FGFR2 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description fibroblast growth factor receptor 2|The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 2263)
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100 substrates of the kinase FGFR2 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
PM20D2 peptidase M20 domain containing 2 99.96
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.94
KCTD12 potassium channel tetramerization domain containing 12 99.91
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 99.89
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.83
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.83
TLK1 tousled-like kinase 1 99.78
ALOX5 arachidonate 5-lipoxygenase 99.76
MCC mutated in colorectal cancers 99.72
TLK2 tousled-like kinase 2 99.67
EIF1B eukaryotic translation initiation factor 1B 99.65
EIF1 eukaryotic translation initiation factor 1 99.65
CEP170B centrosomal protein 170B 99.59
CNOT9 CCR4-NOT transcription complex subunit 9 99.56
MUC16 mucin 16, cell surface associated 99.52
DLG3 discs, large homolog 3 (Drosophila) 99.485
SH2D1B SH2 domain containing 1B 99.48
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 99.45
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 99.45
THEMIS2 thymocyte selection associated family member 2 99.45
DLG2 discs, large homolog 2 (Drosophila) 99.41
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 99.39
MELK maternal embryonic leucine zipper kinase 99.3
GCSAML germinal center-associated, signaling and motility-like 99.21
RABL6 RAB, member RAS oncogene family-like 6 99.1
TRIOBP TRIO and F-actin binding protein 99.08
TRPC6 transient receptor potential cation channel, subfamily C, member 6 98.88
KTN1 kinectin 1 (kinesin receptor) 98.88
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 98.82
KMT5A lysine methyltransferase 5A 98.78
USP31 ubiquitin specific peptidase 31 98.75
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 98.71
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 98.67
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 98.64
SLITRK6 SLIT and NTRK-like family, member 6 98.6
CBFB core-binding factor, beta subunit 98.56
ARHGAP30 Rho GTPase activating protein 30 98.53
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 98.42
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 98.38
RCN2 reticulocalbin 2, EF-hand calcium binding domain 98.36
WWP2 WW domain containing E3 ubiquitin protein ligase 2 98.34
CEP43 centrosomal protein 43 98.01
TIGIT T cell immunoreceptor with Ig and ITIM domains 97.99
IRS4 insulin receptor substrate 4 97.93
PADI2 peptidyl arginine deiminase, type II 97.92
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 97.77
UMPS uridine monophosphate synthetase 97.75
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 97.7
FCHO1 FCH domain only 1 97.64
NIPSNAP1 nipsnap homolog 1 (C. elegans) 97.605
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 97.59
LURAP1L leucine rich adaptor protein 1-like 97.57
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 97.46
CKAP4 cytoskeleton-associated protein 4 97.44
ZNF598 zinc finger protein 598 97.37
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 97.33
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 97.2
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 97.145
FAM107B family with sequence similarity 107, member B 97.13
LAX1 lymphocyte transmembrane adaptor 1 96.94
EPM2AIP1 EPM2A (laforin) interacting protein 1 96.94
PDS5B PDS5 cohesin associated factor B 96.91
MCEMP1 mast cell-expressed membrane protein 1 96.87
CENPE centromere protein E, 312kDa 96.83
MYL12B myosin, light chain 12B, regulatory 96.81
NKD2 naked cuticle homolog 2 (Drosophila) 96.78
IPO9 importin 9 96.72
IL7R interleukin 7 receptor 96.7
PLXDC2 plexin domain containing 2 96.69
HCST hematopoietic cell signal transducer 96.67
PDCD5 programmed cell death 5 96.56
PRRC2B proline-rich coiled-coil 2B 96.5
FHIT fragile histidine triad 96.48
LST1 leukocyte specific transcript 1 96.45
SIPA1L1 signal-induced proliferation-associated 1 like 1 96.39
SH2D4A SH2 domain containing 4A 96.34
THRB thyroid hormone receptor, beta 96.26
SLC39A3 solute carrier family 39 (zinc transporter), member 3 96.21
N4BP3 NEDD4 binding protein 3 96.17
FDFT1 farnesyl-diphosphate farnesyltransferase 1 96.13
GAB3 GRB2-associated binding protein 3 96.115
PELP1 proline, glutamate and leucine rich protein 1 96.11
GRAMD4 GRAM domain containing 4 96.1
NAXE NAD(P)HX epimerase 96.0
TCF25 transcription factor 25 (basic helix-loop-helix) 95.99
MAT2A methionine adenosyltransferase II, alpha 95.89
SH2D3C SH2 domain containing 3C 95.75
FKBP5 FK506 binding protein 5 95.67
CLDN1 claudin 1 95.62
DPF2 D4, zinc and double PHD fingers family 2 95.56
FLRT1 fibronectin leucine rich transmembrane protein 1 95.51
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 95.48
NCBP2 nuclear cap binding protein subunit 2, 20kDa 95.47
PTPRA protein tyrosine phosphatase, receptor type, A 95.43
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 95.34
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 95.335
EIF3I eukaryotic translation initiation factor 3, subunit I 95.23
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 95.19
IPO8 importin 8 95.16
MAGED2 melanoma antigen family D2 95.12