| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/16739265 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in FIPI HCl relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC127 | coiled-coil domain containing 127 | 2.53 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.23 |
| NCOA4 | nuclear receptor coactivator 4 | 1.07 |
| APOB | apolipoprotein B | 1.01 |
| METTL7A | methyltransferase like 7A | 0.93 |
| MOB3A | MOB kinase activator 3A | 0.83 |
| CD63 | CD63 molecule | 0.83 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.82 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.81 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.8 |
| TMEM59 | transmembrane protein 59 | 0.77 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.76 |
| UNC80 | unc-80 homolog (C. elegans) | 0.76 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.73 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.72 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.72 |
| GDF15 | growth differentiation factor 15 | 0.71 |
| SQSTM1 | sequestosome 1 | 0.71 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.66 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.65 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.65 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.64 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.63 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.62 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.6 |
| TMEM200A | transmembrane protein 200A | 0.59 |
| OPTN | optineurin | 0.58 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | 0.57 |
| PXDN | peroxidasin | 0.56 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.55 |
| ABLIM2 | actin binding LIM protein family, member 2 | 0.51 |
| MSMO1 | methylsterol monooxygenase 1 | 0.51 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.5 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.49 |
| NDRG1 | N-myc downstream regulated 1 | 0.49 |
| ALPK3 | alpha-kinase 3 | 0.49 |
| PRSS8 | protease, serine, 8 | 0.48 |
| HPCAL1 | hippocalcin-like 1 | 0.47 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | 0.46 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.46 |
| RHOB | ras homolog family member B | 0.46 |
| IFNGR1 | interferon gamma receptor 1 | 0.45 |
| APOE | apolipoprotein E | 0.45 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 0.45 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.45 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.45 |
| RPS27A | ribosomal protein S27a | 0.45 |
| FN1 | fibronectin 1 | 0.44 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.44 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 0.44 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.44 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.43 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.42 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 0.42 |
| GTSF1 | gametocyte specific factor 1 | 0.42 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.42 |
| CASKIN1 | CASK interacting protein 1 | 0.41 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | 0.41 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.41 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.41 |
| UBN1 | ubinuclein 1 | 0.4 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.4 |
| APOL2 | apolipoprotein L, 2 | 0.4 |
| TPM4 | tropomyosin 4 | 0.4 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.4 |
| SDCBP | syndecan binding protein (syntenin) | 0.4 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.39 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.39 |
| RNF149 | ring finger protein 149 | 0.39 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.39 |
| ZFP90 | ZFP90 zinc finger protein | 0.38 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.38 |
| ATOX1 | antioxidant 1 copper chaperone | 0.38 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.38 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.38 |
| LAMA3 | laminin, alpha 3 | 0.38 |
| RIPOR1 | RHO family interacting cell polarization regulator 1 | 0.38 |
| MYO3A | myosin IIIA | 0.38 |
| RAB6B | RAB6B, member RAS oncogene family | 0.38 |
| KHNYN | KH and NYN domain containing | 0.38 |
| PLPP2 | phospholipid phosphatase 2 | 0.38 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.37 |
| ITM2C | integral membrane protein 2C | 0.37 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.37 |
| TRIP4 | thyroid hormone receptor interactor 4 | 0.37 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.37 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.37 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.36 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 0.36 |
| TMEM263 | transmembrane protein 263 | 0.36 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.36 |
| BRCA2 | breast cancer 2, early onset | 0.36 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.36 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.35 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.35 |
| SMAD3 | SMAD family member 3 | 0.35 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.35 |
| SERINC3 | serine incorporator 3 | 0.35 |
| RAB27B | RAB27B, member RAS oncogene family | 0.35 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.34 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -2.3 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.96 |
| TEN1 | TEN1 CST complex subunit | -1.9 |
| GPR161 | G protein-coupled receptor 161 | -1.62 |
| AHR | aryl hydrocarbon receptor | -1.2 |
| ADCY10 | adenylate cyclase 10 (soluble) | -1.15 |
| FAM13A | family with sequence similarity 13, member A | -1.03 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.83 |
| EME1 | essential meiotic structure-specific endonuclease 1 | -0.7 |
| RXYLT1 | ribitol xylosyltransferase 1 | -0.65 |
| FAM161A | family with sequence similarity 161, member A | -0.6 |
| RUNDC1 | RUN domain containing 1 | -0.59 |
| TOB2 | transducer of ERBB2, 2 | -0.57 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.57 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.57 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.57 |
| ZIC2 | Zic family member 2 | -0.56 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.54 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.53 |
| DUSP6 | dual specificity phosphatase 6 | -0.52 |
| ODC1 | ornithine decarboxylase 1 | -0.51 |
| CLUH | clustered mitochondria (cluA/CLU1) homolog | -0.5 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | -0.49 |
| NEBL | nebulette | -0.49 |
| CEP295 | centrosomal protein 295kDa | -0.48 |
| SELENBP1 | selenium binding protein 1 | -0.48 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.48 |
| KLHL18 | kelch-like family member 18 | -0.46 |
| SBF2 | SET binding factor 2 | -0.45 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | -0.44 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.43 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.42 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.42 |
| ACTR1B | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | -0.42 |
| ZNF267 | zinc finger protein 267 | -0.41 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.4 |
| GABRQ | gamma-aminobutyric acid (GABA) A receptor, theta | -0.4 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.4 |
| CEP128 | centrosomal protein 128kDa | -0.39 |
| TRIM13 | tripartite motif containing 13 | -0.39 |
| FBXO4 | F-box protein 4 | -0.38 |
| ERCC8 | excision repair cross-complementation group 8 | -0.38 |
| NAA20 | N(alpha)-acetyltransferase 20, NatB catalytic subunit | -0.38 |
| ZNF217 | zinc finger protein 217 | -0.38 |
| FBXO33 | F-box protein 33 | -0.38 |
| ZBTB9 | zinc finger and BTB domain containing 9 | -0.37 |
| VSIR | V-set immunoregulatory receptor | -0.37 |
| TAF11 | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | -0.37 |
| STK17A | serine/threonine kinase 17a | -0.37 |
| ELK1 | ELK1, member of ETS oncogene family | -0.37 |
| BAK1 | BCL2-antagonist/killer 1 | -0.37 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | -0.35 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.35 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.35 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | -0.34 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.34 |
| YBX3 | Y box binding protein 3 | -0.34 |
| COQ9 | coenzyme Q9 | -0.34 |
| SNTA1 | syntrophin, alpha 1 | -0.33 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.33 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.33 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.33 |
| CCDC82 | coiled-coil domain containing 82 | -0.33 |
| SLC43A3 | solute carrier family 43, member 3 | -0.33 |
| PEX5 | peroxisomal biogenesis factor 5 | -0.32 |
| SPC24 | SPC24, NDC80 kinetochore complex component | -0.32 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.32 |
| HECA | headcase homolog (Drosophila) | -0.32 |
| USF1 | upstream transcription factor 1 | -0.32 |
| MAST1 | microtubule associated serine/threonine kinase 1 | -0.32 |
| DAB2IP | DAB2 interacting protein | -0.32 |
| ATXN7L3B | ataxin 7-like 3B | -0.31 |
| PACS2 | phosphofurin acidic cluster sorting protein 2 | -0.31 |
| ANK2 | ankyrin 2, neuronal | -0.31 |
| ZNF526 | zinc finger protein 526 | -0.31 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | -0.31 |
| TMEM160 | transmembrane protein 160 | -0.31 |
| PACC1 | proton activated chloride channel 1 | -0.31 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.3 |
| ZC4H2 | zinc finger, C4H2 domain containing | -0.3 |
| ZNF367 | zinc finger protein 367 | -0.29 |
| ZNF286B | zinc finger protein 286B | -0.29 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -0.29 |
| RARA | retinoic acid receptor, alpha | -0.29 |
| CCN1 | cellular communication network factor 1 | -0.29 |
| KIF18B | kinesin family member 18B | -0.29 |
| CNOT6 | CCR4-NOT transcription complex, subunit 6 | -0.29 |
| SNAP47 | synaptosomal-associated protein, 47kDa | -0.28 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.28 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | -0.28 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.28 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.27 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.27 |
| MCM8 | minichromosome maintenance complex component 8 | -0.27 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -0.27 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | -0.27 |
| PRKCQ | protein kinase C, theta | -0.27 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.27 |
| RNF145 | ring finger protein 145 | -0.27 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.27 |
