FOSL1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description FOS-like antigen 1|The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 8061)
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Genes

346 genes differentially expressed following the FOSL1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHA2 protocadherin alpha 2 4.72191
CARD18 caspase recruitment domain family, member 18 4.72191
SCGN secretagogin, EF-hand calcium binding protein 4.72191
DUXA double homeobox A 4.72191
PGAM4 phosphoglycerate mutase family member 4 4.72191
ZNF662 zinc finger protein 662 4.72191
IL5RA interleukin 5 receptor, alpha 4.72191
EPB42 erythrocyte membrane protein band 4.2 4.72191
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 4.72191
OLIG1 oligodendrocyte transcription factor 1 4.72191
SLC30A2 solute carrier family 30 (zinc transporter), member 2 4.72191
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 4.72191
INHBB inhibin, beta B 4.72191
CD6 CD6 molecule 4.72191
LIPK lipase, family member K 4.72191
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 4.72191
TBX20 T-box 20 4.72191
SLC22A10 solute carrier family 22, member 10 4.72191
MEP1B meprin A, beta 4.72191
GPR4 G protein-coupled receptor 4 4.72191
PLVAP plasmalemma vesicle associated protein 4.72191
GJA9 gap junction protein, alpha 9, 59kDa 4.72191
LAPTM5 lysosomal protein transmembrane 5 4.72191
CST11 cystatin 11 4.72191
GYPB glycophorin B (MNS blood group) 4.72191
GPR26 G protein-coupled receptor 26 4.72191
MPL MPL proto-oncogene, thrombopoietin receptor 4.72191
CAPS calcyphosine 4.72191
LGALS4 lectin, galactoside-binding, soluble, 4 4.72191
RNF133 ring finger protein 133 4.72191
CLEC14A C-type lectin domain family 14, member A 4.72191
PRR29 proline rich 29 4.72191
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 4.72191
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 4.72191
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 4.72191
KIAA1755 KIAA1755 4.72191
TAS2R13 taste receptor, type 2, member 13 4.72191
HBD hemoglobin, delta 4.72191
C1GALT1C1L C1GALT1-specific chaperone 1 like 4.72191
CA6 carbonic anhydrase VI 4.72191
CA1 carbonic anhydrase I 4.72191
NCKAP1L NCK-associated protein 1-like 4.72191
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 4.72191
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 4.72191
TDRD6 tudor domain containing 6 4.72191
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 4.72191
CD68 CD68 molecule 4.72191
MAGED4 melanoma antigen family D4 4.72191
TMEM121 transmembrane protein 121 4.72191
RNASE6 ribonuclease, RNase A family, k6 4.72191
LOC107986837 uncharacterized LOC107986837 4.72191
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 4.72191
PROX2 prospero homeobox 2 4.72191
WDR64 WD repeat domain 64 4.72191
TREX2 three prime repair exonuclease 2 4.72191
GPR37L1 G protein-coupled receptor 37 like 1 4.72191
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 4.72191
TBX10 T-box 10 4.72191
CSAG1 chondrosarcoma associated gene 1 4.72191
IL16 interleukin 16 4.72191
GPR85 G protein-coupled receptor 85 4.72191
FMO2 flavin containing monooxygenase 2 (non-functional) 4.72191
FIMP1 fertilization-influencing membrane protein 1 4.72191
TMIGD1 transmembrane and immunoglobulin domain containing 1 4.72191
EXOC1L exocyst complex component 1 like 4.72191
CIMAP1B ciliary microtubule associated protein 1B 4.72191
H1-8 H1.8 linker histone 4.72191
DUSP29 dual specificity phosphatase 29 4.72191
RNF227 ring finger protein 227 4.72191
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 4.72191
PTH1R parathyroid hormone 1 receptor 4.72191
OTOS otospiralin 4.72191
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.72191
GPR35 G protein-coupled receptor 35 4.72191
LRRC73 leucine rich repeat containing 73 4.72191
LRRC71 leucine rich repeat containing 71 4.72191
HAPLN2 hyaluronan and proteoglycan link protein 2 4.72191
UROC1 urocanate hydratase 1 4.72191
C10ORF67 chromosome 10 open reading frame 67 4.72191
SLC22A25 solute carrier family 22, member 25 4.72191
DAO D-amino-acid oxidase 4.72191
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 4.72191
NXPE4 neurexophilin and PC-esterase domain family, member 4 4.72191
CLDN2 claudin 2 4.72191
PCDHB13 protocadherin beta 13 4.72191
PTPRH protein tyrosine phosphatase, receptor type, H 4.72191
IL5 interleukin 5 4.72191
TPTE transmembrane phosphatase with tensin homology 4.72191
GZMM granzyme M (lymphocyte met-ase 1) 4.72191
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 4.72191
TAS1R1 taste receptor, type 1, member 1 4.72191
C6 complement component 6 4.72191
C7ORF57 chromosome 7 open reading frame 57 4.72191
GJD3 gap junction protein, delta 3, 31.9kDa 4.72191
SPDYC speedy/RINGO cell cycle regulator family member C 4.72191
PIWIL3 piwi-like RNA-mediated gene silencing 3 4.72191
C1QTNF8 C1q and tumor necrosis factor related protein 8 4.72191
ZNF257 zinc finger protein 257 4.72191
TBX3 T-box 3 4.72191
PRB4 proline-rich protein BstNI subfamily 4 4.72191
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 4.72191
CCL24 chemokine (C-C motif) ligand 24 4.72191
TPPP3 tubulin polymerization-promoting protein family member 3 4.72191
MORN5 MORN repeat containing 5 4.72191
APOD apolipoprotein D 4.72191
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 4.72191
CALML6 calmodulin-like 6 4.72191
ECM1 extracellular matrix protein 1 4.72191
GPR12 G protein-coupled receptor 12 4.72191
IP6K3 inositol hexakisphosphate kinase 3 4.72191
GPR62 G protein-coupled receptor 62 4.72191
FAM25C family with sequence similarity 25, member C 4.72191
EPX eosinophil peroxidase 4.72191
POTEI POTE ankyrin domain family, member I 4.72191
CTSS cathepsin S 4.72191
POTEE POTE ankyrin domain family, member E 4.72191
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 4.72191
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 4.72191
CT55 cancer/testis antigen 55 4.72191
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 4.72191
F2RL3 coagulation factor II (thrombin) receptor-like 3 4.72191
PCDHGA4 protocadherin gamma subfamily A, 4 4.72191
HPX hemopexin 4.72191
MUC15 mucin 15, cell surface associated 4.72191
PRR23A proline rich 23A 4.72191
TEKT2 tektin 2 (testicular) 4.72191
C20ORF144 chromosome 20 open reading frame 144 4.72191
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 4.72191
AQP6 aquaporin 6, kidney specific 4.72191
S100A14 S100 calcium binding protein A14 4.72191
C8G complement component 8, gamma polypeptide 4.72191
PRR35 proline rich 35 4.72191
TAAR6 trace amine associated receptor 6 4.72191
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 4.72191
DNAH12 dynein, axonemal, heavy chain 12 4.72191
EDN1 endothelin 1 4.72191
ADGRD1 adhesion G protein-coupled receptor D1 4.72191
ITGAD integrin, alpha D 4.72191
SPNS3 spinster homolog 3 (Drosophila) 4.72191
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 4.72191
BPIFC BPI fold containing family C 4.72191
HEPN1 hepatocellular carcinoma, down-regulated 1 4.72191
PADI1 peptidyl arginine deiminase, type I 4.72191
ZPLD1 zona pellucida-like domain containing 1 4.72191
BCL2A1 BCL2-related protein A1 4.72191
NXF3 nuclear RNA export factor 3 4.72191
KCNK15 potassium channel, two pore domain subfamily K, member 15 4.72191
OR52N5 olfactory receptor, family 52, subfamily N, member 5 4.72191
NLRP14 NLR family, pyrin domain containing 14 4.72191
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 4.72191
ZNF648 zinc finger protein 648 4.72191
NEUROD1 neuronal differentiation 1 4.72191
NPC1L1 NPC1-like 1 4.72191
CCNO cyclin O 4.72191
TMEM156 transmembrane protein 156 4.72191
CHAT choline O-acetyltransferase 4.72191
PRAP1 proline-rich acidic protein 1 4.72191
LAMB4 laminin, beta 4 4.72191
CXORF49C chromosome X open reading frame 49C 4.72191
OR14A16 olfactory receptor, family 14, subfamily A, member 16 4.72191
GRAPL GRB2-related adaptor protein-like 4.72191
SIGLEC11 sialic acid binding Ig-like lectin 11 4.72191
MAGEA12 melanoma antigen family A12 4.72191
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 4.72191
ZNF831 zinc finger protein 831 4.72191
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 4.70428
KRTAP13-4 keratin associated protein 13-4 4.70428
GDA guanine deaminase 4.70428
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 4.70428
EXOSC7 exosome component 7 3.98081
LECT2 leukocyte cell-derived chemotaxin 2 3.78164
CCDC121 coiled-coil domain containing 121 3.78164
ADM5 adrenomedullin 5 (putative) 3.78164
ZFP28 ZFP28 zinc finger protein 3.78164
CLDN18 claudin 18 3.78164
FOXA2 forkhead box A2 3.78164
TMEM208 transmembrane protein 208 3.58498
WASHC5 WASH complex subunit 5 3.40489
STARD5 StAR-related lipid transfer (START) domain containing 5 3.29903
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 3.29903
DGKH diacylglycerol kinase, eta 3.27406
PCDHB14 protocadherin beta 14 3.07796
SLC6A16 solute carrier family 6, member 16 3.06982
CIB2 calcium and integrin binding family member 2 3.06442
KATNA1 katanin p60 (ATPase containing) subunit A 1 3.02549
TCN2 transcobalamin II 3.00921
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 3.00921
NAV1 neuron navigator 1 2.97448
MOG myelin oligodendrocyte glycoprotein 2.8999
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 2.84613
SYTL1 synaptotagmin-like 1 2.80766
PRKD1 protein kinase D1 2.64157
SLC7A6OS solute carrier family 7, member 6 opposite strand 2.56495
MRPL48 mitochondrial ribosomal protein L48 2.55781
MSRB2 methionine sulfoxide reductase B2 2.55515
STMN1 stathmin 1 2.49303
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 2.48349
SLC25A40 solute carrier family 25, member 40 2.47515
TSPAN5 tetraspanin 5 2.41355
CENPU centromere protein U 2.34164
PAH phenylalanine hydroxylase 2.34164
CRYBA1 crystallin, beta A1 2.34105
PNMA6F PNMA family member 6F 2.34073
KLHL6 kelch-like family member 6 2.34073
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 2.33549
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2.33184
CAPN2 calpain 2, (m/II) large subunit 2.32557
CLRN2 clarin 2 2.29323
TEX15 testis expressed 15 2.28586
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 2.28381
EXOSC8 exosome component 8 2.27805
KLHL7 kelch-like family member 7 2.27805
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.27202
MT1E metallothionein 1E 2.26357
ZER1 zyg-11 related, cell cycle regulator 2.25969
CCDC38 coiled-coil domain containing 38 2.25836
CDH10 cadherin 10, type 2 (T2-cadherin) 2.25836
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 2.25167
RNASET2 ribonuclease T2 2.22699
SURF1 surfeit 1 2.22699
NEK11 NIMA-related kinase 11 2.21376
JAK1 Janus kinase 1 2.21347
UBXN4 UBX domain protein 4 2.15033
OLFM1 olfactomedin 1 2.14559
PXMP2 peroxisomal membrane protein 2, 22kDa 2.10984
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 2.10984
GALK1 galactokinase 1 2.10321
ACADVL acyl-CoA dehydrogenase, very long chain 2.09352
TPH1 tryptophan hydroxylase 1 2.06316
GAL3ST3 galactose-3-O-sulfotransferase 3 2.04337
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.01115
CBR1 carbonyl reductase 1 2.00924
RPL24 ribosomal protein L24 2.00201
TUBG1 tubulin, gamma 1 2.00117

decreased expression

Symbol Name Standardized Value
SCT secretin -4.72191
AQP3 aquaporin 3 (Gill blood group) -4.72191
YPEL4 yippee-like 4 (Drosophila) -4.72191
GRHL1 grainyhead-like 1 (Drosophila) -4.72191
ANXA9 annexin A9 -4.72191
LRRC39 leucine rich repeat containing 39 -4.72191
GPR22 G protein-coupled receptor 22 -4.61383
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -4.61383
MFAP4 microfibrillar-associated protein 4 -4.61383
C3 complement component 3 -4.61383
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -4.61383
TMEM191B transmembrane protein 191B -4.61383
WFDC1 WAP four-disulfide core domain 1 -4.61383
LOC124900192 uncharacterized LOC124900192 -4.61383
POF1B premature ovarian failure, 1B -4.61383
AKAP14 A kinase (PRKA) anchor protein 14 -4.61383
CD8A CD8a molecule -4.61383
AMER2 APC membrane recruitment protein 2 -4.61383
KCNK2 potassium channel, two pore domain subfamily K, member 2 -4.61383
FBXO40 F-box protein 40 -4.61383
ADIRF adipogenesis regulatory factor -4.61383
IMPG2 interphotoreceptor matrix proteoglycan 2 -4.61383
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -4.61383
SFTA2 surfactant associated 2 -4.61383
WNT4 wingless-type MMTV integration site family, member 4 -4.61383
ESPNL espin-like -4.61383
C11ORF42 chromosome 11 open reading frame 42 -4.61383
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -4.61383
LHX2 LIM homeobox 2 -4.61383
SAMD7 sterile alpha motif domain containing 7 -4.61383
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -4.61383
TSPAN8 tetraspanin 8 -4.61383
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -4.61383
DUSP8 dual specificity phosphatase 8 -4.61383
PCDHGB1 protocadherin gamma subfamily B, 1 -4.61383
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -4.53472
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -4.53472
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -3.8514
CLIC2 chloride intracellular channel 2 -3.39767
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -3.39767
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -3.39767
VSTM2B V-set and transmembrane domain containing 2B -3.33426
NTNG2 netrin G2 -3.30701
BAALC brain and acute leukemia, cytoplasmic -3.28007
NOVA1 neuro-oncological ventral antigen 1 -3.22962
C1RL complement component 1, r subcomponent-like -3.20621
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -3.01736
PRMT3 protein arginine methyltransferase 3 -3.0033
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.95773
FSCN3 fascin actin-bundling protein 3, testicular -2.92762
RUMY3 RUMY family member 3 -2.92762
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.86591
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.83208
DGAT2 diacylglycerol O-acyltransferase 2 -2.77734
OTOA otoancorin -2.77734
MUC19 mucin 19, oligomeric -2.77734
MYO18B myosin XVIIIB -2.75022
NAP1L5 nucleosome assembly protein 1-like 5 -2.75022
ZNF518A zinc finger protein 518A -2.74804
COL1A1 collagen, type I, alpha 1 -2.69939
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.6886
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.64289
IP6K1 inositol hexakisphosphate kinase 1 -2.62446
HIPK2 homeodomain interacting protein kinase 2 -2.58798
LRRC3B leucine rich repeat containing 3B -2.58045
POMT1 protein-O-mannosyltransferase 1 -2.56495
CREB1 cAMP responsive element binding protein 1 -2.54633
ZBTB7C zinc finger and BTB domain containing 7C -2.50811
MUS81 MUS81 structure-specific endonuclease subunit -2.48349
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.48349
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.42326
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -2.41331
FICD FIC domain containing -2.41331
AEBP1 AE binding protein 1 -2.38484
PLXND1 plexin D1 -2.37058
MARCHF8 membrane associated ring-CH-type finger 8 -2.35794
TRAPPC10 trafficking protein particle complex 10 -2.35794
MEAK7 MTOR associated protein, eak-7 homolog -2.31924
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.30661
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.28951
SAE1 SUMO1 activating enzyme subunit 1 -2.28951
IRAK1 interleukin-1 receptor-associated kinase 1 -2.28704
CSNK1G1 casein kinase 1, gamma 1 -2.28586
CGAS cyclic GMP-AMP synthase -2.27202
ENDOV endonuclease V -2.25836
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.25836
TIGD2 tigger transposable element derived 2 -2.25095
CEBPZOS CEBPZ opposite strand -2.24061
PRSS27 protease, serine 27 -2.22751
FAM3C family with sequence similarity 3, member C -2.21347
CFAP144 cilia and flagella associated protein 144 -2.20061
SPON2 spondin 2, extracellular matrix protein -2.20061
TTC27 tetratricopeptide repeat domain 27 -2.17971
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -2.16828
BIK BCL2-interacting killer (apoptosis-inducing) -2.15033
FES FES proto-oncogene, tyrosine kinase -2.14813
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.14462
TSLIG2 tRNA splicing ligase complex subunit 2 -2.13548
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.13414
TMEM221 transmembrane protein 221 -2.13168
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -2.12943
FGFR4 fibroblast growth factor receptor 4 -2.12916
SLX9 SLX9 ribosome biogenesis factor -2.12539
TBC1D23 TBC1 domain family, member 23 -2.11753
INTS8 integrator complex subunit 8 -2.09352
SMAD2 SMAD family member 2 -2.08288
COL24A1 collagen, type XXIV, alpha 1 -2.07665
AKAP13 A kinase (PRKA) anchor protein 13 -2.06316
CARD19 caspase recruitment domain family member 19 -2.06302
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -2.03219
CHMP1A charged multivesicular body protein 1A -2.01938
TTC21B tetratricopeptide repeat domain 21B -2.00117