FGF2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description fibroblast growth factor 2 (basic)|The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2247)
External Link http://www.ncbi.nlm.nih.gov/gene/2247
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Genes

179 interacting proteins for FGF2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANOS1 anosmin 1
API5 apoptosis inhibitor 5
AXL AXL receptor tyrosine kinase
B2M beta-2-microglobulin
BAIAP2 BAI1-associated protein 2
BCR breakpoint cluster region
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTC betacellulin
BTK Bruton agammaglobulinemia tyrosine kinase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD19 CD19 molecule
CD247 CD247 molecule
CD28 CD28 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CD80 CD80 molecule
CD86 CD86 molecule
CDC37 cell division cycle 37
CEP57 centrosomal protein 57kDa
CNTRL centriolin
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRYAB crystallin, alpha B
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CUX1 cut-like homeobox 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
F11R F11 receptor
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF19 fibroblast growth factor 19
FGFBP1 fibroblast growth factor binding protein 1
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FGFR1OP2 FGFR1 oncogene partner 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGFRL1 fibroblast growth factor receptor-like 1
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GPC3 glypican 3
GPC4 glypican 4
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
HBEGF heparin-binding EGF-like growth factor
HLA-E major histocompatibility complex, class I, E
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPG2 heparan sulfate proteoglycan 2
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)
IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker)
IGLC6 immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITK IL2-inducible T-cell kinase
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLB klotho beta
KLRC2 killer cell lectin-like receptor subfamily C, member 2
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MYO18A myosin XVIIIA
NCKAP1 NCK-associated protein 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NRG2 neuregulin 2
NRG3 neuregulin 3
NRG4 neuregulin 4
NRP1 neuropilin 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PF4 platelet factor 4
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRMT1 protein arginine methyltransferase 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTX3 pentraxin 3, long
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RHOA ras homolog family member A
RPL6 ribosomal protein L6
RPS19 ribosomal protein S19
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SDC1 syndecan 1
SDC2 syndecan 2
SDC3 syndecan 3
SDC4 syndecan 4
SH2D2A SH2 domain containing 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYK spleen tyrosine kinase
TEC tec protein tyrosine kinase
THBS1 thrombospondin 1
TRAT1 T cell receptor associated transmembrane adaptor 1
TREM2 triggering receptor expressed on myeloid cells 2
TRIM24 tripartite motif containing 24
TUBG1 tubulin, gamma 1
TXK TXK tyrosine kinase
TYROBP TYRO protein tyrosine kinase binding protein
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VTN vitronectin
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
ZMYM2 zinc finger, MYM-type 2