FHL2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description four and a half LIM domains 2|This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2274)
External Link http://www.ncbi.nlm.nih.gov/gene/2274
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247 interacting proteins for FHL2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ADAM17 ADAM metallopeptidase domain 17
ADIPOR1 adiponectin receptor 1
ADNP activity-dependent neuroprotector homeobox
AFAP1 actin filament associated protein 1
AK1 adenylate kinase 1
AKAP8 A kinase (PRKA) anchor protein 8
ANXA2 annexin A2
APP amyloid beta (A4) precursor protein
AR androgen receptor
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATXN1 ataxin 1
ATXN10 ataxin 10
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAPN1 calpain 1, (mu/I) large subunit
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CARD8 caspase recruitment domain family, member 8
CAV1 caveolin 1, caveolae protein, 22kDa
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDCP1 CUB domain containing protein 1
CDK1 cyclin-dependent kinase 1
CDYL chromodomain protein, Y-like
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CKAP4 cytoskeleton-associated protein 4
CKM creatine kinase, muscle
CNOT1 CCR4-NOT transcription complex, subunit 1
CNOT10 CCR4-NOT transcription complex, subunit 10
CNOT11 CCR4-NOT transcription complex, subunit 11
CNOT12 CCR4-NOT transcription complex subunit 12
CNOT2 CCR4-NOT transcription complex, subunit 2
CNOT3 CCR4-NOT transcription complex, subunit 3
CNOT6 CCR4-NOT transcription complex, subunit 6
CNOT6L CCR4-NOT transcription complex, subunit 6-like
CNOT7 CCR4-NOT transcription complex, subunit 7
CNOT8 CCR4-NOT transcription complex, subunit 8
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSK c-src tyrosine kinase
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTPS1 CTP synthase 1
CYC1 cytochrome c-1
DCTN3 dynactin 3 (p22)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DPF2 D4, zinc and double PHD fingers family 2
DUSP10 dual specificity phosphatase 10
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
ECSIT ECSIT signalling integrator
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1G eukaryotic translation elongation factor 1 gamma
EFNB1 ephrin-B1
EGFR epidermal growth factor receptor
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF6 eukaryotic translation initiation factor 6
EP300 E1A binding protein p300
EP400 E1A binding protein p400
EPHA2 EPH receptor A2
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB2IP erbb2 interacting protein
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERP44 endoplasmic reticulum protein 44
ESR1 estrogen receptor 1
ETV3 ets variant 3
FHL1 four and a half LIM domains 1
FHL3 four and a half LIM domains 3
FHL5 four and a half LIM domains 5
FLNA filamin A, alpha
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXP1 forkhead box P1
GANAB glucosidase, alpha; neutral AB
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GRB2 growth factor receptor-bound protein 2
HAND1 heart and neural crest derivatives expressed 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HEXIM1 hexamethylene bis-acetamide inducible 1
HIPK2 homeodomain interacting protein kinase 2
HIST1H1E histone cluster 1, H1e
HIST1H2BF histone cluster 1, H2bf
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKZF4 IKAROS family zinc finger 4 (Eos)
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA7 integrin, alpha 7
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
KIAA1217 KIAA1217
KPNB1 karyopherin (importin) beta 1
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LMNA lamin A/C
LRRC59 leucine rich repeat containing 59
MAPK1 mitogen-activated protein kinase 1
MAX MYC associated factor X
MCM7 minichromosome maintenance complex component 7
MRPL53 mitochondrial ribosomal protein L53
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZT2B mitotic spindle organizing protein 2B
NABP2 nucleic acid binding protein 2
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NONO non-POU domain containing, octamer-binding
NUP93 nucleoporin 93kDa
OPA1 optic atrophy 1 (autosomal dominant)
P3H1 prolyl 3-hydroxylase 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PEX19 peroxisomal biogenesis factor 19
PFKM phosphofructokinase, muscle
PHB2 prohibitin 2
PHLDB2 pleckstrin homology-like domain, family B, member 2
PKP2 plakophilin 2
PRKCDBP protein kinase C, delta binding protein
PRPF6 pre-mRNA processing factor 6
PSEN2 presenilin 2
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTCH1 patched 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTRF polymerase I and transcript release factor
PUF60 poly-U binding splicing factor 60KDa
PXN paxillin
QPCTL glutaminyl-peptide cyclotransferase-like
RARS arginyl-tRNA synthetase
RAVER1 ribonucleoprotein, PTB-binding 1
RBMS2 RNA binding motif, single stranded interacting protein 2
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REV1 REV1, polymerase (DNA directed)
RFC4 replication factor C (activator 1) 4, 37kDa
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RIF1 replication timing regulatory factor 1
RNF111 ring finger protein 111
RNF130 ring finger protein 130
RNF219 ring finger protein 219
RPL13 ribosomal protein L13
RPS27L ribosomal protein S27-like
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
S100A11 S100 calcium binding protein A11
SAP30BP SAP30 binding protein
SDF2L1 stromal cell-derived factor 2-like 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SH3BP4 SH3-domain binding protein 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMC4 structural maintenance of chromosomes 4
SMTN smoothelin
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRP9 signal recognition particle 9kDa
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SSR1 signal sequence receptor, alpha
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO2 small ubiquitin-like modifier 2
TBRG4 transforming growth factor beta regulator 4
TCF12 transcription factor 12
TF transferrin
TFAM transcription factor A, mitochondrial
TKT transketolase
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNK2 tyrosine kinase, non-receptor, 2
TOB2 transducer of ERBB2, 2
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM21 tripartite motif containing 21
TRIM29 tripartite motif containing 29
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TSN translin
TTN titin
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TXN thioredoxin
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBD ubiquitin D
WT1 Wilms tumor 1
XPOT exportin, tRNA
YBX1 Y box binding protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB16 zinc finger and BTB domain containing 16
ZBTB25 zinc finger and BTB domain containing 25
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF212 zinc finger protein 212
ZNF3 zinc finger protein 3
ZNF331 zinc finger protein 331
ZNF408 zinc finger protein 408
ZNF626 zinc finger protein 626
ZNF638 zinc finger protein 638