FOXP2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description forkhead box P2|This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 93986)
Similar Terms
Downloads & Tools

Genes

332 genes differentially expressed following the FOXP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL19A1 collagen, type XIX, alpha 1 4.27553
GPR179 G protein-coupled receptor 179 4.27553
BEAN1 brain expressed, associated with NEDD4, 1 4.27553
CFAP52 cilia and flagella associated protein 52 4.27553
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 4.27553
FBLN5 fibulin 5 4.27553
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 4.27553
FMR1NB fragile X mental retardation 1 neighbor 4.27553
TLR1 toll-like receptor 1 4.27553
CAMK2B calcium/calmodulin-dependent protein kinase II beta 4.27553
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 4.27553
SV2C synaptic vesicle glycoprotein 2C 4.27553
ISM2 isthmin 2 4.27553
SRRM5 serine/arginine repetitive matrix 5 4.27553
PLA2G4D phospholipase A2, group IVD (cytosolic) 4.27553
APOB apolipoprotein B 4.27553
FMO3 flavin containing monooxygenase 3 4.27553
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 4.27553
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 4.27553
SPATA46 spermatogenesis associated 46 4.27553
SEMG1 semenogelin I 4.27553
CPLX1 complexin 1 4.27553
ASB15 ankyrin repeat and SOCS box containing 15 4.26343
UBA7 ubiquitin-like modifier activating enzyme 7 4.26343
IZUMO3 IZUMO family member 3 4.26343
KLRK1 killer cell lectin-like receptor subfamily K, member 1 4.26343
TMEM176B transmembrane protein 176B 4.26343
EPPIN epididymal peptidase inhibitor 4.26343
OCM2 oncomodulin 2 4.26343
NR1H4 nuclear receptor subfamily 1, group H, member 4 4.26343
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 4.26343
PTK6 protein tyrosine kinase 6 4.26343
HLF hepatic leukemia factor 4.26343
WNT8B wingless-type MMTV integration site family, member 8B 4.26343
LONRF3 LON peptidase N-terminal domain and ring finger 3 4.26343
HLX H2.0-like homeobox 4.26343
TMEM225 transmembrane protein 225 4.26343
MUC6 mucin 6, oligomeric mucus/gel-forming 4.26343
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 4.26343
PKP1 plakophilin 1 4.26343
ZNF467 zinc finger protein 467 4.26343
NPSR1 neuropeptide S receptor 1 4.26343
REN renin 4.26343
OLIG1 oligodendrocyte transcription factor 1 4.26343
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 4.26343
SIGLEC9 sialic acid binding Ig-like lectin 9 4.26343
TUBB1 tubulin, beta 1 class VI 4.26343
TUBB8 tubulin, beta 8 class VIII 4.26343
ADAD2 adenosine deaminase domain containing 2 4.26343
PAX9 paired box 9 4.26343
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 4.26343
GIMAP4 GTPase, IMAP family member 4 4.26343
CASP4 caspase 4, apoptosis-related cysteine peptidase 4.26343
DDN dendrin 4.26343
TBX15 T-box 15 4.26343
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 4.26343
TPSD1 tryptase delta 1 4.26343
CA7 carbonic anhydrase VII 4.26343
EPB42 erythrocyte membrane protein band 4.2 4.26343
GIMAP2 GTPase, IMAP family member 2 4.26343
CFHR3 complement factor H-related 3 4.26343
CTXND1 cortexin domain containing 1 4.26343
UNC93A unc-93 homolog A (C. elegans) 4.26343
ROPN1L rhophilin associated tail protein 1-like 4.26343
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 4.26343
TAS2R60 taste receptor, type 2, member 60 4.26343
C2ORF72 chromosome 2 open reading frame 72 4.26343
SCEL sciellin 4.26343
CXCL13 chemokine (C-X-C motif) ligand 13 4.26343
DNAAF1 dynein, axonemal, assembly factor 1 4.26343
TMEM40 transmembrane protein 40 4.26343
SQOR sulfide quinone oxidoreductase 4.26343
HTD2 hydroxyacyl-thioester dehydratase type 2 4.26343
SPAAR small regulatory polypeptide of amino acid response 4.26343
H3-7 H3.7 histone (putative) 4.26343
AKAIN1 A-kinase anchor inhibitor 1 4.26343
SEPTIN12 septin 12 4.26343
MAJIN membrane anchored junction protein 4.26343
TEKTIP1 tektin bundle interacting protein 1 4.26343
MSANTD5 Myb/SANT DNA binding domain containing 5 4.26343
DEPP1 DEPP autophagy regulator 1 4.26343
TCIM transcriptional and immune response regulator 4.26343
XKRX XK, Kell blood group complex subunit-related, X-linked 4.26343
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 4.26343
RNF183 ring finger protein 183 4.26343
PCDHB13 protocadherin beta 13 4.26343
PTPRH protein tyrosine phosphatase, receptor type, H 4.26343
DTHD1 death domain containing 1 4.26343
IL36G interleukin 36, gamma 4.26343
OR2A1 olfactory receptor, family 2, subfamily A, member 1 4.26343
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 4.26343
HHEX hematopoietically expressed homeobox 4.26343
SPDYE6 speedy/RINGO cell cycle regulator family member E6 4.26343
FPR3 formyl peptide receptor 3 4.26343
ZNF280A zinc finger protein 280A 4.26343
VSX2 visual system homeobox 2 4.26343
COX8C cytochrome c oxidase subunit VIIIC 4.26343
PNPLA1 patatin-like phospholipase domain containing 1 4.26343
PLEK2 pleckstrin 2 4.26343
FGFBP2 fibroblast growth factor binding protein 2 4.26343
SBSN suprabasin 4.26343
BMI1 BMI1 proto-oncogene, polycomb ring finger 4.26343
IL6 interleukin 6 4.26343
CATSPER3 cation channel, sperm associated 3 4.26343
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 4.26343
HNF4A hepatocyte nuclear factor 4, alpha 4.26343
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 4.26343
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 4.26343
ARL13A ADP-ribosylation factor-like 13A 4.26343
MAGEB17 melanoma antigen family B17 4.26343
BOLL boule-like RNA-binding protein 4.26343
PTGDS prostaglandin D2 synthase 21kDa (brain) 4.26343
POU3F2 POU class 3 homeobox 2 4.26343
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 4.26343
CRYBA1 crystallin, beta A1 4.26343
PDCD1LG2 programmed cell death 1 ligand 2 4.26343
POTEI POTE ankyrin domain family, member I 4.26343
CDH17 cadherin 17, LI cadherin (liver-intestine) 4.26343
OR56B1 olfactory receptor, family 56, subfamily B, member 1 4.26343
NR5A1 nuclear receptor subfamily 5, group A, member 1 4.26343
RERGL RERG/RAS-like 4.26343
LAMP5 lysosomal-associated membrane protein family, member 5 4.26343
MORC1 MORC family CW-type zinc finger 1 4.26343
CABP7 calcium binding protein 7 4.26343
KLF2 Kruppel-like factor 2 4.26343
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 4.26343
KLF1 Kruppel-like factor 1 (erythroid) 4.26343
TEX19 testis expressed 19 4.26343
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 4.26343
CYSLTR1 cysteinyl leukotriene receptor 1 4.26343
BTNL3 butyrophilin-like 3 4.26343
TNR tenascin R 4.26343
RAB40AL RAB40A, member RAS oncogene family-like 4.26343
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 4.26343
SVOP SV2 related protein homolog (rat) 4.26343
EXTL1 exostosin-like glycosyltransferase 1 4.26343
CCL25 chemokine (C-C motif) ligand 25 4.26343
ITGB7 integrin, beta 7 4.26343
LRRC43 leucine rich repeat containing 43 4.26343
SLC38A3 solute carrier family 38, member 3 4.26343
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 4.26343
LOXL4 lysyl oxidase-like 4 4.26343
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 4.26343
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 4.26343
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 4.26343
PPP1R3G protein phosphatase 1, regulatory subunit 3G 4.26343
FGF9 fibroblast growth factor 9 4.26343
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 4.26343
BMP3 bone morphogenetic protein 3 4.26343
CFP complement factor properdin 4.26343
PRDM16 PR domain containing 16 4.26343
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 4.26343
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 4.26343
TAS2R19 taste receptor, type 2, member 19 4.26343
ATOH8 atonal homolog 8 (Drosophila) 4.26343
TMEM132C transmembrane protein 132C 4.26343
MB myoglobin 4.26343
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 4.26343
ZNF829 zinc finger protein 829 4.26343
HMGB4 high mobility group box 4 4.26343
CXORF58 chromosome X open reading frame 58 4.26343
PLA2G5 phospholipase A2, group V 4.26343
IL18RAP interleukin 18 receptor accessory protein 4.26343
MMP19 matrix metallopeptidase 19 4.26343
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 4.26343
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 4.26343
OR4M2 olfactory receptor, family 4, subfamily M, member 2 4.26343
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 4.15462
SESN1 sestrin 1 3.53316
RBM18 RNA binding motif protein 18 3.21926
PNMA8C PNMA family member 8C 3.09897
PKLR pyruvate kinase, liver and RBC 3.09897
PRSS35 protease, serine, 35 3.09897
COL8A2 collagen, type VIII, alpha 2 3.09897
POU5F2 POU domain class 5, transcription factor 2 3.09897
FADS6 fatty acid desaturase 6 3.09897
CCK cholecystokinin 3.09897
MAGIX MAGI family member, X-linked 3.09897
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 3.09897
TNS1-AS1 TNS1 antisense RNA 1 3.09897
SOX30 SRY (sex determining region Y)-box 30 3.09897
ACVR1 activin A receptor, type I 2.95701
TMC1 transmembrane channel-like 1 2.90447
HDAC9 histone deacetylase 9 2.82091
SRPX sushi-repeat containing protein, X-linked 2.78776
GKAP1 G kinase anchoring protein 1 2.7717
ZBTB24 zinc finger and BTB domain containing 24 2.76001
SLC25A51 solute carrier family 25, member 51 2.70593
CAPG capping protein (actin filament), gelsolin-like 2.70593
TOP3A topoisomerase (DNA) III alpha 2.64527
CNTNAP5 contactin associated protein-like 5 2.60832
DCLK1 doublecortin-like kinase 1 2.58866
PPP1R10 protein phosphatase 1, regulatory subunit 10 2.5259
DHFR2 dihydrofolate reductase 2 2.50442
FOS FBJ murine osteosarcoma viral oncogene homolog 2.4913
SHISAL2B shisa like 2B 2.4913
CUX1 cut-like homeobox 1 2.49073
HARS2 histidyl-tRNA synthetase 2, mitochondrial 2.47104
RINT1 RAD50 interactor 1 2.45124
ZNF2 zinc finger protein 2 2.43229
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 2.39547
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 2.37577
NSD1 nuclear receptor binding SET domain protein 1 2.37323
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 2.34853
HIPK1 homeodomain interacting protein kinase 1 2.33014
CD68 CD68 molecule 2.31981
TRO trophinin 2.31548
ABI2 abl-interactor 2 2.313
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.29914
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.28954
ZBTB48 zinc finger and BTB domain containing 48 2.2271
C8ORF33 chromosome 8 open reading frame 33 2.21486
DCTN5 dynactin 5 (p25) 2.20126
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 2.19887
AMH anti-Mullerian hormone 2.19616
PTCD3 pentatricopeptide repeat domain 3 2.16515
RNLS renalase, FAD-dependent amine oxidase 2.16309
NEURL2 neuralized E3 ubiquitin protein ligase 2 2.16309
PVR poliovirus receptor 2.15965
PRR19 proline rich 19 2.10107
RIC1 RAB6A GEF complex partner 1 2.10047
DYNLRB1 dynein, light chain, roadblock-type 1 2.08095
C5ORF24 chromosome 5 open reading frame 24 2.07015
LMBR1L limb development membrane protein 1-like 2.07015
LOC122455342 testis-specific serine/proline-rich protein 2.06447
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.04069
BLTP1 bridge-like lipid transfer protein family member 1 2.03866
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 2.0321
RUMY2 RUMY family member 2 2.02856
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 2.01602
TUBB2B tubulin, beta 2B class IIb 2.01602
PCLO piccolo presynaptic cytomatrix protein 2.00153
RAB17 RAB17, member RAS oncogene family 2.00036

decreased expression

Symbol Name Standardized Value
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -4.27553
PROK2 prokineticin 2 -4.27553
JPH2 junctophilin 2 -4.27553
PSORS1C2 psoriasis susceptibility 1 candidate 2 -4.27553
IFI27 interferon, alpha-inducible protein 27 -4.27553
RBM46 RNA binding motif protein 46 -4.27553
CRIP2 cysteine-rich protein 2 -4.27553
LOC107986837 uncharacterized LOC107986837 -4.26343
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -4.26343
EPX eosinophil peroxidase -4.26343
SNTN sentan, cilia apical structure protein -4.26343
MANSC4 MANSC domain containing 4 -4.26343
LEF1 lymphoid enhancer-binding factor 1 -4.26343
DNAI1 dynein, axonemal, intermediate chain 1 -4.26343
CRIP1 cysteine-rich protein 1 (intestinal) -4.26343
SLC10A4 solute carrier family 10, member 4 -4.26343
VENTX VENT homeobox -4.26343
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -4.26343
DCST1 DC-STAMP domain containing 1 -4.26343
EQTN equatorin, sperm acrosome associated -4.26343
CD101 CD101 molecule -4.26343
DNAH8 dynein, axonemal, heavy chain 8 -4.26343
SAPCD1 suppressor APC domain containing 1 -4.26343
VWF von Willebrand factor -4.26343
H4C12 H4 clustered histone 12 -4.26343
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -4.26343
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -4.26343
ERICH6B glutamate-rich 6B -4.26343
FBXO40 F-box protein 40 -4.26343
KLF5 Kruppel-like factor 5 (intestinal) -4.26343
GARIN1A golgi associated RAB2 interactor 1A -4.26343
SMIM45 small integral membrane protein 45 -4.26343
TF transferrin -4.26343
CATSPERT catsper channel auxiliary subunit tau -4.26343
PLPP4 phospholipid phosphatase 4 -4.26343
GPR146 G protein-coupled receptor 146 -4.26343
EBF3 early B-cell factor 3 -4.26343
S100A6 S100 calcium binding protein A6 -3.79062
FAM216A family with sequence similarity 216, member A -3.74584
N4BP2L1 NEDD4 binding protein 2-like 1 -3.74341
CRYL1 crystallin, lambda 1 -3.40891
SETMAR SET domain and mariner transposase fusion gene -3.38453
TRIM59 tripartite motif containing 59 -3.30014
NOSIP nitric oxide synthase interacting protein -3.22535
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -3.17456
CELA2B chymotrypsin-like elastase family, member 2B -3.17456
PDE11A phosphodiesterase 11A -3.17456
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -3.15432
COQ4 coenzyme Q4 -3.14294
HSPA2 heat shock 70kDa protein 2 -3.09897
GSDME gasdermin E -3.04455
PARP11 poly (ADP-ribose) polymerase family, member 11 -3.02738
CNBD2 cyclic nucleotide binding domain containing 2 -2.99577
EBF1 early B-cell factor 1 -2.98361
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.95814
CC2D1B coiled-coil and C2 domain containing 1B -2.95775
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.9168
VIPR2 vasoactive intestinal peptide receptor 2 -2.70489
SHROOM1 shroom family member 1 -2.64003
FST follistatin -2.62974
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.5259
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.50442
DUSP23 dual specificity phosphatase 23 -2.42281
ADGRL3 adhesion G protein-coupled receptor L3 -2.42059
FLT3 fms-related tyrosine kinase 3 -2.39261
ABI3BP ABI family, member 3 (NESH) binding protein -2.39261
EPS8 epidermal growth factor receptor pathway substrate 8 -2.38217
ZNF680 zinc finger protein 680 -2.38217
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -2.37978
ANKRD36B ankyrin repeat domain 36B -2.36667
FAM163B family with sequence similarity 163, member B -2.35271
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -2.33292
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.32323
PANK4 pantothenate kinase 4 -2.3014
C7orf78 chromosome 7 open reading frame 78 -2.3014
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.3014
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -2.28954
PDE10A phosphodiesterase 10A -2.28202
PNPLA8 patatin-like phospholipase domain containing 8 -2.27736
TNC tenascin C -2.27629
SYBU syntabulin (syntaxin-interacting) -2.27629
THOC2 THO complex 2 -2.25785
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.23309
MKRN2OS MKRN2 opposite strand -2.21687
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 -2.21115
BICD2 bicaudal D homolog 2 (Drosophila) -2.17459
DSTYK dual serine/threonine and tyrosine protein kinase -2.15685
RAB3D RAB3D, member RAS oncogene family -2.11585
TOX thymocyte selection-associated high mobility group box -2.11303
ERVH48-1 endogenous retrovirus group 48, member 1 -2.09304
ZNF234 zinc finger protein 234 -2.06709
POU3F1 POU class 3 homeobox 1 -2.06447
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -2.06184
RNF169 ring finger protein 169 -2.06137
MSL3 male-specific lethal 3 homolog (Drosophila) -2.03399
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.02999
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.01493
ARNT aryl hydrocarbon receptor nuclear translocator -2.00924
HYLS1 hydrolethalus syndrome 1 -2.00036