FGFR1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description fibroblast growth factor receptor 1|The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2260)
External Link http://www.ncbi.nlm.nih.gov/gene/2260
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Genes

9 substrates of the kinase FGFR1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AMOTL2 angiomotin like 2
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
ITGB4 integrin, beta 4
LDHA lactate dehydrogenase A
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PKM pyruvate kinase, muscle
ZMYM2 zinc finger, MYM-type 2