FHL2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description four and a half LIM domains 2|This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2274)
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Genes

358 genes differentially expressed following the FHL2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC39A5 solute carrier family 39 (zinc transporter), member 5 4.18539
S100A5 S100 calcium binding protein A5 4.18539
MUC20 mucin 20, cell surface associated 4.18539
MMP28 matrix metallopeptidase 28 4.18539
UTS2 urotensin 2 4.18539
SAA4 serum amyloid A4, constitutive 4.18539
LGALS2 lectin, galactoside-binding, soluble, 2 4.18539
KISS1R KISS1 receptor 4.18539
GRP gastrin-releasing peptide 4.18539
ALG10B ALG10B, alpha-1,2-glucosyltransferase 4.18539
LRRC71 leucine rich repeat containing 71 4.18539
S100A1 S100 calcium binding protein A1 4.18539
LRRIQ4 leucine-rich repeats and IQ motif containing 4 4.18539
MAGED4 melanoma antigen family D4 4.18539
CXCL2 chemokine (C-X-C motif) ligand 2 4.18539
CA4 carbonic anhydrase IV 4.18539
TACR2 tachykinin receptor 2 4.18539
PGLYRP1 peptidoglycan recognition protein 1 4.18539
C9ORF152 chromosome 9 open reading frame 152 4.18539
LCN10 lipocalin 10 4.18539
SPNS2 spinster homolog 2 (Drosophila) 4.18539
CELA1 chymotrypsin-like elastase family, member 1 4.18539
DLX4 distal-less homeobox 4 4.18539
MCOLN3 mucolipin 3 4.18539
PODNL1 podocan-like 1 4.18539
OIT3 oncoprotein induced transcript 3 4.18539
PRR22 proline rich 22 4.18539
DKK2 dickkopf WNT signaling pathway inhibitor 2 4.18539
KIF19 kinesin family member 19 4.18539
CCDC42 coiled-coil domain containing 42 4.18539
AOC1 amine oxidase, copper containing 1 4.18539
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 4.18539
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 4.18539
SOX30 SRY (sex determining region Y)-box 30 4.18539
CDCP2 CUB domain containing protein 2 4.18539
KCNK18 potassium channel, two pore domain subfamily K, member 18 4.18539
ANGPTL3 angiopoietin-like 3 4.18539
BOD1L2 biorientation of chromosomes in cell division 1-like 2 4.18539
IRX3 iroquois homeobox 3 4.18539
VPREB3 pre-B lymphocyte 3 4.18539
NMUR1 neuromedin U receptor 1 4.18539
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 4.18539
NR4A3 nuclear receptor subfamily 4, group A, member 3 4.18539
CLCF1 cardiotrophin-like cytokine factor 1 4.18539
RAMP3 receptor (G protein-coupled) activity modifying protein 3 4.18539
PROM2 prominin 2 4.18539
SMCO3 single-pass membrane protein with coiled-coil domains 3 4.18539
DHRS9 dehydrogenase/reductase (SDR family) member 9 4.18539
TMEM184A transmembrane protein 184A 4.18539
PITX3 paired-like homeodomain 3 4.18539
ANGPTL5 angiopoietin-like 5 4.18539
TMIE transmembrane inner ear 4.18539
SIM2 single-minded family bHLH transcription factor 2 4.18539
STKLD1 serine/threonine kinase-like domain containing 1 4.18539
CD6 CD6 molecule 4.18539
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 4.18539
SCRT2 scratch family zinc finger 2 4.18539
OR2A12 olfactory receptor, family 2, subfamily A, member 12 4.18539
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 4.18539
ZNF492 zinc finger protein 492 4.18539
GPR162 G protein-coupled receptor 162 4.18539
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 4.18539
CLIP4 CAP-GLY domain containing linker protein family, member 4 4.18539
FABP9 fatty acid binding protein 9, testis 4.18539
AKAP3 A kinase (PRKA) anchor protein 3 4.18539
WSCD2 WSC domain containing 2 4.18539
PCDHA7 protocadherin alpha 7 4.18539
PCDHA2 protocadherin alpha 2 4.18539
ATP13A5 ATPase type 13A5 4.18539
CPED1 cadherin-like and PC-esterase domain containing 1 4.18539
FPR3 formyl peptide receptor 3 4.18539
LOC107986837 uncharacterized LOC107986837 4.18539
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 4.18539
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 4.18539
IRF4 interferon regulatory factor 4 4.18539
ENTHD1 ENTH domain containing 1 4.18539
OR52A5 olfactory receptor, family 52, subfamily A, member 5 4.18539
BHLHA9 basic helix-loop-helix family, member a9 4.18539
C6ORF118 chromosome 6 open reading frame 118 4.18539
FOXI3 forkhead box I3 4.18539
MBD3L3 methyl-CpG binding domain protein 3-like 3 4.18539
PAX6 paired box 6 4.18539
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 4.18539
OLIG1 oligodendrocyte transcription factor 1 4.18539
TUBB1 tubulin, beta 1 class VI 4.18539
CIITA class II, major histocompatibility complex, transactivator 4.18539
SFXN3 sideroflexin 3 4.18539
GPR26 G protein-coupled receptor 26 4.18539
C1QTNF1 C1q and tumor necrosis factor related protein 1 4.18539
GZMM granzyme M (lymphocyte met-ase 1) 4.18539
DUSP15 dual specificity phosphatase 15 4.18539
CD163 CD163 molecule 4.18539
ZNF662 zinc finger protein 662 4.18539
PCDHB9 protocadherin beta 9 4.18539
HGD homogentisate 1,2-dioxygenase 4.18539
HES3 hes family bHLH transcription factor 3 4.18539
SOX18 SRY (sex determining region Y)-box 18 4.18539
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 4.18539
TBX15 T-box 15 4.18539
IQCJ IQ motif containing J 4.18539
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 4.18539
FBLN7 fibulin 7 4.18539
KLHL1 kelch-like family member 1 4.18539
C22ORF42 chromosome 22 open reading frame 42 4.18539
DRD3 dopamine receptor D3 4.18539
PCDHGA7 protocadherin gamma subfamily A, 7 4.18539
SHISA8 shisa family member 8 4.18539
CSAG1 chondrosarcoma associated gene 1 4.18539
H2BC12L H2B clustered histone 12 like 4.18539
TEKT2 tektin 2 (testicular) 4.18539
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 4.18539
CFAP47 cilia and flagella associated protein 47 4.18539
SPATA9 spermatogenesis associated 9 4.18539
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 4.18539
PVALEF parvalbumin like EF-hand containing 4.18539
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 4.18539
AQP8 aquaporin 8 4.18539
ARR3 arrestin 3, retinal (X-arrestin) 4.18539
H3-4 H3.4 histone, cluster member 4.18539
TEX55 testis expressed 55 4.18539
CLEC20A C-type lectin domain containing 20A 4.18539
RHEX regulator of hemoglobinization and erythroid cell expansion 4.18539
KLF4 Kruppel-like factor 4 (gut) 4.18539
JSRP1 junctional sarcoplasmic reticulum protein 1 4.18539
WFDC1 WAP four-disulfide core domain 1 4.18539
GOLGA6C golgin A6 family, member C 4.18539
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 4.18539
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 4.18539
LY96 lymphocyte antigen 96 4.18539
DRC5 dynein regulatory complex subunit 5 4.18539
RIN1 Ras and Rab interactor 1 4.18539
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 4.18539
CNR2 cannabinoid receptor 2 (macrophage) 4.18539
C10ORF105 chromosome 10 open reading frame 105 4.18539
WNT3 wingless-type MMTV integration site family, member 3 4.18539
TEX29 testis expressed 29 4.18539
EVI2A ecotropic viral integration site 2A 4.18539
OR1R1 olfactory receptor family 1 subfamily R member 1 4.18539
GOLGA8R golgin A8 family, member R 4.18539
NMBR neuromedin B receptor 4.18539
REELD1 reeler domain containing 1 4.18539
LYPD5 LY6/PLAUR domain containing 5 4.18539
CRYBA1 crystallin, beta A1 4.18539
TF transferrin 4.18539
SMIM17 small integral membrane protein 17 4.18539
MORN5 MORN repeat containing 5 4.18539
H4C15 H4 clustered histone 15 4.18539
GFRAL GDNF family receptor alpha like 4.18539
C17ORF113 chromosome 17 open reading frame 113 4.18539
NR5A1 nuclear receptor subfamily 5, group A, member 1 4.18539
DEFB109B defensin beta 109B 4.18539
CTSO cathepsin O 4.18539
NPPA natriuretic peptide A 4.18539
TRAF3IP3 TRAF3 interacting protein 3 4.18539
APOL6 apolipoprotein L, 6 4.18539
MUSTN1 musculoskeletal, embryonic nuclear protein 1 4.18539
CHRM4 cholinergic receptor, muscarinic 4 4.18539
LST1 leukocyte specific transcript 1 4.18539
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 4.18539
SLC7A4 solute carrier family 7, member 4 4.18539
POU3F2 POU class 3 homeobox 2 4.18539
PRR15L proline rich 15-like 4.18539
PLCZ1 phospholipase C, zeta 1 4.18539
TBC1D28 TBC1 domain family, member 28 4.18539
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 4.18539
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 4.18539
LAMP5 lysosomal-associated membrane protein family, member 5 4.18539
ADAM21 ADAM metallopeptidase domain 21 4.18539
PPP1R3A protein phosphatase 1, regulatory subunit 3A 4.18539
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 4.18539
TGM2 transglutaminase 2 4.18539
PCP4L1 Purkinje cell protein 4 like 1 4.18539
GRAP GRB2-related adaptor protein 4.18539
SYTL3 synaptotagmin-like 3 4.18539
SLC51B solute carrier family 51, beta subunit 4.18539
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 4.18539
CD8B CD8b molecule 4.18539
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 4.18539
DMTN dematin actin binding protein 4.18539
ANKRD62 ankyrin repeat domain 62 4.18539
MISP3 MISP family member 3 4.18539
TMEM132E transmembrane protein 132E 4.18539
KCNK3 potassium channel, two pore domain subfamily K, member 3 4.18539
KCNK4 potassium channel, two pore domain subfamily K, member 4 4.18539
SLA2 Src-like-adaptor 2 4.18539
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 4.18539
ERICH6 glutamate-rich 6 4.18539
CCN5 cellular communication network factor 5 4.18539
SPACDR sperm acrosome developmental regulator 4.18539
GPR12 G protein-coupled receptor 12 4.18539
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 4.18539
A3GALT2 alpha 1,3-galactosyltransferase 2 4.18539
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 4.18539
ADGRG3 adhesion G protein-coupled receptor G3 4.18539
KPNA7 karyopherin alpha 7 (importin alpha 8) 4.18539
CNBD2 cyclic nucleotide binding domain containing 2 4.18539
CCER2 coiled-coil glutamate-rich protein 2 4.18539
RAG1 recombination activating gene 1 4.18539
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 4.18539
TLE5 TLE family member 5, transcriptional modulator 4.18539
NGB neuroglobin 4.18539
HGFAC HGF activator 4.18539
GP1BA glycoprotein Ib (platelet), alpha polypeptide 4.18539
LYG1 lysozyme G-like 1 4.18539
MROH9 maestro heat-like repeat family member 9 3.63469
PARM1 prostate androgen-regulated mucin-like protein 1 3.59891
TMEM45B transmembrane protein 45B 3.32484
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 3.16244
ADNP2 ADNP homeobox 2 3.15511
ADRA1D adrenoceptor alpha 1D 3.12398
MSS51 MSS51 mitochondrial translational activator 3.12398
SMIM24 small integral membrane protein 24 3.12398
KREMEN2 kringle containing transmembrane protein 2 3.12398
OR3A2 olfactory receptor, family 3, subfamily A, member 2 3.12398
PCDHB16 protocadherin beta 16 3.12398
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 3.12398
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.06289
EPRS1 glutamyl-prolyl-tRNA synthetase 1 3.04299
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.96185
AMOTL2 angiomotin like 2 2.95401
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.94798
SOCS1 suppressor of cytokine signaling 1 2.94587
LRRC4 leucine rich repeat containing 4 2.91189
SP1 Sp1 transcription factor 2.78988
RPL7A ribosomal protein L7a 2.67445
PRAM1 PML-RARA regulated adaptor molecule 1 2.66727
ZNF24 zinc finger protein 24 2.66727
NECAB3 N-terminal EF-hand calcium binding protein 3 2.63115
NAIF1 nuclear apoptosis inducing factor 1 2.63115
KCTD18 potassium channel tetramerization domain containing 18 2.63115
RPS17 ribosomal protein S17 2.6281
ATG10 autophagy related 10 2.62327
BFAR bifunctional apoptosis regulator 2.61
RPP40 ribonuclease P/MRP 40kDa subunit 2.5684
TMEM37 transmembrane protein 37 2.56477
AADACL3 arylacetamide deacetylase-like 3 2.54138
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 2.53848
CTTNBP2 cortactin binding protein 2 2.47441
FGF22 fibroblast growth factor 22 2.44536
LIG4 ligase IV, DNA, ATP-dependent 2.4329
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.40552
EPS15 epidermal growth factor receptor pathway substrate 15 2.36648
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.32051
SNED1 sushi, nidogen and EGF-like domains 1 2.29566
RSPRY1 ring finger and SPRY domain containing 1 2.28903
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.28584
FER1L5 fer-1-like family member 5 2.2783
PTPRG protein tyrosine phosphatase, receptor type, G 2.26608
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.25316
DMKN dermokine 2.25224
CHRM3 cholinergic receptor, muscarinic 3 2.22091
CNIH4 cornichon family AMPA receptor auxiliary protein 4 2.18792
SRGAP2B SLIT-ROBO Rho GTPase activating protein 2B 2.17479
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.15321
APH1B APH1B gamma secretase subunit 2.15285
FHOD3 formin homology 2 domain containing 3 2.13032
ERBB2 erb-b2 receptor tyrosine kinase 2 2.09547
TMEM161B transmembrane protein 161B 2.0931
TPRKB TP53RK binding protein 2.03583
SCPEP1 serine carboxypeptidase 1 2.03288
TTYH1 tweety family member 1 2.02604

decreased expression

Symbol Name Standardized Value
ZNF624 zinc finger protein 624 -4.18539
NPIPB12 nuclear pore complex interacting protein family member B12 -4.18539
SOWAHD sosondowah ankyrin repeat domain family member D -4.18539
TMEM121B transmembrane protein 121B -4.18539
NTS neurotensin -4.18539
DTX3L deltex 3 like, E3 ubiquitin ligase -4.08805
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -4.08805
SLC10A4 solute carrier family 10, member 4 -4.08805
ARMCX6 armadillo repeat containing, X-linked 6 -4.08805
EMILIN2 elastin microfibril interfacer 2 -4.08805
IL23A interleukin 23, alpha subunit p19 -4.08805
RDH16 retinol dehydrogenase 16 (all-trans) -4.08805
ADPRH ADP-ribosylarginine hydrolase -4.08805
DOK7 docking protein 7 -4.08805
C5ORF58 chromosome 5 open reading frame 58 -4.08805
ALOX15 arachidonate 15-lipoxygenase -4.08805
MYRF myelin regulatory factor -4.08805
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -4.08805
BTN3A3 butyrophilin, subfamily 3, member A3 -4.08805
MYCT1 myc target 1 -4.08805
GPR183 G protein-coupled receptor 183 -4.08805
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 -4.08805
ZNF324B zinc finger protein 324B -4.08805
SMC1B structural maintenance of chromosomes 1B -4.08805
TMPRSS11D transmembrane protease, serine 11D -4.08805
MPL MPL proto-oncogene, thrombopoietin receptor -4.08805
SOX21 SRY (sex determining region Y)-box 21 -4.08805
TULP2 tubby like protein 2 -4.08805
ANKRD37 ankyrin repeat domain 37 -4.08805
C9ORF43 chromosome 9 open reading frame 43 -4.08805
OAZ3 ornithine decarboxylase antizyme 3 -4.08805
NEURL1 neuralized E3 ubiquitin protein ligase 1 -4.08805
SH2D4B SH2 domain containing 4B -4.08805
SNX31 sorting nexin 31 -4.08805
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -4.08805
PHETA2 PH domain containing endocytic trafficking adaptor 2 -4.08805
XIRP2 xin actin binding repeat containing 2 -4.08805
RAB27B RAB27B, member RAS oncogene family -4.08805
PCDHAC1 protocadherin alpha subfamily C, 1 -4.08805
C1QTNF12 C1q and TNF related 12 -4.08805
G0S2 G0/G1 switch 2 -4.08805
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -4.08805
EMID1 EMI domain containing 1 -4.08805
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -4.08805
CCDC152 coiled-coil domain containing 152 -4.08805
FNDC5 fibronectin type III domain containing 5 -4.08805
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -3.81125
PDE4DIP phosphodiesterase 4D interacting protein -3.66298
SCYL3 SCY1-like 3 (S. cerevisiae) -3.63145
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -3.36958
HAUS1 HAUS augmin-like complex, subunit 1 -3.36325
FHL2 four and a half LIM domains 2 -3.21319
ZNF639 zinc finger protein 639 -3.20713
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -3.14594
VAMP8 vesicle-associated membrane protein 8 -3.1232
UBIAD1 UbiA prenyltransferase domain containing 1 -3.06289
TM2D1 TM2 domain containing 1 -2.96381
CLN5 ceroid-lipofuscinosis, neuronal 5 -2.96185
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -2.96185
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide -2.92851
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 -2.91667
SEH1L SEH1-like (S. cerevisiae) -2.82219
CYB5R1 cytochrome b5 reductase 1 -2.7785
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.7785
NPR1 natriuretic peptide receptor 1 -2.7785
PCED1A PC-esterase domain containing 1A -2.7785
PCDH19 protocadherin 19 -2.7785
BAIAP2L2 BAI1-associated protein 2-like 2 -2.7785
CD37 CD37 molecule -2.7785
CRYGS crystallin, gamma S -2.7785
GHR growth hormone receptor -2.7785
ZFP69 ZFP69 zinc finger protein -2.7785
BEGAIN brain-enriched guanylate kinase-associated -2.67588
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -2.66485
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.63115
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 -2.52118
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.45188
ASPH aspartate beta-hydroxylase -2.4046
SNX19 sorting nexin 19 -2.33731
FAS Fas cell surface death receptor -2.33233
CCN2 cellular communication network factor 2 -2.31264
ESRRB estrogen-related receptor beta -2.282
SCGB2B2 secretoglobin, family 2B, member 2 -2.2695
CTHRC1 collagen triple helix repeat containing 1 -2.26546
BASP1 brain abundant, membrane attached signal protein 1 -2.20871
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.20818
KATNIP katanin interacting protein -2.1934
URGCP upregulator of cell proliferation -2.17479
MRPS22 mitochondrial ribosomal protein S22 -2.14833
RPS13 ribosomal protein S13 -2.09953
IQSEC3 IQ motif and Sec7 domain 3 -2.09547
RPL31 ribosomal protein L31 -2.09547
ETV1 ets variant 1 -2.05503
GLUL glutamate-ammonia ligase -2.04564
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 -2.04093
ASB1 ankyrin repeat and SOCS box containing 1 -2.02604
STK38L serine/threonine kinase 38 like -2.01986