FGF signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and relies on Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases. (Pathway Ontology, PW_0000328)
External Link http://public.ndexbio.org/#/network/98ed0df6-6192-11e5-8ac5-06603eb7f303
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59 proteins participating in the FGF signaling pathway pathway from the PID Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
BGLAP bone gamma-carboxyglutamate (gla) protein
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
DUSP6 dual specificity phosphatase 6
FGF1 fibroblast growth factor 1 (acidic)
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FGF4 fibroblast growth factor 4
FGF6 fibroblast growth factor 6
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FRS2 fibroblast growth factor receptor substrate 2
GAB1 GRB2-associated binding protein 1
GRB2 growth factor receptor-bound protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IL17RD interleukin 17 receptor D
JUN jun proto-oncogene
KL klotho
KLB klotho beta
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MMP9 matrix metallopeptidase 9
NCAM1 neural cell adhesion molecule 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLCG1 phospholipase C, gamma 1
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUNX2 runt-related transcription factor 2
SDC2 syndecan 2
SDC4 syndecan 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOS1 son of sevenless homolog 1 (Drosophila)
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSH1 slingshot protein phosphatase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B