FOXO3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description forkhead box O3|This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2309)
External Link http://www.ncbi.nlm.nih.gov/gene/2309
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Genes

272 interacting proteins for FOXO3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABLIM1 actin binding LIM protein 1
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMPD2 adenosine monophosphate deaminase 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARG1 arginase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATG13 autophagy related 13
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1QBP complement component 1, q subcomponent binding protein
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBR1 carbonyl reductase 1
CCDC6 coiled-coil domain containing 6
CDC25C cell division cycle 25C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CEP250 centrosomal protein 250kDa
CGN cingulin
CHUK conserved helix-loop-helix ubiquitous kinase
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
COPA coatomer protein complex, subunit alpha
CREBBP CREB binding protein
CRTC1 CREB regulated transcription coactivator 1
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CSNK1A1 casein kinase 1, alpha 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCAF7 DDB1 and CUL4 associated factor 7
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1A DENN/MADD domain containing 1A
DENND4A DENN/MADD domain containing 4A
DENND4C DENN/MADD domain containing 4C
DMTN dematin actin binding protein
DOCK11 dedicator of cytokinesis 11
DSC1 desmocollin 1
EDC3 enhancer of mRNA decapping 3
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2IP erbb2 interacting protein
ESR1 estrogen receptor 1
ETFA electron-transfer-flavoprotein, alpha polypeptide
EXO1 exonuclease 1
FAM53C family with sequence similarity 53, member C
FANCD2 Fanconi anemia, complementation group D2
FKBP4 FK506 binding protein 4, 59kDa
FOXG1 forkhead box G1
FOXM1 forkhead box M1
GANAB glucosidase, alpha; neutral AB
GAPVD1 GTPase activating protein and VPS9 domains 1
GBAS glioblastoma amplified sequence
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GRIP1 glutamate receptor interacting protein 1
H2AFX H2A histone family, member X
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HCFC1 host cell factor C1
HCFC2 host cell factor C2
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK1 hexokinase 1
HSPA8 heat shock 70kDa protein 8
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP5F inositol polyphosphate-5-phosphatase F
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KAT2B K(lysine) acetyltransferase 2B
KIAA0355 KIAA0355
KIAA0930 KIAA0930
KIAA1671 KIAA1671
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
KIF23 kinesin family member 23
KIF5B kinesin family member 5B
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KLC3 kinesin light chain 3
KLC4 kinesin light chain 4
KRT77 keratin 77, type II
KSR1 kinase suppressor of ras 1
LARP1 La ribonucleoprotein domain family, member 1
LARS leucyl-tRNA synthetase
LIMA1 LIM domain and actin binding 1
LMO7 LIM domain 7
LONP1 lon peptidase 1, mitochondrial
LRPPRC leucine-rich pentatricopeptide repeat containing
LSR lipolysis stimulated lipoprotein receptor
LUZP1 leucine zipper protein 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MAST2 microtubule associated serine/threonine kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MST1 macrophage stimulating 1
MTA2 metastasis associated 1 family, member 2
MTMR12 myotubularin related protein 12
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH4 myosin, heavy chain 4, skeletal muscle
NADK NAD kinase
NAV1 neuron navigator 1
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NF1 neurofibromin 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NLK nemo-like kinase
NPEPPS aminopeptidase puromycin sensitive
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
OSBPL3 oxysterol binding protein-like 3
PA2G4 proliferation-associated 2G4, 38kDa
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARP1 poly (ADP-ribose) polymerase 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PCNA proliferating cell nuclear antigen
PDZD11 PDZ domain containing 11
PFAS phosphoribosylformylglycinamidine synthase
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHLDB2 pleckstrin homology-like domain, family B, member 2
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKP2 plakophilin 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCI protein kinase C, iota
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PUM1 pumilio RNA-binding family member 1
R3HDM1 R3H domain containing 1
R3HDM2 R3H domain containing 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RAD17 RAD17 homolog (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAN RAN, member RAS oncogene family
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASAL2 RAS protein activator like 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RECQL RecQ helicase-like
REEP1 receptor accessory protein 1
REEP4 receptor accessory protein 4
RICTOR RPTOR independent companion of MTOR, complex 2
RPA1 replication protein A1, 70kDa
RTKN rhotekin
SACK1B scaffolding CK1 anchoring protein B
SAMD4A sterile alpha motif domain containing 4A
SAMD4B sterile alpha motif domain containing 4B
SGK1 serum/glucocorticoid regulated kinase 1
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHKBP1 SH3KBP1 binding protein 1
SHROOM2 shroom family member 2
SHROOM3 shroom family member 3
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIRT3 sirtuin 3
SIRT4 sirtuin 4
SIRT5 sirtuin 5
SIRT6 sirtuin 6
SIRT7 sirtuin 7
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSRP1 structure specific recognition protein 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TARS threonyl-tRNA synthetase
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBC1D22B TBC1 domain family, member 22B
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TIAM1 T-cell lymphoma invasion and metastasis 1
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRIM32 tripartite motif containing 32
TRIP11 thyroid hormone receptor interactor 11
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTC28 tetratricopeptide repeat domain 28
UBA5 ubiquitin-like modifier activating enzyme 5
UBC ubiquitin C
UHRF1BP1L UHRF1 binding protein 1-like
ULK1 unc-51 like autophagy activating kinase 1
USP54 ubiquitin specific peptidase 54
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
VAMP8 vesicle-associated membrane protein 8
VARS valyl-tRNA synthetase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WDR62 WD repeat domain 62
WNK1 WNK lysine deficient protein kinase 1
XPO1 exportin 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2