FLT3 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description fms-related tyrosine kinase 3|This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] (NCBI Entrez Gene Database, 2322)
External Link http://www.ncbi.nlm.nih.gov/gene/2322
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2 substrates of the kinase FLT3 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
FLT3 fms-related tyrosine kinase 3
PDK1 pyruvate dehydrogenase kinase, isozyme 1