FGFR1 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description fibroblast growth factor receptor 1|The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2260)
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100 substrates of the kinase FGFR1 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
PM20D2 peptidase M20 domain containing 2 99.96
SH2D1B SH2 domain containing 1B 99.94
DLG3 discs, large homolog 3 (Drosophila) 99.925
DLG2 discs, large homolog 2 (Drosophila) 99.8
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 99.74
KMT5A lysine methyltransferase 5A 99.69
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 99.67
ALOX5 arachidonate 5-lipoxygenase 99.58
KCTD12 potassium channel tetramerization domain containing 12 99.56
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 99.47
TRPC6 transient receptor potential cation channel, subfamily C, member 6 99.43
CHAF1B chromatin assembly factor 1, subunit B (p60) 99.43
ATXN1 ataxin 1 99.41
ARHGAP30 Rho GTPase activating protein 30 99.36
TIGIT T cell immunoreceptor with Ig and ITIM domains 99.36
TLK1 tousled-like kinase 1 99.34
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.32
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.32
EIF1B eukaryotic translation initiation factor 1B 99.26
EIF1 eukaryotic translation initiation factor 1 99.26
CNOT9 CCR4-NOT transcription complex subunit 9 99.15
TLK2 tousled-like kinase 2 99.1
THEMIS2 thymocyte selection associated family member 2 99.06
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 99.02
CEP170B centrosomal protein 170B 98.99
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 98.95
FCHO1 FCH domain only 1 98.93
MELK maternal embryonic leucine zipper kinase 98.88
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 98.84
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 98.78
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 98.77
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 98.71
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 98.67
MAP4 microtubule-associated protein 4 98.53
LURAP1L leucine rich adaptor protein 1-like 98.51
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 98.43
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 98.4
CARD9 caspase recruitment domain family, member 9 98.32
RCN2 reticulocalbin 2, EF-hand calcium binding domain 98.31
TRIOBP TRIO and F-actin binding protein 98.28
SIPA1L1 signal-induced proliferation-associated 1 like 1 98.2
UNG uracil-DNA glycosylase 98.18
GCSAML germinal center-associated, signaling and motility-like 98.16
RPL8 ribosomal protein L8 98.07
HCST hematopoietic cell signal transducer 98.03
IRS4 insulin receptor substrate 4 98.0
MUC16 mucin 16, cell surface associated 97.96
SLITRK4 SLIT and NTRK-like family, member 4 97.94
GNL1 guanine nucleotide binding protein-like 1 97.92
SLITRK6 SLIT and NTRK-like family, member 6 97.9
LST1 leukocyte specific transcript 1 97.9
MAT2A methionine adenosyltransferase II, alpha 97.81
PRUNE2 prune homolog 2 (Drosophila) 97.75
CMKLR1 chemerin chemokine-like receptor 1 97.75
FKBP5 FK506 binding protein 5 97.62
CLMP CXADR-like membrane protein 97.61
PLPPR4 phospholipid phosphatase related 4 97.55
GRAMD4 GRAM domain containing 4 97.53
IL7R interleukin 7 receptor 97.5
TFIP11 tuftelin interacting protein 11 97.5
FAF2 Fas associated factor family member 2 97.37
USP31 ubiquitin specific peptidase 31 97.35
SH2B1 SH2B adaptor protein 1 97.33
FPR2 formyl peptide receptor 2 97.33
RERE arginine-glutamic acid dipeptide (RE) repeats 97.33
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 97.27
MCC mutated in colorectal cancers 97.24
EML4 echinoderm microtubule associated protein like 4 97.18
GCHFR GTP cyclohydrolase I feedback regulator 97.13
LRRK1 leucine-rich repeat kinase 1 97.09
MYL12B myosin, light chain 12B, regulatory 97.09
RABL6 RAB, member RAS oncogene family-like 6 97.04
ZCCHC3 zinc finger, CCHC domain containing 3 97.0
NOLC1 nucleolar and coiled-body phosphoprotein 1 96.96
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 96.87
TERB1 telomere repeat binding bouquet formation protein 1 96.85
STARD13 StAR-related lipid transfer (START) domain containing 13 96.81
PDS5B PDS5 cohesin associated factor B 96.76
SRL sarcalumenin 96.74
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 96.67
DDIAS DNA damage-induced apoptosis suppressor 96.43
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 96.42
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 96.34
SH2D3C SH2 domain containing 3C 96.3
DCAF13 DDB1 and CUL4 associated factor 13 96.28
MRTFB myocardin related transcription factor B 96.26
PTBP3 polypyrimidine tract binding protein 3 96.13
CLDN1 claudin 1 96.08
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 96.05
LAX1 lymphocyte transmembrane adaptor 1 96.02
HINT1 histidine triad nucleotide binding protein 1 96.0
NIPSNAP1 nipsnap homolog 1 (C. elegans) 95.905
NAV1 neuron navigator 1 95.84
N4BP3 NEDD4 binding protein 3 95.82
MRPS27 mitochondrial ribosomal protein S27 95.8
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 95.71
THADA thyroid adenoma associated 95.47
TRIP11 thyroid hormone receptor interactor 11 95.42
DGAT1 diacylglycerol O-acyltransferase 1 95.42
LRP4 low density lipoprotein receptor-related protein 4 95.4