FECH Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ferrochelatase|The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 2235)
External Link http://www.ncbi.nlm.nih.gov/gene/2235
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Genes

170 interacting proteins for FECH from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
AHCYL1 adenosylhomocysteinase-like 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMOT angiomotin
ANAPC2 anaphase promoting complex subunit 2
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARL1 ADP-ribosylation factor-like 1
ARMC10 armadillo repeat containing 10
ARRB2 arrestin, beta 2
ATAD3B ATPase family, AAA domain containing 3B
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BMS1 BMS1 ribosome biogenesis factor
C14ORF169 chromosome 14 open reading frame 169
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CLEC4M C-type lectin domain family 4, member M
COPS5 COP9 signalosome subunit 5
COPS6 COP9 signalosome subunit 6
CPNE3 copine III
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CTSB cathepsin B
CUL3 cullin 3
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
ECI2 enoyl-CoA delta isomerase 2
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF3L eukaryotic translation initiation factor 3, subunit L
ELAVL1 ELAV like RNA binding protein 1
FAAH fatty acid amide hydrolase
FAHD1 fumarylacetoacetate hydrolase domain containing 1
FBXO6 F-box protein 6
FLOT2 flotillin 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
GRB2 growth factor receptor-bound protein 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIST1H2AI histone cluster 1, H2ai
HSPA1B heat shock 70kDa protein 1B
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK2 interleukin-1 receptor-associated kinase 2
ITFG3 integrin alpha FG-GAP repeat containing 3
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KPNA3 karyopherin alpha 3 (importin alpha 4)
KRT10 keratin 10, type I
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LMNA lamin A/C
LONP1 lon peptidase 1, mitochondrial
LRRC47 leucine rich repeat containing 47
LRRC59 leucine rich repeat containing 59
MAP7D1 MAP7 domain containing 1
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MINOS1 mitochondrial inner membrane organizing system 1
MME membrane metallo-endopeptidase
MRPL44 mitochondrial ribosomal protein L44
MRPS14 mitochondrial ribosomal protein S14
MRPS21 mitochondrial ribosomal protein S21
MRPS25 mitochondrial ribosomal protein S25
MRPS26 mitochondrial ribosomal protein S26
MRPS31 mitochondrial ribosomal protein S31
MRPS34 mitochondrial ribosomal protein S34
MRPS35 mitochondrial ribosomal protein S35
MRVI1 murine retrovirus integration site 1 homolog
MTDH metadherin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYH9 myosin, heavy chain 9, non-muscle
MYO1A myosin IA
MYO1C myosin IC
N4BP3 NEDD4 binding protein 3
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEURL4 neuralized E3 ubiquitin protein ligase 4
NNT nicotinamide nucleotide transhydrogenase
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDC nudC nuclear distribution protein
NUP153 nucleoporin 153kDa
OPA1 optic atrophy 1 (autosomal dominant)
OSBPL3 oxysterol binding protein-like 3
PCNA proliferating cell nuclear antigen
PDIA5 protein disulfide isomerase family A, member 5
PDIA6 protein disulfide isomerase family A, member 6
PELO pelota homolog (Drosophila)
PLEC plectin
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK1 polo-like kinase 1
PLRG1 pleiotropic regulator 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POTEH POTE ankyrin domain family, member H
PPME1 protein phosphatase methylesterase 1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RANBP9 RAN binding protein 9
RAP2B RAP2B, member of RAS oncogene family
RBM39 RNA binding motif protein 39
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGPD6 RANBP2-like and GRIP domain containing 6
RPL30 ribosomal protein L30
RPS10 ribosomal protein S10
RPS23 ribosomal protein S23
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SACK1F scaffolding CK1 anchoring protein F
SDF4 stromal cell derived factor 4
SGOL1 shugoshin-like 1 (S. pombe)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRRM2 serine/arginine repetitive matrix 2
SRSF11 serine/arginine-rich splicing factor 11
SSR4 signal sequence receptor, delta
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SUN2 Sad1 and UNC84 domain containing 2
SYTL4 synaptotagmin-like 4
TEX10 testis expressed 10
TM9SF1 transmembrane 9 superfamily member 1
TNPO1 transportin 1
TUBB8 tubulin, beta 8 class VIII
TYSND1 trypsin domain containing 1
UBAC2 UBA domain containing 2
UBC ubiquitin C
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USP20 ubiquitin specific peptidase 20
USP42 ubiquitin specific peptidase 42
UTRN utrophin
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VDAC2 voltage-dependent anion channel 2
WDR18 WD repeat domain 18
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YTHDC2 YTH domain containing 2
ZMPSTE24 zinc metallopeptidase STE24
ZNF770 zinc finger protein 770