FGFR2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description fibroblast growth factor receptor 2|The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 2263)
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Genes

301 genes differentially expressed following the FGFR2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MAGEB1 melanoma antigen family B1 3.03947
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 3.03947
CD274 CD274 molecule 3.03947
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.03947
ZNF503 zinc finger protein 503 3.03947
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.03947
XAF1 XIAP associated factor 1 3.03947
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.03947
PRICKLE4 prickle homolog 4 (Drosophila) 3.03947
RNF17 ring finger protein 17 3.03947
LHCGR luteinizing hormone/choriogonadotropin receptor 3.03947
SLC22A10 solute carrier family 22, member 10 3.03947
MAGEB3 melanoma antigen family B3 3.03947
CLDN5 claudin 5 3.03947
VIT vitrin 3.03947
KLHL33 kelch-like family member 33 3.03947
FOXD1 forkhead box D1 3.03947
CD300LG CD300 molecule-like family member g 3.03947
RS1 retinoschisin 1 3.03947
FPR2 formyl peptide receptor 2 3.03947
SCGB3A1 secretoglobin, family 3A, member 1 3.03947
FOXA1 forkhead box A1 3.03947
TNNI2 troponin I type 2 (skeletal, fast) 3.03947
ARSF arylsulfatase F 3.03947
GFI1 growth factor independent 1 transcription repressor 3.03947
OTUD6A OTU deubiquitinase 6A 3.03947
FAM221B family with sequence similarity 221, member B 3.03947
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.03947
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.03947
LRRC10B leucine rich repeat containing 10B 3.03947
GPHB5 glycoprotein hormone beta 5 3.03947
ASPA aspartoacylase 3.03947
SMPX small muscle protein, X-linked 3.03947
NEU4 sialidase 4 3.03947
GPR151 G protein-coupled receptor 151 3.03947
SSTR1 somatostatin receptor 1 3.03947
UNC13C unc-13 homolog C (C. elegans) 3.03947
UPB1 ureidopropionase, beta 3.03947
GRXCR2 glutaredoxin, cysteine rich 2 3.03947
GSTM5 glutathione S-transferase mu 5 3.03947
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.03947
PLCH2 phospholipase C, eta 2 3.03947
PSCA prostate stem cell antigen 3.03947
SAXO3 stabilizer of axonemal microtubules 3 3.03947
PHF24 PHD finger protein 24 3.03947
TMOD4 tropomodulin 4 (muscle) 3.03947
HAO2 hydroxyacid oxidase 2 (long chain) 3.03947
ARX aristaless related homeobox 3.03947
AVPR1A arginine vasopressin receptor 1A 3.03947
TYROBP TYRO protein tyrosine kinase binding protein 3.03947
RAX2 retina and anterior neural fold homeobox 2 3.03947
PNLIPRP2 pancreatic lipase-related protein 2 3.03947
DEPP1 DEPP autophagy regulator 1 3.03947
JAML junction adhesion molecule like 3.03947
CFAP100 cilia and flagella associated protein 100 3.03947
EPCIP exosomal polycystin 1 interacting protein 3.03947
EXOC1L exocyst complex component 1 like 3.03947
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.03947
H3C13 H3 clustered histone 13 3.03947
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.03947
SMIM31 small integral membrane protein 31 3.03947
CLEC20A C-type lectin domain containing 20A 3.03947
ELOA2 elongin A2 3.03947
SRGN serglycin 3.03947
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.03947
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.03947
SLAMF6 SLAM family member 6 3.03947
C1ORF162 chromosome 1 open reading frame 162 3.03947
DNASE2B deoxyribonuclease II beta 3.03947
TMEM235 transmembrane protein 235 3.03947
SLC22A25 solute carrier family 22, member 25 3.03947
OLAH oleoyl-ACP hydrolase 3.03947
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 3.03947
TRIM67 tripartite motif containing 67 3.03947
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 3.03947
EXOC3L4 exocyst complex component 3-like 4 3.03947
S100G S100 calcium binding protein G 3.03947
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.03947
F5 coagulation factor V (proaccelerin, labile factor) 3.03947
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.03947
IL16 interleukin 16 3.03947
PNPLA1 patatin-like phospholipase domain containing 1 3.03947
MPPED1 metallophosphoesterase domain containing 1 3.03947
PGA4 pepsinogen 4, group I (pepsinogen A) 3.03947
C7ORF57 chromosome 7 open reading frame 57 3.03947
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 3.03947
APOC4 apolipoprotein C-IV 3.03947
MAPK11 mitogen-activated protein kinase 11 3.03947
TBC1D26 TBC1 domain family, member 26 3.03947
ANKRD33 ankyrin repeat domain 33 3.03947
NUTM2B NUT family member 2B 3.03947
NUTM2A NUT family member 2A 3.03947
ANTXRL anthrax toxin receptor-like 3.03947
ZC3H12D zinc finger CCCH-type containing 12D 3.03947
FGF18 fibroblast growth factor 18 3.03947
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 3.03947
RBM20 RNA binding motif protein 20 3.03947
LRRC31 leucine rich repeat containing 31 3.03947
GPR68 G protein-coupled receptor 68 3.03947
CA5A carbonic anhydrase VA, mitochondrial 3.03947
RGS8 regulator of G-protein signaling 8 3.03947
PFN4 profilin family, member 4 3.03947
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.03947
LRRC15 leucine rich repeat containing 15 3.03947
SPATA3 spermatogenesis associated 3 3.03947
WFDC9 WAP four-disulfide core domain 9 3.03947
PRM1 protamine 1 3.03947
DXO decapping exoribonuclease 3.03947
EPO erythropoietin 3.03947
NLRP14 NLR family, pyrin domain containing 14 3.03947
CTAGE15 CTAGE family, member 15 3.03947
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.03947
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.03947
CCL24 chemokine (C-C motif) ligand 24 3.03947
GFI1B growth factor independent 1B transcription repressor 3.03947
NPPA natriuretic peptide A 3.03947
TSLP thymic stromal lymphopoietin 3.03947
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.03947
KRT13 keratin 13, type I 3.03947
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.03947
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.03947
ERAP2 endoplasmic reticulum aminopeptidase 2 3.03947
LAMB4 laminin, beta 4 3.03947
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.03947
CCNA1 cyclin A1 3.03947
LOC102724877 uncharacterized LOC102724877 3.03947
IL18R1 interleukin 18 receptor 1 3.03947
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.03947
LMX1A LIM homeobox transcription factor 1, alpha 3.03947
CLEC18B C-type lectin domain family 18, member B 3.03947
AIRE autoimmune regulator 3.03947
LGALS2 lectin, galactoside-binding, soluble, 2 3.03947
PRDM12 PR domain containing 12 3.03947
HBM hemoglobin, mu 3.03947
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 3.03947
TRIM42 tripartite motif containing 42 3.03947
MEIKIN meiotic kinetochore factor 3.03947
GRP gastrin-releasing peptide 3.03947
TPRX1 tetra-peptide repeat homeobox 1 3.03947
HLA-DMB major histocompatibility complex, class II, DM beta 3.03947
ASCL5 achaete-scute family bHLH transcription factor 5 3.03947
CLNK cytokine-dependent hematopoietic cell linker 3.03947
CD34 CD34 molecule 3.03947
AREG amphiregulin 3.03947
IL27 interleukin 27 3.03947
PADI6 peptidyl arginine deiminase, type VI 3.03947
HPGDS hematopoietic prostaglandin D synthase 3.03947
ARL13A ADP-ribosylation factor-like 13A 2.95555
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.95555
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 2.93335
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.93335
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.86304
PIGBOS1 PIGB opposite strand 1 2.83013
ZNF180 zinc finger protein 180 2.74499
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.63986
TTC33 tetratricopeptide repeat domain 33 2.62616
NIFK nucleolar protein interacting with the FHA domain of MKI67 2.60679
IWS1 IWS1 homolog (S. cerevisiae) 2.60679
DMAP1 DNA methyltransferase 1 associated protein 1 2.59445
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 2.59164
NOL10 nucleolar protein 10 2.56662
DCAF17 DDB1 and CUL4 associated factor 17 2.53005
AMOT angiomotin 2.52904
DHFR dihydrofolate reductase 2.50686
FGFRL1 fibroblast growth factor receptor-like 1 2.50522
DDHD2 DDHD domain containing 2 2.47754
RPL26L1 ribosomal protein L26-like 1 2.47569
TRAM2 translocation associated membrane protein 2 2.47569
LAS1L LAS1-like (S. cerevisiae) 2.4289
PRRT1 proline-rich transmembrane protein 1 2.4289
BLVRA biliverdin reductase A 2.39887
EMC4 ER membrane protein complex subunit 4 2.39559
GLO1 glyoxalase I 2.39527
CLPSL1 colipase-like 1 2.39309
ASGR1 asialoglycoprotein receptor 1 2.37196
CXCR6 chemokine (C-X-C motif) receptor 6 2.35045
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.35045
PPIF peptidylprolyl isomerase F 2.33383
ZBTB1 zinc finger and BTB domain containing 1 2.2956
COX8C cytochrome c oxidase subunit VIIIC 2.28582
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.27341
PALB2 partner and localizer of BRCA2 2.23792
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.23472
SYT10 synaptotagmin X 2.22062
DCST1 DC-STAMP domain containing 1 2.21356
WDR13 WD repeat domain 13 2.19447
CYTIP cytohesin 1 interacting protein 2.18895
HTATSF1 HIV-1 Tat specific factor 1 2.18895
UCK2 uridine-cytidine kinase 2 2.16967
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 2.16967
TTLL5 tubulin tyrosine ligase-like family member 5 2.14284
FGFR1OP2 FGFR1 oncogene partner 2 2.13183
NCK2 NCK adaptor protein 2 2.11622
NME8 NME/NM23 family member 8 2.11615
CDK1 cyclin-dependent kinase 1 2.11615
FAM114A2 family with sequence similarity 114, member A2 2.06948
RFXANK regulatory factor X-associated ankyrin-containing protein 2.05526
HEBP2 heme binding protein 2 2.05086
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 2.04394
CCDC88A coiled-coil domain containing 88A 2.03699
LRRTM3 leucine rich repeat transmembrane neuronal 3 2.03224
SCAF1 SR-related CTD-associated factor 1 2.03224

decreased expression

Symbol Name Standardized Value
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 -3.03947
EDN3 endothelin 3 -3.03947
CH25H cholesterol 25-hydroxylase -3.03947
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -3.03947
ARMC12 armadillo repeat containing 12 -3.03947
PCDHA5 protocadherin alpha 5 -3.03947
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 -3.03947
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -3.03947
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -3.03947
STMND1 stathmin domain containing 1 -3.03947
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -3.03947
PTPRK protein tyrosine phosphatase, receptor type, K -3.03947
TECTA tectorin alpha -3.03947
CEP170 centrosomal protein 170kDa -3.03947
CD8A CD8a molecule -3.03947
AGBL1 ATP/GTP binding protein-like 1 -3.03947
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -3.03947
NDRG1 N-myc downstream regulated 1 -3.03947
USP50 ubiquitin specific peptidase 50 -3.03947
GDI2 GDP dissociation inhibitor 2 -3.03947
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.03947
ADAP1 ArfGAP with dual PH domains 1 -3.03947
DLX3 distal-less homeobox 3 -3.03947
EFNB1 ephrin-B1 -3.03947
HES3 hes family bHLH transcription factor 3 -3.03947
SLC25A45 solute carrier family 25, member 45 -3.03947
CDC20B cell division cycle 20B -3.03947
MAMLD1 mastermind-like domain containing 1 -3.03947
TMEM100 transmembrane protein 100 -3.03947
PROZ protein Z, vitamin K-dependent plasma glycoprotein -3.03947
GIMAP4 GTPase, IMAP family member 4 -3.03947
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -3.03947
SLC22A24 solute carrier family 22, member 24 -3.03947
SETD1A SET domain containing 1A -3.03454
RRM1 ribonucleotide reductase M1 -2.98287
MTSS1 metastasis suppressor 1 -2.87722
IL23A interleukin 23, alpha subunit p19 -2.84451
TTLL9 tubulin tyrosine ligase-like family member 9 -2.78263
C1ORF122 chromosome 1 open reading frame 122 -2.77068
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.77068
SCN5A sodium channel, voltage gated, type V alpha subunit -2.62616
SYPL1 synaptophysin-like 1 -2.59729
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -2.53046
NGF nerve growth factor (beta polypeptide) -2.52971
PRKCA protein kinase C, alpha -2.52904
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.51287
H3C1 H3 clustered histone 1 -2.49152
TLR7 toll-like receptor 7 -2.49152
WIF1 WNT inhibitory factor 1 -2.49114
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.47569
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.44211
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.40562
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -2.40456
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -2.39887
ZNF664-RFLNA ZNF664-RFLNA readthrough -2.3938
FASTKD3 FAST kinase domains 3 -2.38747
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.37067
USP30 ubiquitin specific peptidase 30 -2.32893
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.30171
EFCAB7 EF-hand calcium binding domain 7 -2.2956
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -2.28899
TTN titin -2.28559
CRTC1 CREB regulated transcription coactivator 1 -2.27341
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -2.25575
HNRNPL heterogeneous nuclear ribonucleoprotein L -2.24964
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -2.23243
JUN jun proto-oncogene -2.21341
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit -2.21341
SEC24B SEC24 family member B -2.21341
MYT1L myelin transcription factor 1-like -2.21341
CA4 carbonic anhydrase IV -2.21341
PF4 platelet factor 4 -2.21341
ANGPT1 angiopoietin 1 -2.21341
ARHGAP30 Rho GTPase activating protein 30 -2.21341
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.20048
CISD1 CDGSH iron sulfur domain 1 -2.19649
LAT linker for activation of T cells -2.19046
CNTN3 contactin 3 (plasmacytoma associated) -2.19046
RAB39A RAB39A, member RAS oncogene family -2.16824
METAP1D methionyl aminopeptidase type 1D (mitochondrial) -2.16781
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.16336
RGPD6 RANBP2-like and GRIP domain containing 6 -2.16336
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator -2.16336
MCOLN3 mucolipin 3 -2.15752
SETD7 SET domain containing (lysine methyltransferase) 7 -2.14756
CMTR1 cap methyltransferase 1 -2.13397
IL6ST interleukin 6 signal transducer -2.11622
RPAP3 RNA polymerase II associated protein 3 -2.11615
GRM4 glutamate receptor, metabotropic 4 -2.09402
LSR lipolysis stimulated lipoprotein receptor -2.08596
EDNRA endothelin receptor type A -2.06598
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.0599
C1ORF159 chromosome 1 open reading frame 159 -2.0585
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 -2.04772
MRRF mitochondrial ribosome recycling factor -2.04318
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.02549
SERINC3 serine incorporator 3 -2.01515
SPESP1 sperm equatorial segment protein 1 -2.00515
NRP1 neuropilin 1 -2.00515