FBXO7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description F-box protein 7|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 25793)
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Genes

327 genes differentially expressed following the FBXO7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IGFL3 IGF-like family member 3 2.83736
NYX nyctalopin 2.71367
BIN2 bridging integrator 2 2.71367
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.71367
TMPRSS5 transmembrane protease, serine 5 2.71367
F11R F11 receptor 2.71367
GLB1L galactosidase, beta 1-like 2.71367
DGCR6 DiGeorge syndrome critical region gene 6 2.71367
CAPN9 calpain 9 2.71367
CCDC68 coiled-coil domain containing 68 2.71367
HPX hemopexin 2.71367
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.71367
TMPRSS15 transmembrane protease, serine 15 2.71367
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.71367
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 2.71367
CIDEC cell death-inducing DFFA-like effector c 2.71367
NOS2 nitric oxide synthase 2, inducible 2.71367
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.71367
IL19 interleukin 19 2.71367
KIF12 kinesin family member 12 2.71367
EPHB3 EPH receptor B3 2.67931
NMUR2 neuromedin U receptor 2 2.67931
FAM178B family with sequence similarity 178, member B 2.67931
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.67931
IRF5 interferon regulatory factor 5 2.67931
MYO16 myosin XVI 2.67931
ATOH7 atonal homolog 7 (Drosophila) 2.67931
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.67931
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.67931
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.67931
AQP1 aquaporin 1 (Colton blood group) 2.67931
TMEM86A transmembrane protein 86A 2.67931
GCM1 glial cells missing homolog 1 (Drosophila) 2.67931
TWIST1 twist family bHLH transcription factor 1 2.67931
ACAN aggrecan 2.67931
MMP13 matrix metallopeptidase 13 2.67931
NKPD1 NTPase, KAP family P-loop domain containing 1 2.67931
TESPA1 thymocyte expressed, positive selection associated 1 2.67931
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.67931
FXYD5 FXYD domain containing ion transport regulator 5 2.67931
SNAI2 snail family zinc finger 2 2.67931
VCX3A variable charge, X-linked 3A 2.67931
FMR1NB fragile X mental retardation 1 neighbor 2.67931
BFSP2 beaded filament structural protein 2, phakinin 2.67931
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.67931
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.67931
KCNRG potassium channel regulator 2.67931
SYCP2 synaptonemal complex protein 2 2.67931
RSPO3 R-spondin 3 2.67931
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.67931
GJA4 gap junction protein, alpha 4, 37kDa 2.67931
TMPRSS11A transmembrane protease, serine 11A 2.67931
CD274 CD274 molecule 2.67931
CRYGB crystallin, gamma B 2.67931
JOSD2 Josephin domain containing 2 2.67931
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.67931
SLC35G6 solute carrier family 35, member G6 2.67931
GLUD2 glutamate dehydrogenase 2 2.67931
NXPH4 neurexophilin 4 2.67931
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.67931
SCARA5 scavenger receptor class A, member 5 2.67931
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.67931
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.67931
CRYGA crystallin, gamma A 2.67931
RLN3 relaxin 3 2.67931
MISP mitotic spindle positioning 2.67931
NPIPA3 nuclear pore complex interacting protein family, member A3 2.67931
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 2.67931
ASPHD2 aspartate beta-hydroxylase domain containing 2 2.67931
SOWAHB sosondowah ankyrin repeat domain family member B 2.67931
MAGED4 melanoma antigen family D4 2.67931
TRIM42 tripartite motif containing 42 2.67931
FAM170A family with sequence similarity 170, member A 2.67931
TNS4 tensin 4 2.67931
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 2.67931
GMFG glia maturation factor, gamma 2.67931
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.67931
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.67931
CRYBB2 crystallin, beta B2 2.67931
C8G complement component 8, gamma polypeptide 2.67931
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.67931
ASTL astacin-like metallo-endopeptidase (M12 family) 2.67931
SST somatostatin 2.67931
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.67931
FBXO41 F-box protein 41 2.67931
COL6A5 collagen, type VI, alpha 5 2.67931
KHDC1L KH homology domain containing 1-like 2.67931
HAO2 hydroxyacid oxidase 2 (long chain) 2.67931
OTOF otoferlin 2.67931
MCHR1 melanin-concentrating hormone receptor 1 2.67931
ROPN1B rhophilin associated tail protein 1B 2.67931
TBC1D24 TBC1 domain family, member 24 2.67931
DRD2 dopamine receptor D2 2.67931
GFRAL GDNF family receptor alpha like 2.67931
SPATS1 spermatogenesis associated, serine-rich 1 2.67931
SQOR sulfide quinone oxidoreductase 2.67931
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.67931
ACKR5 atypical chemokine receptor 5 2.67931
C22ORF31 chromosome 22 open reading frame 31 2.67931
DRC5 dynein regulatory complex subunit 5 2.67931
CEND1 cell cycle exit and neuronal differentiation 1 2.67931
RIPK3 receptor-interacting serine-threonine kinase 3 2.67931
LGALS12 lectin, galactoside-binding, soluble, 12 2.67931
GREP1 glycine rich extracellular protein 1 2.67931
CCNI2 cyclin I family, member 2 2.67931
CYTH2 cytohesin 2 2.67931
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.67931
RGS8 regulator of G-protein signaling 8 2.67931
YBX1 Y box binding protein 1 2.67931
H2BC3 H2B clustered histone 3 2.67931
CLEC4D C-type lectin domain family 4, member D 2.67931
VN1R2 vomeronasal 1 receptor 2 2.67931
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.67931
RGS13 regulator of G-protein signaling 13 2.67931
MYL10 myosin, light chain 10, regulatory 2.67931
RBMXL3 RNA binding motif protein, X-linked-like 3 2.67931
LY6K lymphocyte antigen 6 complex, locus K 2.67931
MYF6 myogenic factor 6 (herculin) 2.67931
MAGIX MAGI family member, X-linked 2.67931
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.67931
APOF apolipoprotein F 2.67931
CPZ carboxypeptidase Z 2.67931
MAGEB17 melanoma antigen family B17 2.67931
GATA4 GATA binding protein 4 2.67931
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.67931
PNPLA1 patatin-like phospholipase domain containing 1 2.67931
MAPK11 mitogen-activated protein kinase 11 2.67931
LRRC71 leucine rich repeat containing 71 2.67931
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.67931
C20ORF202 chromosome 20 open reading frame 202 2.67931
SMLR1 small leucine-rich protein 1 2.67931
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.67931
FAM177B family with sequence similarity 177, member B 2.67931
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.67931
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.67931
CLRN1 clarin 1 2.67931
ARL4A ADP-ribosylation factor-like 4A 2.67931
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 2.67931
NPFFR1 neuropeptide FF receptor 1 2.67931
SERINC4 serine incorporator 4 2.67931
RDH8 retinol dehydrogenase 8 (all-trans) 2.67931
PLCZ1 phospholipase C, zeta 1 2.67931
GP6 glycoprotein VI (platelet) 2.65925
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.62984
SLC30A10 solute carrier family 30, member 10 2.58953
PRR7 proline rich 7 (synaptic) 2.57843
RPP25L ribonuclease P/MRP 25kDa subunit-like 2.56893
RPS26 ribosomal protein S26 2.55046
MRPL20 mitochondrial ribosomal protein L20 2.48765
RUMY3 RUMY family member 3 2.48765
FAM86B2 family with sequence similarity 86, member B2 2.48765
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.48765
ATXN10 ataxin 10 2.4782
CISH cytokine inducible SH2-containing protein 2.46246
ARMCX6 armadillo repeat containing, X-linked 6 2.46246
DRP2 dystrophin related protein 2 2.46246
ZNF365 zinc finger protein 365 2.46246
SSRP1 structure specific recognition protein 1 2.45864
VWDE von Willebrand factor D and EGF domains 2.44447
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 2.44339
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.43754
TECTA tectorin alpha 2.4277
CCDC92 coiled-coil domain containing 92 2.4277
TUBB2A tubulin, beta 2A class IIa 2.42096
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.39532
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 2.38516
UPK3BL1 uroplakin 3B like 1 2.37815
UNC5D unc-5 homolog D (C. elegans) 2.37706
PXMP2 peroxisomal membrane protein 2, 22kDa 2.37706
ZC3H18 zinc finger CCCH-type containing 18 2.36406
CPLX1 complexin 1 2.36046
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 2.35436
CISD2 CDGSH iron sulfur domain 2 2.31007
WDR86 WD repeat domain 86 2.29222
LENG8 leukocyte receptor cluster (LRC) member 8 2.28759
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 2.28251
KIAA1328 KIAA1328 2.2547
MFF mitochondrial fission factor 2.23514
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.23221
CCDC180 coiled-coil domain containing 180 2.2124
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.21215
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 2.21102
SPATA1 spermatogenesis associated 1 2.20705
METRNL meteorin, glial cell differentiation regulator-like 2.1755
SYK spleen tyrosine kinase 2.16281
ENHO energy homeostasis associated 2.16281
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.14267
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.14243
SNIP1 Smad nuclear interacting protein 1 2.14213
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.13889
RAB30 RAB30, member RAS oncogene family 2.13494
C17ORF58 chromosome 17 open reading frame 58 2.1283
TDRD12 tudor domain containing 12 2.10346
TFE3 transcription factor binding to IGHM enhancer 3 2.08081
POLN polymerase (DNA directed) nu 2.06894
TSPYL2 TSPY-like 2 2.0654
TWNK twinkle mtDNA helicase 2.06262
SOD1 superoxide dismutase 1, soluble 2.05873
TCAIM T cell activation inhibitor, mitochondrial 2.05873
FDPS farnesyl diphosphate synthase 2.05873
AK4 adenylate kinase 4 2.05545
FAM221A family with sequence similarity 221, member A 2.04398
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 2.04126
MAP7D3 MAP7 domain containing 3 2.04021
PCDH10 protocadherin 10 2.0307
CFAP20 cilia and flagella associated protein 20 2.0228
CENPM centromere protein M 2.02268
ZNF639 zinc finger protein 639 2.021
TMEM128 transmembrane protein 128 2.01335
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2.00321

decreased expression

Symbol Name Standardized Value
KLRD1 killer cell lectin-like receptor subfamily D, member 1 -2.71367
NT5C3B 5'-nucleotidase, cytosolic IIIB -2.71367
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.67931
TEX2 testis expressed 2 -2.67931
SFRP5 secreted frizzled-related protein 5 -2.67931
NHSL3 NHS like 3 -2.67931
ACTG2 actin, gamma 2, smooth muscle, enteric -2.67931
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.67931
TASP1 taspase, threonine aspartase, 1 -2.67931
TMEM263 transmembrane protein 263 -2.67931
ZNF587B zinc finger protein 587B -2.67931
FBXO7 F-box protein 7 -2.67931
IL6ST-DT IL6ST divergent transcript -2.67931
GPHA2 glycoprotein hormone alpha 2 -2.67931
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.67931
TESMIN testis expressed metallothionein like protein -2.67931
BMP6 bone morphogenetic protein 6 -2.67931
TMEM150A transmembrane protein 150A -2.6651
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 -2.63535
STK24 serine/threonine kinase 24 -2.58494
LOC730098 uncharacterized LOC730098 -2.57843
CFAP53 cilia and flagella associated protein 53 -2.55046
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.55046
DUSP15 dual specificity phosphatase 15 -2.55046
H2BC8 H2B clustered histone 8 -2.51323
PCDHB12 protocadherin beta 12 -2.51323
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.51323
RPS21-DT RPS21 divergent transcript -2.48765
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.48765
SLC10A4 solute carrier family 10, member 4 -2.48765
FGF9 fibroblast growth factor 9 -2.48765
LOC124906010 uncharacterized LOC124906010 -2.48765
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.48765
SART3 squamous cell carcinoma antigen recognized by T cells 3 -2.48765
TLE6 transducin-like enhancer of split 6 -2.48765
CCDC92B coiled-coil domain containing 92B -2.48765
PTOV1 prostate tumor overexpressed 1 -2.48765
AMBP alpha-1-microglobulin/bikunin precursor -2.48765
INHBE inhibin, beta E -2.48765
FAM43B family with sequence similarity 43, member B -2.48765
UNC80 unc-80 homolog (C. elegans) -2.48765
H3C13 H3 clustered histone 13 -2.48765
CD160 CD160 molecule -2.48765
GARIN1B golgi associated RAB2 interactor 1B -2.48765
ASGR2 asialoglycoprotein receptor 2 -2.48765
TMEM184A transmembrane protein 184A -2.48765
CTRL chymotrypsin-like -2.48765
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.48765
MZB1 marginal zone B and B1 cell-specific protein -2.48765
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.48765
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.48765
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.48765
ROM1 retinal outer segment membrane protein 1 -2.48765
SWAP70 SWAP switching B-cell complex 70kDa subunit -2.48765
DCDC2B doublecortin domain containing 2B -2.48765
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.48765
ZDHHC11B zinc finger, DHHC-type containing 11B -2.48765
RTN4RL1 reticulon 4 receptor-like 1 -2.48765
UPK1B uroplakin 1B -2.48765
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -2.48765
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.48765
AGBL1 ATP/GTP binding protein-like 1 -2.48765
PARP15 poly (ADP-ribose) polymerase family, member 15 -2.48765
ADGRD2 adhesion G protein-coupled receptor D2 -2.4782
RAD9A RAD9 homolog A (S. pombe) -2.46989
KIF20A kinesin family member 20A -2.45522
BRMS1L breast cancer metastasis-suppressor 1-like -2.44447
LCMT2 leucine carboxyl methyltransferase 2 -2.44447
INPP5J inositol polyphosphate-5-phosphatase J -2.43754
ZFYVE1 zinc finger, FYVE domain containing 1 -2.43185
NUP188 nucleoporin 188kDa -2.42096
DMGDH dimethylglycine dehydrogenase -2.38066
TRIM58 tripartite motif containing 58 -2.37706
MSH4 mutS homolog 4 -2.37706
TRAPPC14 trafficking protein particle complex subunit 14 -2.37706
TMEM161A transmembrane protein 161A -2.3655
ATP9A ATPase, class II, type 9A -2.36406
ERCC8 excision repair cross-complementation group 8 -2.35436
RWDD2A RWD domain containing 2A -2.34705
ALPK3 alpha-kinase 3 -2.34705
SEC31A SEC31 homolog A (S. cerevisiae) -2.3432
PITPNM3 PITPNM family member 3 -2.34312
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -2.34312
NLGN4X neuroligin 4, X-linked -2.2547
SHLD2 shieldin complex subunit 2 -2.2547
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.23221
CLCN4 chloride channel, voltage-sensitive 4 -2.2011
CCDC157 coiled-coil domain containing 157 -2.2011
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -2.18173
SLC25A43 solute carrier family 25, member 43 -2.1755
NCKIPSD NCK interacting protein with SH3 domain -2.17304
PUS3 pseudouridylate synthase 3 -2.16281
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.1596
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.15336
PNMA6A paraneoplastic Ma antigen family member 6A -2.15336
TMT1B thiol methyltransferase 1B -2.15336
FMC1 formation of mitochondrial complex V assembly factor 1 homolog -2.1458
KMT5B lysine methyltransferase 5B -2.1358
CCND1 cyclin D1 -2.13494
FBXL16 F-box and leucine-rich repeat protein 16 -2.13494
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 -2.13494
LRRC37B leucine rich repeat containing 37B -2.13226
TSPAN5 tetraspanin 5 -2.12238
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.10461
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.10117
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.09706
SEC31B SEC31 homolog B (S. cerevisiae) -2.08789
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.07647
SPATA16 spermatogenesis associated 16 -2.05465
NLRC5 NLR family, CARD domain containing 5 -2.05465
ZBTB41 zinc finger and BTB domain containing 41 -2.03618
MIS12 MIS12 kinetochore complex component -2.03618
PDCD6IP programmed cell death 6 interacting protein -2.03342
TARS3 threonyl-tRNA synthetase 3 -2.03124
UTP25 UTP25 small subunit processome component -2.02899
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.01335
ISY1 ISY1 splicing factor homolog (S. cerevisiae) -2.00321