FGFR3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description fibroblast growth factor receptor 3|This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 2261)
Similar Terms
Downloads & Tools

Genes

316 genes differentially expressed following the FGFR3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
STOML3 stomatin (EPB72)-like 3 3.1536
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.1536
REN renin 3.1536
UNC45B unc-45 homolog B (C. elegans) 3.1536
PTGFR prostaglandin F receptor (FP) 3.1536
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.1536
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.1536
GMFG glia maturation factor, gamma 3.1536
OR1L6 olfactory receptor, family 1, subfamily L, member 6 3.1536
RSPO1 R-spondin 1 3.1536
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.1536
TEX13B testis expressed 13B 3.1536
MGAM2 maltase-glucoamylase 2 (putative) 3.1536
FOXA1 forkhead box A1 3.1536
MBLAC1 metallo-beta-lactamase domain containing 1 3.1536
TM4SF1 transmembrane 4 L six family member 1 3.1536
OSR2 odd-skipped related transciption factor 2 3.1536
GJB5 gap junction protein, beta 5, 31.1kDa 3.1536
GJB2 gap junction protein, beta 2, 26kDa 3.1536
GLRA3 glycine receptor, alpha 3 3.1536
RGPD6 RANBP2-like and GRIP domain containing 6 3.1536
OR56A5 olfactory receptor, family 56, subfamily A, member 5 3.1536
SPAG8 sperm associated antigen 8 3.1536
PRSS22 protease, serine, 22 3.1536
RBP4 retinol binding protein 4, plasma 3.1536
NRGN neurogranin (protein kinase C substrate, RC3) 3.1536
NEUROD1 neuronal differentiation 1 3.1536
CD101 CD101 molecule 3.1536
ASCL3 achaete-scute family bHLH transcription factor 3 3.1536
RTP1 receptor (chemosensory) transporter protein 1 3.1536
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.1536
CRX cone-rod homeobox 3.1536
CPB2 carboxypeptidase B2 (plasma) 3.1536
OC90 otoconin 90 3.1536
DLL4 delta-like 4 (Drosophila) 3.1536
BFSP2 beaded filament structural protein 2, phakinin 3.1536
TAS2R19 taste receptor, type 2, member 19 3.1536
MPL MPL proto-oncogene, thrombopoietin receptor 3.1536
JCHAIN joining chain of multimeric IgA and IgM 3.1536
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.1536
MYBPHL myosin binding protein H-like 3.1536
SMPX small muscle protein, X-linked 3.1536
IMPG1 interphotoreceptor matrix proteoglycan 1 3.1536
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.1536
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 3.1536
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.1536
LRRN4CL LRRN4 C-terminal like 3.1536
LTK leukocyte receptor tyrosine kinase 3.1536
PTS 6-pyruvoyltetrahydropterin synthase 3.1536
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.1536
ZNF229 zinc finger protein 229 3.1536
DRC5 dynein regulatory complex subunit 5 3.1536
CFAP97D1 CFAP97 domain containing 1 3.1536
CCDC198 coiled-coil domain containing 198 3.1536
GASK1B golgi associated kinase 1B 3.1536
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.1536
H1-6 H1.6 linker histone, cluster member 3.1536
SPI1 Spi-1 proto-oncogene 3.1536
HTRA4 HtrA serine peptidase 4 3.1536
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.1536
PRRT4 proline-rich transmembrane protein 4 3.1536
PCDHB13 protocadherin beta 13 3.1536
OASL 2'-5'-oligoadenylate synthetase-like 3.1536
HBA2 hemoglobin, alpha 2 3.1536
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.1536
NRN1 neuritin 1 3.1536
GPR4 G protein-coupled receptor 4 3.1536
CFHR3 complement factor H-related 3 3.1536
CCDC117 coiled-coil domain containing 117 3.1536
PCDHB10 protocadherin beta 10 3.1536
THPO thrombopoietin 3.1536
ESR1 estrogen receptor 1 3.1536
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.1536
MIA melanoma inhibitory activity 3.1536
TLR8 toll-like receptor 8 3.1536
C10ORF67 chromosome 10 open reading frame 67 3.1536
ULBP1 UL16 binding protein 1 3.1536
ANXA13 annexin A13 3.1536
BBS5 Bardet-Biedl syndrome 5 3.1536
SPMAP2L sperm microtubule associated protein 2 like 3.1536
HSPA1L heat shock 70kDa protein 1-like 3.1536
CAGE1 cancer antigen 1 3.1536
OR6C74 olfactory receptor, family 6, subfamily C, member 74 3.1536
NUPR1 nuclear protein, transcriptional regulator, 1 3.1536
BCO1 beta-carotene oxygenase 1 3.1536
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.1536
EGR2 early growth response 2 3.1536
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.1536
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.1536
SPATA9 spermatogenesis associated 9 3.1536
BATF2 basic leucine zipper transcription factor, ATF-like 2 3.1536
CHIT1 chitinase 1 (chitotriosidase) 3.1536
SPTBN5 spectrin, beta, non-erythrocytic 5 3.1536
CCL25 chemokine (C-C motif) ligand 25 3.1536
EDN3 endothelin 3 3.1536
GCOM1 GRINL1A complex locus 1 3.1536
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 3.1536
RETNLB resistin like beta 3.1536
NPFFR1 neuropeptide FF receptor 1 3.1536
C11ORF91 chromosome 11 open reading frame 91 3.1536
THTPA thiamine triphosphatase 3.1536
TAS2R50 taste receptor, type 2, member 50 3.1536
SERINC4 serine incorporator 4 3.1536
LCT lactase 3.1536
DNAH12 dynein, axonemal, heavy chain 12 3.1536
SPINK9 serine peptidase inhibitor, Kazal type 9 3.1536
ITGB7 integrin, beta 7 3.1536
AMH anti-Mullerian hormone 3.1536
TPPP3 tubulin polymerization-promoting protein family member 3 3.1536
NXF2B nuclear RNA export factor 2B 3.1536
PADI4 peptidyl arginine deiminase, type IV 3.1536
NOTCH4 notch 4 3.1536
PLA2G2C phospholipase A2, group IIC 3.1536
OPTC opticin 3.1536
LMX1B LIM homeobox transcription factor 1, beta 3.1536
EVI2A ecotropic viral integration site 2A 3.1536
MMP13 matrix metallopeptidase 13 3.1536
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.1536
SHISA3 shisa family member 3 3.1536
BHLHA15 basic helix-loop-helix family, member a15 3.1536
TRIM7 tripartite motif containing 7 3.1536
TCAP titin-cap 3.1536
PENK proenkephalin 3.1536
DMRT2 doublesex and mab-3 related transcription factor 2 3.1536
SLITRK1 SLIT and NTRK-like family, member 1 3.1536
PRH2 proline-rich protein HaeIII subfamily 2 3.1536
POTEF POTE ankyrin domain family, member F 3.1536
NT5C1A 5'-nucleotidase, cytosolic IA 3.1536
ITGAD integrin, alpha D 3.1536
BIN2 bridging integrator 2 3.1536
POU4F1 POU class 4 homeobox 1 3.1536
IL10RA interleukin 10 receptor, alpha 3.1536
GPR68 G protein-coupled receptor 68 3.1536
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.1536
ADPRH ADP-ribosylarginine hydrolase 3.07721
CCDC63 coiled-coil domain containing 63 3.07721
GLB1L galactosidase, beta 1-like 3.07721
LIMS2 LIM and senescent cell antigen-like domains 2 3.07721
IGSF22 immunoglobulin superfamily, member 22 3.04434
CCDC92B coiled-coil domain containing 92B 2.99459
RPL10 ribosomal protein L10 2.92424
CLNK cytokine-dependent hematopoietic cell linker 2.82829
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.80113
PRDX1 peroxiredoxin 1 2.78027
NTAN1 N-terminal asparagine amidase 2.75631
ITLN2 intelectin 2 2.754
RBM12B RNA binding motif protein 12B 2.754
RASD1 RAS, dexamethasone-induced 1 2.754
RPS18 ribosomal protein S18 2.7414
RGS3 regulator of G-protein signaling 3 2.67979
ZMYM1 zinc finger, MYM-type 1 2.67783
RPL11 ribosomal protein L11 2.65763
TMEM192 transmembrane protein 192 2.63894
TRUB2 TruB pseudouridine (psi) synthase family member 2 2.58914
OMG oligodendrocyte myelin glycoprotein 2.57967
GAS2 growth arrest-specific 2 2.57272
GLIPR1L1 GLI pathogenesis-related 1 like 1 2.48597
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 2.46336
SIX3 SIX homeobox 3 2.4616
ABHD15 abhydrolase domain containing 15 2.4616
TMEM179 transmembrane protein 179 2.44332
FGF8 fibroblast growth factor 8 (androgen-induced) 2.43498
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.43498
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.43498
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.41566
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.39794
SURF6 surfeit 6 2.36178
FUNDC1 FUN14 domain containing 1 2.34238
CERS2 ceramide synthase 2 2.32268
MCM8 minichromosome maintenance complex component 8 2.31674
XPO1 exportin 1 2.30486
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 2.30315
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.28565
C4ORF33 chromosome 4 open reading frame 33 2.2566
SIGMAR1 sigma non-opioid intracellular receptor 1 2.24266
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.23256
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.22526
LRRN4 leucine rich repeat neuronal 4 2.22526
CADPS Ca++-dependent secretion activator 2.22349
TRIM13 tripartite motif containing 13 2.20274
LMNB2 lamin B2 2.1956
ZFX zinc finger protein, X-linked 2.1704
MEIOB meiosis specific with OB domains 2.1704
GSG1L GSG1-like 2.1704
ADRA1A adrenoceptor alpha 1A 2.1704
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 2.1704
LRRC10B leucine rich repeat containing 10B 2.1704
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.1704
S100A4 S100 calcium binding protein A4 2.1704
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.1704
SLC30A10 solute carrier family 30, member 10 2.1704
SLC16A12 solute carrier family 16, member 12 2.1704
ANKRD63 ankyrin repeat domain 63 2.1704
HEXA hexosaminidase A (alpha polypeptide) 2.1704
OVGP1 oviductal glycoprotein 1, 120kDa 2.1704
TMEM267 transmembrane protein 267 2.15605
ANGEL2 angel homolog 2 (Drosophila) 2.13274
ZNF607 zinc finger protein 607 2.12631
GPX4 glutathione peroxidase 4 2.12458
EEF1G eukaryotic translation elongation factor 1 gamma 2.12177
RPS15A ribosomal protein S15a 2.12125
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 2.11533
EDF1 endothelial differentiation-related factor 1 2.10563
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 2.10563
NPDC1 neural proliferation, differentiation and control, 1 2.09504
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 2.07661
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.06838
POMP proteasome maturation protein 2.06153
APOE apolipoprotein E 2.05308
SPATA17 spermatogenesis associated 17 2.05308
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.04123
SLC45A3 solute carrier family 45, member 3 2.0362
PEX19 peroxisomal biogenesis factor 19 2.03337
RPL24 ribosomal protein L24 2.02018
ASGR1 asialoglycoprotein receptor 1 2.00994
SHCBP1 SHC SH2-domain binding protein 1 2.00328

decreased expression

Symbol Name Standardized Value
TERB1 telomere repeat binding bouquet formation protein 1 -3.1536
C6ORF52 chromosome 6 open reading frame 52 -3.1536
PRODH proline dehydrogenase (oxidase) 1 -3.1536
TPST2 tyrosylprotein sulfotransferase 2 -3.1536
EBI3 Epstein-Barr virus induced 3 -3.1536
SHBG sex hormone-binding globulin -3.1536
SDSL serine dehydratase-like -3.1536
RGPD5 RANBP2-like and GRIP domain containing 5 -3.1536
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -3.1536
HSF5 heat shock transcription factor family member 5 -3.1536
TMEM150B transmembrane protein 150B -3.1536
ZFP57 ZFP57 zinc finger protein -3.1536
HRH1 histamine receptor H1 -3.1536
TM6SF2 transmembrane 6 superfamily member 2 -3.1536
MPIG6B megakaryocyte and platelet inhibitory receptor G6b -3.1536
PANK2 pantothenate kinase 2 -3.1536
ALX4 ALX homeobox 4 -3.1536
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -3.1536
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.1536
HSH2D hematopoietic SH2 domain containing -3.1536
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.1536
SIM2 single-minded family bHLH transcription factor 2 -3.1536
GOLGA6L4 golgin A6 family-like 4 -3.1536
LRRC8C-DT LRRC8C divergent transcript -3.1536
HHIP hedgehog interacting protein -3.1536
NLRC3 NLR family, CARD domain containing 3 -3.1536
CLEC6A C-type lectin domain family 6, member A -3.1536
TEKT2 tektin 2 (testicular) -3.1536
SLC22A24 solute carrier family 22, member 24 -3.1536
CSDC2 cold shock domain containing C2, RNA binding -3.1536
C11ORF16 chromosome 11 open reading frame 16 -3.1536
ILDR2 immunoglobulin-like domain containing receptor 2 -3.1536
SHANK1 SH3 and multiple ankyrin repeat domains 1 -3.1536
NEIL1 nei endonuclease VIII-like 1 (E. coli) -3.1536
QRICH2 glutamine rich 2 -3.13449
FTCD formimidoyltransferase cyclodeaminase -3.07721
TEDC1 tubulin epsilon and delta complex 1 -3.03457
SRRM3 serine/arginine repetitive matrix 3 -3.02668
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.82829
PNMA3 paraneoplastic Ma antigen 3 -2.80524
ZFP28 ZFP28 zinc finger protein -2.80524
PKP4 plakophilin 4 -2.80416
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 -2.6632
ZNF671 zinc finger protein 671 -2.64954
SEPTIN8 septin 8 -2.60841
DVL2 dishevelled segment polarity protein 2 -2.4616
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.44049
ADGRD2 adhesion G protein-coupled receptor D2 -2.44049
OSBPL7 oxysterol binding protein-like 7 -2.43498
STOML1 stomatin (EPB72)-like 1 -2.43498
RUMY3 RUMY family member 3 -2.43498
ZNF773 zinc finger protein 773 -2.43498
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -2.42899
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.42394
DOCK9 dedicator of cytokinesis 9 -2.35873
MAST4 microtubule associated serine/threonine kinase family member 4 -2.34842
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.3309
ARL14EP ADP-ribosylation factor-like 14 effector protein -2.3309
NID1 nidogen 1 -2.32941
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.27299
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.26307
MAP2K4 mitogen-activated protein kinase kinase 4 -2.26188
BMS1 BMS1 ribosome biogenesis factor -2.23692
UNC93B1 unc-93 homolog B1 (C. elegans) -2.22349
GAP43 growth associated protein 43 -2.22349
NPIPA2 nuclear pore complex interacting protein family, member A2 -2.22349
TCF4 transcription factor 4 -2.22349
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -2.22349
MOG myelin oligodendrocyte glycoprotein -2.22349
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.22092
CCK cholecystokinin -2.21754
CNTD1 cyclin N-terminal domain containing 1 -2.20857
EFHB EF-hand domain family, member B -2.20857
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.20857
FAM107A family with sequence similarity 107, member A -2.20857
PLD6 phospholipase D family, member 6 -2.20857
SGMS2 sphingomyelin synthase 2 -2.1704
MKS1 Meckel syndrome, type 1 -2.1704
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.1704
PPP4R2 protein phosphatase 4, regulatory subunit 2 -2.12442
CFAP92 cilia and flagella associated protein 92 (putative) -2.11766
KIF17 kinesin family member 17 -2.09504
RNF26 ring finger protein 26 -2.09199
TBC1D10B TBC1 domain family, member 10B -2.09161
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.08941
ZNF280C zinc finger protein 280C -2.07147
MBD5 methyl-CpG binding domain protein 5 -2.0695
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.06838
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.06715
LPAR6 lysophosphatidic acid receptor 6 -2.04283
LAMA4 laminin, alpha 4 -2.04283
PTCD2 pentatricopeptide repeat domain 2 -2.04283
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.04283
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.02487
SCN11A sodium channel, voltage gated, type XI alpha subunit -2.02487
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -2.02233
IGSF21 immunoglobin superfamily, member 21 -2.02233
CCDC61 coiled-coil domain containing 61 -2.01258
CTNND1 catenin (cadherin-associated protein), delta 1 -2.00893
MED27 mediator complex subunit 27 -2.0089