FGFR4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description fibroblast growth factor receptor 4|The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2264)
Similar Terms
Downloads & Tools

Genes

328 genes differentially expressed following the FGFR4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.63471
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.63471
HAMP hepcidin antimicrobial peptide 2.63471
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.63471
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.63471
C9ORF152 chromosome 9 open reading frame 152 2.63471
DMRT1 doublesex and mab-3 related transcription factor 1 2.63471
CXCL16 chemokine (C-X-C motif) ligand 16 2.63471
BHLHA9 basic helix-loop-helix family, member a9 2.63471
GOLGA6D golgin A6 family, member D 2.63471
RBM45 RNA binding motif protein 45 2.63471
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.63471
DAND5 DAN domain family member 5, BMP antagonist 2.63471
GPR149 G protein-coupled receptor 149 2.63471
ZNF703 zinc finger protein 703 2.63471
ATOH8 atonal homolog 8 (Drosophila) 2.63471
CIMAP1B ciliary microtubule associated protein 1B 2.63471
PNPLA1 patatin-like phospholipase domain containing 1 2.63471
SERTM2 serine rich and transmembrane domain containing 2 2.63471
C3ORF22 chromosome 3 open reading frame 22 2.63471
GARIN1A golgi associated RAB2 interactor 1A 2.63471
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.63471
AURKAIP1 aurora kinase A interacting protein 1 2.53269
BRI3 brain protein I3 2.53269
PTMA prothymosin, alpha 2.5289
ZNF492 zinc finger protein 492 2.5289
GJA10 gap junction protein, alpha 10, 62kDa 2.5289
PCDHGB3 protocadherin gamma subfamily B, 3 2.5289
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.5289
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.5289
GOLGA2 golgin A2 2.5289
DUXB double homeobox B 2.5289
ADGRE1 adhesion G protein-coupled receptor E1 2.5289
VWA5B2 von Willebrand factor A domain containing 5B2 2.5289
CD93 CD93 molecule 2.5289
LRRC53 leucine rich repeat containing 53 2.5289
PAX8 paired box 8 2.5289
ADGB androglobin 2.5289
AVPR2 arginine vasopressin receptor 2 2.5289
ARSG arylsulfatase G 2.5289
HBZ hemoglobin, zeta 2.5289
GALP galanin-like peptide 2.5289
CELA1 chymotrypsin-like elastase family, member 1 2.5289
HBM hemoglobin, mu 2.5289
CRYGA crystallin, gamma A 2.5289
HCRTR2 hypocretin (orexin) receptor 2 2.5289
TGFB1 transforming growth factor, beta 1 2.5289
PAX4 paired box 4 2.5289
ESX1 ESX homeobox 1 2.5289
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.5289
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.5289
RSPO1 R-spondin 1 2.5289
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.5289
MFAP5 microfibrillar associated protein 5 2.5289
PECAM1 platelet/endothelial cell adhesion molecule 1 2.5289
VSX1 visual system homeobox 1 2.5289
SPEGNB SPEG neighbor 2.5289
HBG2 hemoglobin, gamma G 2.5289
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.5289
SPRR2F small proline-rich protein 2F 2.5289
PKD2L1 polycystic kidney disease 2-like 1 2.5289
IQCF3 IQ motif containing F3 2.5289
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.5289
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.5289
ASB9 ankyrin repeat and SOCS box containing 9 2.5289
ROPN1L rhophilin associated tail protein 1-like 2.5289
ZNF726 zinc finger protein 726 2.5289
TBC1D3I TBC1 domain family member 3I 2.5289
CD8B2 CD8b2 molecule 2.5289
H3-7 H3.7 histone (putative) 2.5289
MAJIN membrane anchored junction protein 2.5289
CCDC187 coiled-coil domain containing 187 2.5289
BNIP5 BCL2 interacting protein 5 2.5289
ANKRD40CL ANKRD40 C-terminal like 2.5289
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.5289
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.5289
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.5289
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.5289
MSX2 msh homeobox 2 2.5289
CD79A CD79a molecule, immunoglobulin-associated alpha 2.5289
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.5289
PTPRM protein tyrosine phosphatase, receptor type, M 2.5289
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.5289
TBX20 T-box 20 2.5289
COL19A1 collagen, type XIX, alpha 1 2.5289
GJA3 gap junction protein, alpha 3, 46kDa 2.5289
MIP major intrinsic protein of lens fiber 2.5289
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.5289
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 2.5289
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.5289
ASIC1 acid sensing (proton gated) ion channel 1 2.5289
GDF9 growth differentiation factor 9 2.5289
TAS1R2 taste receptor, type 1, member 2 2.5289
BARX2 BARX homeobox 2 2.5289
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.5289
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 2.5289
SIX3 SIX homeobox 3 2.5289
LGALS2 lectin, galactoside-binding, soluble, 2 2.5289
EDN3 endothelin 3 2.5289
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.5289
GH1 growth hormone 1 2.5289
VCAM1 vascular cell adhesion molecule 1 2.5289
EVPLL envoplakin-like 2.5289
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.5289
NNMT nicotinamide N-methyltransferase 2.5289
RNF225 ring finger protein 225 2.5289
CATIP ciliogenesis associated TTC17 interacting protein 2.5289
TGM4 transglutaminase 4 2.5289
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.5289
PDCD1LG2 programmed cell death 1 ligand 2 2.5289
PRSS37 protease, serine, 37 2.5289
PAGE2B P antigen family, member 2B 2.5289
DHRS7C dehydrogenase/reductase (SDR family) member 7C 2.5289
CRYBB3 crystallin, beta B3 2.5289
MR1 major histocompatibility complex, class I-related 2.5289
SPATA31E1 SPATA31 subfamily E, member 1 2.5289
ANKRD60 ankyrin repeat domain 60 2.5289
PCDHGB2 protocadherin gamma subfamily B, 2 2.5289
TBC1D10C TBC1 domain family, member 10C 2.5289
PITPNB phosphatidylinositol transfer protein, beta 2.5289
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.5289
SPATA3 spermatogenesis associated 3 2.5289
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 2.5289
ZMYND10 zinc finger, MYND-type containing 10 2.5289
CLEC4D C-type lectin domain family 4, member D 2.5289
PGR progesterone receptor 2.5289
TRIM7 tripartite motif containing 7 2.5289
ANXA8 annexin A8 2.5289
IL24 interleukin 24 2.5289
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2.5289
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.5289
ZNF804A zinc finger protein 804A 2.5289
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.5289
IL23R interleukin 23 receptor 2.5289
WNT2 wingless-type MMTV integration site family member 2 2.5289
C22ORF31 chromosome 22 open reading frame 31 2.5289
TPPP tubulin polymerization promoting protein 2.5289
LDHC lactate dehydrogenase C 2.5289
MRC1 mannose receptor, C type 1 2.5289
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.5289
RBM8A RNA binding motif protein 8A 2.5289
CLEC1A C-type lectin domain family 1, member A 2.5289
SSX1 synovial sarcoma, X breakpoint 1 2.5289
SLC38A11 solute carrier family 38, member 11 2.5289
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.5289
ZNF648 zinc finger protein 648 2.5289
C14ORF180 chromosome 14 open reading frame 180 2.5289
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 2.5289
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.5289
SLN sarcolipin 2.5289
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.5289
GRM6 glutamate receptor, metabotropic 6 2.5289
WARS1 tryptophanyl-tRNA synthetase 1 2.48539
H3C4 H3 clustered histone 4 2.47816
TBX22 T-box 22 2.47615
DYNAP dynactin associated protein 2.47615
BTNL8 butyrophilin-like 8 2.47615
MST1 macrophage stimulating 1 2.47615
RPL12 ribosomal protein L12 2.47308
PLAU plasminogen activator, urokinase 2.43971
GPR75-ASB3 GPR75-ASB3 readthrough 2.43971
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.4264
TMC8 transmembrane channel-like 8 2.4227
CRIPTO3 cripto, EGF-CFC family member 3 2.4227
AANAT aralkylamine N-acetyltransferase 2.4227
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit 2.4227
WNT16 wingless-type MMTV integration site family, member 16 2.4227
KRT15 keratin 15, type I 2.41543
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.41543
COX17 COX17 cytochrome c oxidase copper chaperone 2.37297
CDC45 cell division cycle 45 2.37297
FRMD4B FERM domain containing 4B 2.36958
CENPK centromere protein K 2.36547
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 2.3532
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.33929
CFAP36 cilia and flagella associated protein 36 2.32574
ZNF76 zinc finger protein 76 2.30594
PCID2 PCI domain containing 2 2.30107
FAM219B family with sequence similarity 219, member B 2.26755
UEVLD UEV and lactate/malate dehyrogenase domains 2.26755
ANAPC13 anaphase promoting complex subunit 13 2.26755
PTRH1 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) 2.24755
SUGP2 SURP and G patch domain containing 2 2.23926
ZNF549 zinc finger protein 549 2.23008
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.22921
AHNAK2 AHNAK nucleoprotein 2 2.21893
SPATA20 spermatogenesis associated 20 2.21893
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.20906
KIZ kizuna centrosomal protein 2.20906
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.20411
SUOX sulfite oxidase 2.19717
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.19687
MTSS1 metastasis suppressor 1 2.19687
NRBP1 nuclear receptor binding protein 1 2.19687
SUGCT succinyl-CoA:glutarate-CoA transferase 2.18453
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.17994
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.17913
CEP104 centrosomal protein 104kDa 2.15738
EPHX3 epoxide hydrolase 3 2.15738
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 2.15029
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 2.12766
TSKS testis-specific serine kinase substrate 2.11597
LUC7L LUC7-like (S. cerevisiae) 2.11524
CNTNAP3 contactin associated protein-like 3 2.10832
EXOC8 exocyst complex component 8 2.07738
POGLUT3 protein O-glucosyltransferase 3 2.05395
DBF4B DBF4 zinc finger B 2.05395
ARL2 ADP-ribosylation factor-like 2 2.04428
U2AF1 U2 small nuclear RNA auxiliary factor 1 2.04361
HMOX1 heme oxygenase 1 2.0404
SACK1G scaffolding CK1 anchoring protein G 2.02914
PHF1 PHD finger protein 1 2.02914
GRIK3 glutamate receptor, ionotropic, kainate 3 2.02505
LTN1 listerin E3 ubiquitin protein ligase 1 2.01854
MYT1L myelin transcription factor 1-like 2.01854
PRDX3 peroxiredoxin 3 2.00958
SMC1B structural maintenance of chromosomes 1B 2.00823
C12ORF57 chromosome 12 open reading frame 57 2.0027
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.0027

decreased expression

Symbol Name Standardized Value
BAIAP3 BAI1-associated protein 3 -2.63471
TICAM1 toll-like receptor adaptor molecule 1 -2.63471
BTBD8 BTB (POZ) domain containing 8 -2.63471
PRB3 proline-rich protein BstNI subfamily 3 -2.63471
POMZP3 POM121 and ZP3 fusion -2.63471
PARVG parvin, gamma -2.53269
MYL7 myosin, light chain 7, regulatory -2.53269
BTBD18 BTB (POZ) domain containing 18 -2.53269
MMP26 matrix metallopeptidase 26 -2.53269
CIMAP2 ciliary microtubule associated protein 2 -2.53269
AMBP alpha-1-microglobulin/bikunin precursor -2.5289
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.5289
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -2.5289
SARDH sarcosine dehydrogenase -2.5289
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -2.5289
MSH3 mutS homolog 3 -2.5289
FAM171B family with sequence similarity 171, member B -2.5289
JPT1 Jupiter microtubule associated homolog 1 -2.5289
DHRS12 dehydrogenase/reductase (SDR family) member 12 -2.5289
SMIM26 small integral membrane protein 26 -2.5289
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.5289
WDCP WD repeat and coiled coil containing -2.50903
LRRC37A2 leucine rich repeat containing 37, member A2 -2.47127
ZNF749 zinc finger protein 749 -2.46273
MAPK1 mitogen-activated protein kinase 1 -2.46273
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.45008
RB1CC1 RB1-inducible coiled-coil 1 -2.44847
FBXW10 F-box and WD repeat domain containing 10 -2.43971
DCTD dCMP deaminase -2.4264
KL klotho -2.4227
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.4227
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 -2.4227
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) -2.4227
CAPN9 calpain 9 -2.4227
GBP4 guanylate binding protein 4 -2.4227
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.4227
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -2.4227
TRPV5 transient receptor potential cation channel, subfamily V, member 5 -2.4227
CCR3 chemokine (C-C motif) receptor 3 -2.4227
SBSN suprabasin -2.4227
GJA5 gap junction protein, alpha 5, 40kDa -2.4227
GSC goosecoid homeobox -2.4227
COLEC10 collectin sub-family member 10 (C-type lectin) -2.4227
IZUMO3 IZUMO family member 3 -2.4227
TMEM176B transmembrane protein 176B -2.4227
SAMD11 sterile alpha motif domain containing 11 -2.4227
HIC1 hypermethylated in cancer 1 -2.4227
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.4227
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -2.4227
CARD9 caspase recruitment domain family, member 9 -2.4227
HSPB2 heat shock 27kDa protein 2 -2.4227
MAGEB17 melanoma antigen family B17 -2.4227
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 -2.4227
CNTNAP1 contactin associated protein 1 -2.4227
RSAD2 radical S-adenosyl methionine domain containing 2 -2.4227
CLDN34 claudin 34 -2.4227
SHISA8 shisa family member 8 -2.4227
ZNF843 zinc finger protein 843 -2.4227
LY96 lymphocyte antigen 96 -2.4227
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.4227
ADAM29 ADAM metallopeptidase domain 29 -2.4227
GJB5 gap junction protein, beta 5, 31.1kDa -2.4227
GPR179 G protein-coupled receptor 179 -2.4227
NLRP3 NLR family, pyrin domain containing 3 -2.4227
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.4227
ZNF853 zinc finger protein 853 -2.4203
EXT1 exostosin glycosyltransferase 1 -2.41543
ZC4H2 zinc finger, C4H2 domain containing -2.39429
NEFH neurofilament, heavy polypeptide -2.35375
SPEN spen family transcriptional repressor -2.30594
GTF2A1L general transcription factor IIA, 1-like -2.30438
PHF21B PHD finger protein 21B -2.2995
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -2.26998
CAVIN1 caveolae associated protein 1 -2.26998
GBA1 glucosylceramidase beta 1 -2.24541
PRR22 proline rich 22 -2.24325
BARX1 BARX homeobox 1 -2.24325
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -2.24325
SLC38A9 solute carrier family 38, member 9 -2.23416
NDRG2 NDRG family member 2 -2.23416
CHMP5 charged multivesicular body protein 5 -2.21893
NXT2 nuclear transport factor 2-like export factor 2 -2.20906
IFRD1 interferon-related developmental regulator 1 -2.20906
RELL2 RELT-like 2 -2.18425
BCAS3 breast carcinoma amplified sequence 3 -2.16295
SPINDOC spindlin interactor and repressor of chromatin binding -2.14694
PHLDB2 pleckstrin homology-like domain, family B, member 2 -2.14459
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.14459
BRD2 bromodomain containing 2 -2.13286
RAD54L RAD54-like (S. cerevisiae) -2.13286
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -2.1319
ATMIN ATM interactor -2.1319
BNC2 basonuclin 2 -2.12707
ICAM5 intercellular adhesion molecule 5, telencephalin -2.11597
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.11524
PPCDC phosphopantothenoylcysteine decarboxylase -2.11085
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.10218
SMC5 structural maintenance of chromosomes 5 -2.09083
AMIGO2 adhesion molecule with Ig-like domain 2 -2.09083
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.08965
ZNF219 zinc finger protein 219 -2.06732
NUP153 nucleoporin 153kDa -2.06338
SNTG2 syntrophin, gamma 2 -2.05749
PKD1 polycystic kidney disease 1 (autosomal dominant) -2.04676
CDK20 cyclin-dependent kinase 20 -2.02951
GDE1 glycerophosphodiester phosphodiesterase 1 -2.02914
VEGFA vascular endothelial growth factor A -2.01854
SLC60A1 solute carrier family 60 member 1 -2.00496
TUBGCP5 tubulin, gamma complex associated protein 5 -2.00163