FHL3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description four and a half LIM domains 3|The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2275)
Similar Terms
Downloads & Tools

Genes

337 genes differentially expressed following the FHL3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RGS9BP regulator of G protein signaling 9 binding protein 3.63592
IQCJ IQ motif containing J 3.63592
SLC25A45 solute carrier family 25, member 45 3.63592
CABS1 calcium-binding protein, spermatid-specific 1 3.63592
TKTL2 transketolase-like 2 3.63592
DSG3 desmoglein 3 3.63592
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.63592
TNIP3 TNFAIP3 interacting protein 3 3.63592
PECAM1 platelet/endothelial cell adhesion molecule 1 3.63592
TRIM74 tripartite motif containing 74 3.63592
TBX15 T-box 15 3.63592
DPEP2 dipeptidase 2 3.63592
BTC betacellulin 3.63592
PVRIG poliovirus receptor related immunoglobulin domain containing 3.63592
CPED1 cadherin-like and PC-esterase domain containing 1 3.63592
PDILT protein disulfide isomerase-like, testis expressed 3.63592
NDRG1 N-myc downstream regulated 1 3.63592
GJA5 gap junction protein, alpha 5, 40kDa 3.63592
TMEM212 transmembrane protein 212 3.63592
NPAP1 nuclear pore associated protein 1 3.63592
DUXB double homeobox B 3.63592
IGFL3 IGF-like family member 3 3.63592
ARSI arylsulfatase family, member I 3.63592
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.63592
GLRA3 glycine receptor, alpha 3 3.63592
ICAM2 intercellular adhesion molecule 2 3.63592
MAGEC3 melanoma antigen family C3 3.63592
NLRP4 NLR family, pyrin domain containing 4 3.63592
ZNF648 zinc finger protein 648 3.63592
OR52I2 olfactory receptor, family 52, subfamily I, member 2 3.63592
KCNK18 potassium channel, two pore domain subfamily K, member 18 3.63592
SSX1 synovial sarcoma, X breakpoint 1 3.63592
TGM3 transglutaminase 3 3.63592
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.63592
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.63592
CD34 CD34 molecule 3.63592
PRSS21 protease, serine, 21 (testisin) 3.63592
CPB2 carboxypeptidase B2 (plasma) 3.63592
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.63592
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.63592
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.63592
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.63592
MRC1 mannose receptor, C type 1 3.63592
CLEC14A C-type lectin domain family 14, member A 3.63592
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.63592
CCDC83 coiled-coil domain containing 83 3.63592
TMEM156 transmembrane protein 156 3.63592
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.63592
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.63592
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.63592
ERVW-1 endogenous retrovirus group W, member 1 3.63592
RAG2 recombination activating gene 2 3.63592
AVPR1A arginine vasopressin receptor 1A 3.63592
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.63592
PLN phospholamban 3.63592
STX11 syntaxin 11 3.63592
FIMP1 fertilization-influencing membrane protein 1 3.63592
PAPOLB poly(A) polymerase beta (testis specific) 3.63592
CCDC190 coiled-coil domain containing 190 3.63592
CFAP157 cilia and flagella associated protein 157 3.63592
MYMK myomaker, myoblast fusion factor 3.63592
SPMAP1 sperm microtubule associated protein 1 3.63592
SAXO5 stabilizer of axonemal microtubules 5 3.63592
SPMIP10 sperm microtubule inner protein 10 3.63592
PPIAP39 peptidylprolyl isomerase A pseudogene 39 3.63592
KIF1C-AS1 KIF1C antisense RNA 1 3.63592
C1ORF232 chromosome 1 open reading frame 230 3.63592
C8ORF90 chromosome 8 open reading frame 90 3.63592
CIMAP1B ciliary microtubule associated protein 1B 3.63592
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.63592
SAG S-antigen; retina and pineal gland (arrestin) 3.63592
LY6K lymphocyte antigen 6 complex, locus K 3.63592
IMPG1 interphotoreceptor matrix proteoglycan 1 3.63592
MYH15 myosin, heavy chain 15 3.63592
TFEC transcription factor EC 3.63592
OVOL3 ovo-like zinc finger 3 3.63592
KRABD1 KRAB domain containing 1 3.63592
NPIPB9 nuclear pore complex interacting protein family, member B9 3.63592
MSX2 msh homeobox 2 3.63592
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.63592
CATSPER3 cation channel, sperm associated 3 3.63592
DAO D-amino-acid oxidase 3.63592
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 3.63592
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.63592
CNTFR ciliary neurotrophic factor receptor 3.63592
NDP Norrie disease (pseudoglioma) 3.63592
RNF183 ring finger protein 183 3.63592
SOAT2 sterol O-acyltransferase 2 3.63592
BEST3 bestrophin 3 3.63592
ASIC3 acid sensing (proton gated) ion channel 3 3.63592
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.63592
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) 3.63592
C7ORF57 chromosome 7 open reading frame 57 3.63592
BARX2 BARX homeobox 2 3.63592
OASL 2'-5'-oligoadenylate synthetase-like 3.63592
TMEM204 transmembrane protein 204 3.63592
CST5 cystatin D 3.63592
EGR2 early growth response 2 3.63592
CSTA cystatin A (stefin A) 3.63592
RGSL1 regulator of G-protein signaling like 1 3.63592
C18ORF63 chromosome 18 open reading frame 63 3.63592
DYDC1 DPY30 domain containing 1 3.63592
TEX12 testis expressed 12 3.63592
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.63592
RAD21L1 RAD21-like 1 (S. pombe) 3.63592
CFAP47 cilia and flagella associated protein 47 3.63592
ZSCAN4 zinc finger and SCAN domain containing 4 3.63592
ARHGAP20 Rho GTPase activating protein 20 3.63592
C8G complement component 8, gamma polypeptide 3.63592
CCL27 chemokine (C-C motif) ligand 27 3.63592
TMEM31 transmembrane protein 31 3.63592
KIAA1210 KIAA1210 3.63592
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.63592
WFDC9 WAP four-disulfide core domain 9 3.63592
GOLGA6A golgin A6 family, member A 3.63592
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.63592
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.63592
C11ORF16 chromosome 11 open reading frame 16 3.63592
MAB21L2 mab-21-like 2 (C. elegans) 3.63592
NOX3 NADPH oxidase 3 3.63592
BTNL9 butyrophilin-like 9 3.63592
PCDHGA7 protocadherin gamma subfamily A, 7 3.63592
XK X-linked Kx blood group 3.63592
UBQLNL ubiquilin-like 3.63592
EFCAB3 EF-hand calcium binding domain 3 3.63592
CCL17 chemokine (C-C motif) ligand 17 3.63592
VWA3B von Willebrand factor A domain containing 3B 3.63592
IL1A interleukin 1, alpha 3.63592
CCDC152 coiled-coil domain containing 152 3.63592
FGB fibrinogen beta chain 3.63592
TPPP2 tubulin polymerization-promoting protein family member 2 3.63592
NUTM2D NUT family member 2D 3.63592
CLEC18A C-type lectin domain family 18, member A 3.63592
POU3F2 POU class 3 homeobox 2 3.63592
EPX eosinophil peroxidase 3.63592
CARNS1 carnosine synthase 1 3.63592
SIDT1 SID1 transmembrane family, member 1 3.63592
LAMP3 lysosomal-associated membrane protein 3 3.63592
CRTAM cytotoxic and regulatory T cell molecule 3.63592
CORO6 coronin 6 3.63592
ZBED6 zinc finger, BED-type containing 6 3.63592
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.63592
MAGEA12 melanoma antigen family A12 3.63592
NNMT nicotinamide N-methyltransferase 3.63592
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.63592
PLGLB1 plasminogen-like B1 3.63592
A3GALT2 alpha 1,3-galactosyltransferase 2 3.63592
C10ORF105 chromosome 10 open reading frame 105 3.63592
PCDHGB1 protocadherin gamma subfamily B, 1 3.63592
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.63592
MAGED4B melanoma antigen family D4B 3.63592
SPHKAP SPHK1 interactor, AKAP domain containing 3.63592
KRT17 keratin 17, type I 3.63592
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.63592
NUMBL numb homolog (Drosophila)-like 3.63592
CTSF cathepsin F 3.63592
AGBL4 ATP/GTP binding protein-like 4 3.63592
LYPD5 LY6/PLAUR domain containing 5 3.63592
CYTH4 cytohesin 4 3.63592
HMGB4 high mobility group box 4 3.63592
MYADML2 myeloid-associated differentiation marker-like 2 3.63592
ANKRD33 ankyrin repeat domain 33 3.63592
C5AR2 complement component 5a receptor 2 3.63592
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 3.60299
DLEC1 deleted in lung and esophageal cancer 1 3.55921
TLR5 toll-like receptor 5 3.55921
SPEF2 sperm flagellar 2 3.55921
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.55921
ANGEL1 angel homolog 1 (Drosophila) 3.55628
MAGEF1 melanoma antigen family F1 3.37182
RASD2 RASD family, member 2 3.16098
PCNA proliferating cell nuclear antigen 2.91654
ABHD5 abhydrolase domain containing 5 2.88567
PAIP2 poly(A) binding protein interacting protein 2 2.82062
PLEKHM3 pleckstrin homology domain containing, family M, member 3 2.70602
HEATR6 HEAT repeat containing 6 2.68481
LIMA1 LIM domain and actin binding 1 2.65826
HEATR5A HEAT repeat containing 5A 2.65227
S100A10 S100 calcium binding protein A10 2.64931
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.63517
TRIM68 tripartite motif containing 68 2.63517
PEX5 peroxisomal biogenesis factor 5 2.63517
TSPAN6 tetraspanin 6 2.63517
TSPO translocator protein (18kDa) 2.59552
TTLL7 tubulin tyrosine ligase-like family member 7 2.57872
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 2.57455
IGSF11 immunoglobulin superfamily, member 11 2.55838
GABARAPL1 GABA(A) receptor-associated protein like 1 2.55838
TBC1D3L TBC1 domain family, member 3L 2.55112
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 2.55112
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.55112
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.55112
RASL10A RAS-like, family 10, member A 2.55112
SPDYE2 speedy/RINGO cell cycle regulator family member E2 2.5228
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 2.51722
CD300LF CD300 molecule-like family member f 2.41836
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.41836
TCERG1 transcription elongation regulator 1 2.40888
CHMP1A charged multivesicular body protein 1A 2.40888
MRPL34 mitochondrial ribosomal protein L34 2.37309
SOCS1 suppressor of cytokine signaling 1 2.36733
KLF3 Kruppel-like factor 3 (basic) 2.36733
TMEM100 transmembrane protein 100 2.36334
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.341
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.30157
DLC1 DLC1 Rho GTPase activating protein 2.2871
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.27941
OGA O-GlcNAcase 2.21224
PARVB parvin, beta 2.20552
ACOT6 acyl-CoA thioesterase 6 2.20552
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.20164
PHF23 PHD finger protein 23 2.19813
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.19794
CHSY1 chondroitin sulfate synthase 1 2.18186
NCAPD3 non-SMC condensin II complex, subunit D3 2.18186
PLBD2 phospholipase B domain containing 2 2.18186
OAT ornithine aminotransferase 2.16805
WDR4 WD repeat domain 4 2.16049
LPXN leupaxin 2.14504
BOP1 block of proliferation 1 2.13335
BPHL biphenyl hydrolase-like (serine hydrolase) 2.13335
CRIP3 cysteine-rich protein 3 2.12925
GALK1 galactokinase 1 2.12867
NCAPH non-SMC condensin I complex, subunit H 2.11693
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.11693
NRARP NOTCH-regulated ankyrin repeat protein 2.11096
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.11096
RBP5 retinol binding protein 5, cellular 2.0906
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 2.08915
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 2.08915
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 2.0721
CRYBA4 crystallin, beta A4 2.06167
GPN2 GPN-loop GTPase 2 2.03106
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.02805
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.02662
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 2.01817
PDGFRL platelet-derived growth factor receptor-like 2.00818

decreased expression

Symbol Name Standardized Value
MDC1 mediator of DNA-damage checkpoint 1 -3.63592
XG Xg blood group -3.63592
AOAH acyloxyacyl hydrolase (neutrophil) -3.63592
PCDHA9 protocadherin alpha 9 -3.63592
SERF1B small EDRK-rich factor 1B (centromeric) -3.63592
N4BP2L1 NEDD4 binding protein 2-like 1 -3.63592
KIAA1614 KIAA1614 -3.63592
MINAR2 membrane integral NOTCH2 associated receptor 2 -3.63592
ZDHHC20 zinc finger, DHHC-type containing 20 -3.63592
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -3.55628
RBM44 RNA binding motif protein 44 -3.55628
CCDC159 coiled-coil domain containing 159 -3.55628
ZAR1L zygote arrest 1-like -3.55628
LRRC55 leucine rich repeat containing 55 -3.55628
ASIC4 acid sensing (proton gated) ion channel family member 4 -3.55628
BHLHE41 basic helix-loop-helix family, member e41 -3.55628
MMP19 matrix metallopeptidase 19 -3.55628
FER1L6 fer-1-like family member 6 -3.55628
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.55628
AKAP14 A kinase (PRKA) anchor protein 14 -3.55628
GMFG glia maturation factor, gamma -3.55628
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -3.55628
MMP21 matrix metallopeptidase 21 -3.55628
NOTO notochord homeobox -3.55628
MYO16 myosin XVI -3.55628
SPHK1 sphingosine kinase 1 -3.55628
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.55628
WNK4 WNK lysine deficient protein kinase 4 -3.55628
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -3.55628
TEKT5 tektin 5 -3.55628
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -3.55628
LMOD3 leiomodin 3 (fetal) -3.55628
MSMP microseminoprotein, prostate associated -3.55628
TMPPE transmembrane protein with metallophosphoesterase domain -3.55628
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B -3.55628
LINC02798 long intergenic non-protein coding RNA 2798 -3.55628
SVOP SV2 related protein homolog (rat) -3.55628
NSG2 neuronal vesicle trafficking associated 2 -3.55628
DRD4 dopamine receptor D4 -3.55628
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 -3.55628
SYNPO synaptopodin -3.55628
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -3.55628
CPA4 carboxypeptidase A4 -3.55628
SHROOM1 shroom family member 1 -3.41969
ZNF688 zinc finger protein 688 -3.41969
C3 complement component 3 -3.30795
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -3.15283
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.94594
POLK polymerase (DNA directed) kappa -2.93318
RPP30 ribonuclease P/MRP 30kDa subunit -2.86981
TMEM144 transmembrane protein 144 -2.85791
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -2.63517
RAD54B RAD54 homolog B (S. cerevisiae) -2.63409
ITSN1 intersectin 1 (SH3 domain protein) -2.56641
ST7 suppression of tumorigenicity 7 -2.55112
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.55112
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 -2.55112
H4C4 H4 clustered histone 4 -2.49562
BST1 bone marrow stromal cell antigen 1 -2.49562
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.49562
RCC1 regulator of chromosome condensation 1 -2.47573
ETV3 ets variant 3 -2.45717
DUSP19 dual specificity phosphatase 19 -2.37309
PHKB phosphorylase kinase, beta -2.37309
GARNL3 GTPase activating Rap/RanGAP domain-like 3 -2.36733
GRM5 glutamate receptor, metabotropic 5 -2.36213
SAPCD1 suppressor APC domain containing 1 -2.34537
SCIMP SLP adaptor and CSK interacting membrane protein -2.34537
ZNF233 zinc finger protein 233 -2.34537
C2CD2L C2CD2-like -2.34537
RELT RELT tumor necrosis factor receptor -2.34537
TMEM61 transmembrane protein 61 -2.34537
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.34365
TLR2 toll-like receptor 2 -2.341
GLIPR1 GLI pathogenesis-related 1 -2.341
KAT6A K(lysine) acetyltransferase 6A -2.33722
MPG N-methylpurine-DNA glycosylase -2.31851
HSF5 heat shock transcription factor family member 5 -2.2871
BTN2A1 butyrophilin, subfamily 2, member A1 -2.28108
SV2A synaptic vesicle glycoprotein 2A -2.27723
ETV6 ets variant 6 -2.2441
DNAI3 dynein axonemal intermediate chain 3 -2.24289
PUM1 pumilio RNA-binding family member 1 -2.22166
CENPK centromere protein K -2.19205
CERS6 ceramide synthase 6 -2.18186
AP4B1 adaptor-related protein complex 4, beta 1 subunit -2.16963
NOXO1 NADPH oxidase organizer 1 -2.16805
ACD adrenocortical dysplasia homolog (mouse) -2.16805
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.16805
SYN2 synapsin II -2.16702
KLRG2 killer cell lectin-like receptor subfamily G, member 2 -2.1188
ZNF81 zinc finger protein 81 -2.11575
SAMD8 sterile alpha motif domain containing 8 -2.11352
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.0906
MRPS36 mitochondrial ribosomal protein S36 -2.0895
PCSK6 proprotein convertase subtilisin/kexin type 6 -2.07814
CADM1 cell adhesion molecule 1 -2.03178
TCAF1 TRPM8 channel-associated factor 1 -2.03106
MPV17L2 MPV17 mitochondrial membrane protein-like 2 -2.01144
RANBP3 RAN binding protein 3 -2.00818