FOSB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description FBJ murine osteosarcoma viral oncogene homolog B|The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2354)
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Genes

358 genes differentially expressed following the FOSB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CSF1R colony stimulating factor 1 receptor 4.07889
CD200R1 CD200 receptor 1 4.07889
POTEJ POTE ankyrin domain family, member J 4.07889
SCN10A sodium channel, voltage gated, type X alpha subunit 4.07889
TMC8 transmembrane channel-like 8 4.07889
LOC124905976 uncharacterized LOC124905976 4.07889
BCL2L15 BCL2-like 15 4.07889
TBXA2R thromboxane A2 receptor 4.07889
MFAP5 microfibrillar associated protein 5 4.07889
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 4.07889
VSX2 visual system homeobox 2 4.07889
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 4.07889
FOXE3 forkhead box E3 4.07889
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 4.07889
R3HDML R3H domain containing-like 4.07889
ZPLD1 zona pellucida-like domain containing 1 4.07889
GSDMA gasdermin A 4.07889
CELA2A chymotrypsin-like elastase family, member 2A 4.07889
IL33 interleukin 33 4.07889
CD68 CD68 molecule 4.07889
MAJIN membrane anchored junction protein 4.07889
VWF von Willebrand factor 4.07889
LGALS2 lectin, galactoside-binding, soluble, 2 4.07889
GBX2 gastrulation brain homeobox 2 4.07889
FLACC1 flagellum associated containing coiled-coil domains 1 4.07889
ATP10B ATPase, class V, type 10B 4.07889
RFPL3 ret finger protein-like 3 3.99949
PECAM1 platelet/endothelial cell adhesion molecule 1 3.99949
RSPO3 R-spondin 3 3.99949
WNT3A wingless-type MMTV integration site family, member 3A 3.99949
UMOD uromodulin 3.99949
NRAP nebulin-related anchoring protein 3.99949
LRRC56 leucine rich repeat containing 56 3.99949
MTTP microsomal triglyceride transfer protein 3.99949
SHCBP1L SHC SH2-domain binding protein 1-like 3.99949
ARHGAP36 Rho GTPase activating protein 36 3.99949
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 3.99949
EPPIN epididymal peptidase inhibitor 3.99949
PNOC prepronociceptin 3.99949
GNRH2 gonadotropin-releasing hormone 2 3.99949
SPAG6 sperm associated antigen 6 3.99949
KRTAP5-5 keratin associated protein 5-5 3.99949
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.99949
BTBD19 BTB (POZ) domain containing 19 3.99949
TPH1 tryptophan hydroxylase 1 3.99949
TRIM38 tripartite motif containing 38 3.99949
IRX5 iroquois homeobox 5 3.99949
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.99949
FOXG1 forkhead box G1 3.99949
IL37 interleukin 37 3.99949
STAP1 signal transducing adaptor family member 1 3.99949
EPHB3 EPH receptor B3 3.99949
MUC20 mucin 20, cell surface associated 3.99949
MYO16 myosin XVI 3.99949
GALR3 galanin receptor 3 3.99949
NLRP5 NLR family, pyrin domain containing 5 3.99949
ASGR2 asialoglycoprotein receptor 2 3.99949
SP6 Sp6 transcription factor 3.99949
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.99949
STEAP4 STEAP family member 4 3.99949
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 3.99949
ST18 suppression of tumorigenicity 18, zinc finger 3.99949
FAM3D family with sequence similarity 3, member D 3.99949
UNC93A unc-93 homolog A (C. elegans) 3.99949
MCHR2 melanin-concentrating hormone receptor 2 3.99949
TYROBP TYRO protein tyrosine kinase binding protein 3.99949
PNLIPRP1 pancreatic lipase-related protein 1 3.99949
ACER1 alkaline ceramidase 1 3.99949
FRG2C FSHD region gene 2 family, member C 3.99949
KRT86 keratin 86, type II 3.99949
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.99949
ASB5 ankyrin repeat and SOCS box containing 5 3.99949
PCDHGA9 protocadherin gamma subfamily A, 9 3.99949
SQOR sulfide quinone oxidoreductase 3.99949
SPMAP2L sperm microtubule associated protein 2 like 3.99949
FAM240A family with sequence similarity 240 member A 3.99949
INSYN1 inhibitory synaptic factor 1 3.99949
RAMACL RNA guanine-7 methyltransferase activating subunit like 3.99949
CBY2 chibby family member 2 3.99949
DNAI3 dynein axonemal intermediate chain 3 3.99949
DIPK1C divergent protein kinase domain 1C 3.99949
CCN3 cellular communication network factor 3 3.99949
ANGPTL8 angiopoietin like 8 3.99949
TSPAN8 tetraspanin 8 3.99949
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.99949
PTPRC protein tyrosine phosphatase, receptor type, C 3.99949
CAPN14 calpain 14 3.99949
GPR75 G protein-coupled receptor 75 3.99949
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.99949
PROKR1 prokineticin receptor 1 3.99949
IGFL2 IGF-like family member 2 3.99949
HEATR9 HEAT repeat containing 9 3.99949
CD19 CD19 molecule 3.99949
TMEM176B transmembrane protein 176B 3.99949
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.99949
CALCA calcitonin-related polypeptide alpha 3.99949
CNGA3 cyclic nucleotide gated channel alpha 3 3.99949
LTA lymphotoxin alpha 3.99949
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.99949
GPR85 G protein-coupled receptor 85 3.99949
PNPLA1 patatin-like phospholipase domain containing 1 3.99949
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.99949
BHLHA9 basic helix-loop-helix family, member a9 3.99949
ZIC4 Zic family member 4 3.99949
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.99949
NXPH3 neurexophilin 3 3.99949
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.99949
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.99949
CD53 CD53 molecule 3.99949
IRGM immunity-related GTPase family, M 3.99949
ZNF735 zinc finger protein 735 3.99949
DRD2 dopamine receptor D2 3.99949
ASTL astacin-like metallo-endopeptidase (M12 family) 3.99949
FSHR follicle stimulating hormone receptor 3.99949
SVOP SV2 related protein homolog (rat) 3.99949
ERICH6B glutamate-rich 6B 3.99949
OR11L1 olfactory receptor, family 11, subfamily L, member 1 3.99949
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.99949
BRDT bromodomain, testis-specific 3.99949
CLIC2 chloride intracellular channel 2 3.99949
CDC20B cell division cycle 20B 3.99949
WNT7A wingless-type MMTV integration site family, member 7A 3.99949
BTNL8 butyrophilin-like 8 3.99949
CRYBB2 crystallin, beta B2 3.99949
ANKRD65 ankyrin repeat domain 65 3.99949
ANTXRL anthrax toxin receptor-like 3.99949
PRR35 proline rich 35 3.99949
MYLK2 myosin light chain kinase 2 3.99949
RBBP8NL RBBP8 N-terminal like 3.99949
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.99949
ADAM18 ADAM metallopeptidase domain 18 3.99949
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.99949
TEX29 testis expressed 29 3.99949
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.99949
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.99949
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.99949
SLC38A3 solute carrier family 38, member 3 3.99949
ITGA10 integrin, alpha 10 3.99949
ARL13A ADP-ribosylation factor-like 13A 3.99949
TF transferrin 3.99949
DLX5 distal-less homeobox 5 3.99949
OTOP1 otopetrin 1 3.99949
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.99949
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.99949
DND1 DND microRNA-mediated repression inhibitor 1 3.99949
CCL27 chemokine (C-C motif) ligand 27 3.99949
TSPAN32 tetraspanin 32 3.99949
ERMN ermin, ERM-like protein 3.99949
NPAS4 neuronal PAS domain protein 4 3.99949
DEFB134 defensin, beta 134 3.99949
KRT14 keratin 14, type I 3.99949
GH2 growth hormone 2 3.99949
SLC25A34 solute carrier family 25, member 34 3.99949
SPRN shadow of prion protein homolog (zebrafish) 3.99949
POTEF POTE ankyrin domain family, member F 3.99949
ZMYND10 zinc finger, MYND-type containing 10 3.99949
CALML6 calmodulin-like 6 3.99949
NUTM2A NUT family member 2A 3.99949
IL12A interleukin 12A 3.99949
PATE2 prostate and testis expressed 2 3.99949
ITPKA inositol-trisphosphate 3-kinase A 3.99949
TBPL2 TATA box binding protein like 2 3.99949
FNDC1 fibronectin type III domain containing 1 3.99949
A3GALT2 alpha 1,3-galactosyltransferase 2 3.99949
FOXP3 forkhead box P3 3.99949
SYTL4 synaptotagmin-like 4 3.99949
GRAPL GRB2-related adaptor protein-like 3.99949
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.99949
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.8848
NGFR nerve growth factor receptor 3.8848
CD70 CD70 molecule 3.8848
CTF1 cardiotrophin 1 3.8848
DCLK2 doublecortin-like kinase 2 3.33673
RAP1GAP2 RAP1 GTPase activating protein 2 3.25388
APOE apolipoprotein E 3.21671
NEBL nebulette 3.15621
ACTC1 actin, alpha, cardiac muscle 1 3.12802
PGLYRP1 peptidoglycan recognition protein 1 3.04454
CAMKMT calmodulin-lysine N-methyltransferase 2.93573
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.89094
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.83408
SCIMP SLP adaptor and CSK interacting membrane protein 2.78986
PEBP4 phosphatidylethanolamine-binding protein 4 2.78986
EXD1 exonuclease 3'-5' domain containing 1 2.78986
SGPP2 sphingosine-1-phosphate phosphatase 2 2.78986
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.64539
STOML2 stomatin (EPB72)-like 2 2.62798
AOAH acyloxyacyl hydrolase (neutrophil) 2.60888
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 2.60888
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.57959
MT1F metallothionein 1F 2.5439
TOP2B topoisomerase (DNA) II beta 180kDa 2.54223
TMEM67 transmembrane protein 67 2.52797
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.52777
ZNF367 zinc finger protein 367 2.52777
POGLUT2 protein O-glucosyltransferase 2 2.5168
MYO7A myosin VIIA 2.41134
TCF25 transcription factor 25 (basic helix-loop-helix) 2.37133
ADAT1 adenosine deaminase, tRNA-specific 1 2.35267
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.32643
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.29992
PARP15 poly (ADP-ribose) polymerase family, member 15 2.29992
NPIPB11 nuclear pore complex interacting protein family, member B11 2.29072
FAM9B family with sequence similarity 9, member B 2.28439
SOST sclerostin 2.28439
ALX3 ALX homeobox 3 2.28439
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.2723
KIDINS220 kinase D-interacting substrate, 220kDa 2.25742
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 2.25274
ELOVL6 ELOVL fatty acid elongase 6 2.2232
GPR19 G protein-coupled receptor 19 2.2232
MVB12B multivesicular body subunit 12B 2.20898
MRPL48 mitochondrial ribosomal protein L48 2.20497
ZBTB47 zinc finger and BTB domain containing 47 2.20326
CHD9 chromodomain helicase DNA binding protein 9 2.1917
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.1871
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.14691
FAM117A family with sequence similarity 117, member A 2.13771
STMN2 stathmin 2 2.13771
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 2.11439
RAD21 RAD21 homolog (S. pombe) 2.11439
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 2.11439
TOX3 TOX high mobility group box family member 3 2.11012
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.11012
ZNF415 zinc finger protein 415 2.10418
BCL3 B-cell CLL/lymphoma 3 2.08825
XPO5 exportin 5 2.08331
CTHRC1 collagen triple helix repeat containing 1 2.06424
CCR10 chemokine (C-C motif) receptor 10 2.02615
TRMT10B tRNA methyltransferase 10 homolog B (S. cerevisiae) 2.02522
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.02502
EFNA4 ephrin-A4 2.01582
ZBTB40 zinc finger and BTB domain containing 40 2.01582
DOT1L DOT1-like histone H3K79 methyltransferase 2.01455
DCAF13 DDB1 and CUL4 associated factor 13 2.00877
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.00772
PANK1 pantothenate kinase 1 2.00722
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 2.00322
MTX1 metaxin 1 2.00322

decreased expression

Symbol Name Standardized Value
PLAC8 placenta-specific 8 -4.07889
TOGARAM2 TOG array regulator of axonemal microtubules 2 -4.07889
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -4.07889
VSTM5 V-set and transmembrane domain containing 5 -4.07889
VN1R1 vomeronasal 1 receptor 1 -4.07889
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -4.07889
NXPH4 neurexophilin 4 -3.99949
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -3.99949
ZNF593OS ZNF593 opposite strand -3.99949
LIX1 Lix1 homolog (chicken) -3.99949
FLT3LG fms-related tyrosine kinase 3 ligand -3.99949
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -3.99949
RUFY4 RUN and FYVE domain containing 4 -3.99949
BTLA B and T lymphocyte associated -3.99949
TMEM132D transmembrane protein 132D -3.99949
FOXP2 forkhead box P2 -3.99949
CD300A CD300a molecule -3.99949
DIO1 deiodinase, iodothyronine, type I -3.99949
POPDC2 popeye domain containing 2 -3.99949
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -3.99949
ACKR3 atypical chemokine receptor 3 -3.99949
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -3.99949
KCTD21 potassium channel tetramerization domain containing 21 -3.99949
TMEM238L transmembrane protein 238 like -3.99949
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -3.99949
C2ORF72 chromosome 2 open reading frame 72 -3.99949
PFN4 profilin family, member 4 -3.99949
ZNF524 zinc finger protein 524 -3.99949
DAW1 dynein assembly factor with WDR repeat domains 1 -3.99949
MGAM maltase-glucoamylase -3.99949
FMO3 flavin containing monooxygenase 3 -3.99949
PLCZ1 phospholipase C, zeta 1 -3.99949
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 -3.99949
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -3.99949
NTN5 netrin 5 -3.99949
WNT9B wingless-type MMTV integration site family, member 9B -3.99949
C4ORF50 chromosome 4 open reading frame 50 -3.99949
RAB36 RAB36, member RAS oncogene family -3.99949
LY6H lymphocyte antigen 6 complex, locus H -3.99949
DENND3 DENN/MADD domain containing 3 -3.67823
TEX22 testis expressed 22 -3.64925
NAGLU N-acetylglucosaminidase, alpha -3.2677
FCGBP Fc fragment of IgG binding protein -3.14054
DBR1 debranching RNA lariats 1 -3.12303
CDCA5 cell division cycle associated 5 -3.07867
ARMC5 armadillo repeat containing 5 -3.07867
GAR1 GAR1 ribonucleoprotein -3.07867
FNBP1L formin binding protein 1-like -3.02821
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -3.01247
GAS1 growth arrest-specific 1 -3.01247
FOXL2 forkhead box L2 -3.01247
C3ORF49 chromosome 3 open reading frame 49 -3.01247
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -3.01247
MYRF myelin regulatory factor -2.93192
SIRT2 sirtuin 2 -2.93192
TRIM58 tripartite motif containing 58 -2.9032
MRRF mitochondrial ribosome recycling factor -2.83408
CDYL chromodomain protein, Y-like -2.82979
ZNF732 zinc finger protein 732 -2.7723
CHD7 chromodomain helicase DNA binding protein 7 -2.76973
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -2.74895
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 -2.70436
MRPL38 mitochondrial ribosomal protein L38 -2.6044
ZNF248 zinc finger protein 248 -2.58536
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.58448
GK glycerol kinase -2.51723
RPIA ribose 5-phosphate isomerase A -2.5168
FAM50B family with sequence similarity 50, member B -2.50681
LYPD1 LY6/PLAUR domain containing 1 -2.50681
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.49991
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.47779
APCDD1 adenomatosis polyposis coli down-regulated 1 -2.47618
KCTD4 potassium channel tetramerization domain containing 4 -2.44852
SIX3 SIX homeobox 3 -2.44852
KIF21B kinesin family member 21B -2.43395
JARID2 jumonji, AT rich interactive domain 2 -2.43395
ATRN attractin -2.4198
ACBD3 acyl-CoA binding domain containing 3 -2.41438
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.37133
SH3BP2 SH3-domain binding protein 2 -2.37133
ZMYM4 zinc finger, MYM-type 4 -2.37133
ZBTB32 zinc finger and BTB domain containing 32 -2.36406
ZNF649 zinc finger protein 649 -2.35072
TRIM16 tripartite motif containing 16 -2.32683
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.31807
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.29476
WWC1 WW and C2 domain containing 1 -2.28999
SPATA18 spermatogenesis associated 18 -2.28439
IGIP IgA-inducing protein -2.28439
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -2.2533
TOX2 TOX high mobility group box family member 2 -2.24872
INTS7 integrator complex subunit 7 -2.24872
JMJD8 jumonji domain containing 8 -2.24719
PMPCB peptidase (mitochondrial processing) beta -2.23954
PARP1 poly (ADP-ribose) polymerase 1 -2.2232
COLEC11 collectin sub-family member 11 -2.22304
GPATCH2L G patch domain containing 2-like -2.20927
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -2.20914
MORN2 MORN repeat containing 2 -2.1871
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -2.17234
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -2.16222
PRPF4 pre-mRNA processing factor 4 -2.13946
COX19 COX19 cytochrome c oxidase assembly factor -2.13946
RTN4 reticulon 4 -2.13946
LRTM1 leucine-rich repeats and transmembrane domains 1 -2.12769
POLG polymerase (DNA directed), gamma -2.0999
ANKRD29 ankyrin repeat domain 29 -2.08825
PARM1 prostate androgen-regulated mucin-like protein 1 -2.08376
SLC10A7 solute carrier family 10, member 7 -2.08224
CAAP1 caspase activity and apoptosis inhibitor 1 -2.07167
C11ORF58 chromosome 11 open reading frame 58 -2.06336
PLA2G3 phospholipase A2, group III -2.06126
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -2.06126
MYO3B myosin IIIB -2.02968
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.02522
PTPRR protein tyrosine phosphatase, receptor type, R -2.02502
ANKFY1 ankyrin repeat and FYVE domain containing 1 -2.02442
C1GALT1C1 C1GALT1-specific chaperone 1 -2.02042
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.00877