
OSR2 odd-skipped related transciption factor 2 3.76406
TMEM100 transmembrane protein 100 3.76406
CD68 CD68 molecule 3.76406
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 3.76406
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.76406
HTD2 hydroxyacyl-thioester dehydratase type 2 3.76406
SPATS1 spermatogenesis associated, serine-rich 1 3.76406
ALDOB aldolase B, fructose-bisphosphate 3.76406
VN1R1 vomeronasal 1 receptor 1 3.76406
DUSP9 dual specificity phosphatase 9 3.76406
POM121L2 POM121 transmembrane nucleoporin-like 2 3.76406
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.76406
LOC107986837 uncharacterized LOC107986837 3.76406
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.76406
FAM240B family with sequence similarity 240 member B 3.76406
PMIS2 PMIS2 transmembrane protein 3.76406
SPATA31F3 SPATA31 subfamily F member 3 3.76406
SPMIP2 sperm microtubule inner protein 2 3.76406
EPCIP exosomal polycystin 1 interacting protein 3.76406
PPIAP39 peptidylprolyl isomerase A pseudogene 39 3.76406
RPS21-DT RPS21 divergent transcript 3.76406
TERB1 telomere repeat binding bouquet formation protein 1 3.76406
DUSP29 dual specificity phosphatase 29 3.76406
CFAP119 cilia and flagella associated protein 119 3.76406
CCN6 cellular communication network factor 6 3.76406
ADRB1 adrenoceptor beta 1 3.76406
MIOX myo-inositol oxygenase 3.76406
OR51M1 olfactory receptor, family 51, subfamily M, member 1 3.76406
TFEC transcription factor EC 3.76406
NHLRC4 NHL repeat containing 4 3.76406
SCRT2 scratch family zinc finger 2 3.76406
LOC124901449 uncharacterized LOC124901449 3.76406
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.76406
GOLGA6L2 golgin A6 family-like 2 3.76406
MAGEB3 melanoma antigen family B3 3.76406
TUBA3E tubulin, alpha 3e 3.76406
PTPRH protein tyrosine phosphatase, receptor type, H 3.76406
MYH13 myosin, heavy chain 13, skeletal muscle 3.76406
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.76406
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.76406
LTK leukocyte receptor tyrosine kinase 3.76406
WNT9B wingless-type MMTV integration site family, member 9B 3.76406
GPR132 G protein-coupled receptor 132 3.76406
PTH parathyroid hormone 3.76406
C6 complement component 6 3.76406
PGLYRP2 peptidoglycan recognition protein 2 3.76406
BARX2 BARX homeobox 2 3.76406
S100P S100 calcium binding protein P 3.76406
PRB4 proline-rich protein BstNI subfamily 4 3.76406
ANKK1 ankyrin repeat and kinase domain containing 1 3.76406
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.76406
POF1B premature ovarian failure, 1B 3.76406
HHLA2 HERV-H LTR-associating 2 3.76406
SDSL serine dehydratase-like 3.76406
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.76406
CPSF4L cleavage and polyadenylation specific factor 4-like 3.76406
HEPACAM hepatic and glial cell adhesion molecule 3.76406
AKNAD1 AKNA domain containing 1 3.76406
DRD2 dopamine receptor D2 3.76406
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.76406
ZNF648 zinc finger protein 648 3.76406
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.76406
UNCX UNC homeobox 3.76406
TSSK1B testis-specific serine kinase 1B 3.76406
ZBED6 zinc finger, BED-type containing 6 3.76406
LAMP3 lysosomal-associated membrane protein 3 3.76406
TMEM86B transmembrane protein 86B 3.76406
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.76406
PRSS55 protease, serine, 55 3.76406
IER5L immediate early response 5-like 3.76406
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.76406
APOF apolipoprotein F 3.76406
SLITRK6 SLIT and NTRK-like family, member 6 3.76406
SLITRK1 SLIT and NTRK-like family, member 1 3.76406
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.76406
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 3.76406
CLDN34 claudin 34 3.76406
HHIPL2 HHIP-like 2 3.76406
RERGL RERG/RAS-like 3.76406
ITPKA inositol-trisphosphate 3-kinase A 3.76406
WFDC11 WAP four-disulfide core domain 11 3.76406
NRSN1 neurensin 1 3.76406
GRM6 glutamate receptor, metabotropic 6 3.76406
GRIFIN galectin-related inter-fiber protein 3.76406
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 3.76406
LGALS4 lectin, galactoside-binding, soluble, 4 3.76406
ART1 ADP-ribosyltransferase 1 3.76406
CFB complement factor B 3.76406
TYR tyrosinase 3.76406
CORO6 coronin 6 3.76406
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.76406
LRRC24 leucine rich repeat containing 24 3.76406
HBM hemoglobin, mu 3.76406
SPAG8 sperm associated antigen 8 3.76406
ITGAD integrin, alpha D 3.76406
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3.76406
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.76406
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.76406
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.76406
LYZ lysozyme 3.76406
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.76406
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.76406
LHX2 LIM homeobox 2 3.76406
CCDC78 coiled-coil domain containing 78 3.69644
LINC02798 long intergenic non-protein coding RNA 2798 3.69644
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 3.69644
ZNF175 zinc finger protein 175 3.4354
PER1 period circadian clock 1 3.03017
TMEM272 transmembrane protein 272 2.98508
PRR15L proline rich 15-like 2.972
CATIP ciliogenesis associated TTC17 interacting protein 2.96175
FAM135A family with sequence similarity 135, member A 2.844
PROM1 prominin 1 2.8433
DCXR dicarbonyl/L-xylulose reductase 2.81077
KLKB1 kallikrein B, plasma (Fletcher factor) 1 2.79714
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.75418
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.66334
LDHAL6A lactate dehydrogenase A-like 6A 2.66334
AZU1 azurocidin 1 2.66334
MIXL1 Mix paired-like homeobox 2.66334
PCDHB12 protocadherin beta 12 2.66334
IFI16 interferon, gamma-inducible protein 16 2.66334
ZNF398 zinc finger protein 398 2.59949
SNURF SNRPN upstream reading frame 2.58255
DCDC2C doublecortin domain containing 2C 2.5433
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.52421
SPATA32 spermatogenesis associated 32 2.52421
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.50177
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.47373
ARL17A ADP-ribosylation factor-like 17A 2.4414
MICU2 mitochondrial calcium uptake 2 2.4414
ANXA8 annexin A8 2.4238
NPPA natriuretic peptide A 2.4238
ZNF154 zinc finger protein 154 2.42248
KDM1A lysine (K)-specific demethylase 1A 2.38202
SDC1 syndecan 1 2.38115
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.37171
ZNF471 zinc finger protein 471 2.37171
VTCN1 V-set domain containing T cell activation inhibitor 1 2.37171
MARK3 MAP/microtubule affinity-regulating kinase 3 2.34347
EPS8 epidermal growth factor receptor pathway substrate 8 2.31714
TSLIG2 tRNA splicing ligase complex subunit 2 2.31574
POLK polymerase (DNA directed) kappa 2.30439
TRIM3 tripartite motif containing 3 2.28011
COX14 COX14 cytochrome c oxidase assembly factor 2.23709
TBC1D4 TBC1 domain family, member 4 2.23702
DNMBP dynamin binding protein 2.23702
ZNF704 zinc finger protein 704 2.22836
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.22646
ZNF615 zinc finger protein 615 2.20273
GREB1L growth regulation by estrogen in breast cancer-like 2.19735
ARMCX4 armadillo repeat containing, X-linked 4 2.18494
PDLIM3 PDZ and LIM domain 3 2.16287
FMN1 formin 1 2.15963
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.15086
H4C6 H4 clustered histone 6 2.14912
ZBTB43 zinc finger and BTB domain containing 43 2.1298
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 2.12977
CHD4 chromodomain helicase DNA binding protein 4 2.1213
FN1 fibronectin 1 2.09049
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.07716
MED24 mediator complex subunit 24 2.07038
MASTL microtubule associated serine/threonine kinase-like 2.07038
TPR translocated promoter region, nuclear basket protein 2.05319
TJP1 tight junction protein 1 2.05096
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.03947
SYT15B synaptotagmin 15B 2.03379
VANGL1 VANGL planar cell polarity protein 1 2.03222
CAPRIN2 caprin family member 2 2.0182
TACR1 tachykinin receptor 1 2.0182
BMP7 bone morphogenetic protein 7 2.0182
EVL Enah/Vasp-like 2.01739
RPL38 ribosomal protein L38 2.00451

decreased expression

Symbol Name Standardized Value
MROH7 maestro heat-like repeat family member 7 -3.78688
LRRK2 leucine-rich repeat kinase 2 -3.76406
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -3.76406
PLCZ1 phospholipase C, zeta 1 -3.76406
VWA3A von Willebrand factor A domain containing 3A -3.76406
DOCK10 dedicator of cytokinesis 10 -3.76406
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -3.76406
DDTL D-dopachrome tautomerase-like -3.76406
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.76406
CHADL chondroadherin-like -3.76406
ABHD15 abhydrolase domain containing 15 -3.76406
CXCR2 chemokine (C-X-C motif) receptor 2 -3.76406
CCR3 chemokine (C-C motif) receptor 3 -3.76406
C1QTNF2 C1q and tumor necrosis factor related protein 2 -3.76406
LTBP2 latent transforming growth factor beta binding protein 2 -3.76406
CA1 carbonic anhydrase I -3.76406
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.76406
TMPRSS7 transmembrane protease, serine 7 -3.76406
RAB7B RAB7B, member RAS oncogene family -3.76406
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -3.76406
GBX1 gastrulation brain homeobox 1 -3.76406
MUCL3 mucin like 3 -3.76406
ADCY4 adenylate cyclase 4 -3.76406
STOML1 stomatin (EPB72)-like 1 -3.76406
GPR150 G protein-coupled receptor 150 -3.76406
NMBR neuromedin B receptor -3.76406
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -3.76406
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -3.76406
RTL5 retrotransposon Gag like 5 -3.76406
ECM1 extracellular matrix protein 1 -3.76406
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.76406
TNS4 tensin 4 -3.76406
SPEGNB SPEG neighbor -3.76406
DONSON downstream neighbor of SON -3.50921
CHMP6 charged multivesicular body protein 6 -3.49873
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -3.26278
TENT5A terminal nucleotidyltransferase 5A -3.24753
HMCN2 hemicentin 2 -3.23393
C16ORF95 chromosome 16 open reading frame 95 -3.22078
POC5 POC5 centriolar protein -3.19904
ASNS asparagine synthetase (glutamine-hydrolyzing) -3.14762
EID3 EP300 interacting inhibitor of differentiation 3 -3.14762
ZNF723 zinc finger protein 723 -3.13765
TMEM106A transmembrane protein 106A -3.11935
ZNF836 zinc finger protein 836 -3.09961
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -3.03084
PRKD1 protein kinase D1 -3.03084
TMEM190 transmembrane protein 190 -3.01763
SYN2 synapsin II -2.81077
CAPN3 calpain 3, (p94) -2.80876
NME7 NME/NM23 family member 7 -2.7271
MSR1 macrophage scavenger receptor 1 -2.7271
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.68804
HMOX1 heme oxygenase 1 -2.67886
MRPL47 mitochondrial ribosomal protein L47 -2.67841
CLSPN claspin -2.66072
SLC35E3 solute carrier family 35, member E3 -2.66072
NCR1 natural cytotoxicity triggering receptor 1 -2.64282
FGF22 fibroblast growth factor 22 -2.64282
CASR calcium-sensing receptor -2.64282
FRMPD2 FERM and PDZ domain containing 2 -2.64282
LSM11 LSM11, U7 small nuclear RNA associated -2.63528
CLIC1 chloride intracellular channel 1 -2.59547
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -2.59086
KIF4A kinesin family member 4A -2.55612
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.49005
FASTKD2 FAST kinase domains 2 -2.4879
CDIN1 CDAN1 interacting nuclease 1 -2.45538
FPGT fucose-1-phosphate guanylyltransferase -2.4414
INCENP inner centromere protein antigens 135/155kDa -2.44121
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -2.43666
CREG2 cellular repressor of E1A-stimulated genes 2 -2.43666
CCDC157 coiled-coil domain containing 157 -2.4238
BRICD5 BRICHOS domain containing 5 -2.40948
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.40948
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.38517
CALB1 calbindin 1, 28kDa -2.36054
EFHC1 EF-hand domain (C-terminal) containing 1 -2.36054
MRPL38 mitochondrial ribosomal protein L38 -2.35388
SHISAL2A shisa like 2A -2.2866
CRLF3 cytokine receptor-like factor 3 -2.2866
CFAP20 cilia and flagella associated protein 20 -2.25427
SGCZ sarcoglycan, zeta -2.23657
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -2.20855
PHB2 prohibitin 2 -2.20088
SELENOT selenoprotein T -2.19735
SVOPL SVOP-like -2.19727
U2AF1 U2 small nuclear RNA auxiliary factor 1 -2.19609
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.19609
ZNF717 zinc finger protein 717 -2.17224
SPEG SPEG complex locus -2.16287
MTRFR mitochondrial translation release factor in rescue -2.12267
SLC22A31 solute carrier family 22, member 31 -2.12182
LYPD6 LY6/PLAUR domain containing 6 -2.12182
BTBD17 BTB (POZ) domain containing 17 -2.12182
FOXN2 forkhead box N2 -2.07982
DPP10 dipeptidyl-peptidase 10 (non-functional) -2.06879
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.06072
CDC34 cell division cycle 34 -2.05921
CRYBB1 crystallin, beta B1 -2.0528
MFF mitochondrial fission factor -2.05096
TKT transketolase -2.04474
SNED1 sushi, nidogen and EGF-like domains 1 -2.04282
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.04282
TIAM2 T-cell lymphoma invasion and metastasis 2 -2.0422
FNBP4 formin binding protein 4 -2.0422
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.03607
RABL6 RAB, member RAS oncogene family-like 6 -2.03421
RBM12 RNA binding motif protein 12 -2.03421
MTMR8 myotubularin related protein 8 -2.03379
GLRX2 glutaredoxin 2 -2.03379
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.03379
CLDN4 claudin 4 -2.03379
CTBP1 C-terminal binding protein 1 -2.02647
COPS9 COP9 signalosome subunit 9 -2.02647
GPATCH1 G patch domain containing 1 -2.02647
LMTK3 lemur tyrosine kinase 3 -2.01755
DSCAM Down syndrome cell adhesion molecule -2.00962
RPAIN RPA interacting protein -2.00444
RNF19B ring finger protein 19B -2.00268