FBXW2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description F-box and WD repeat domain containing 2|F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 26190)
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Genes

267 genes differentially expressed following the FBXW2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ITGA8 integrin, alpha 8 2.65658
LOC124901449 uncharacterized LOC124901449 2.65658
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.65658
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.65658
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.65658
CEL carboxyl ester lipase 2.65658
FFAR4 free fatty acid receptor 4 2.65658
OXER1 oxoeicosanoid (OXE) receptor 1 2.65658
TMPRSS11A transmembrane protease, serine 11A 2.65658
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.65658
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.65658
NMUR1 neuromedin U receptor 1 2.65658
CSAG1 chondrosarcoma associated gene 1 2.65658
TRAPPC13 trafficking protein particle complex 13 2.65658
CCDC170 coiled-coil domain containing 170 2.65658
CPNE8-AS1 CPNE8 antisense RNA 1 2.65658
SLC22A25 solute carrier family 22, member 25 2.65658
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.65658
OOSP4B oocyte secreted protein family member 4B 2.65658
GPR20 G protein-coupled receptor 20 2.65658
DAO D-amino-acid oxidase 2.65658
TMPRSS13 transmembrane protease, serine 13 2.65658
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.59547
OR11H4 olfactory receptor, family 11, subfamily H, member 4 2.59547
CD6 CD6 molecule 2.59547
SIX2 SIX homeobox 2 2.59547
IL12RB1 interleukin 12 receptor, beta 1 2.59547
GDA guanine deaminase 2.59547
TUBA3E tubulin, alpha 3e 2.59547
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.59547
THPO thrombopoietin 2.59547
ZNF503 zinc finger protein 503 2.59547
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.59547
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.59547
LACRT lacritin 2.59547
GPR21 G protein-coupled receptor 21 2.59547
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.59547
NUGGC nuclear GTPase, germinal center associated 2.59547
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.59547
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.59547
PDE7B phosphodiesterase 7B 2.59547
TKTL2 transketolase-like 2 2.59547
FOXI1 forkhead box I1 2.59547
ADTRP androgen-dependent TFPI-regulating protein 2.59547
GRXCR2 glutaredoxin, cysteine rich 2 2.59547
GLUD2 glutamate dehydrogenase 2 2.59547
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.59547
PRELP proline/arginine-rich end leucine-rich repeat protein 2.59547
CD1C CD1c molecule 2.59547
NPIPA8 nuclear pore complex interacting protein family, member A8 2.59547
ESM1 endothelial cell-specific molecule 1 2.59547
TMPRSS7 transmembrane protease, serine 7 2.59547
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.59547
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.59547
C20ORF202 chromosome 20 open reading frame 202 2.59547
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.59547
SPRR2F small proline-rich protein 2F 2.59547
MGAT4D MGAT4 family, member D 2.59547
ARID1A AT rich interactive domain 1A (SWI-like) 2.59547
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.59547
TMEM275 transmembrane protein 275 2.59547
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.59547
TMEM273 transmembrane protein 273 2.59547
SMIM35 small integral membrane protein 35 2.59547
CD8B2 CD8b2 molecule 2.59547
C1ORF232 chromosome 1 open reading frame 230 2.59547
ANKRD42-DT ANKRD42 divergent transcript 2.59547
LY6S-AS1 LY6S antisense RNA 1 2.59547
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.59547
ASB4 ankyrin repeat and SOCS box containing 4 2.59547
BDKRB1 bradykinin receptor B1 2.59547
C10ORF67 chromosome 10 open reading frame 67 2.59547
INAFM2 InaF-motif containing 2 2.59547
TLR8 toll-like receptor 8 2.59547
PGC progastricsin (pepsinogen C) 2.59547
MIP major intrinsic protein of lens fiber 2.59547
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.59547
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.59547
CFAP45 cilia and flagella associated protein 45 2.59547
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.59547
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.59547
OOSP1 oocyte secreted protein 1, pseudogene 2.59547
GPR83 G protein-coupled receptor 83 2.59547
DYNAP dynactin associated protein 2.59547
LRRN4CL LRRN4 C-terminal like 2.59547
GATA6 GATA binding protein 6 2.59547
GATA3 GATA binding protein 3 2.59547
LY6K lymphocyte antigen 6 complex, locus K 2.59547
LOC124906892 uncharacterized LOC124906892 2.59547
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2.59547
BCL2A1 BCL2-related protein A1 2.59547
OSM oncostatin M 2.59547
APOC2 apolipoprotein C-II 2.59547
CLEC4D C-type lectin domain family 4, member D 2.59547
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.59547
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.59547
TRIM50 tripartite motif containing 50 2.59547
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.59547
PCDHGA2 protocadherin gamma subfamily A, 2 2.59547
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.59547
PKDREJ polycystin (PKD) family receptor for egg jelly 2.59547
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.59547
RPA4 replication protein A4, 30kDa 2.59547
GLYATL3 glycine-N-acyltransferase-like 3 2.59547
CDC20B cell division cycle 20B 2.59547
CERKL ceramide kinase-like 2.59547
HHATL hedgehog acyltransferase-like 2.59547
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.59547
FAM177B family with sequence similarity 177, member B 2.59547
AGXT2 alanine--glyoxylate aminotransferase 2 2.59547
TAT tyrosine aminotransferase 2.59547
CYTH4 cytohesin 4 2.59547
CSF1R colony stimulating factor 1 receptor 2.59547
MYLK2 myosin light chain kinase 2 2.59547
DEFB135 defensin, beta 135 2.59547
HPGDS hematopoietic prostaglandin D synthase 2.59547
C22ORF31 chromosome 22 open reading frame 31 2.59547
GOLGA8K golgin A8 family, member K 2.59547
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.59547
GPR62 G protein-coupled receptor 62 2.59547
OTOP3 otopetrin 3 2.59547
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.59547
IL1B interleukin 1, beta 2.59547
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.59547
TTC16 tetratricopeptide repeat domain 16 2.59547
SAMD5 sterile alpha motif domain containing 5 2.59547
VSTM4 V-set and transmembrane domain containing 4 2.59547
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.59547
PRH2 proline-rich protein HaeIII subfamily 2 2.59547
PRSS57 protease, serine, 57 2.59547
PASD1 PAS domain containing 1 2.59547
FGF10 fibroblast growth factor 10 2.59547
GPBAR1 G protein-coupled bile acid receptor 1 2.59547
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.59547
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.59547
TMEM86A transmembrane protein 86A 2.59547
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.59547
KIAA1755 KIAA1755 2.59547
CLCNKB chloride channel, voltage-sensitive Kb 2.59547
MAGEA12 melanoma antigen family A12 2.59547
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.59547
GALP galanin-like peptide 2.59547
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.59547
SPNS3 spinster homolog 3 (Drosophila) 2.59547
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.59547
CHRM4 cholinergic receptor, muscarinic 4 2.59547
MT1A metallothionein 1A 2.59547
TAS2R13 taste receptor, type 2, member 13 2.59547
TAS2R10 taste receptor, type 2, member 10 2.59547
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.59547
SUN3 Sad1 and UNC84 domain containing 3 2.59547
NUTM2F NUT family member 2F 2.59547
MRC1 mannose receptor, C type 1 2.59547
ATOH1 atonal homolog 1 (Drosophila) 2.59547
TSLP thymic stromal lymphopoietin 2.56055
GGACT gamma-glutamylamine cyclotransferase 2.56055
CNTD1 cyclin N-terminal domain containing 1 2.56055
GAPVD1 GTPase activating protein and VPS9 domains 1 2.56055
CDHR5 cadherin-related family member 5 2.56055
SERF1A small EDRK-rich factor 1A (telomeric) 2.56055
ALOXE3 arachidonate lipoxygenase 3 2.56055
TOR3A torsin family 3, member A 2.55727
FAM114A2 family with sequence similarity 114, member A2 2.54736
SPRTN SprT-like N-terminal domain 2.52089
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 2.49632
DPY19L2 dpy-19-like 2 (C. elegans) 2.43727
LARP7 La ribonucleoprotein domain family, member 7 2.30543
ARRB1 arrestin, beta 1 2.30242
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.30242
GSTZ1 glutathione S-transferase zeta 1 2.30242
PACRGL PARK2 co-regulated-like 2.26
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.25397
MAP3K3 mitogen-activated protein kinase kinase kinase 3 2.20001
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.17125
AKAP1 A kinase (PRKA) anchor protein 1 2.15928
BCAR3 breast cancer anti-estrogen resistance 3 2.14606
DIAPH3 diaphanous-related formin 3 2.14021
LRRC8B leucine rich repeat containing 8 family, member B 2.13964
DYNLL2 dynein, light chain, LC8-type 2 2.09144
TMEM179 transmembrane protein 179 2.08997
MLPH melanophilin 2.07125
LRGUK leucine-rich repeats and guanylate kinase domain containing 2.04055
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.04055
CCNB3 cyclin B3 2.04055
RHOJ ras homolog family member J 2.04055
PYY peptide YY 2.00705
PTGFRN prostaglandin F2 receptor inhibitor 2.00246

decreased expression

Symbol Name Standardized Value
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.65658
CD47 CD47 molecule -2.59547
TXN thioredoxin -2.59547
RBMX2 RNA binding motif protein, X-linked 2 -2.59547
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) -2.59547
METTL26 methyltransferase like 26 -2.59547
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.59547
IL4I1 interleukin 4 induced 1 -2.5673
POU3F2 POU class 3 homeobox 2 -2.56055
PRAM1 PML-RARA regulated adaptor molecule 1 -2.56055
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.56055
CD8A CD8a molecule -2.56055
RIMBP2 RIMS binding protein 2 -2.56055
DNAH7 dynein, axonemal, heavy chain 7 -2.56055
USP50 ubiquitin specific peptidase 50 -2.56055
TNMD tenomodulin -2.56055
SOX30 SRY (sex determining region Y)-box 30 -2.56055
SLC25A41 solute carrier family 25, member 41 -2.56055
MUSK muscle, skeletal, receptor tyrosine kinase -2.56055
CXCL2 chemokine (C-X-C motif) ligand 2 -2.56055
RORC RAR-related orphan receptor C -2.56055
SLC46A3 solute carrier family 46, member 3 -2.56055
GDPGP1 GDP-D-glucose phosphorylase 1 -2.56055
CIMAP1B ciliary microtubule associated protein 1B -2.56055
TAFA1 TAFA chemokine like family member 1 -2.56055
XIRP2 xin actin binding repeat containing 2 -2.56055
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.56055
MROH5 maestro heat-like repeat family member 5 -2.56055
IL1R1 interleukin 1 receptor, type I -2.56055
IFNL4 interferon, lambda 4 (gene/pseudogene) -2.56055
C2CD4B C2 calcium-dependent domain containing 4B -2.56055
CBX8 chromobox homolog 8 -2.56055
AMIGO1 adhesion molecule with Ig-like domain 1 -2.56055
CLDN34 claudin 34 -2.56055
ZNF541 zinc finger protein 541 -2.56055
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) -2.56055
CATSPERH catsper channel auxiliary subunit eta -2.56055
TMX1 thioredoxin-related transmembrane protein 1 -2.55727
FBXW2 F-box and WD repeat domain containing 2 -2.55288
RERG RAS-like, estrogen-regulated, growth inhibitor -2.4607
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator -2.4607
PGAM2 phosphoglycerate mutase 2 (muscle) -2.45773
CNGA4 cyclic nucleotide gated channel alpha 4 -2.43616
SPATA32 spermatogenesis associated 32 -2.43616
DDTL D-dopachrome tautomerase-like -2.43616
OLIG1 oligodendrocyte transcription factor 1 -2.43616
ORM2 orosomucoid 2 -2.43616
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.43124
ZNF18 zinc finger protein 18 -2.4096
SFN stratifin -2.40934
TNS4 tensin 4 -2.34891
SBK2 SH3 domain binding kinase family, member 2 -2.33636
RLN2 relaxin 2 -2.31452
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -2.31436
ELAVL1 ELAV like RNA binding protein 1 -2.30242
NCOR1 nuclear receptor corepressor 1 -2.28003
LYSMD4 LysM, putative peptidoglycan-binding, domain containing 4 -2.2289
RPN1 ribophorin I -2.20001
XPA xeroderma pigmentosum, complementation group A -2.19872
THADA thyroid adenoma associated -2.19872
C19ORF73 chromosome 19 open reading frame 73 -2.19834
SIK2 salt-inducible kinase 2 -2.19834
CBARP CACN subunit beta associated regulatory protein -2.19627
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.19391
SMIM12 small integral membrane protein 12 -2.1829
PPAN peter pan homolog (Drosophila) -2.17799
TNS1-AS1 TNS1 antisense RNA 1 -2.15101
CD96 CD96 molecule -2.15101
PCDHA11 protocadherin alpha 11 -2.15101
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -2.15101
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -2.13572
TMEM35A transmembrane protein 35A -2.13011
FKTN fukutin -2.12608
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.1135
HIPK4 homeodomain interacting protein kinase 4 -2.10074
ARHGAP44 Rho GTPase activating protein 44 -2.08076
ALKAL2 ALK and LTK ligand 2 -2.04055
ANXA7 annexin A7 -2.04055
SON SON DNA binding protein -2.0248
COPA coatomer protein complex, subunit alpha -2.0082