FOXO1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description forkhead box O1|This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2308)
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Genes

362 genes differentially expressed following the FOXO1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SELPLG selectin P ligand 3.18441
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.18441
GLYAT glycine-N-acyltransferase 3.18441
HORMAD1 HORMA domain containing 1 3.18441
APLN apelin 3.18441
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.18441
PAX9 paired box 9 3.18441
PAX3 paired box 3 3.18441
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.18441
APOA2 apolipoprotein A-II 3.18441
GPR151 G protein-coupled receptor 151 3.18441
PKP1 plakophilin 1 3.18441
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.18441
CARD18 caspase recruitment domain family, member 18 3.18441
XAF1 XIAP associated factor 1 3.18441
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.18441
CD14 CD14 molecule 3.18441
IL22RA1 interleukin 22 receptor, alpha 1 3.18441
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.18441
MGAM2 maltase-glucoamylase 2 (putative) 3.18441
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.18441
OLFM4 olfactomedin 4 3.18441
PBOV1 prostate and breast cancer overexpressed 1 3.18441
PECAM1 platelet/endothelial cell adhesion molecule 1 3.18441
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 3.18441
HIC1 hypermethylated in cancer 1 3.18441
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 3.18441
TDO2 tryptophan 2,3-dioxygenase 3.18441
PMCH pro-melanin-concentrating hormone 3.18441
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.18441
ERAP2 endoplasmic reticulum aminopeptidase 2 3.18441
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.18441
WFDC13 WAP four-disulfide core domain 13 3.18441
MYO16 myosin XVI 3.18441
NPIPA8 nuclear pore complex interacting protein family, member A8 3.18441
SP7 Sp7 transcription factor 3.18441
RFPL3 ret finger protein-like 3 3.18441
C3ORF22 chromosome 3 open reading frame 22 3.18441
DEFB124 defensin, beta 124 3.18441
TMEM217 transmembrane protein 217 3.18441
OR51L1 olfactory receptor, family 51, subfamily L, member 1 3.18441
COX8C cytochrome c oxidase subunit VIIIC 3.18441
CELA1 chymotrypsin-like elastase family, member 1 3.18441
OC90 otoconin 90 3.18441
ANKRD30A ankyrin repeat domain 30A 3.18441
CATSPERH catsper channel auxiliary subunit eta 3.18441
GBP1 guanylate binding protein 1, interferon-inducible 3.18441
ROPN1L rhophilin associated tail protein 1-like 3.18441
VGLL2 vestigial-like family member 2 3.18441
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.18441
IQCF1 IQ motif containing F1 3.18441
SRPK3 SRSF protein kinase 3 3.18441
TTR transthyretin 3.18441
RNF183 ring finger protein 183 3.18441
HNF1A HNF1 homeobox A 3.18441
HTD2 hydroxyacyl-thioester dehydratase type 2 3.18441
LORICRIN loricrin cornified envelope precursor protein 3.18441
SPATA31F3 SPATA31 subfamily F member 3 3.18441
CIMIP2A ciliary microtubule inner protein 2A 3.18441
C8ORF90 chromosome 8 open reading frame 90 3.18441
TMA7B translation machinery associated 7 homolog B 3.18441
C20ORF204 chromosome 20 open reading frame 204 3.18441
H3-7 H3.7 histone (putative) 3.18441
STPG3 sperm-tail PG-rich repeat containing 3 3.18441
KASH5 KASH domain containing 5 3.18441
CCDC198 coiled-coil domain containing 198 3.18441
DLK2 delta-like 2 homolog (Drosophila) 3.18441
ZAR1L zygote arrest 1-like 3.18441
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.18441
ITK IL2-inducible T-cell kinase 3.18441
PTPRC protein tyrosine phosphatase, receptor type, C 3.18441
IL12RB1 interleukin 12 receptor, beta 1 3.18441
IZUMO4 IZUMO family member 4 3.18441
HHEX hematopoietically expressed homeobox 3.18441
CD300E CD300e molecule 3.18441
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.18441
SCARA5 scavenger receptor class A, member 5 3.18441
SLC22A10 solute carrier family 22, member 10 3.18441
TSGA10IP testis specific, 10 interacting protein 3.18441
CHRD chordin 3.18441
S100P S100 calcium binding protein P 3.18441
MIP major intrinsic protein of lens fiber 3.18441
GZMM granzyme M (lymphocyte met-ase 1) 3.18441
GDF10 growth differentiation factor 10 3.18441
NHLRC4 NHL repeat containing 4 3.18441
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.18441
CD79A CD79a molecule, immunoglobulin-associated alpha 3.18441
IL31RA interleukin 31 receptor A 3.18441
ESM1 endothelial cell-specific molecule 1 3.18441
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.18441
GHRH growth hormone releasing hormone 3.18441
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.18441
PYHIN1 pyrin and HIN domain family, member 1 3.18441
SKAP1 src kinase associated phosphoprotein 1 3.18441
GSTA1 glutathione S-transferase alpha 1 3.18441
SLFN12L schlafen family member 12-like 3.18441
C8ORF89 chromosome 8 open reading frame 89 3.18441
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.18441
PENK proenkephalin 3.18441
OR4D10 olfactory receptor, family 4, subfamily D, member 10 3.18441
PRR15L proline rich 15-like 3.18441
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.18441
FAM25A family with sequence similarity 25, member A 3.18441
MEFV Mediterranean fever 3.18441
MOBP myelin-associated oligodendrocyte basic protein 3.18441
DRD2 dopamine receptor D2 3.18441
FCRLB Fc receptor-like B 3.18441
CABP7 calcium binding protein 7 3.18441
NOX1 NADPH oxidase 1 3.18441
C20ORF144 chromosome 20 open reading frame 144 3.18441
ASTL astacin-like metallo-endopeptidase (M12 family) 3.18441
CTAGE9 CTAGE family, member 9 3.18441
CXCR5 chemokine (C-X-C motif) receptor 5 3.18441
NLRP14 NLR family, pyrin domain containing 14 3.18441
AQP7 aquaporin 7 3.18441
HCRT hypocretin (orexin) neuropeptide precursor 3.18441
POF1B premature ovarian failure, 1B 3.18441
AICDA activation-induced cytidine deaminase 3.18441
TTC16 tetratricopeptide repeat domain 16 3.18441
LRRC46 leucine rich repeat containing 46 3.18441
LRCOL1 leucine rich colipase-like 1 3.18441
C11ORF16 chromosome 11 open reading frame 16 3.18441
NYX nyctalopin 3.18441
AQP1 aquaporin 1 (Colton blood group) 3.18441
KRTAP8-1 keratin associated protein 8-1 3.18441
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.18441
TAS2R43 taste receptor, type 2, member 43 3.18441
CCL22 chemokine (C-C motif) ligand 22 3.18441
ANGPTL5 angiopoietin-like 5 3.18441
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.18441
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.18441
GJC2 gap junction protein, gamma 2, 47kDa 3.18441
TTC24 tetratricopeptide repeat domain 24 3.18441
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.18441
DSC1 desmocollin 1 3.18441
IL25 interleukin 25 3.18441
HELT helt bHLH transcription factor 3.18441
CCNO cyclin O 3.18441
RTN4RL1 reticulon 4 receptor-like 1 3.18441
CFI complement factor I 3.18441
POU4F3 POU class 4 homeobox 3 3.18441
BIN2 bridging integrator 2 3.18441
NLRP11 NLR family, pyrin domain containing 11 3.18441
HRCT1 histidine rich carboxyl terminus 1 3.18441
LMOD2 leiomodin 2 (cardiac) 3.18441
BPIFC BPI fold containing family C 3.18441
PADI1 peptidyl arginine deiminase, type I 3.18441
AKNAD1 AKNA domain containing 1 3.14897
MUC19 mucin 19, oligomeric 3.14897
DYNLT1 dynein, light chain, Tctex-type 1 2.97711
ZNF337 zinc finger protein 337 2.96881
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.96881
SEPTIN11 septin 11 2.96492
TERF2IP telomeric repeat binding factor 2, interacting protein 2.92962
HM13 histocompatibility (minor) 13 2.90479
PARP14 poly (ADP-ribose) polymerase family, member 14 2.86814
ARHGAP27 Rho GTPase activating protein 27 2.81861
DRG1 developmentally regulated GTP binding protein 1 2.79248
CBX3 chromobox homolog 3 2.71877
SUMO2 small ubiquitin-like modifier 2 2.69599
BTN1A1 butyrophilin, subfamily 1, member A1 2.68777
RGS7BP regulator of G-protein signaling 7 binding protein 2.68137
LDHB lactate dehydrogenase B 2.65596
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.58916
CDV3 CDV3 homolog (mouse) 2.50982
MORN4 MORN repeat containing 4 2.45551
C10ORF90 chromosome 10 open reading frame 90 2.44455
WNT4 wingless-type MMTV integration site family, member 4 2.44455
C8ORF48 chromosome 8 open reading frame 48 2.44455
ASCL2 achaete-scute family bHLH transcription factor 2 2.44455
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.43222
NUP214 nucleoporin 214kDa 2.42491
GRHL3 grainyhead-like 3 (Drosophila) 2.41577
PCDHGA12 protocadherin gamma subfamily A, 12 2.4155
GJB3 gap junction protein, beta 3, 31kDa 2.4155
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.4155
SP100 SP100 nuclear antigen 2.4155
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 2.4041
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.40387
GDNF glial cell derived neurotrophic factor 2.39956
KISS1 KiSS-1 metastasis-suppressor 2.39512
SLC39A13 solute carrier family 39 (zinc transporter), member 13 2.38778
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.35174
HAPLN2 hyaluronan and proteoglycan link protein 2 2.35174
CSAG3 CSAG family, member 3 2.35174
USP3 ubiquitin specific peptidase 3 2.3463
LTA4H leukotriene A4 hydrolase 2.30346
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 2.28942
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 2.28942
CLCN5 chloride channel, voltage-sensitive 5 2.28915
WRNIP1 Werner helicase interacting protein 1 2.27785
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 2.27529
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.27032
CFAP96 cilia and flagella associated protein 96 2.23699
ZNF235 zinc finger protein 235 2.23677
ZFC3H1 zinc finger, C3H1-type containing 2.22787
STEAP2 STEAP family member 2, metalloreductase 2.22592
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 2.21842
CENPO centromere protein O 2.18845
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.18244
HHIP hedgehog interacting protein 2.17229
MIS18BP1 MIS18 binding protein 1 2.14781
HNRNPK heterogeneous nuclear ribonucleoprotein K 2.13967
EPHA4 EPH receptor A4 2.13961
FAM171B family with sequence similarity 171, member B 2.13764
ASXL2 additional sex combs like transcriptional regulator 2 2.1321
PTCHD1 patched domain containing 1 2.13044
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.13044
FBXW4 F-box and WD repeat domain containing 4 2.12977
ZNF814 zinc finger protein 814 2.11798
PKN2 protein kinase N2 2.1149
QPRT quinolinate phosphoribosyltransferase 2.10983
MTFR1L mitochondrial fission regulator 1-like 2.10305
MORN3 MORN repeat containing 3 2.10199
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.10084
WDR24 WD repeat domain 24 2.09064
FRMD1 FERM domain containing 1 2.08582
CEP44 centrosomal protein 44kDa 2.08582
EGLN1 egl-9 family hypoxia-inducible factor 1 2.08422
KIF1A kinesin family member 1A 2.07402
ELF1 E74-like factor 1 (ets domain transcription factor) 2.07402
WDR45 WD repeat domain 45 2.0736
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.0606
WIPF3 WAS/WASL interacting protein family, member 3 2.05013
OMD osteomodulin 2.04188
PNPO pyridoxamine 5'-phosphate oxidase 2.04147
TRIM22 tripartite motif containing 22 2.03354
AKAP12 A kinase (PRKA) anchor protein 12 2.03148
DUSP3 dual specificity phosphatase 3 2.03135
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.0175
ATF1 activating transcription factor 1 2.00159

decreased expression

Symbol Name Standardized Value
TF transferrin -3.18441
FOXO1 forkhead box O1 -3.18441
PAQR6 progestin and adipoQ receptor family member VI -3.18441
SLC16A11 solute carrier family 16, member 11 -3.18441
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -3.18441
FGF20 fibroblast growth factor 20 -3.18441
SMIM29 small integral membrane protein 29 -3.18441
RBM41 RNA binding motif protein 41 -3.12933
RSPRY1 ring finger and SPRY domain containing 1 -3.06045
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 -2.96881
BTC betacellulin -2.96881
MRC1 mannose receptor, C type 1 -2.96881
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.96881
NWD2 NACHT and WD repeat domain containing 2 -2.96881
VPREB3 pre-B lymphocyte 3 -2.96881
VWC2L von Willebrand factor C domain containing protein 2-like -2.96881
TRAM1L1 translocation associated membrane protein 1-like 1 -2.96881
CD8A CD8a molecule -2.96881
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.96881
FZD1 frizzled class receptor 1 -2.96881
SPMAP2L sperm microtubule associated protein 2 like -2.96881
C8ORF74 chromosome 8 open reading frame 74 -2.96881
REN renin -2.96881
ADAD2 adenosine deaminase domain containing 2 -2.96881
XKRX XK, Kell blood group complex subunit-related, X-linked -2.96881
MOV10L1 Mov10 RISC complex RNA helicase like 1 -2.96881
OVOL3 ovo-like zinc finger 3 -2.96881
CALCA calcitonin-related polypeptide alpha -2.96881
IRF5 interferon regulatory factor 5 -2.96881
HBA2 hemoglobin, alpha 2 -2.96881
TMPRSS11F transmembrane protease, serine 11F -2.96881
CFAP74 cilia and flagella associated protein 74 -2.96881
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.96881
EFL1 elongation factor like GTPase 1 -2.96881
CCN3 cellular communication network factor 3 -2.96881
CNTNAP4 contactin associated protein-like 4 -2.96881
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.96881
CTSE cathepsin E -2.96881
RBBP8NL RBBP8 N-terminal like -2.96881
CDC20B cell division cycle 20B -2.96881
PIH1D2 PIH1 domain containing 2 -2.96881
CFAP126 cilia and flagella associated protein 126 -2.96881
CLEC1A C-type lectin domain family 1, member A -2.96881
RTBDN retbindin -2.96881
LCNL1 lipocalin-like 1 -2.96881
CEP120 centrosomal protein 120kDa -2.96881
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.96881
GPR149 G protein-coupled receptor 149 -2.96881
PCSK5 proprotein convertase subtilisin/kexin type 5 -2.96026
ABHD2 abhydrolase domain containing 2 -2.91761
CSPG4 chondroitin sulfate proteoglycan 4 -2.84944
KRTDAP keratinocyte differentiation-associated protein -2.83949
RGS22 regulator of G-protein signaling 22 -2.83949
ZNF660-ZNF197 ZNF660-ZNF197 readthrough -2.75628
CEP83 centrosomal protein 83kDa -2.71468
TENT2 terminal nucleotidyltransferase 2 -2.71468
VCPKMT valosin containing protein lysine (K) methyltransferase -2.71468
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -2.71035
AAGAB alpha- and gamma-adaptin binding protein -2.59222
NEK10 NIMA-related kinase 10 -2.58624
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -2.58065
KMT5C lysine methyltransferase 5C -2.57326
HLA-DRA major histocompatibility complex, class II, DR alpha -2.57056
FOXP4 forkhead box P4 -2.55481
MYOZ3 myozenin 3 -2.51981
PRKD1 protein kinase D1 -2.4988
SGK3 serum/glucocorticoid regulated kinase family, member 3 -2.49108
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -2.49108
OSBPL7 oxysterol binding protein-like 7 -2.49108
SBSPON somatomedin B and thrombospondin, type 1 domain containing -2.49108
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 -2.45313
TM9SF4 transmembrane 9 superfamily protein member 4 -2.42602
WWC3 WWC family member 3 -2.42586
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 -2.42536
THOC1 THO complex 1 -2.41813
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.4155
SH2B2 SH2B adaptor protein 2 -2.39529
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -2.39512
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.39158
ARID4B AT rich interactive domain 4B (RBP1-like) -2.37063
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.3475
FAM120A family with sequence similarity 120A -2.3463
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.32138
TMOD1 tropomodulin 1 -2.31293
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -2.31293
AUH AU RNA binding protein/enoyl-CoA hydratase -2.30717
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.30346
TCEAL3 transcription elongation factor A (SII)-like 3 -2.30058
MORC2 MORC family CW-type zinc finger 2 -2.29975
SV2B synaptic vesicle glycoprotein 2B -2.28942
TFF3 trefoil factor 3 (intestinal) -2.28942
BBS2 Bardet-Biedl syndrome 2 -2.27529
LYRM2 LYR motif containing 2 -2.2497
RAB20 RAB20, member RAS oncogene family -2.24332
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.24332
NGEF neuronal guanine nucleotide exchange factor -2.23975
WNT3A wingless-type MMTV integration site family, member 3A -2.23975
ZMAT4 zinc finger, matrin-type 4 -2.23893
SLC44A1 solute carrier family 44 (choline transporter), member 1 -2.22787
TMEM39B transmembrane protein 39B -2.22787
RIOK1 RIO kinase 1 -2.21856
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -2.20884
JOSD2 Josephin domain containing 2 -2.20112
ZIM3 zinc finger, imprinted 3 -2.1923
DEK DEK proto-oncogene -2.17312
LRRTM3 leucine rich repeat transmembrane neuronal 3 -2.17229
SUSD4 sushi domain containing 4 -2.16451
MTTP microsomal triglyceride transfer protein -2.15785
ABRAXAS1 abraxas 1, BRCA1 A complex subunit -2.14586
TMEM43 transmembrane protein 43 -2.13961
GET3 guided entry of tail-anchored proteins factor 3, ATPase -2.13044
PRDM15 PR domain containing 15 -2.13044
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.13044
KIF15 kinesin family member 15 -2.12384
ANKRD7 ankyrin repeat domain 7 -2.11013
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -2.10981
CHRDL1 chordin-like 1 -2.10852
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.0974
NELFA negative elongation factor complex member A -2.09558
STRIT1 small transmembrane regulator of ion transport 1 -2.09403
NRIP1 nuclear receptor interacting protein 1 -2.09064
CLBA1 clathrin binding box of aftiphilin containing 1 -2.08582
MACROD2 MACRO domain containing 2 -2.07221
FAM227B family with sequence similarity 227, member B -2.05013
XRRA1 X-ray radiation resistance associated 1 -2.04147
KDM6A lysine (K)-specific demethylase 6A -2.03555
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 -2.03354
ACSS2 acyl-CoA synthetase short-chain family member 2 -2.03102
SVBP small vasohibin binding protein -2.02152
ZNF277 zinc finger protein 277 -2.0175
ZFX zinc finger protein, X-linked -2.01372