FLNA Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description filamin A, alpha|The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 2316)
External Link http://www.ncbi.nlm.nih.gov/gene/2316
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Genes

131 interacting proteins for hub protein FLNA from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTB actin, beta
ACTG1 actin gamma 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APC adenomatous polyposis coli
AR androgen receptor
ARHGAP24 Rho GTPase activating protein 24
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATG2A autophagy related 2A
BANF1 barrier to autointegration factor 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTK Bruton agammaglobulinemia tyrosine kinase
CALCR calcitonin receptor
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CMIP c-Maf inducing protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DCN decorin
DMWD dystrophia myotonica, WD repeat containing
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBLIM1 filamin binding LIM protein 1
FILIP1 filamin A interacting protein 1
FLNA filamin A, alpha
FLNB filamin B, beta
FURIN furin (paired basic amino acid cleaving enzyme)
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GRB2 growth factor receptor-bound protein 2
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK3 glutamate receptor, ionotropic, kainate 3
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GSK3B glycogen synthase kinase 3 beta
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
ITGB7 integrin, beta 7
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LMNA lamin A/C
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK14 mitogen-activated protein kinase 14
MTNR1A melatonin receptor 1A
MTNR1B melatonin receptor 1B
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYOT myotilin
MYOZ1 myozenin 1
MYOZ2 myozenin 2
NPHP1 nephronophthisis 1 (juvenile)
OPRM1 opioid receptor, mu 1
OTUD1 OTU deubiquitinase 1
OTUD5 OTU deubiquitinase 5
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCBP2 poly(rC) binding protein 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRR5 proline rich 5 (renal)
PSEN1 presenilin 1
PSEN2 presenilin 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RHOA ras homolog family member A
RICTOR RPTOR independent companion of MTOR, complex 2
RIPK3 receptor-interacting serine-threonine kinase 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SELE selectin E
SH2B3 SH2B adaptor protein 3
SHBG sex hormone-binding globulin
SIGLEC10 sialic acid binding Ig-like lectin 10
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SVIL supervillin
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TJP1 tight junction protein 1
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNIP2 TNFAIP3 interacting protein 2
TRAF2 TNF receptor-associated factor 2
TRIO trio Rho guanine nucleotide exchange factor
TSGA10 testis specific, 10
TTN titin
ULK2 unc-51 like autophagy activating kinase 2
USP45 ubiquitin specific peptidase 45
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta