FGFRL1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description fibroblast growth factor receptor-like 1|The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 53834)
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Genes

277 genes differentially expressed following the FGFRL1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 2.57037
PAX2 paired box 2 2.57037
PLCH1 phospholipase C, eta 1 2.57037
PLCH2 phospholipase C, eta 2 2.57037
XCL2 chemokine (C motif) ligand 2 2.57037
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.57037
GYPB glycophorin B (MNS blood group) 2.57037
PBOV1 prostate and breast cancer overexpressed 1 2.57037
SHCBP1L SHC SH2-domain binding protein 1-like 2.57037
SPICE1 spindle and centriole associated protein 1 2.57037
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.57037
GPR52 G protein-coupled receptor 52 2.57037
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.57037
CD19 CD19 molecule 2.57037
TEX13B testis expressed 13B 2.57037
FGL1 fibrinogen-like 1 2.57037
DNASE1L2 deoxyribonuclease I-like 2 2.57037
FOXA2 forkhead box A2 2.57037
ADGRG4 adhesion G protein-coupled receptor G4 2.57037
REN renin 2.57037
PTGFR prostaglandin F receptor (FP) 2.57037
C3ORF22 chromosome 3 open reading frame 22 2.57037
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.57037
SPACA7 sperm acrosome associated 7 2.57037
NMUR2 neuromedin U receptor 2 2.57037
SLC10A5 solute carrier family 10, member 5 2.57037
CCDC83 coiled-coil domain containing 83 2.57037
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.57037
FAM81B family with sequence similarity 81, member B 2.57037
TPH1 tryptophan hydroxylase 1 2.57037
CRYAA crystallin, alpha A 2.57037
C21ORF140 chromosome 21 open reading frame 140 2.57037
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.57037
EDDM3A epididymal protein 3A 2.57037
OR52B6 olfactory receptor, family 52, subfamily B, member 6 2.57037
ANKK1 ankyrin repeat and kinase domain containing 1 2.57037
NUDCD2 NudC domain containing 2 2.57037
NPIPA3 nuclear pore complex interacting protein family, member A3 2.57037
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.57037
KRT72 keratin 72, type II 2.57037
DSPP dentin sialophosphoprotein 2.57037
PRRT1B proline rich transmembrane protein 1B 2.57037
CCN5 cellular communication network factor 5 2.57037
PLAAT4 phospholipase A and acyltransferase 4 2.57037
ALPG alkaline phosphatase, germ cell 2.57037
VSIR V-set immunoregulatory receptor 2.57037
PHF24 PHD finger protein 24 2.57037
ARX aristaless related homeobox 2.57037
GBP6 guanylate binding protein family, member 6 2.57037
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.57037
PLAAT2 phospholipase A and acyltransferase 2 2.57037
ACOD1 aconitate decarboxylase 1 2.57037
GNG5B G protein subunit gamma 5B 2.57037
H2BC12L H2B clustered histone 12 like 2.57037
SMIM31 small integral membrane protein 31 2.57037
CLEC20A C-type lectin domain containing 20A 2.57037
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.57037
SEPTIN12 septin 12 2.57037
CFAP107 cilia and flagella associated protein 107 2.57037
DYNLT4 dynein light chain Tctex-type 4 2.57037
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.57037
ASB9 ankyrin repeat and SOCS box containing 9 2.57037
BDKRB1 bradykinin receptor B1 2.57037
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.57037
PTPRC protein tyrosine phosphatase, receptor type, C 2.57037
SECTM1 secreted and transmembrane 1 2.57037
IL12RB1 interleukin 12 receptor, beta 1 2.57037
FPR1 formyl peptide receptor 1 2.57037
AGTR1 angiotensin II receptor, type 1 2.57037
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.57037
LRRD1 leucine-rich repeats and death domain containing 1 2.57037
AMBN ameloblastin (enamel matrix protein) 2.57037
EEF2K eukaryotic elongation factor 2 kinase 2.57037
LTK leukocyte receptor tyrosine kinase 2.57037
FGFBP1 fibroblast growth factor binding protein 1 2.57037
TACR2 tachykinin receptor 2 2.57037
CELA2A chymotrypsin-like elastase family, member 2A 2.57037
GJD4 gap junction protein, delta 4, 40.1kDa 2.57037
SPDYE16 speedy/RINGO cell cycle regulator family member E16 2.57037
TLR4 toll-like receptor 4 2.57037
NPIPB9 nuclear pore complex interacting protein family, member B9 2.57037
CARD18 caspase recruitment domain family, member 18 2.57037
ART1 ADP-ribosyltransferase 1 2.57037
OR52K1 olfactory receptor, family 52, subfamily K, member 1 2.57037
PCDHGA4 protocadherin gamma subfamily A, 4 2.57037
DRD1 dopamine receptor D1 2.57037
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 2.57037
TMEM65 transmembrane protein 65 2.57037
PTF1A pancreas specific transcription factor, 1a 2.57037
ADAMDEC1 ADAM-like, decysin 1 2.57037
EFCAB3 EF-hand calcium binding domain 3 2.57037
GPR149 G protein-coupled receptor 149 2.57037
NXNL1 nucleoredoxin-like 1 2.57037
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like 2.57037
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.57037
BRDT bromodomain, testis-specific 2.57037
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.57037
SLC25A52 solute carrier family 25, member 52 2.57037
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.57037
SMIM22 small integral membrane protein 22 2.57037
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.57037
HELT helt bHLH transcription factor 2.57037
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.57037
ZNF831 zinc finger protein 831 2.57037
C22ORF31 chromosome 22 open reading frame 31 2.57037
WNT2 wingless-type MMTV integration site family member 2 2.57037
WNT10B wingless-type MMTV integration site family, member 10B 2.57037
IL27 interleukin 27 2.57037
IL26 interleukin 26 2.57037
HMGB4 high mobility group box 4 2.57037
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.57037
PRSS38 protease, serine, 38 2.57037
VAV1 vav 1 guanine nucleotide exchange factor 2.57037
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.57037
TBX1 T-box 1 2.57037
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 2.57037
KLK12 kallikrein-related peptidase 12 2.57037
KLK15 kallikrein-related peptidase 15 2.57037
RGCC regulator of cell cycle 2.57037
IL12A interleukin 12A 2.57037
FIGLA folliculogenesis specific basic helix-loop-helix 2.57037
NR2E1 nuclear receptor subfamily 2, group E, member 1 2.57037
R3HCC1L R3H domain and coiled-coil containing 1-like 2.57037
CHRM4 cholinergic receptor, muscarinic 4 2.57037
MMRN1 multimerin 1 2.57037
NEUROD4 neuronal differentiation 4 2.57037
CGA glycoprotein hormones, alpha polypeptide 2.57037
SPNS3 spinster homolog 3 (Drosophila) 2.57037
SYTL4 synaptotagmin-like 4 2.57037
ICAM5 intercellular adhesion molecule 5, telencephalin 2.57037
OR51Q1 olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene) 2.57037
NLRP11 NLR family, pyrin domain containing 11 2.57037
TMPRSS15 transmembrane protease, serine 15 2.57037
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 2.57037
ANGPTL3 angiopoietin-like 3 2.57037
NLRP3 NLR family, pyrin domain containing 3 2.57037
AREG amphiregulin 2.57037
AOC1 amine oxidase, copper containing 1 2.57037
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.57037
C9ORF50 chromosome 9 open reading frame 50 2.57037
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 2.57037
ASCL5 achaete-scute family bHLH transcription factor 5 2.57037
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.57037
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.57037
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.57037
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.57037
DEFB123 defensin, beta 123 2.57037
CYB561A3 cytochrome b561 family, member A3 2.54773
CSDC2 cold shock domain containing C2, RNA binding 2.50965
SH2D4B SH2 domain containing 4B 2.50965
GFRA3 GDNF family receptor alpha 3 2.50965
DIO1 deiodinase, iodothyronine, type I 2.50965
UBXN10 UBX domain protein 10 2.50965
TDRP testis development related protein 2.4866
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 2.4851
CDK17 cyclin-dependent kinase 17 2.4278
HPS3 Hermansky-Pudlak syndrome 3 2.42451
SFR1 SWI5-dependent recombination repair 1 2.42451
GTPBP1 GTP binding protein 1 2.41131
TSSK6 testis-specific serine kinase 6 2.41131
INTS7 integrator complex subunit 7 2.41131
ZNF691 zinc finger protein 691 2.40681
FBXO3 F-box protein 3 2.39991
RPL12 ribosomal protein L12 2.39443
COA6 cytochrome c oxidase assembly factor 6 2.3891
RPS24 ribosomal protein S24 2.35257
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.33525
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.29799
PLPP5 phospholipid phosphatase 5 2.29799
KLHL11 kelch-like family member 11 2.28569
TTC24 tetratricopeptide repeat domain 24 2.2381
PDCD7 programmed cell death 7 2.22291
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.21943
KRT15 keratin 15, type I 2.19664
LRRC66 leucine rich repeat containing 66 2.16998
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 2.16259
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.12764
LMO7 LIM domain 7 2.11607
LZTFL1 leucine zipper transcription factor-like 1 2.1098
RPL4 ribosomal protein L4 2.10225
TENT4B terminal nucleotidyltransferase 4B 2.0882
ZNF680 zinc finger protein 680 2.05495
FAM110D family with sequence similarity 110, member D 2.04229
STAC SH3 and cysteine rich domain 2.032
TMEM268 transmembrane protein 268 2.024
MRPS18C mitochondrial ribosomal protein S18C 2.024
MATN4 matrilin 4 2.01692
YEATS2 YEATS domain containing 2 2.01186
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.00099

decreased expression

Symbol Name Standardized Value
H3C14 H3 clustered histone 14 -2.57037
FAM167B family with sequence similarity 167, member B -2.57037
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.57037
SLC30A8 solute carrier family 30 (zinc transporter), member 8 -2.57037
GCKR glucokinase (hexokinase 4) regulator -2.57037
HAS3 hyaluronan synthase 3 -2.57037
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -2.57037
LCN12 lipocalin 12 -2.57037
OCSTAMP osteoclast stimulatory transmembrane protein -2.57037
LGALS1 lectin, galactoside-binding, soluble, 1 -2.57037
RBP2 retinol binding protein 2, cellular -2.57037
GLB1L galactosidase, beta 1-like -2.57037
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -2.57037
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.57037
GPR75 G protein-coupled receptor 75 -2.57037
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.57037
GARIN6 golgi associated RAB2 interactor family member 6 -2.57037
TENT5C terminal nucleotidyltransferase 5C -2.57037
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -2.57037
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B -2.57037
SCAMP4 secretory carrier membrane protein 4 -2.57037
OR52E5 olfactory receptor, family 52, subfamily E, member 5 -2.57037
RFXANK regulatory factor X-associated ankyrin-containing protein -2.57037
RNF113B ring finger protein 113B -2.57037
OVOL3 ovo-like zinc finger 3 -2.57037
DNASE2B deoxyribonuclease II beta -2.57037
ERVFRD-1 endogenous retrovirus group FRD, member 1 -2.57037
ZNF280C zinc finger protein 280C -2.57037
ZNF534 zinc finger protein 534 -2.57037
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 -2.57037
SPTBN5 spectrin, beta, non-erythrocytic 5 -2.57037
CFAP47 cilia and flagella associated protein 47 -2.57037
CRYBB3 crystallin, beta B3 -2.57037
IRGM immunity-related GTPase family, M -2.57037
NIM1K NIM1 serine/threonine protein kinase -2.57037
SMYD1 SET and MYND domain containing 1 -2.57037
INHA inhibin, alpha -2.57037
ALOXE3 arachidonate lipoxygenase 3 -2.57037
FOXH1 forkhead box H1 -2.57037
MORN5 MORN repeat containing 5 -2.57037
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -2.55513
IER5L immediate early response 5-like -2.52215
ZBTB7C zinc finger and BTB domain containing 7C -2.49515
H4C12 H4 clustered histone 12 -2.46058
CCDC178 coiled-coil domain containing 178 -2.44381
CRHR2 corticotropin releasing hormone receptor 2 -2.43818
COL4A2 collagen, type IV, alpha 2 -2.4278
MTMR12 myotubularin related protein 12 -2.38497
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.36922
N4BP2L1 NEDD4 binding protein 2-like 1 -2.31754
BMX BMX non-receptor tyrosine kinase -2.31141
MZB1 marginal zone B and B1 cell-specific protein -2.31141
CD86 CD86 molecule -2.31141
CFP complement factor properdin -2.31141
NOTCH2 notch 2 -2.30628
ACY1 aminoacylase 1 -2.28708
BST2 bone marrow stromal cell antigen 2 -2.28708
C10ORF105 chromosome 10 open reading frame 105 -2.24939
DAGLB diacylglycerol lipase, beta -2.2381
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -2.2381
SVIL supervillin -2.20809
MAPRE3 microtubule-associated protein, RP/EB family, member 3 -2.1803
ANXA5 annexin A5 -2.1529
OSGEP O-sialoglycoprotein endopeptidase -2.13002
MYZAP myocardial zonula adherens protein -2.12764
ZNF277 zinc finger protein 277 -2.12764
BAAT bile acid CoA:amino acid N-acyltransferase -2.12764
TMEM33 transmembrane protein 33 -2.1187
ADIPOR2 adiponectin receptor 2 -2.1187
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -2.11607
FSCN3 fascin actin-bundling protein 3, testicular -2.10225
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.08388
CDK7 cyclin-dependent kinase 7 -2.07569
CAPN11 calpain 11 -2.07124
PLA2G2C phospholipase A2, group IIC -2.05983
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.05983
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.05983
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -2.05495
BEND6 BEN domain containing 6 -2.05495
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -2.04903
ADPRH ADP-ribosylarginine hydrolase -2.04753
STX18 syntaxin 18 -2.04229
TRPV1 transient receptor potential cation channel, subfamily V, member 1 -2.032
CINP cyclin-dependent kinase 2 interacting protein -2.02532
MREG melanoregulin -2.024
ZNF280B zinc finger protein 280B -2.024
UPK3BL1 uroplakin 3B like 1 -2.02382
SMIM41 small integral membrane protein 41 -2.01186