FGFR4 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description fibroblast growth factor receptor 4|The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2264)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase FGFR4 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 100.0
PELP1 proline, glutamate and leucine rich protein 1 99.98
CEP68 centrosomal protein 68kDa 99.96
MARVELD3 MARVEL domain containing 3 99.93
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 99.91
MCC mutated in colorectal cancers 99.87
KCTD12 potassium channel tetramerization domain containing 12 99.85
GPATCH11 G patch domain containing 11 99.83
THEMIS2 thymocyte selection associated family member 2 99.74
CEP43 centrosomal protein 43 99.71
ALOX5 arachidonate 5-lipoxygenase 99.59
FAM107B family with sequence similarity 107, member B 99.58
CCT8 chaperonin containing TCP1, subunit 8 (theta) 99.56
PDCD5 programmed cell death 5 99.45
CHAF1B chromatin assembly factor 1, subunit B (p60) 99.39
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.36
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.36
SLITRK6 SLIT and NTRK-like family, member 6 99.32
ARHGAP30 Rho GTPase activating protein 30 99.28
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 99.25
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 99.23
TRPC6 transient receptor potential cation channel, subfamily C, member 6 99.04
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 98.995
RNF2 ring finger protein 2 98.97
VSTM4 V-set and transmembrane domain containing 4 98.82
PTPN7 protein tyrosine phosphatase, non-receptor type 7 98.8
PRRC2B proline-rich coiled-coil 2B 98.75
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 98.73
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 98.71
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 98.69
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 98.66
DLG3 discs, large homolog 3 (Drosophila) 98.63
EIF1 eukaryotic translation initiation factor 1 98.58
EIF1B eukaryotic translation initiation factor 1B 98.58
SIPA1L1 signal-induced proliferation-associated 1 like 1 98.47
MUC16 mucin 16, cell surface associated 98.42
MAT2A methionine adenosyltransferase II, alpha 98.34
TIGIT T cell immunoreceptor with Ig and ITIM domains 98.32
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 98.32
PM20D2 peptidase M20 domain containing 2 98.25
RABL6 RAB, member RAS oncogene family-like 6 98.23
ZNF598 zinc finger protein 598 98.21
HAVCR1 hepatitis A virus cellular receptor 1 98.18
FCRL6 Fc receptor-like 6 98.1
KRT19 keratin 19, type I 98.09
SH2D1B SH2 domain containing 1B 98.07
EXPH5 exophilin 5 98.01
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 97.99
LRRK1 leucine-rich repeat kinase 1 97.99
USP25 ubiquitin specific peptidase 25 97.97
GAB3 GRB2-associated binding protein 3 97.925
CDC5L cell division cycle 5-like 97.92
EPM2AIP1 EPM2A (laforin) interacting protein 1 97.88
CKAP4 cytoskeleton-associated protein 4 97.86
TRIOBP TRIO and F-actin binding protein 97.785
N4BP3 NEDD4 binding protein 3 97.77
MLEC malectin 97.74
CLEC12B C-type lectin domain family 12, member B 97.72
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 97.7
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 97.695
PTPRH protein tyrosine phosphatase, receptor type, H 97.68
ARID4B AT rich interactive domain 4B (RBP1-like) 97.64
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 97.59
ZNF169 zinc finger protein 169 97.5
LIFR leukemia inhibitory factor receptor alpha 97.48
IPO8 importin 8 97.46
ARHGAP5 Rho GTPase activating protein 5 97.44
CD300LB CD300 molecule-like family member b 97.4
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 97.39
TRPV2 transient receptor potential cation channel, subfamily V, member 2 97.37
CHD2 chromodomain helicase DNA binding protein 2 97.26
DPF2 D4, zinc and double PHD fingers family 2 97.2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 97.11
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 97.09
CBFB core-binding factor, beta subunit 97.07
LURAP1L leucine rich adaptor protein 1-like 96.96
ZCCHC3 zinc finger, CCHC domain containing 3 96.93
SPRY4 sprouty homolog 4 (Drosophila) 96.83
CD300LF CD300 molecule-like family member f 96.81
FGFR2 fibroblast growth factor receptor 2 96.74
CSTB cystatin B (stefin B) 96.65
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 96.63
DMAP1 DNA methyltransferase 1 associated protein 1 96.58
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 96.58
EIF3I eukaryotic translation initiation factor 3, subunit I 96.56
POLR1A polymerase (RNA) I polypeptide A, 194kDa 96.54
MRPS27 mitochondrial ribosomal protein S27 96.52
KLRC1 killer cell lectin-like receptor subfamily C, member 1 96.495
OSTF1 osteoclast stimulating factor 1 96.45
STK38 serine/threonine kinase 38 96.43
BYSL bystin-like 96.39
WWC1 WW and C2 domain containing 1 96.32
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 96.285
CEP170B centrosomal protein 170B 96.24
KLRF2 killer cell lectin-like receptor subfamily F, member 2 96.23
MGAM maltase-glucoamylase 96.23
FHIT fragile histidine triad 96.23
ARHGAP35 Rho GTPase activating protein 35 96.155
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 96.11
PLD1 phospholipase D1, phosphatidylcholine-specific 96.1