FEN1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description flap structure-specific endonuclease 1|The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2237)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_FEN1
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Genes

110 co-expressed genes for FEN1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALG8 ALG8, alpha-1,3-glucosyltransferase
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BUB3 BUB3 mitotic checkpoint protein
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPF centromere protein F, 350/400kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CKS2 CDC28 protein kinase regulatory subunit 2
COPS3 COP9 signalosome subunit 3
CSNK2B casein kinase 2, beta polypeptide
CYCS cytochrome c, somatic
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DHFR dihydrofolate reductase
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GAR1 GAR1 ribonucleoprotein
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GSPT1 G1 to S phase transition 1
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HCCS holocytochrome c synthase
HDDC2 HD domain containing 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA4 heat shock 70kDa protein 4
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPE1 heat shock 10kDa protein 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
METAP2 methionyl aminopeptidase 2
MFAP1 microfibrillar-associated protein 1
MSH2 mutS homolog 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NASP nuclear autoantigenic sperm protein (histone-binding)
NDC80 NDC80 kinetochore complex component
NHP2 NHP2 ribonucleoprotein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUDC nudC nuclear distribution protein
NUP205 nucleoporin 205kDa
NUSAP1 nucleolar and spindle associated protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRC1 protein regulator of cytokinesis 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RBM14 RNA binding motif protein 14
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
SHCBP1 SHC SH2-domain binding protein 1
SMC4 structural maintenance of chromosomes 4
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SOD1 superoxide dismutase 1, soluble
SRSF1 serine/arginine-rich splicing factor 1
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TARDBP TAR DNA binding protein
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM28 tripartite motif containing 28
TTK TTK protein kinase
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
VBP1 von Hippel-Lindau binding protein 1
VDAC1 voltage-dependent anion channel 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein