FBXO11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description F-box protein 11|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 80204)
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Genes

279 genes differentially expressed following the FBXO11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.52131
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.52131
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.52131
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.52131
CLDN22 claudin 22 2.52131
PRG4 proteoglycan 4 2.52131
LCA5L Leber congenital amaurosis 5-like 2.52131
MID2 midline 2 2.52131
PAX5 paired box 5 2.52131
MEOX1 mesenchyme homeobox 1 2.52131
SHISA3 shisa family member 3 2.52131
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.52131
HLF hepatic leukemia factor 2.52131
SYTL5 synaptotagmin-like 5 2.52131
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.52131
TEX13B testis expressed 13B 2.52131
IZUMO1 izumo sperm-egg fusion 1 2.52131
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.52131
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.52131
HCRTR2 hypocretin (orexin) receptor 2 2.52131
TM4SF19 transmembrane 4 L six family member 19 2.52131
MYO16 myosin XVI 2.52131
LOC105378220 macrophage receptor MARCO-like 2.52131
BTBD16 BTB (POZ) domain containing 16 2.52131
THEMIS thymocyte selection associated 2.52131
ALX4 ALX homeobox 4 2.52131
LRRC8C-DT LRRC8C divergent transcript 2.52131
FMO1 flavin containing monooxygenase 1 2.52131
SPMIP7 sperm microtubule inner protein 7 2.52131
GNLY granulysin 2.30108
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.30108
OR51G2 olfactory receptor, family 51, subfamily G, member 2 2.30108
NBEA neurobeachin 2.30108
ZFP57 ZFP57 zinc finger protein 2.30108
GALR3 galanin receptor 3 2.30108
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.30108
CXCL2 chemokine (C-X-C motif) ligand 2 2.30108
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.30108
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.30108
UNC45B unc-45 homolog B (C. elegans) 2.30108
PCDHB1 protocadherin beta 1 2.30108
FOXA1 forkhead box A1 2.30108
BGN biglycan 2.30108
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.30108
ADAD2 adenosine deaminase domain containing 2 2.30108
ASPA aspartoacylase 2.30108
MSC musculin 2.30108
TMEM72 transmembrane protein 72 2.30108
LCN12 lipocalin 12 2.30108
TTLL8 tubulin tyrosine ligase-like family member 8 2.30108
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.30108
PRDM12 PR domain containing 12 2.30108
MYEF2 myelin expression factor 2 2.30108
PAX8 paired box 8 2.30108
PGBDF plakoglobin binding and degradation factor 2.30108
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.30108
ADGRE2 adhesion G protein-coupled receptor E2 2.30108
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.30108
SMLR1 small leucine-rich protein 1 2.30108
PROX2 prospero homeobox 2 2.30108
ASB5 ankyrin repeat and SOCS box containing 5 2.30108
SELL selectin L 2.30108
TBX10 T-box 10 2.30108
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.30108
ZNF705D zinc finger protein 705D 2.30108
DNAAF1 dynein, axonemal, assembly factor 1 2.30108
CLDN14 claudin 14 2.30108
CPNE8-AS1 CPNE8 antisense RNA 1 2.30108
CIMAP1C ciliary microtubule associated protein 1C 2.30108
MDFIC2 MyoD family inhibitor domain containing 2 2.30108
MUCL3 mucin like 3 2.30108
CATSPERZ catsper channel auxiliary subunit zeta 2.30108
CLXN calaxin 2.30108
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.30108
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.30108
MLANA melan-A 2.30108
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.30108
HHEX hematopoietically expressed homeobox 2.30108
GUCA1C guanylate cyclase activator 1C 2.30108
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.30108
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.30108
SIX3 SIX homeobox 3 2.30108
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.30108
TREM2 triggering receptor expressed on myeloid cells 2 2.30108
ZNF503 zinc finger protein 503 2.30108
RS1 retinoschisin 1 2.30108
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.30108
CCR3 chemokine (C-C motif) receptor 3 2.30108
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.30108
BBS5 Bardet-Biedl syndrome 5 2.30108
CLEC3A C-type lectin domain family 3, member A 2.30108
IRF7 interferon regulatory factor 7 2.30108
LTBP2 latent transforming growth factor beta binding protein 2 2.30108
RPS15 ribosomal protein S15 2.30108
PRB4 proline-rich protein BstNI subfamily 4 2.30108
TBC1D3I TBC1 domain family member 3I 2.30108
MMP12 matrix metallopeptidase 12 2.30108
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.30108
TAT tyrosine aminotransferase 2.30108
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.30108
MAB21L1 mab-21-like 1 (C. elegans) 2.30108
HPX hemopexin 2.30108
ZNF626 zinc finger protein 626 2.30108
GML glycosylphosphatidylinositol anchored molecule like 2.30108
BPIFB1 BPI fold containing family B, member 1 2.30108
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.30108
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.30108
MR1 major histocompatibility complex, class I-related 2.30108
EBF2 early B-cell factor 2 2.30108
KRT15 keratin 15, type I 2.30108
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.30108
SCLY selenocysteine lyase 2.30108
WDR76 WD repeat domain 76 2.30108
MC5R melanocortin 5 receptor 2.30108
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.30108
RRH retinal pigment epithelium-derived rhodopsin homolog 2.30108
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.30108
SLC17A2 solute carrier family 17, member 2 2.30108
DRC7 dynein regulatory complex subunit 7 2.30108
EOMES eomesodermin 2.30108
CXORF58 chromosome X open reading frame 58 2.30108
POU4F3 POU class 4 homeobox 3 2.30108
SPTA1 spectrin, alpha, erythrocytic 1 2.30108
FAIM2 Fas apoptotic inhibitory molecule 2 2.30108
NOTCH4 notch 4 2.30108
CAPS2 calcyphosine 2 2.30108
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.30108
LHX2 LIM homeobox 2 2.30108
CA5A carbonic anhydrase VA, mitochondrial 2.30108
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.30108
GFRAL GDNF family receptor alpha like 2.30108
DOCK1 dedicator of cytokinesis 1 2.30108
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 2.30108
CDCA4 cell division cycle associated 4 2.30108
NUTM2B NUT family member 2B 2.30108
DCST1 DC-STAMP domain containing 1 2.30108
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 2.30108
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.30108
TLN2 talin 2 2.30108
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.30108
IL23A interleukin 23, alpha subunit p19 2.30108
BTBD19 BTB (POZ) domain containing 19 2.30108
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.30108
MEIG1 meiosis/spermiogenesis associated 1 2.30108
ADAM20 ADAM metallopeptidase domain 20 2.30108
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.30108
CD3G CD3g molecule, gamma (CD3-TCR complex) 2.30108
GPR179 G protein-coupled receptor 179 2.30108
PITX2 paired-like homeodomain 2 2.30108
CHRDL2 chordin-like 2 2.30108
PASD1 PAS domain containing 1 2.30108
TGM4 transglutaminase 4 2.30108
TTC36 tetratricopeptide repeat domain 36 2.30108
RGPD5 RANBP2-like and GRIP domain containing 5 2.30108
POU3F3 POU class 3 homeobox 3 2.30108
CHRM1 cholinergic receptor, muscarinic 1 2.30108
LAMP3 lysosomal-associated membrane protein 3 2.30108
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.30108
ANXA8 annexin A8 2.30108
PRAP1 proline-rich acidic protein 1 2.30108
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.30108
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.30108
STEAP2 STEAP family member 2, metalloreductase 2.30108
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2.30108
CIB4 calcium and integrin binding family member 4 2.30108
KSR2 kinase suppressor of ras 2 2.268
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 2.26709
GGPS1 geranylgeranyl diphosphate synthase 1 2.2561
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 2.24625
NEK1 NIMA-related kinase 1 2.2049
EIF4E2 eukaryotic translation initiation factor 4E family member 2 2.2044
MAU2 MAU2 sister chromatid cohesion factor 2.20286
GPR83 G protein-coupled receptor 83 2.17532
NOL10 nucleolar protein 10 2.17377
RHEB Ras homolog enriched in brain 2.17377
TTC39C tetratricopeptide repeat domain 39C 2.14823
HLA-DRA major histocompatibility complex, class II, DR alpha 2.147
SLC7A14 solute carrier family 7, member 14 2.147
ELMOD1 ELMO/CED-12 domain containing 1 2.147
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.14344
STAC2 SH3 and cysteine rich domain 2 2.11906
SPRY3 sprouty homolog 3 (Drosophila) 2.11803
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.11325
LRRN1 leucine rich repeat neuronal 1 2.09931
CA5B carbonic anhydrase VB, mitochondrial 2.09931
CD81 CD81 molecule 2.07534
EBPL emopamil binding protein-like 2.07534
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.07126
RBBP8 retinoblastoma binding protein 8 2.04479
CCDC61 coiled-coil domain containing 61 2.04479
MLF2 myeloid leukemia factor 2 2.02254
CSAD cysteine sulfinic acid decarboxylase 2.00406
SFRP2 secreted frizzled-related protein 2 2.00406

decreased expression

Symbol Name Standardized Value
C4ORF51 chromosome 4 open reading frame 51 -2.52131
MAP3K19 mitogen-activated protein kinase kinase kinase 19 -2.52131
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.52131
FBXO4 F-box protein 4 -2.52131
SNTA1 syntrophin, alpha 1 -2.52131
NOXA1 NADPH oxidase activator 1 -2.52131
ORM2 orosomucoid 2 -2.52131
CHADL chondroadherin-like -2.52131
MAN1C1 mannosidase, alpha, class 1C, member 1 -2.52131
ZNF207 zinc finger protein 207 -2.30108
OR10A2 olfactory receptor, family 10, subfamily A, member 2 -2.30108
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.30108
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.30108
LOC122526780 uncharacterized LOC122526780 -2.30108
PSIP1 PC4 and SFRS1 interacting protein 1 -2.30108
PNKP polynucleotide kinase 3'-phosphatase -2.30108
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.30108
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -2.30108
SBF2 SET binding factor 2 -2.30108
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -2.30108
MVK mevalonate kinase -2.30108
RAD23A RAD23 homolog A (S. cerevisiae) -2.30108
TMPRSS11D transmembrane protease, serine 11D -2.30108
EZHIP EZH inhibitory protein -2.30108
CCNP cyclin P -2.30108
KASH5 KASH domain containing 5 -2.30108
BICRAL BICRA like chromatin remodeling complex associated protein -2.30108
NUP58 nucleoporin 58 -2.30108
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.30108
RIPOR1 RHO family interacting cell polarization regulator 1 -2.30108
MCHR1 melanin-concentrating hormone receptor 1 -2.30108
ACSL1 acyl-CoA synthetase long-chain family member 1 -2.30108
GCK glucokinase (hexokinase 4) -2.30108
BARX1 BARX homeobox 1 -2.30108
CATSPERT catsper channel auxiliary subunit tau -2.30108
MSX1 msh homeobox 1 -2.30108
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.30108
MMP13 matrix metallopeptidase 13 -2.30108
SCARF2 scavenger receptor class F, member 2 -2.30108
LRRC32 leucine rich repeat containing 32 -2.30108
TSNAXIP1 translin-associated factor X interacting protein 1 -2.30108
KRTAP5-11 keratin associated protein 5-11 -2.30108
ISLR immunoglobulin superfamily containing leucine-rich repeat -2.30108
GPR68 G protein-coupled receptor 68 -2.30108
F10 coagulation factor X -2.30108
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -2.30108
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -2.30108
CST6 cystatin E/M -2.30108
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -2.30108
TNS2 tensin 2 -2.30108
DGAT2 diacylglycerol O-acyltransferase 2 -2.30108
BCL2L14 BCL2-like 14 (apoptosis facilitator) -2.30108
CLEC4A C-type lectin domain family 4, member A -2.30108
TYMP thymidine phosphorylase -2.30108
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.30108
PRCD progressive rod-cone degeneration -2.30108
CLUL1 clusterin-like 1 (retinal) -2.30108
INTS10 integrator complex subunit 10 -2.28241
BBS12 Bardet-Biedl syndrome 12 -2.25797
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.2561
HID1 HID1 domain containing -2.22094
D2HGDH D-2-hydroxyglutarate dehydrogenase -2.20582
ARL14EP ADP-ribosylation factor-like 14 effector protein -2.2044
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 -2.16344
TWF1 twinfilin actin binding protein 1 -2.147
ZNHIT6 zinc finger, HIT-type containing 6 -2.147
TRMT61B tRNA methyltransferase 61B -2.14112
EFCAB7 EF-hand calcium binding domain 7 -2.1269
ONECUT1 one cut homeobox 1 -2.11906
GYPC glycophorin C (Gerbich blood group) -2.10958
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.10712
STAT1 signal transducer and activator of transcription 1, 91kDa -2.09931
PGGT1B protein geranylgeranyltransferase type I, beta subunit -2.09112
TUSC2 tumor suppressor candidate 2 -2.08573
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.07534
DSCAML1 Down syndrome cell adhesion molecule like 1 -2.05866
TSPAN33 tetraspanin 33 -2.05866
ATF1 activating transcription factor 1 -2.05866
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -2.04479
SCTR secretin receptor -2.04479
TMEM86B transmembrane protein 86B -2.04479
ZNF345 zinc finger protein 345 -2.03719
KLHL22 kelch-like family member 22 -2.03322
LEPROTL1 leptin receptor overlapping transcript-like 1 -2.00603
SLC22A15 solute carrier family 22, member 15 -2.00252
KLRG2 killer cell lectin-like receptor subfamily G, member 2 -2.00252