FH Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description fumarate hydratase|The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2271)
External Link http://www.ncbi.nlm.nih.gov/gene/2271
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Genes

330 interacting proteins for FH from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
ACAT2 acetyl-CoA acetyltransferase 2
ACTB actin, beta
ACTN1 actinin, alpha 1
AHCY adenosylhomocysteinase
AHNAK AHNAK nucleoprotein
AHSG alpha-2-HS-glycoprotein
ALB albumin
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDOA aldolase A, fructose-bisphosphate
ANGPT2 angiopoietin 2
ANKAR ankyrin and armadillo repeat containing
ANXA1 annexin A1
ANXA2 annexin A2
ANXA3 annexin A3
ANXA5 annexin A5
APMAP adipocyte plasma membrane associated protein
ARF1 ADP-ribosylation factor 1
ARF4 ADP-ribosylation factor 4
ASB6 ankyrin repeat and SOCS box containing 6
ASPH aspartate beta-hydroxylase
ATF2 activating transcription factor 2
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BASP1 brain abundant, membrane attached signal protein 1
BCAP31 B-cell receptor-associated protein 31
BOLA2 bolA family member 2
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
BSG basigin (Ok blood group)
CAB39 calcium binding protein 39
CALB1 calbindin 1, 28kDa
CALCOCO2 calcium binding and coiled-coil domain 2
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALR calreticulin
CALU calumenin
CANX calnexin
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD44 CD44 molecule (Indian blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK2 cyclin-dependent kinase 2
CEP290 centrosomal protein 290kDa
CFL1 cofilin 1 (non-muscle)
CKB creatine kinase, brain
CKM creatine kinase, muscle
CKMT1A creatine kinase, mitochondrial 1A
CLIC1 chloride intracellular channel 1
CNTNAP2 contactin associated protein-like 2
COLGALT1 collagen beta(1-O)galactosyltransferase 1
CPLX1 complexin 1
CPOX coproporphyrinogen oxidase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CS citrate synthase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
DCD dermcidin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DES desmin
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNM1 dynamin 1
DPYSL2 dihydropyrimidinase-like 2
DSG1 desmoglein 1
DSP desmoplakin
DTD1 D-tyrosyl-tRNA deacylase 1
DYNLL1 dynein, light chain, LC8-type 1
ECH1 enoyl CoA hydratase 1, peroxisomal
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF2 eukaryotic translation elongation factor 2
EIF5A eukaryotic translation initiation factor 5A
EIF6 eukaryotic translation initiation factor 6
EMD emerin
ENO1 enolase 1, (alpha)
ENO3 enolase 3 (beta, muscle)
ERC2 ELKS/RAB6-interacting/CAST family member 2
ERO1L ERO1-like (S. cerevisiae)
ERP29 endoplasmic reticulum protein 29
EXOC1 exocyst complex component 1
EXOC4 exocyst complex component 4
EZR ezrin
FAR1 fatty acyl CoA reductase 1
FBXO2 F-box protein 2
FLG2 filaggrin family member 2
FLNA filamin A, alpha
FLNC filamin C, gamma
FSCN1 fascin actin-bundling protein 1
FUBP1 far upstream element (FUSE) binding protein 1
FYCO1 FYVE and coiled-coil domain containing 1
GANAB glucosidase, alpha; neutral AB
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAS8 growth arrest-specific 8
GDI1 GDP dissociation inhibitor 1
GDI2 GDP dissociation inhibitor 2
GEMIN2 gem (nuclear organelle) associated protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GLS glutaminase
GLUD2 glutamate dehydrogenase 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPC4 glypican 4
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
H2AFV H2A histone family, member V
H2AFZ H2A histone family, member Z
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HBA2 hemoglobin, alpha 2
HEXB hexosaminidase B (beta polypeptide)
HIRIP3 HIRA interacting protein 3
HK1 hexokinase 1
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMMT inner membrane protein, mitochondrial
IQCB1 IQ motif containing B1
IQGAP3 IQ motif containing GTPase activating protein 3
ITGA11 integrin, alpha 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB4 integrin, beta 4
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LDHA lactate dehydrogenase A
LDHAL6A lactate dehydrogenase A-like 6A
LDHB lactate dehydrogenase B
LOX lysyl oxidase
LPCAT2 lysophosphatidylcholine acyltransferase 2
LTN1 listerin E3 ubiquitin protein ligase 1
MAG myelin associated glycoprotein
MAP1B microtubule-associated protein 1B
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MDH1 malate dehydrogenase 1, NAD (soluble)
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MRPL16 mitochondrial ribosomal protein L16
MSN moesin
MSR1 macrophage scavenger receptor 1
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYDGF myeloid-derived growth factor
MYH9 myosin, heavy chain 9, non-muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO1C myosin IC
NACA nascent polypeptide-associated complex alpha subunit
NAP1L1 nucleosome assembly protein 1-like 1
NEFM neurofilament, medium polypeptide
NME2P1 NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1
NSFL1C NSFL1 (p97) cofactor (p47)
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUP188 nucleoporin 188kDa
OAT ornithine aminotransferase
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1
OXCT1 3-oxoacid CoA transferase 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCBP1 poly(rC) binding protein 1
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PCP4L1 Purkinje cell protein 4 like 1
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PEA15 phosphoprotein enriched in astrocytes 15
PEBP1 phosphatidylethanolamine binding protein 1
PFDN2 prefoldin subunit 2
PFN1 profilin 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHB prohibitin
PHB2 prohibitin 2
PKM pyruvate kinase, muscle
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIF peptidylprolyl isomerase F
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRDX1 peroxiredoxin 1
PRDX3 peroxiredoxin 3
PRDX5 peroxiredoxin 5
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSAT1 phosphoserine aminotransferase 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTMA prothymosin, alpha
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PYGB phosphorylase, glycogen; brain
PYGL phosphorylase, glycogen, liver
QDPR quinoid dihydropteridine reductase
RAB11A RAB11A, member RAS oncogene family
RAB14 RAB14, member RAS oncogene family
RAB1A RAB1A, member RAS oncogene family
RAB2A RAB2A, member RAS oncogene family
RAB2B RAB2B, member RAS oncogene family
RAB35 RAB35, member RAS oncogene family
RAB3C RAB3C, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RHOC ras homolog family member C
RNH1 ribonuclease/angiogenin inhibitor 1
RPN1 ribophorin I
RRBP1 ribosome binding protein 1
RTN4 reticulon 4
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SEC16A SEC16 homolog A (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFXN1 sideroflexin 1
SGPL1 sphingosine-1-phosphate lyase 1
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIRT7 sirtuin 7
SKP1 S-phase kinase-associated protein 1
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMN2 survival of motor neuron 2, centromeric
SPATA24 spermatogenesis associated 24
SQRDL sulfide quinone reductase-like (yeast)
STIP1 stress-induced phosphoprotein 1
STXBP1 syntaxin binding protein 1
SUMO2 small ubiquitin-like modifier 2
SVOPL SVOP-like
SYN2 synapsin II
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TATDN1 TatD DNase domain containing 1
TCP1 t-complex 1
TFRC transferrin receptor
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMX1 thioredoxin-related transmembrane protein 1
TPI1 triosephosphate isomerase 1
TPM1 tropomyosin 1 (alpha)
TPM3 tropomyosin 3
TPM4 tropomyosin 4
TRIM21 tripartite motif containing 21
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA4A tubulin, alpha 4a
TUBA4B tubulin, alpha 4b
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TWF2 twinfilin actin binding protein 2
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UBA1 ubiquitin-like modifier activating enzyme 1
UBC ubiquitin C
UBE2K ubiquitin-conjugating enzyme E2K
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBE3B ubiquitin protein ligase E3B
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
VIM vimentin
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XPOT exportin, tRNA
YBX1 Y box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta