FLT3 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description fms-related tyrosine kinase 3|This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] (NCBI Entrez Gene Database, 2322)
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100 substrates of the kinase FLT3 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 99.93
SMG8 SMG8 nonsense mediated mRNA decay factor 99.89
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.85
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 99.85
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 99.69
THRB thyroid hormone receptor, beta 99.69
MARVELD3 MARVEL domain containing 3 99.59
EIF3I eukaryotic translation initiation factor 3, subunit I 99.56
EPM2AIP1 EPM2A (laforin) interacting protein 1 99.45
HSPB1 heat shock 27kDa protein 1 99.41
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 99.39
SHROOM1 shroom family member 1 99.36
CHD2 chromodomain helicase DNA binding protein 2 99.32
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 99.3
MCC mutated in colorectal cancers 99.28
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 99.26
PM20D2 peptidase M20 domain containing 2 99.25
EML4 echinoderm microtubule associated protein like 4 99.15
MRPS27 mitochondrial ribosomal protein S27 99.06
NIPSNAP1 nipsnap homolog 1 (C. elegans) 99.015
GRAMD4 GRAM domain containing 4 98.99
TIGIT T cell immunoreceptor with Ig and ITIM domains 98.91
TCF25 transcription factor 25 (basic helix-loop-helix) 98.9
ZNF169 zinc finger protein 169 98.88
PADI2 peptidyl arginine deiminase, type II 98.82
WWP2 WW domain containing E3 ubiquitin protein ligase 2 98.8
SEC14L2 SEC14-like 2 (S. cerevisiae) 98.77
SEC14L3 SEC14-like 3 (S. cerevisiae) 98.77
UBE2E3 ubiquitin-conjugating enzyme E2E 3 98.64
UBE2E1 ubiquitin-conjugating enzyme E2E 1 98.64
UBE2E2 ubiquitin-conjugating enzyme E2E 2 98.64
RBM25 RNA binding motif protein 25 98.49
DDIAS DNA damage-induced apoptosis suppressor 98.45
CCT8 chaperonin containing TCP1, subunit 8 (theta) 98.42
TFIP11 tuftelin interacting protein 11 98.36
FKBP5 FK506 binding protein 5 98.34
DLG3 discs, large homolog 3 (Drosophila) 98.28
RASGRP4 RAS guanyl releasing protein 4 98.21
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 98.2
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 98.14
SPATS2L spermatogenesis associated, serine-rich 2-like 98.12
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 98.1
SEC14L1 SEC14-like 1 (S. cerevisiae) 98.09
EIF1 eukaryotic translation initiation factor 1 97.83
EIF1B eukaryotic translation initiation factor 1B 97.83
LRRK1 leucine-rich repeat kinase 1 97.77
STX16 syntaxin 16 97.75
CKS1B CDC28 protein kinase regulatory subunit 1B 97.72
CADM1 cell adhesion molecule 1 97.68
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 97.64
ALKBH3 alkB, alkylation repair homolog 3 (E. coli) 97.62
PDCD5 programmed cell death 5 97.57
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 97.55
FBXO11 F-box protein 11 97.53
LURAP1L leucine rich adaptor protein 1-like 97.51
GIMAP4 GTPase, IMAP family member 4 97.5
NFYA nuclear transcription factor Y, alpha 97.46
MAPK6 mitogen-activated protein kinase 6 97.35
GSDMD gasdermin D 97.33
TERB1 telomere repeat binding bouquet formation protein 1 97.26
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 97.24
TLK1 tousled-like kinase 1 97.16
FCRL6 Fc receptor-like 6 97.11
HINT1 histidine triad nucleotide binding protein 1 97.07
PTPN7 protein tyrosine phosphatase, non-receptor type 7 96.96
UQCRC2 ubiquinol-cytochrome c reductase core protein II 96.8
ZNF639 zinc finger protein 639 96.78
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 96.69
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 96.67
FDFT1 farnesyl-diphosphate farnesyltransferase 1 96.56
CHERP calcium homeostasis endoplasmic reticulum protein 96.545
C1ORF210 chromosome 1 open reading frame 210 96.5
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 96.45
CD300LB CD300 molecule-like family member b 96.45
IKZF3 IKAROS family zinc finger 3 (Aiolos) 96.35
OPHN1 oligophrenin 1 96.34
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 96.3
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 96.3
DLG2 discs, large homolog 2 (Drosophila) 96.26
KTN1 kinectin 1 (kinesin receptor) 96.17
GREB1 growth regulation by estrogen in breast cancer 1 96.13
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 96.11
TMEM132A transmembrane protein 132A 96.0
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 95.95
CEP170B centrosomal protein 170B 95.89
SH2D1B SH2 domain containing 1B 95.67
CNOT9 CCR4-NOT transcription complex subunit 9 95.62
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 95.6
RUSC2 RUN and SH3 domain containing 2 95.58
TRPV2 transient receptor potential cation channel, subfamily V, member 2 95.56
TLK2 tousled-like kinase 2 95.54
CUL3 cullin 3 95.54
BCAS2 breast carcinoma amplified sequence 2 95.47
STK3 serine/threonine kinase 3 95.47
ANKZF1 ankyrin repeat and zinc finger domain containing 1 95.43
CALML5 calmodulin-like 5 95.34
FCHO1 FCH domain only 1 95.29
THADA thyroid adenoma associated 95.12
TRIOBP TRIO and F-actin binding protein 95.11
STEAP1 six transmembrane epithelial antigen of the prostate 1 95.1