FOXO3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description forkhead box O3|This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2309)
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Genes

353 genes differentially expressed following the FOXO3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.5828
CSAG3 CSAG family, member 3 3.5828
GUCY2F guanylate cyclase 2F, retinal 3.5828
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.5828
DEFB134 defensin, beta 134 3.5828
PTGDR prostaglandin D2 receptor (DP) 3.5828
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.5828
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 3.5828
MAJIN membrane anchored junction protein 3.5828
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.5828
CRYBB2 crystallin, beta B2 3.5828
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.5828
SLC16A6 solute carrier family 16, member 6 3.5828
LY6H lymphocyte antigen 6 complex, locus H 3.5828
CAPN14 calpain 14 3.5828
IGSF22 immunoglobulin superfamily, member 22 3.5828
MMP20 matrix metallopeptidase 20 3.5828
RS1 retinoschisin 1 3.5828
HABP2 hyaluronan binding protein 2 3.5828
C1ORF87 chromosome 1 open reading frame 87 3.5828
ADAT3 adenosine deaminase, tRNA-specific 3 3.5828
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.5828
HMX1 H6 family homeobox 1 3.46169
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.46169
ADAD2 adenosine deaminase domain containing 2 3.46169
CRIP1 cysteine-rich protein 1 (intestinal) 3.46169
PXDC1 PX domain containing 1 3.46169
GYS2 glycogen synthase 2 (liver) 3.46169
PTH parathyroid hormone 3.46169
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.46169
CAPN8 calpain 8 3.46169
CEP19 centrosomal protein 19kDa 3.46169
SLC23A3 solute carrier family 23, member 3 3.46169
TNIP3 TNFAIP3 interacting protein 3 3.46169
RLN3 relaxin 3 3.46169
CPB1 carboxypeptidase B1 (tissue) 3.46169
CLEC12A C-type lectin domain family 12, member A 3.46169
USP50 ubiquitin specific peptidase 50 3.46169
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.46169
ZG16B zymogen granule protein 16B 3.46169
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.46169
OTUD6A OTU deubiquitinase 6A 3.46169
SLC9C2 solute carrier family 9, member C2 (putative) 3.46169
TRPC5OS TRPC5 opposite strand 3.46169
C12ORF71 chromosome 12 open reading frame 71 3.46169
PECAM1 platelet/endothelial cell adhesion molecule 1 3.46169
BIRC7 baculoviral IAP repeat containing 7 3.46169
C19ORF67 chromosome 19 open reading frame 67 3.46169
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 3.46169
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.46169
MYO7B myosin VIIB 3.46169
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.46169
LY86 lymphocyte antigen 86 3.46169
ELF4 E74-like factor 4 (ets domain transcription factor) 3.46169
FOXQ1 forkhead box Q1 3.46169
GJA8 gap junction protein, alpha 8, 50kDa 3.46169
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.46169
SLC22A25 solute carrier family 22, member 25 3.46169
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.46169
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.46169
CBLN3 cerebellin 3 precursor 3.46169
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.46169
CALCA calcitonin-related polypeptide alpha 3.46169
RAB44 RAB44, member RAS oncogene family 3.46169
NKX2-2 NK2 homeobox 2 3.46169
MTNR1B melatonin receptor 1B 3.46169
CXCL16 chemokine (C-X-C motif) ligand 16 3.46169
TIFAB TRAF-interacting protein with forkhead-associated domain, family member B 3.46169
HAPLN2 hyaluronan and proteoglycan link protein 2 3.46169
SKOR2 SKI family transcriptional corepressor 2 3.46169
GJA10 gap junction protein, alpha 10, 62kDa 3.46169
DUSP10 dual specificity phosphatase 10 3.46169
CCR3 chemokine (C-C motif) receptor 3 3.46169
MILR1 mast cell immunoglobulin-like receptor 1 3.46169
TNNI1 troponin I type 1 (skeletal, slow) 3.46169
PON1 paraoxonase 1 3.46169
TLR4 toll-like receptor 4 3.46169
OR51A7 olfactory receptor, family 51, subfamily A, member 7 3.46169
CELF3 CUGBP, Elav-like family member 3 3.46169
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.46169
MAGEB16 melanoma antigen family B16 3.46169
WDR87 WD repeat domain 87 3.46169
IL6 interleukin 6 3.46169
MAP3K7CL MAP3K7 C-terminal like 3.46169
DMBX1 diencephalon/mesencephalon homeobox 1 3.46169
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.46169
CCDC87 coiled-coil domain containing 87 3.46169
ITGA8 integrin, alpha 8 3.46169
ITGB7 integrin, beta 7 3.46169
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3.46169
SAMD7 sterile alpha motif domain containing 7 3.46169
SAMD9 sterile alpha motif domain containing 9 3.46169
CPNE8-AS1 CPNE8 antisense RNA 1 3.46169
LRRK2 leucine-rich repeat kinase 2 3.46169
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.46169
ALOXE3 arachidonate lipoxygenase 3 3.46169
MUCL1 mucin-like 1 3.46169
RANBP3L RAN binding protein 3-like 3.46169
LY6L lymphocyte antigen 6 family member L 3.46169
HOATZ HOATZ cilia and flagella associated protein 3.46169
NIPAL4 NIPA-like domain containing 4 3.46169
NOX1 NADPH oxidase 1 3.46169
OR9A2 olfactory receptor, family 9, subfamily A, member 2 3.46169
OR9A4 olfactory receptor, family 9, subfamily A, member 4 3.46169
FAM240C family with sequence similarity 240 member C 3.46169
SPEGNB SPEG neighbor 3.46169
SIGLEC15 sialic acid binding Ig-like lectin 15 3.46169
PHOX2A paired-like homeobox 2a 3.46169
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.46169
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.46169
TM4SF19 transmembrane 4 L six family member 19 3.46169
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.46169
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.46169
MYADML2 myeloid-associated differentiation marker-like 2 3.46169
NKX6-1 NK6 homeobox 1 3.46169
SPMIP10 sperm microtubule inner protein 10 3.46169
LGALS12 lectin, galactoside-binding, soluble, 12 3.46169
CA5A carbonic anhydrase VA, mitochondrial 3.46169
ADGRD1 adhesion G protein-coupled receptor D1 3.46169
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.46169
DRC5 dynein regulatory complex subunit 5 3.46169
OR56B2 olfactory receptor family 56 subfamily B member 2 3.46169
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.46169
UBQLNL ubiquilin-like 3.46169
NOG noggin 3.46169
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.46169
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.46169
SELE selectin E 3.46169
ADRA1B adrenoceptor alpha 1B 3.46169
NECTIN4 nectin cell adhesion molecule 4 3.46169
CIB4 calcium and integrin binding family member 4 3.46169
GRAPL GRB2-related adaptor protein-like 3.46169
PXT1 peroxisomal, testis specific 1 3.46169
SLITRK1 SLIT and NTRK-like family, member 1 3.46169
ERVV-1 endogenous retrovirus group V, member 1 3.46169
MMP12 matrix metallopeptidase 12 3.46169
VPREB3 pre-B lymphocyte 3 3.46169
ASCL5 achaete-scute family bHLH transcription factor 5 3.46169
NLRP5 NLR family, pyrin domain containing 5 3.46169
ZNF396 zinc finger protein 396 3.46169
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.46169
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.46169
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.46169
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.46169
PAGE2B P antigen family, member 2B 3.46169
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.46169
FNDC8 fibronectin type III domain containing 8 3.46169
PALMD palmdelphin 3.46169
CATSPERZ catsper channel auxiliary subunit zeta 3.46169
A3GALT2 alpha 1,3-galactosyltransferase 2 3.46169
HAMP hepcidin antimicrobial peptide 3.46169
ZNF132 zinc finger protein 132 3.46169
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.46169
DES desmin 3.46169
PDCD1 programmed cell death 1 3.46169
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.46169
EREG epiregulin 3.46169
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.46169
FZD1 frizzled class receptor 1 3.46169
CAGE1 cancer antigen 1 3.37522
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 3.37522
ETFRF1 electron transfer flavoprotein regulatory factor 1 3.20199
CCDC177 coiled-coil domain containing 177 3.15322
GLO1 glyoxalase I 3.1389
C5ORF58 chromosome 5 open reading frame 58 3.07398
CENATAC centrosomal AT-AC splicing factor 3.06606
CREM cAMP responsive element modulator 3.0172
SQSTM1 sequestosome 1 2.99046
EGFL8 EGF-like-domain, multiple 8 2.94635
SRM spermidine synthase 2.94088
YPEL3 yippee-like 3 (Drosophila) 2.8961
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.88406
NOL6 nucleolar protein 6 (RNA-associated) 2.84347
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.79832
IL17RA interleukin 17 receptor A 2.76709
FAM32A family with sequence similarity 32, member A 2.73782
BAIAP3 BAI1-associated protein 3 2.65184
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.65184
EID2 EP300 interacting inhibitor of differentiation 2 2.58067
RPS4X ribosomal protein S4, X-linked 2.56661
RPL11 ribosomal protein L11 2.51479
TMEM196 transmembrane protein 196 2.51398
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.51398
TUBE1 tubulin, epsilon 1 2.4831
HMGN2 high mobility group nucleosomal binding domain 2 2.483
MAP9 microtubule-associated protein 9 2.46396
ARID4B AT rich interactive domain 4B (RBP1-like) 2.44242
KCTD17 potassium channel tetramerization domain containing 17 2.43021
HABP4 hyaluronan binding protein 4 2.43018
BCL7B B-cell CLL/lymphoma 7B 2.4291
ABHD13 abhydrolase domain containing 13 2.40235
OPRL1 opiate receptor-like 1 2.39397
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.39397
PAPOLB poly(A) polymerase beta (testis specific) 2.39397
ZIC4 Zic family member 4 2.39397
RESF1 retroelement silencing factor 1 2.39397
ATG9B autophagy related 9B 2.39397
CAMSAP1 calmodulin regulated spectrin-associated protein 1 2.39397
CRLF2 cytokine receptor-like factor 2 2.39397
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.39397
FAM186B family with sequence similarity 186, member B 2.39397
GPR34 G protein-coupled receptor 34 2.39397
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.37723
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.37723
SLC25A48 solute carrier family 25, member 48 2.36879
ZBTB9 zinc finger and BTB domain containing 9 2.35705
RNF213 ring finger protein 213 2.35135
ZSCAN12 zinc finger and SCAN domain containing 12 2.33294
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.31399
DCTN3 dynactin 3 (p22) 2.23742
STEAP3 STEAP family member 3, metalloreductase 2.22472
PPP1R3E protein phosphatase 1, regulatory subunit 3E 2.20324
TMEM106A transmembrane protein 106A 2.19339
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.19339
CD99L2 CD99 molecule-like 2 2.18955
ZNF699 zinc finger protein 699 2.1865
DMTF1 cyclin D binding myb-like transcription factor 1 2.17265
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.13913
CCN2 cellular communication network factor 2 2.12685
UNC119 unc-119 homolog (C. elegans) 2.12291
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 2.12104
BAG1 BCL2-associated athanogene 2.11193
SAXO2 stabilizer of axonemal microtubules 2 2.05845
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 2.05701
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.05306
UBR5 ubiquitin protein ligase E3 component n-recognin 5 2.04911
WDR3 WD repeat domain 3 2.04467
TMEM169 transmembrane protein 169 2.03131
MCUR1 mitochondrial calcium uniporter regulator 1 2.0257
TMEM37 transmembrane protein 37 2.02254
PLLP plasmolipin 2.0077
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.0077
RHOBTB1 Rho-related BTB domain containing 1 2.00475

decreased expression

Symbol Name Standardized Value
OTOA otoancorin -3.5828
HSPA1L heat shock 70kDa protein 1-like -3.5828
SLC46A1 solute carrier family 46 (folate transporter), member 1 -3.5828
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -3.5828
WDR72 WD repeat domain 72 -3.5828
ADIRF adipogenesis regulatory factor -3.5828
CLPSL2 colipase-like 2 -3.5828
ACAN aggrecan -3.5828
CLDN18 claudin 18 -3.5828
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -3.5828
HAP1 huntingtin-associated protein 1 -3.5828
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -3.5828
CXXC4 CXXC finger protein 4 -3.514
SLC15A5 solute carrier family 15, member 5 -3.46169
ACOT12 acyl-CoA thioesterase 12 -3.46169
CXCR2 chemokine (C-X-C motif) receptor 2 -3.46169
FAM167B family with sequence similarity 167, member B -3.46169
BRICD5 BRICHOS domain containing 5 -3.46169
RGPD4 RANBP2-like and GRIP domain containing 4 -3.46169
APOH apolipoprotein H (beta-2-glycoprotein I) -3.46169
RASA4B RAS p21 protein activator 4B -3.46169
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -3.46169
BIRC3 baculoviral IAP repeat containing 3 -3.46169
PLIN1 perilipin 1 -3.46169
FCMR Fc fragment of IgM receptor -3.46169
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.46169
SCNN1B sodium channel, non voltage gated 1 beta subunit -3.46169
PDF peptide deformylase (mitochondrial) -3.46169
FBXL22 F-box and leucine-rich repeat protein 22 -3.46169
PCDHA13 protocadherin alpha 13 -3.46169
CHIT1 chitinase 1 (chitotriosidase) -3.46169
MEAF6 MYST/Esa1-associated factor 6 -3.46169
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -3.46169
LOC124902436 talanin -3.46169
PLCD4 phospholipase C, delta 4 -3.46169
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -3.38065
SOCS2 suppressor of cytokine signaling 2 -3.02036
ZNF536 zinc finger protein 536 -2.94772
MCM9 minichromosome maintenance complex component 9 -2.92473
ERBIN erbb2 interacting protein -2.87647
PKP3 plakophilin 3 -2.8044
WNT5A wingless-type MMTV integration site family, member 5A -2.8044
MYH14 myosin, heavy chain 14, non-muscle -2.77827
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.77462
THAP5 THAP domain containing 5 -2.74419
ZNF343 zinc finger protein 343 -2.72351
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 -2.6844
RHOU ras homolog family member U -2.68176
TIGD4 tigger transposable element derived 4 -2.6069
SF3B3 splicing factor 3b, subunit 3, 130kDa -2.59904
FOXP1 forkhead box P1 -2.51851
ZDHHC4 zinc finger, DHHC-type containing 4 -2.4831
ZNF572 zinc finger protein 572 -2.4831
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.47244
ADAM17 ADAM metallopeptidase domain 17 -2.45557
LIME1 Lck interacting transmembrane adaptor 1 -2.44242
SRRD SRR1 domain containing -2.4291
DMRTA1 DMRT-like family A1 -2.40595
KCNIP2 Kv channel interacting protein 2 -2.39397
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.39397
C17ORF114 chromosome 17 open reading frame 114 -2.39397
BTBD18 BTB (POZ) domain containing 18 -2.39397
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -2.39397
ADRA1A adrenoceptor alpha 1A -2.39397
ABLIM3 actin binding LIM protein family, member 3 -2.39397
SGCZ sarcoglycan, zeta -2.39397
MASP2 mannan-binding lectin serine peptidase 2 -2.39397
FOXO3 forkhead box O3 -2.37723
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.36879
SYT15B synaptotagmin 15B -2.36879
IQCJ IQ motif containing J -2.36879
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.36879
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -2.36589
ATRX alpha thalassemia/mental retardation syndrome X-linked -2.36093
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -2.36087
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.36087
CD247 CD247 molecule -2.36087
USP3 ubiquitin specific peptidase 3 -2.35999
VCP valosin containing protein -2.34393
NKD2 naked cuticle homolog 2 (Drosophila) -2.34178
CSPG4 chondroitin sulfate proteoglycan 4 -2.34178
C2ORF80 chromosome 2 open reading frame 80 -2.34178
PRC1 protein regulator of cytokinesis 1 -2.33254
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.33233
ARMCX6 armadillo repeat containing, X-linked 6 -2.33233
PJVK pejvakin -2.33231
C3ORF62 chromosome 3 open reading frame 62 -2.33231
WDR46 WD repeat domain 46 -2.32449
ZBTB34 zinc finger and BTB domain containing 34 -2.31399
MRPS28 mitochondrial ribosomal protein S28 -2.31399
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.27514
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -2.25816
CERS5 ceramide synthase 5 -2.24087
AZIN2 antizyme inhibitor 2 -2.23742
C19ORF38 chromosome 19 open reading frame 38 -2.23742
NUP62 nucleoporin 62kDa -2.20935
STRBP spermatid perinuclear RNA binding protein -2.1975
MIMS2 mitochondrial inner membrane scaffold 2 -2.19339
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.19148
CNTNAP3 contactin associated protein-like 3 -2.18261
GAMT guanidinoacetate N-methyltransferase -2.18069
HYDIN HYDIN, axonemal central pair apparatus protein -2.15152
CHN1 chimerin 1 -2.14131
CHSY1 chondroitin sulfate synthase 1 -2.13067
SCAMP1 secretory carrier membrane protein 1 -2.1297
ANKDD1A ankyrin repeat and death domain containing 1A -2.1193
BCAP31 B-cell receptor-associated protein 31 -2.11462
COL25A1 collagen, type XXV, alpha 1 -2.09157
ACACB acetyl-CoA carboxylase beta -2.07593
DPH6 diphthamine biosynthesis 6 -2.06675
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.06675
TCP10L t-complex 10-like -2.06021
DOCK8 dedicator of cytokinesis 8 -2.05245
NODAL nodal growth differentiation factor -2.04467
CCDC134 coiled-coil domain containing 134 -2.04189
TULP4 tubby like protein 4 -2.04095
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.02254
MTA1 metastasis associated 1 -2.01534
RAVER2 ribonucleoprotein, PTB-binding 2 -2.0077
FAF2 Fas associated factor family member 2 -2.0077