FOXA2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description forkhead box A2|This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 3170)
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Genes

315 genes differentially expressed following the FOXA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KLF17 Kruppel-like factor 17 3.15006
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.15006
ALOX15 arachidonate 15-lipoxygenase 3.15006
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.15006
SLC46A3 solute carrier family 46, member 3 3.15006
GNLY granulysin 3.15006
SPINK4 serine peptidase inhibitor, Kazal type 4 3.15006
NANOS3 nanos homolog 3 (Drosophila) 3.15006
TRIM15 tripartite motif containing 15 3.15006
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.15006
CEMP1 cementum protein 1 3.15006
SOX1 SRY (sex determining region Y)-box 1 3.15006
FAM3D family with sequence similarity 3, member D 3.15006
NRN1 neuritin 1 3.15006
WEE2 WEE1 homolog 2 (S. pombe) 3.15006
CFHR4 complement factor H-related 4 3.15006
GJA3 gap junction protein, alpha 3, 46kDa 3.15006
OR5P2 olfactory receptor, family 5, subfamily P, member 2 3.15006
HLF hepatic leukemia factor 3.15006
LY86 lymphocyte antigen 86 3.15006
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.15006
GPR151 G protein-coupled receptor 151 3.15006
HORMAD1 HORMA domain containing 1 3.15006
FSCN2 fascin actin-bundling protein 2, retinal 3.15006
CPB1 carboxypeptidase B1 (tissue) 3.15006
ACVRL1 activin A receptor type II-like 1 3.15006
TAS2R10 taste receptor, type 2, member 10 3.15006
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.15006
LGALS2 lectin, galactoside-binding, soluble, 2 3.15006
CPLX3 complexin 3 3.15006
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.15006
TDRD6 tudor domain containing 6 3.15006
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 3.15006
C3ORF22 chromosome 3 open reading frame 22 3.15006
IL5RA interleukin 5 receptor, alpha 3.15006
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.15006
SSTR3 somatostatin receptor 3 3.15006
GYPB glycophorin B (MNS blood group) 3.15006
MFAP5 microfibrillar associated protein 5 3.15006
SLC9C2 solute carrier family 9, member C2 (putative) 3.15006
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.15006
TPSD1 tryptase delta 1 3.15006
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 3.15006
DAO D-amino-acid oxidase 3.15006
LOC124903317 uncharacterized LOC124903317 3.15006
ALDOB aldolase B, fructose-bisphosphate 3.15006
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.15006
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.15006
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.15006
GPX2 glutathione peroxidase 2 3.15006
CCER2 coiled-coil glutamate-rich protein 2 3.15006
LDB3 LIM domain binding 3 3.15006
STX11 syntaxin 11 3.15006
MISP3 MISP family member 3 3.15006
SPACA9 sperm acrosome associated 9 3.15006
CLXN calaxin 3.15006
CATSPERH catsper channel auxiliary subunit eta 3.15006
SPATA31G1 SPATA31 subfamily G member 1 3.15006
ACKR5 atypical chemokine receptor 5 3.15006
CD8B2 CD8b2 molecule 3.15006
RHEX regulator of hemoglobinization and erythroid cell expansion 3.15006
SERTM2 serine rich and transmembrane domain containing 2 3.15006
GLYATL1B glycine-N-acyltransferase like 1B 3.15006
DNAAF6 dynein axonemal assembly factor 6 3.15006
PDC phosducin 3.15006
TMPRSS4 transmembrane protease, serine 4 3.15006
FOXC2 forkhead box C2 3.15006
SBSN suprabasin 3.15006
CDSN corneodesmosin 3.15006
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.15006
GDF10 growth differentiation factor 10 3.15006
NPIPB9 nuclear pore complex interacting protein family, member B9 3.15006
C10ORF67 chromosome 10 open reading frame 67 3.15006
ANXA13 annexin A13 3.15006
GOLGA6L4 golgin A6 family-like 4 3.15006
C7ORF57 chromosome 7 open reading frame 57 3.15006
BLNK B-cell linker 3.15006
SAMD11 sterile alpha motif domain containing 11 3.15006
DOK2 docking protein 2, 56kDa 3.15006
CFC1 cripto, FRL-1, cryptic family 1 3.15006
GCSAM germinal center-associated, signaling and motility 3.15006
ACE2 angiotensin I converting enzyme 2 3.15006
PXDC1 PX domain containing 1 3.15006
LRRC71 leucine rich repeat containing 71 3.15006
TAS1R1 taste receptor, type 1, member 1 3.15006
IGF1R insulin-like growth factor 1 receptor 3.15006
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 3.15006
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.15006
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.15006
DPRX divergent-paired related homeobox 3.15006
CLRN1 clarin 1 3.15006
CPSF4L cleavage and polyadenylation specific factor 4-like 3.15006
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 3.15006
ERICH6B glutamate-rich 6B 3.15006
CPA5 carboxypeptidase A5 3.15006
APOC4 apolipoprotein C-IV 3.15006
CLEC4D C-type lectin domain family 4, member D 3.15006
MAMLD1 mastermind-like domain containing 1 3.15006
HHATL hedgehog acyltransferase-like 3.15006
BTNL3 butyrophilin-like 3 3.15006
CIDEA cell death-inducing DFFA-like effector a 3.15006
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.15006
KRT15 keratin 15, type I 3.15006
LRCOL1 leucine rich colipase-like 1 3.15006
ENDOU endonuclease, polyU-specific 3.15006
CCL27 chemokine (C-C motif) ligand 27 3.15006
CH25H cholesterol 25-hydroxylase 3.15006
UBQLNL ubiquilin-like 3.15006
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.15006
FOXE3 forkhead box E3 3.15006
SHISA8 shisa family member 8 3.15006
GSTA1 glutathione S-transferase alpha 1 3.15006
CCNI2 cyclin I family, member 2 3.15006
HMGB4 high mobility group box 4 3.15006
GPR143 G protein-coupled receptor 143 3.15006
C11ORF42 chromosome 11 open reading frame 42 3.15006
ARHGAP40 Rho GTPase activating protein 40 3.15006
ADAM18 ADAM metallopeptidase domain 18 3.15006
WNT2 wingless-type MMTV integration site family member 2 3.15006
TEX26 testis expressed 26 3.15006
DMRT1 doublesex and mab-3 related transcription factor 1 3.15006
GFRAL GDNF family receptor alpha like 3.15006
MUC15 mucin 15, cell surface associated 3.15006
MUC17 mucin 17, cell surface associated 3.15006
ALOXE3 arachidonate lipoxygenase 3 3.15006
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.15006
IL1B interleukin 1, beta 3.15006
KISS1 KiSS-1 metastasis-suppressor 3.15006
ZNF80 zinc finger protein 80 3.15006
CHIT1 chitinase 1 (chitotriosidase) 3.15006
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.15006
ADRA2A adrenoceptor alpha 2A 3.15006
CDH26 cadherin 26 3.15006
FAM9B family with sequence similarity 9, member B 3.15006
ZNF804B zinc finger protein 804B 3.15006
LRRC74B leucine rich repeat containing 74B 3.15006
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.15006
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.15006
TMPRSS15 transmembrane protease, serine 15 3.15006
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 3.15006
KIAA1755 KIAA1755 3.15006
CELF3 CUGBP, Elav-like family member 3 3.15006
LEP leptin 3.15006
FGF7 fibroblast growth factor 7 3.15006
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.15006
IRX5 iroquois homeobox 5 3.15006
RNF224 ring finger protein 224 3.15006
FZD1 frizzled class receptor 1 3.15006
HAND1 heart and neural crest derivatives expressed 1 3.15006
C2ORF66 chromosome 2 open reading frame 66 3.15006
VTCN1 V-set domain containing T cell activation inhibitor 1 3.15006
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.15006
SPAG8 sperm associated antigen 8 3.15006
CARD9 caspase recruitment domain family, member 9 3.15006
RRAGD Ras-related GTP binding D 3.08927
TIAM2 T-cell lymphoma invasion and metastasis 2 3.00939
CLYBL citrate lyase beta like 2.95485
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 2.95479
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.94234
DRC11 dynein regulatory complex subunit 11 2.92176
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.91004
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.87108
APOOL apolipoprotein O-like 2.82268
S100PBP S100P binding protein 2.67345
ZNF892 zinc finger protein 892 2.66277
H4C16 H4 histone 16 2.60485
RCSD1 RCSD domain containing 1 2.55321
NOP9 NOP9 nucleolar protein 2.54264
TUB tubby bipartite transcription factor 2.50316
DCPH1 damage control phosphatase 1 2.43713
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.43588
ATXN10 ataxin 10 2.38209
SH3GL3 SH3-domain GRB2-like 3 2.34779
OPCML opioid binding protein/cell adhesion molecule-like 2.34384
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.32553
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.32553
ALPK2 alpha-kinase 2 2.29449
APH1A APH1A gamma secretase subunit 2.267
NCEH1 neutral cholesterol ester hydrolase 1 2.25918
MYO16 myosin XVI 2.25918
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.25004
RAB14 RAB14, member RAS oncogene family 2.21012
AFP alpha-fetoprotein 2.20075
RHOC ras homolog family member C 2.1997
NLRP7 NLR family, pyrin domain containing 7 2.18506
LOXL4 lysyl oxidase-like 4 2.18506
SLC16A6 solute carrier family 16, member 6 2.18506
COL11A2 collagen, type XI, alpha 2 2.18506
IFIH1 interferon induced with helicase C domain 1 2.18506
CA7 carbonic anhydrase VII 2.18506
VSTM2B V-set and transmembrane domain containing 2B 2.18506
KAT2B K(lysine) acetyltransferase 2B 2.15989
NCR1 natural cytotoxicity triggering receptor 1 2.15989
SLCO6A1 solute carrier organic anion transporter family, member 6A1 2.15547
HMGXB4 HMG box domain containing 4 2.14661
TULP4 tubby like protein 4 2.13111
ATXN7L3 ataxin 7-like 3 2.07816
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.0388
IL32 interleukin 32 2.03783
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.03783
RAI14 retinoic acid induced 14 2.03251
RAD54L RAD54-like (S. cerevisiae) 2.00417

decreased expression

Symbol Name Standardized Value
CFAP141 cilia and flagella associated protein 141 -3.15006
CATSPERT catsper channel auxiliary subunit tau -3.15006
FAM216B family with sequence similarity 216, member B -3.15006
ADH6 alcohol dehydrogenase 6 (class V) -3.15006
THEMIS thymocyte selection associated -3.15006
LPO lactoperoxidase -3.15006
TMEM151A transmembrane protein 151A -3.15006
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 -3.15006
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -3.15006
MMP3 matrix metallopeptidase 3 -3.15006
SCN3B sodium channel, voltage gated, type III beta subunit -3.15006
ACKR3 atypical chemokine receptor 3 -3.15006
C19ORF67 chromosome 19 open reading frame 67 -3.15006
LMO1 LIM domain only 1 (rhombotin 1) -3.15006
TTLL13 tubulin tyrosine ligase like 13 -3.15006
GPR33 G protein-coupled receptor 33 (gene/pseudogene) -3.15006
CFAP52 cilia and flagella associated protein 52 -3.15006
C1QTNF1 C1q and tumor necrosis factor related protein 1 -3.15006
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -3.15006
ISM2 isthmin 2 -3.15006
NDRG1 N-myc downstream regulated 1 -3.15006
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.15006
CHADL chondroadherin-like -3.15006
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -3.15006
SPINK1 serine peptidase inhibitor, Kazal type 1 -3.15006
SEMG1 semenogelin I -3.15006
GSDMA gasdermin A -3.15006
IL1A interleukin 1, alpha -3.15006
IGIP IgA-inducing protein -3.15006
CD53 CD53 molecule -3.15006
DRD2 dopamine receptor D2 -3.15006
MTM1 myotubularin 1 -3.15006
CTAGE9 CTAGE family, member 9 -3.15006
GBX2 gastrulation brain homeobox 2 -3.15006
DAW1 dynein assembly factor with WDR repeat domains 1 -3.15006
EVI2A ecotropic viral integration site 2A -3.15006
AQP4 aquaporin 4 -3.15006
BCO1 beta-carotene oxygenase 1 -3.15006
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -3.15006
ZNF703 zinc finger protein 703 -3.15006
COL17A1 collagen, type XVII, alpha 1 -3.15006
ATP10B ATPase, class V, type 10B -3.15006
CCDC24 coiled-coil domain containing 24 -2.8052
MEOX2 mesenchyme homeobox 2 -2.79699
LIN9 lin-9 DREAM MuvB core complex component -2.772
SMG7 SMG7 nonsense mediated mRNA decay factor -2.76159
UNC79 unc-79 homolog (C. elegans) -2.6274
NABP1 nucleic acid binding protein 1 -2.62337
ICE2 interactor of little elongation complex ELL subunit 2 -2.6015
ZIC5 Zic family member 5 -2.5525
LRATD1 LRAT domain containing 1 -2.54264
LHX8 LIM homeobox 8 -2.52889
KLK8 kallikrein-related peptidase 8 -2.4732
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.46948
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.36715
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.34779
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -2.34779
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.34779
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.34779
SLC30A8 solute carrier family 30 (zinc transporter), member 8 -2.32821
HSPB2 heat shock 27kDa protein 2 -2.32553
CPLX4 complexin 4 -2.32553
ZNF354C zinc finger protein 354C -2.32092
CENPX centromere protein X -2.28968
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -2.28121
MIA2 melanoma inhibitory activity 2 -2.28039
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -2.26976
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.267
FAAP20 FA core complex associated protein 20 -2.25918
RNF167 ring finger protein 167 -2.25918
PDAP1 PDGFA associated protein 1 -2.25918
C19ORF47 chromosome 19 open reading frame 47 -2.25918
C17ORF114 chromosome 17 open reading frame 114 -2.24819
FAM78A family with sequence similarity 78, member A -2.24819
SERTM1 serine-rich and transmembrane domain containing 1 -2.24819
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -2.24678
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.24416
JAG2 jagged 2 -2.24416
NUTM2G NUT family member 2G -2.23118
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -2.23118
GPR108 G protein-coupled receptor 108 -2.22617
RPP14 ribonuclease P/MRP 14kDa subunit -2.22488
FKBP9 FK506 binding protein 9, 63 kDa -2.20075
REEP2 receptor accessory protein 2 -2.1997
MRPS33 mitochondrial ribosomal protein S33 -2.1997
LDOC1 leucine zipper, down-regulated in cancer 1 -2.18251
TRAF2 TNF receptor-associated factor 2 -2.17701
HDAC1 histone deacetylase 1 -2.1757
SCPEP1 serine carboxypeptidase 1 -2.15115
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -2.14745
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) -2.14661
RAB40B RAB40B, member RAS oncogene family -2.13111
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.11279
ZC3H11A zinc finger CCCH-type containing 11A -2.10792
TNC tenascin C -2.10792
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.10315
PSPN persephin -2.0918
LOC112694756 uncharaterized LOC112694756 -2.0918
C4ORF50 chromosome 4 open reading frame 50 -2.0918
CSF1 colony stimulating factor 1 (macrophage) -2.0918
MID2 midline 2 -2.0918
LRRC7 leucine rich repeat containing 7 -2.07229
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.0662
CGAS cyclic GMP-AMP synthase -2.04997
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) -2.04697
MTA1 metastasis associated 1 -2.02583
TPGS2 tubulin polyglutamylase complex subunit 2 -2.02271
ZNF566 zinc finger protein 566 -2.02259
PCBP1 poly(rC) binding protein 1 -2.00417
PRR3 proline rich 3 -2.00417
MFAP1 microfibrillar-associated protein 1 -2.00417
ZNF536 zinc finger protein 536 -2.0026
ATP5PD ATP synthase peripheral stalk subunit d -2.00036