FGFR3 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description fibroblast growth factor receptor 3|This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 2261)
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100 substrates of the kinase FGFR3 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 100.0
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.96
TRPC6 transient receptor potential cation channel, subfamily C, member 6 99.96
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.96
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 99.93
KCTD12 potassium channel tetramerization domain containing 12 99.91
MCC mutated in colorectal cancers 99.89
THEMIS2 thymocyte selection associated family member 2 99.87
PM20D2 peptidase M20 domain containing 2 99.76
MUC16 mucin 16, cell surface associated 99.65
SH2D1B SH2 domain containing 1B 99.54
DLG3 discs, large homolog 3 (Drosophila) 99.525
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 99.47
SLITRK6 SLIT and NTRK-like family, member 6 99.405
ALOX5 arachidonate 5-lipoxygenase 99.37
TLK1 tousled-like kinase 1 99.23
DLG2 discs, large homolog 2 (Drosophila) 99.21
CEP43 centrosomal protein 43 99.17
CEP170B centrosomal protein 170B 99.15
TIGIT T cell immunoreceptor with Ig and ITIM domains 99.13
TRIOBP TRIO and F-actin binding protein 99.03
PELP1 proline, glutamate and leucine rich protein 1 98.99
RCN2 reticulocalbin 2, EF-hand calcium binding domain 98.97
MELK maternal embryonic leucine zipper kinase 98.93
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 98.93
KTN1 kinectin 1 (kinesin receptor) 98.91
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 98.9
RABL6 RAB, member RAS oncogene family-like 6 98.88
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 98.88
PDCD5 programmed cell death 5 98.86
CNOT9 CCR4-NOT transcription complex subunit 9 98.84
GCSAML germinal center-associated, signaling and motility-like 98.825
EIF1B eukaryotic translation initiation factor 1B 98.78
EIF1 eukaryotic translation initiation factor 1 98.78
CBFB core-binding factor, beta subunit 98.67
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 98.62
TLK2 tousled-like kinase 2 98.6
ARHGAP30 Rho GTPase activating protein 30 98.51
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 98.36
EML4 echinoderm microtubule associated protein like 4 98.27
IRS4 insulin receptor substrate 4 98.26
IL7R interleukin 7 receptor 98.25
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 98.23
LURAP1L leucine rich adaptor protein 1-like 98.18
MRPS27 mitochondrial ribosomal protein S27 98.01
GAB3 GRB2-associated binding protein 3 97.985
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 97.97
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 97.9
MAT2A methionine adenosyltransferase II, alpha 97.79
USP31 ubiquitin specific peptidase 31 97.62
EPM2AIP1 EPM2A (laforin) interacting protein 1 97.61
N4BP3 NEDD4 binding protein 3 97.55
KMT5A lysine methyltransferase 5A 97.53
NIPSNAP1 nipsnap homolog 1 (C. elegans) 97.48
PRRC2B proline-rich coiled-coil 2B 97.42
PDS5B PDS5 cohesin associated factor B 97.4
ZNF598 zinc finger protein 598 97.39
IPO8 importin 8 97.27
LRRK1 leucine-rich repeat kinase 1 97.27
CENPE centromere protein E, 312kDa 97.2
LAX1 lymphocyte transmembrane adaptor 1 97.18
SH2D3C SH2 domain containing 3C 97.18
HBS1L HBS1-like translational GTPase 96.98
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 96.81
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 96.74
STARD13 StAR-related lipid transfer (START) domain containing 13 96.72
RNF2 ring finger protein 2 96.67
MAGED2 melanoma antigen family D2 96.65
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 96.61
NKD2 naked cuticle homolog 2 (Drosophila) 96.59
KRT19 keratin 19, type I 96.56
FCHO1 FCH domain only 1 96.48
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 96.46
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 96.45
FAM107B family with sequence similarity 107, member B 96.43
MCEMP1 mast cell-expressed membrane protein 1 96.41
IPO9 importin 9 96.37
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 96.355
FGFR2 fibroblast growth factor receptor 2 96.23
FHIT fragile histidine triad 96.19
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 96.19
CADM1 cell adhesion molecule 1 96.17
CHAF1B chromatin assembly factor 1, subunit B (p60) 96.1
CEP68 centrosomal protein 68kDa 96.02
SIPA1L1 signal-induced proliferation-associated 1 like 1 95.99
SH2D4A SH2 domain containing 4A 95.97
MARVELD3 MARVEL domain containing 3 95.95
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 95.93
TRIP11 thyroid hormone receptor interactor 11 95.89
FDFT1 farnesyl-diphosphate farnesyltransferase 1 95.88
JAK1 Janus kinase 1 95.86
ARID4B AT rich interactive domain 4B (RBP1-like) 95.82
NIBAN1 niban apoptosis regulator 1 95.8
GOLM1 golgi membrane protein 1 95.78
HCST hematopoietic cell signal transducer 95.78
ESYT2 extended synaptotagmin-like protein 2 95.73
GCSAM germinal center-associated, signaling and motility 95.615
IKZF3 IKAROS family zinc finger 3 (Aiolos) 95.6
GPATCH11 G patch domain containing 11 95.56
MYL12B myosin, light chain 12B, regulatory 95.54