FOXD1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description forkhead box D1|This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014] (NCBI Entrez Gene Database, 2297)
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Genes

323 genes differentially expressed following the FOXD1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 3.1166
MYBPC3 myosin binding protein C, cardiac 3.1166
FRMD1 FERM domain containing 1 3.1166
TKTL1 transketolase-like 1 3.1166
HBA1 hemoglobin, alpha 1 3.1166
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.1166
FETUB fetuin B 3.1166
DMRTC1B DMRT-like family C1B 3.1166
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.1166
GPR26 G protein-coupled receptor 26 3.1166
HES5 hes family bHLH transcription factor 5 3.1166
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.1166
CFHR5 complement factor H-related 5 3.1166
TPBGL trophoblast glycoprotein-like 3.1166
GJA5 gap junction protein, alpha 5, 40kDa 3.1166
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.1166
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.1166
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.1166
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.1166
SPINK6 serine peptidase inhibitor, Kazal type 6 3.1166
CD163 CD163 molecule 3.1166
GIMAP4 GTPase, IMAP family member 4 3.1166
ALPK2 alpha-kinase 2 3.1166
PRDM16 PR domain containing 16 3.1166
TMC3 transmembrane channel-like 3 3.1166
HMX1 H6 family homeobox 1 3.1166
CRYAA crystallin, alpha A 3.1166
TDO2 tryptophan 2,3-dioxygenase 3.1166
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.1166
KRTAP5-2 keratin associated protein 5-2 3.1166
FGF7 fibroblast growth factor 7 3.1166
CCDC87 coiled-coil domain containing 87 3.1166
ADH6 alcohol dehydrogenase 6 (class V) 3.1166
PTK6 protein tyrosine kinase 6 3.1166
LYZL6 lysozyme-like 6 3.1166
OTUD6A OTU deubiquitinase 6A 3.1166
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.1166
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.1166
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.1166
PKP1 plakophilin 1 3.1166
F2 coagulation factor II (thrombin) 3.1166
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.1166
S100A1 S100 calcium binding protein A1 3.1166
PCDHGA12 protocadherin gamma subfamily A, 12 3.1166
CIMIP2C ciliary microtubule inner protein 2C 3.1166
TMEM271 transmembrane protein 271 3.1166
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.1166
ALDOB aldolase B, fructose-bisphosphate 3.1166
AVPR1A arginine vasopressin receptor 1A 3.1166
TTR transthyretin 3.1166
MYL10 myosin, light chain 10, regulatory 3.1166
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.1166
GATA6 GATA binding protein 6 3.1166
ACE2 angiotensin I converting enzyme 2 3.1166
H2AC25 H2A clustered histone 25 3.1166
MAB21L4 mab-21 like 4 3.1166
LITAFD LITAF domain containing 3.1166
DEFB109B defensin beta 109B 3.1166
ZNF593OS ZNF593 opposite strand 3.1166
SPAAR small regulatory polypeptide of amino acid response 3.1166
H4C12 H4 clustered histone 12 3.1166
EZHIP EZH inhibitory protein 3.1166
TEX55 testis expressed 55 3.1166
TERB1 telomere repeat binding bouquet formation protein 1 3.1166
DUSP29 dual specificity phosphatase 29 3.1166
PCDHGC4 protocadherin gamma subfamily C, 4 3.1166
ASIC3 acid sensing (proton gated) ion channel 3 3.1166
SERTAD4 SERTA domain containing 4 3.1166
C4ORF17 chromosome 4 open reading frame 17 3.1166
TUBA3D tubulin, alpha 3d 3.1166
NKX2-6 NK2 homeobox 6 3.1166
PCDHA7 protocadherin alpha 7 3.1166
HDC histidine decarboxylase 3.1166
TMEM229A transmembrane protein 229A 3.1166
LIPC lipase, hepatic 3.1166
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 3.1166
TMPRSS3 transmembrane protease, serine 3 3.1166
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 3.1166
LRRC72 leucine rich repeat containing 72 3.1166
SAMD11 sterile alpha motif domain containing 11 3.1166
SASH3 SAM and SH3 domain containing 3 3.1166
TACR2 tachykinin receptor 2 3.1166
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.1166
RNF113B ring finger protein 113B 3.1166
MYH15 myosin, heavy chain 15 3.1166
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.1166
ANXA13 annexin A13 3.1166
PDILT protein disulfide isomerase-like, testis expressed 3.1166
PRM1 protamine 1 3.1166
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.1166
RAB40AL RAB40A, member RAS oncogene family-like 3.1166
KLK15 kallikrein-related peptidase 15 3.1166
KLK7 kallikrein-related peptidase 7 3.1166
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.1166
CPZ carboxypeptidase Z 3.1166
KRT17 keratin 17, type I 3.1166
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.1166
CD200R1 CD200 receptor 1 3.1166
VAV1 vav 1 guanine nucleotide exchange factor 3.1166
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 3.1166
IP6K3 inositol hexakisphosphate kinase 3 3.1166
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.1166
LRRC46 leucine rich repeat containing 46 3.1166
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.1166
AKNAD1 AKNA domain containing 1 3.1166
C9ORF64 chromosome 9 open reading frame 64 3.1166
BTNL2 butyrophilin-like 2 3.1166
TNR tenascin R 3.1166
CST1 cystatin SN 3.1166
CST5 cystatin D 3.1166
APOC4 apolipoprotein C-IV 3.1166
EDN3 endothelin 3 3.1166
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.1166
MRGPRE MAS-related GPR, member E 3.1166
CLEC4C C-type lectin domain family 4, member C 3.1166
NIM1K NIM1 serine/threonine protein kinase 3.1166
TEX12 testis expressed 12 3.1166
PRSS55 protease, serine, 55 3.1166
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.1166
GRAP2 GRB2-related adaptor protein 2 3.1166
RNF148 ring finger protein 148 3.1166
ANXA8 annexin A8 3.1166
OR8J1 olfactory receptor, family 8, subfamily J, member 1 3.1166
WNT2 wingless-type MMTV integration site family member 2 3.1166
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.1166
HKDC1 hexokinase domain containing 1 3.1166
CLEC18B C-type lectin domain family 18, member B 3.1166
PASD1 PAS domain containing 1 3.1166
IRX1 iroquois homeobox 1 3.1166
CNGB1 cyclic nucleotide gated channel beta 1 3.1166
FXYD4 FXYD domain containing ion transport regulator 4 3.1166
C22ORF31 chromosome 22 open reading frame 31 3.1166
ZNF831 zinc finger protein 831 3.1166
GPR150 G protein-coupled receptor 150 3.1166
LRRC74B leucine rich repeat containing 74B 3.1166
TBC1D26 TBC1 domain family, member 26 3.1166
PRR15L proline rich 15-like 3.1166
FAM25A family with sequence similarity 25, member A 3.1166
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.1166
CDH22 cadherin 22, type 2 3.1166
CLEC1A C-type lectin domain family 1, member A 3.1166
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.1166
NKX6-1 NK6 homeobox 1 3.1166
SLITRK2 SLIT and NTRK-like family, member 2 3.1166
EFCC1 EF-hand and coiled-coil domain containing 1 3.1166
SCN7A sodium channel, voltage gated, type VII alpha subunit 3.03105
NPSR1 neuropeptide S receptor 1 3.017
PYDC1 PYD (pyrin domain) containing 1 3.017
DCHS2 dachsous cadherin-related 2 3.017
TBC1D31 TBC1 domain family, member 31 2.99891
CCDC180 coiled-coil domain containing 180 2.89854
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.84888
ZNF324B zinc finger protein 324B 2.84888
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.81068
NLGN1 neuroligin 1 2.77843
ZNF70 zinc finger protein 70 2.76664
CLIP2 CAP-GLY domain containing linker protein 2 2.6628
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.63466
RP9 retinitis pigmentosa 9 (autosomal dominant) 2.63466
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.58292
PKLR pyruvate kinase, liver and RBC 2.55271
ORM2 orosomucoid 2 2.54228
SART1 squamous cell carcinoma antigen recognized by T cells 2.53307
CBX2 chromobox homolog 2 2.524
RYR2 ryanodine receptor 2 (cardiac) 2.47212
RIOX1 ribosomal oxygenase 1 2.44596
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 2.44031
CEP44 centrosomal protein 44kDa 2.40218
BTBD19 BTB (POZ) domain containing 19 2.3941
SEPTIN11 septin 11 2.3941
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.3941
EFHD1 EF-hand domain family, member D1 2.38711
FMOD fibromodulin 2.36603
STX3 syntaxin 3 2.36603
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 2.36603
KANSL1L KAT8 regulatory NSL complex subunit 1-like 2.33304
NOA1 nitric oxide associated 1 2.33073
BCAN brevican 2.33073
WDR74 WD repeat domain 74 2.3019
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) 2.29703
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.2856
PORCN porcupine homolog (Drosophila) 2.26588
TMEM38B transmembrane protein 38B 2.26225
SCN9A sodium channel, voltage gated, type IX alpha subunit 2.26123
LRRC4C leucine rich repeat containing 4C 2.25453
PNLIPRP2 pancreatic lipase-related protein 2 2.24904
FXYD6 FXYD domain containing ion transport regulator 6 2.24628
MEF2D myocyte enhancer factor 2D 2.2368
MTNR1A melatonin receptor 1A 2.22921
EML1 echinoderm microtubule associated protein like 1 2.22506
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 2.20936
GPC1 glypican 1 2.1993
KLHL18 kelch-like family member 18 2.1993
NRK Nik related kinase 2.19671
FRY furry homolog (Drosophila) 2.19648
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.16018
SOX10 SRY (sex determining region Y)-box 10 2.15262
PRKCA protein kinase C, alpha 2.14938
BRAT1 BRCA1-associated ATM activator 1 2.14718
WNK3 WNK lysine deficient protein kinase 3 2.13459
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2.12125
FCHO1 FCH domain only 1 2.11934
MRPS9 mitochondrial ribosomal protein S9 2.11518
CEP72 centrosomal protein 72kDa 2.09272
P3H3 prolyl 3-hydroxylase 3 2.07264
IGSF6 immunoglobulin superfamily, member 6 2.06889
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.06889
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.06889
MAPK15 mitogen-activated protein kinase 15 2.06889
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 2.06058
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 2.06058
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 2.04927
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2.0381
TSPYL2 TSPY-like 2 2.03589
GMPPA GDP-mannose pyrophosphorylase A 2.03573
BAALC brain and acute leukemia, cytoplasmic 2.0142
ZYG11A zyg-11 family member A, cell cycle regulator 2.00407
ATE1 arginyltransferase 1 2.00406

decreased expression

Symbol Name Standardized Value
WLS wntless Wnt ligand secretion mediator -3.1166
CFAP99 cilia and flagella associated protein 99 -3.1166
PARP15 poly (ADP-ribose) polymerase family, member 15 -3.1166
SYTL4 synaptotagmin-like 4 -3.1166
KIF1C-AS1 KIF1C antisense RNA 1 -3.1166
VWC2 von Willebrand factor C domain containing 2 -3.1166
CD48 CD48 molecule -3.1166
CATSPERD catsper channel auxiliary subunit delta -3.1166
KPNA7 karyopherin alpha 7 (importin alpha 8) -3.1166
NBPF8 neuroblastoma breakpoint family, member 8 -3.1166
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -3.1166
IL15RA interleukin 15 receptor, alpha -3.1166
RBP4 retinol binding protein 4, plasma -3.1166
HORMAD2 HORMA domain containing 2 -3.1166
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -3.1166
NXPH3 neurexophilin 3 -3.1166
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -3.1166
TBX22 T-box 22 -3.1166
MPL MPL proto-oncogene, thrombopoietin receptor -3.1166
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -3.1166
PRSS22 protease, serine, 22 -3.1166
CYSRT1 cysteine-rich tail protein 1 -3.1166
SCRG1 stimulator of chondrogenesis 1 -3.1166
OOSP1 oocyte secreted protein 1, pseudogene -3.1166
MYBBP1A MYB binding protein (P160) 1a -3.1166
SAMD5 sterile alpha motif domain containing 5 -3.1166
CHIT1 chitinase 1 (chitotriosidase) -3.1166
LDB3 LIM domain binding 3 -3.1166
VSIR V-set immunoregulatory receptor -3.1166
VWF von Willebrand factor -3.1166
PRSS33 protease, serine, 33 -3.1166
IDI2 isopentenyl-diphosphate delta isomerase 2 -3.1166
MYOCOS myocilin opposite strand -3.1166
TMEM272 transmembrane protein 272 -3.1166
RAB40B RAB40B, member RAS oncogene family -3.1166
TMEM130 transmembrane protein 130 -3.1166
FAM107A family with sequence similarity 107, member A -3.1166
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 -3.1166
ARR3 arrestin 3, retinal (X-arrestin) -3.1166
TMEM204 transmembrane protein 204 -3.1166
ACKR4 atypical chemokine receptor 4 -3.02589
TRAPPC6B trafficking protein particle complex 6B -3.02589
UBQLN2 ubiquilin 2 -3.00711
RTL8C retrotransposon Gag like 8C -2.88091
HCFC2 host cell factor C2 -2.81251
ZEB1 zinc finger E-box binding homeobox 1 -2.79886
NTF4 neurotrophin 4 -2.79886
HAPSTR1 HUWE1 associated protein modifying stress responses -2.77123
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -2.68255
RPP30 ribonuclease P/MRP 30kDa subunit -2.67732
SLC39A13 solute carrier family 39 (zinc transporter), member 13 -2.67586
ZNF583 zinc finger protein 583 -2.65799
IRF9 interferon regulatory factor 9 -2.54228
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.54228
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.51797
SSUH2 ssu-2 homolog (C. elegans) -2.51797
ZNF597 zinc finger protein 597 -2.51797
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.51797
CCDC127 coiled-coil domain containing 127 -2.48177
VASN vasorin -2.48177
ATCAY ataxia, cerebellar, Cayman type -2.47545
PBX2 pre-B-cell leukemia homeobox 2 -2.47531
ZC3H6 zinc finger CCCH-type containing 6 -2.45175
TMEM223 transmembrane protein 223 -2.44992
ZNF527 zinc finger protein 527 -2.39206
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.38711
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.38545
GRB2 growth factor receptor-bound protein 2 -2.33874
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.33073
TMEM151B transmembrane protein 151B -2.31367
PEX14 peroxisomal biogenesis factor 14 -2.3019
BCL9L B-cell CLL/lymphoma 9-like -2.30168
ZBED11 zinc finger BED-type containing 11 -2.26593
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.26515
PABPC1L poly(A) binding protein, cytoplasmic 1-like -2.2635
STOML1 stomatin (EPB72)-like 1 -2.26123
CFAP210 cilia and flagella associated protein 210 -2.26123
AFF4 AF4/FMR2 family, member 4 -2.25817
MARCHF7 membrane associated ring-CH-type finger 7 -2.24628
CALY calcyon neuron-specific vesicular protein -2.20936
JHY junctional cadherin complex regulator -2.20936
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.20936
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.1993
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 -2.18631
RNASEH2B ribonuclease H2, subunit B -2.17049
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -2.16018
VARS1 valyl-tRNA synthetase 1 -2.15262
C2CD2L C2CD2-like -2.14938
PDZD9 PDZ domain containing 9 -2.12125
HSPB2 heat shock 27kDa protein 2 -2.12125
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.12125
YBX1 Y box binding protein 1 -2.11644
HMCN1 hemicentin 1 -2.11518
PUM3 pumilio RNA binding family member 3 -2.11518
CDC25A cell division cycle 25A -2.11518
ZBTB20 zinc finger and BTB domain containing 20 -2.09734
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.05838
LIPG lipase, endothelial -2.05546
CATSPERB catsper channel auxiliary subunit beta -2.04277
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -2.038
LNP1 leukemia NUP98 fusion partner 1 -2.03589
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -2.02084
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.00982
SPATC1L spermatogenesis and centriole associated 1-like -2.00406
VSTM4 V-set and transmembrane domain containing 4 -2.00406