FGR Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description FGR proto-oncogene, Src family tyrosine kinase|This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2268)
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100 substrates of the kinase FGR from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 99.93
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 99.83
MCC mutated in colorectal cancers 99.56
KLC1 kinesin light chain 1 99.5
FAM20B family with sequence similarity 20, member B 99.43
MEGF10 multiple EGF-like-domains 10 99.39
KIF20A kinesin family member 20A 99.32
RFTN1 raftlin, lipid raft linker 1 99.28
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 99.26
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 99.12
TENT4A terminal nucleotidyltransferase 4A 99.1
PARD6B par-6 family cell polarity regulator beta 99.08
PRMT1 protein arginine methyltransferase 1 99.06
ANKRD26 ankyrin repeat domain 26 98.93
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 98.91
TNRC6B trinucleotide repeat containing 6B 98.9
PTPRA protein tyrosine phosphatase, receptor type, A 98.88
FCMR Fc fragment of IgM receptor 98.86
RPL36AL ribosomal protein L36a-like 98.66
PLPP2 phospholipid phosphatase 2 98.64
CGN cingulin 98.58
LURAP1L leucine rich adaptor protein 1-like 98.55
GRAMD4 GRAM domain containing 4 98.47
VCP valosin containing protein 98.42
CORO1C coronin, actin binding protein, 1C 98.4
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 98.38
ZCCHC3 zinc finger, CCHC domain containing 3 98.32
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 98.21
SMG8 SMG8 nonsense mediated mRNA decay factor 98.18
MX2 MX dynamin-like GTPase 2 98.14
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 98.1
LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 98.09
PTPRE protein tyrosine phosphatase, receptor type, E 98.05
CSNK2A2 casein kinase 2, alpha prime polypeptide 97.99
NIBAN2 niban apoptosis regulator 2 97.99
MID2 midline 2 97.86
NAV1 neuron navigator 1 97.85
SIN3A SIN3 transcription regulator family member A 97.81
GNL1 guanine nucleotide binding protein-like 1 97.77
WASHC2A WASH complex subunit 2A 97.74
WASHC2C WASH complex subunit 2C 97.74
ACE2 angiotensin I converting enzyme 2 97.7
LMTK2 lemur tyrosine kinase 2 97.61
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 97.57
RALY RALY heterogeneous nuclear ribonucleoprotein 97.55
DOK3 docking protein 3 97.51
EFHD1 EF-hand domain family, member D1 97.29
RPS14 ribosomal protein S14 97.27
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 97.24
HNRNPM heterogeneous nuclear ribonucleoprotein M 97.16
EFHD2 EF-hand domain family, member D2 97.0
TRPV4 transient receptor potential cation channel, subfamily V, member 4 96.99
NOLC1 nucleolar and coiled-body phosphoprotein 1 96.93
TTC28 tetratricopeptide repeat domain 28 96.85
THRB thyroid hormone receptor, beta 96.85
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 96.83
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 96.81
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 96.78
EIF4A3 eukaryotic translation initiation factor 4A3 96.76
CDK15 cyclin-dependent kinase 15 96.65
CDK14 cyclin-dependent kinase 14 96.65
CKAP4 cytoskeleton-associated protein 4 96.46
FBXO11 F-box protein 11 96.45
AHCY adenosylhomocysteinase 96.43
CHKA choline kinase alpha 96.29
N4BP3 NEDD4 binding protein 3 96.28
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 96.26
RGS10 regulator of G-protein signaling 10 96.24
PVRIG poliovirus receptor related immunoglobulin domain containing 96.19
TRAF3IP2 TRAF3 interacting protein 2 96.17
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 96.17
PLRG1 pleiotropic regulator 1 96.06
SHANK2 SH3 and multiple ankyrin repeat domains 2 96.04
PPIA peptidylprolyl isomerase A (cyclophilin A) 95.95
INTS7 integrator complex subunit 7 95.93
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 95.91
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 95.77
EXPH5 exophilin 5 95.73
EXOC4 exocyst complex component 4 95.67
FXR1 fragile X mental retardation, autosomal homolog 1 95.58
KAT2B K(lysine) acetyltransferase 2B 95.53
SH2B2 SH2B adaptor protein 2 95.45
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 95.3
CEP89 centrosomal protein 89kDa 95.27
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 95.23
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 95.16
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 95.16
CD33 CD33 molecule 95.11
SIPA1L1 signal-induced proliferation-associated 1 like 1 95.1
SRCIN1 SRC kinase signaling inhibitor 1 95.095
UBE2E3 ubiquitin-conjugating enzyme E2E 3 95.08
UBE2E1 ubiquitin-conjugating enzyme E2E 1 95.08
UBE2E2 ubiquitin-conjugating enzyme E2E 2 95.08
TMEM185B transmembrane protein 185B 95.03
CHERP calcium homeostasis endoplasmic reticulum protein 94.985
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 94.94
MKNK1 MAP kinase interacting serine/threonine kinase 1 94.81
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 94.77
RGS14 regulator of G-protein signaling 14 94.75
USP24 ubiquitin specific peptidase 24 94.73