FBXW7 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 55294)
External Link http://www.ncbi.nlm.nih.gov/gene/55294
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320 interacting proteins for FBXW7 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ACOT8 acyl-CoA thioesterase 8
ACTL6A actin-like 6A
AKAP8 A kinase (PRKA) anchor protein 8
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL1 ADP-ribosylation factor-like 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASS1 argininosuccinate synthase 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
AURKA aurora kinase A
AURKB aurora kinase B
BCR breakpoint cluster region
BTG1 B-cell translocation gene 1, anti-proliferative
C1QBP complement component 1, q subcomponent binding protein
CCDC6 coiled-coil domain containing 6
CCNC cyclin C
CCNE1 cyclin E1
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDC34 cell division cycle 34
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEPT1 choline/ethanolamine phosphotransferase 1
CHD4 chromodomain helicase DNA binding protein 4
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CHUK conserved helix-loop-helix ubiquitous kinase
COPG1 coatomer protein complex, subunit gamma 1
COPG2 coatomer protein complex, subunit gamma 2
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CUL1 cullin 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2IP DAB2 interacting protein
DCLRE1C DNA cross-link repair 1C
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EBNA1BP2 EBNA1 binding protein 2
EEF1G eukaryotic translation elongation factor 1 gamma
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EP400 E1A binding protein p400
ERCC3 excision repair cross-complementation group 3
ETFA electron-transfer-flavoprotein, alpha polypeptide
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM101A family with sequence similarity 101, member A
FANCD2 Fanconi anemia, complementation group D2
FBL fibrillarin
FBXW8 F-box and WD repeat domain containing 8
GANAB glucosidase, alpha; neutral AB
GCDH glutaryl-CoA dehydrogenase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GLMN glomulin, FKBP associated protein
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GSG2 germ cell associated 2 (haspin)
GSK3B glycogen synthase kinase 3 beta
GTF2I general transcription factor IIi
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HELLS helicase, lymphoid-specific
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BL histone cluster 1, H2bl
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ILVBL ilvB (bacterial acetolactate synthase)-like
IPO13 importin 13
IPO4 importin 4
IPO7 importin 7
IPO9 importin 9
IQGAP2 IQ motif containing GTPase activating protein 2
IQGAP3 IQ motif containing GTPase activating protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS4 insulin receptor substrate 4
JAG1 jagged 1
JUN jun proto-oncogene
KIAA1875 KIAA1875
KLF2 Kruppel-like factor 2
KLF5 Kruppel-like factor 5 (intestinal)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNB1 karyopherin (importin) beta 1
LINGO1 leucine rich repeat and Ig domain containing 1
LMNA lamin A/C
LONP1 lon peptidase 1, mitochondrial
LRPPRC leucine-rich pentatricopeptide repeat containing
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPKAP1 mitogen-activated protein kinase associated protein 1
MARS methionyl-tRNA synthetase
MAX MYC associated factor X
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MED10 mediator complex subunit 10
MED11 mediator complex subunit 11
MED12 mediator complex subunit 12
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
MED14 mediator complex subunit 14
MED15 mediator complex subunit 15
MED16 mediator complex subunit 16
MED17 mediator complex subunit 17
MED19 mediator complex subunit 19
MED20 mediator complex subunit 20
MED21 mediator complex subunit 21
MED22 mediator complex subunit 22
MED23 mediator complex subunit 23
MED24 mediator complex subunit 24
MED27 mediator complex subunit 27
MED28 mediator complex subunit 28
MED29 mediator complex subunit 29
MED30 mediator complex subunit 30
MED31 mediator complex subunit 31
MED4 mediator complex subunit 4
MED6 mediator complex subunit 6
MED8 mediator complex subunit 8
MED9 mediator complex subunit 9
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MMS22L MMS22-like, DNA repair protein
MOGS mannosyl-oligosaccharide glucosidase
MRPS22 mitochondrial ribosomal protein S22
MRPS34 mitochondrial ribosomal protein S34
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO5C myosin VC
MYO9A myosin IXA
MYO9B myosin IXB
NCOA3 nuclear receptor coactivator 3
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NEK9 NIMA-related kinase 9
NFE2L1 nuclear factor, erythroid 2-like 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NONO non-POU domain containing, octamer-binding
NOP56 NOP56 ribonucleoprotein
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
NUCLEOLIN nucleolin multifunctional protein
NUDCD2 NudC domain containing 2
NUP133 nucleoporin 133kDa
NUP153 nucleoporin 153kDa
OAT ornithine aminotransferase
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PARK2 parkin RBR E3 ubiquitin protein ligase
PCBP1 poly(rC) binding protein 1
PELO pelota homolog (Drosophila)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP6C protein phosphatase 6, catalytic subunit
PPT1 palmitoyl-protein thioesterase 1
PRKCA protein kinase C, alpha
PRKCI protein kinase C, iota
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF6 pre-mRNA processing factor 6
PSEN1 presenilin 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSME4 proteasome (prosome, macropain) activator subunit 4
PTEN phosphatase and tensin homolog
PTGES2 prostaglandin E synthase 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANBP2 RAN binding protein 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RICTOR RPTOR independent companion of MTOR, complex 2
RNGTT RNA guanylyltransferase and 5'-phosphatase
RNH1 ribonuclease/angiogenin inhibitor 1
RPN1 ribophorin I
RPN2 ribophorin II
RPP30 ribonuclease P/MRP 30kDa subunit
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SARS seryl-tRNA synthetase
SEC16A SEC16 homolog A (S. cerevisiae)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SKP1 S-phase kinase-associated protein 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLIT2 slit homolog 2 (Drosophila)
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SSR4 signal sequence receptor, delta
STOML1 stomatin (EPB72)-like 1
SUCLG1 succinate-CoA ligase, alpha subunit
SUMF2 sulfatase modifying factor 2
TCP1 t-complex 1
TMPO thymopoietin
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TP63 tumor protein p63
TRIM28 tripartite motif containing 28
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TRRAP transformation/transcription domain-associated protein
TTC27 tetratricopeptide repeat domain 27
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
TUBGCP2 tubulin, gamma complex associated protein 2
U2SURP U2 snRNP-associated SURP domain containing
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1
UBE3C ubiquitin protein ligase E3C
UBR2 ubiquitin protein ligase E3 component n-recognin 2
USP28 ubiquitin specific peptidase 28
USP9X ubiquitin specific peptidase 9, X-linked
WDR77 WD repeat domain 77
XPO1 exportin 1
XPO5 exportin 5
XPOT exportin, tRNA
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XRN1 5'-3' exoribonuclease 1
YAP1 Yes-associated protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF121 zinc finger protein 121
ZNF281 zinc finger protein 281