FBXO11 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description F-box protein 11|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 80204)
External Link http://www.ncbi.nlm.nih.gov/gene/80204
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74 interacting proteins for FBXO11 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BCL6 B-cell CLL/lymphoma 6
BTBD1 BTB (POZ) domain containing 1
BTBD2 BTB (POZ) domain containing 2
BTBD9 BTB (POZ) domain containing 9
CKS1B CDC28 protein kinase regulatory subunit 1B
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COPS2 COP9 signalosome subunit 2
COPS3 COP9 signalosome subunit 3
COPS4 COP9 signalosome subunit 4
COPS5 COP9 signalosome subunit 5
COPS6 COP9 signalosome subunit 6
COPS7A COP9 signalosome subunit 7A
COPS7B COP9 signalosome subunit 7B
COPS8 COP9 signalosome subunit 8
CRBN cereblon
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
DCAF11 DDB1 and CUL4 associated factor 11
DCAF4 DDB1 and CUL4 associated factor 4
DDA1 DET1 and DDB1 associated 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
EFHD1 EF-hand domain family, member D1
ELAVL1 ELAV like RNA binding protein 1
ERCC8 excision repair cross-complementation group 8
FBXO17 F-box protein 17
FBXO22 F-box protein 22
FBXO44 F-box protein 44
FBXO7 F-box protein 7
FBXW9 F-box and WD repeat domain containing 9
FEM1B fem-1 homolog b (C. elegans)
GDI1 GDP dissociation inhibitor 1
GPS1 G protein pathway suppressor 1
GXYLT1 glucoside xylosyltransferase 1
HDAC6 histone deacetylase 6
HSPE1 heat shock 10kDa protein 1
KCTD3 potassium channel tetramerization domain containing 3
KLHL13 kelch-like family member 13
KLHL15 kelch-like family member 15
KLHL18 kelch-like family member 18
KLHL20 kelch-like family member 20
KLHL22 kelch-like family member 22
KLHL24 kelch-like family member 24
KLHL42 kelch-like family member 42
KLHL8 kelch-like family member 8
KLHL9 kelch-like family member 9
LRR1 leucine rich repeat protein 1
LRRC14 leucine rich repeat containing 14
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MYEOV2 myeloma overexpressed 2
NAE1 NEDD8 activating enzyme E1 subunit 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
RBX1 ring-box 1, E3 ubiquitin protein ligase
SHKBP1 SH3KBP1 binding protein 1
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TKT transketolase
TOR1AIP2 torsin A interacting protein 2
TP53 tumor protein p53
TXN thioredoxin
UBA3 ubiquitin-like modifier activating enzyme 3
UBC ubiquitin C
UBE2M ubiquitin-conjugating enzyme E2M
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USP16 ubiquitin specific peptidase 16
VPRBP Vpr (HIV-1) binding protein
ZYG11B zyg-11 family member B, cell cycle regulator