FOXP3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description forkhead box P3|The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 50943)
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Genes

346 genes differentially expressed following the FOXP3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IL11RA interleukin 11 receptor, alpha 4.27859
BTLA B and T lymphocyte associated 4.27859
GPR151 G protein-coupled receptor 151 4.27859
OR10A2 olfactory receptor, family 10, subfamily A, member 2 4.27859
VSTM2A V-set and transmembrane domain containing 2A 4.27859
MTTP microsomal triglyceride transfer protein 4.27859
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 4.27859
NPSR1 neuropeptide S receptor 1 4.27859
APOA2 apolipoprotein A-II 4.27859
CSMD3 CUB and Sushi multiple domains 3 4.27859
DMRTC1B DMRT-like family C1B 4.27859
TRIM15 tripartite motif containing 15 4.27859
FABP1 fatty acid binding protein 1, liver 4.27859
CELF6 CUGBP, Elav-like family member 6 4.27859
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 4.27859
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 4.27859
FGF21 fibroblast growth factor 21 4.27859
EQTN equatorin, sperm acrosome associated 4.27859
USP26 ubiquitin specific peptidase 26 4.27859
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 4.27859
OR52H1 olfactory receptor, family 52, subfamily H, member 1 4.27859
SLC26A1 solute carrier family 26 (anion exchanger), member 1 4.27859
ADGRE1 adhesion G protein-coupled receptor E1 4.27859
GNLY granulysin 4.27859
SCNN1G sodium channel, non voltage gated 1 gamma subunit 4.27859
SPINT3 serine peptidase inhibitor, Kunitz type, 3 4.27859
TRPV3 transient receptor potential cation channel, subfamily V, member 3 4.27859
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 4.27859
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 4.27859
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 4.27859
FGF5 fibroblast growth factor 5 4.27859
CCDC83 coiled-coil domain containing 83 4.27859
PRSS22 protease, serine, 22 4.27859
HRG histidine-rich glycoprotein 4.27859
NR2F2 nuclear receptor subfamily 2, group F, member 2 4.27859
GALP galanin-like peptide 4.27859
CD33 CD33 molecule 4.27859
IMPG1 interphotoreceptor matrix proteoglycan 1 4.27859
ETV7 ets variant 7 4.27859
TMC8 transmembrane channel-like 8 4.27859
ADAMTSL2 ADAMTS-like 2 4.27859
GUCY2F guanylate cyclase 2F, retinal 4.27859
GNAT3 guanine nucleotide binding protein, alpha transducing 3 4.27859
SMIM9 small integral membrane protein 9 4.27859
CPB2 carboxypeptidase B2 (plasma) 4.27859
C8ORF74 chromosome 8 open reading frame 74 4.27859
NPIPA8 nuclear pore complex interacting protein family, member A8 4.27859
WNT8B wingless-type MMTV integration site family, member 8B 4.27859
MISP mitotic spindle positioning 4.27859
BFSP2 beaded filament structural protein 2, phakinin 4.27859
LOXL4 lysyl oxidase-like 4 4.27859
EXOC1L exocyst complex component 1 like 4.27859
MYH1 myosin, heavy chain 1, skeletal muscle, adult 4.27859
KRT86 keratin 86, type II 4.27859
FOXN4 forkhead box N4 4.27859
PDC phosducin 4.27859
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 4.27859
PAPOLB poly(A) polymerase beta (testis specific) 4.27859
GC group-specific component (vitamin D binding protein) 4.27859
XKR3 XK, Kell blood group complex subunit-related family, member 3 4.27859
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 4.27859
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 4.27859
AANAT aralkylamine N-acetyltransferase 4.27859
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 4.27859
ALDOB aldolase B, fructose-bisphosphate 4.27859
SYT15B synaptotagmin 15B 4.27859
C17ORF113 chromosome 17 open reading frame 113 4.27859
H3C13 H3 clustered histone 13 4.27859
SPAAR small regulatory polypeptide of amino acid response 4.27859
ACP7 acid phosphatase 7, tartrate resistant (putative) 4.27859
DNAAF6 dynein axonemal assembly factor 6 4.27859
RTL5 retrotransposon Gag like 5 4.27859
CBLIF cobalamin binding intrinsic factor 4.27859
TMEM275 transmembrane protein 275 4.27859
ANGPTL8 angiopoietin like 8 4.27859
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 4.27859
GPR84 G protein-coupled receptor 84 4.27859
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 4.27859
CCDC13 coiled-coil domain containing 13 4.27859
KLHL33 kelch-like family member 33 4.27859
PCDHA1 protocadherin alpha 1 4.27859
ATP13A4 ATPase type 13A4 4.27859
ISM2 isthmin 2 4.27859
EPCIP exosomal polycystin 1 interacting protein 4.27859
GPR75 G protein-coupled receptor 75 4.27859
CCDC116 coiled-coil domain containing 116 4.27859
CD274 CD274 molecule 4.27859
AGTR1 angiotensin II receptor, type 1 4.27859
EDAR ectodysplasin A receptor 4.27859
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 4.27859
CBLN3 cerebellin 3 precursor 4.27859
TAS1R1 taste receptor, type 1, member 1 4.27859
OR2D3 olfactory receptor, family 2, subfamily D, member 3 4.27859
BARX2 BARX homeobox 2 4.27859
GSC goosecoid homeobox 4.27859
EXOC3L1 exocyst complex component 3-like 1 4.27859
RASAL3 RAS protein activator like 3 4.27859
KCNT1 potassium channel, sodium activated subfamily T, member 1 4.27859
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 4.27859
CCDC92 coiled-coil domain containing 92 4.27859
OR2A14 olfactory receptor, family 2, subfamily A, member 14 4.27859
SOX1 SRY (sex determining region Y)-box 1 4.27859
LPA lipoprotein, Lp(a) 4.27859
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 4.27859
EBLN1 endogenous Bornavirus-like nucleoprotein 1 4.27859
SYNE3 spectrin repeat containing, nuclear envelope family member 3 4.27859
BTNL2 butyrophilin-like 2 4.27859
CRYBB2 crystallin, beta B2 4.27859
CYSLTR1 cysteinyl leukotriene receptor 1 4.27859
KLF2 Kruppel-like factor 2 4.27859
GOLGA6C golgin A6 family, member C 4.27859
TRIM50 tripartite motif containing 50 4.27859
OR56A4 olfactory receptor, family 56, subfamily A, member 4 4.27859
CT55 cancer/testis antigen 55 4.27859
FCN1 ficolin (collagen/fibrinogen domain containing) 1 4.27859
DYTN dystrotelin 4.27859
ADAM2 ADAM metallopeptidase domain 2 4.27859
CCDC154 coiled-coil domain containing 154 4.27859
LRRC43 leucine rich repeat containing 43 4.27859
TMEM132E transmembrane protein 132E 4.27859
KCNK7 potassium channel, two pore domain subfamily K, member 7 4.27859
NIM1K NIM1 serine/threonine protein kinase 4.27859
C2CD4B C2 calcium-dependent domain containing 4B 4.27859
LMOD2 leiomodin 2 (cardiac) 4.27859
C11ORF42 chromosome 11 open reading frame 42 4.27859
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 4.27859
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 4.27859
CPN2 carboxypeptidase N, polypeptide 2 4.27859
FKBP1C FK506 binding protein 1C 4.27859
DRC7 dynein regulatory complex subunit 7 4.27859
TEX26 testis expressed 26 4.27859
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 4.27859
DND1 DND microRNA-mediated repression inhibitor 1 4.27859
NOBOX NOBOX oogenesis homeobox 4.27859
MUC19 mucin 19, oligomeric 4.27859
FBXO40 F-box protein 40 4.27859
ZFP92 ZFP92 zinc finger protein 4.27859
EPGN epithelial mitogen 4.27859
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 4.27859
SIGLEC15 sialic acid binding Ig-like lectin 15 4.27859
DLX2 distal-less homeobox 2 4.27859
TMEM31 transmembrane protein 31 4.27859
MAGEB17 melanoma antigen family B17 4.27859
NKPD1 NTPase, KAP family P-loop domain containing 1 4.27859
PRRX1 paired related homeobox 1 4.27859
TAS2R43 taste receptor, type 2, member 43 4.27859
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 4.27859
FRMPD2 FERM and PDZ domain containing 2 4.27859
SLC51B solute carrier family 51, beta subunit 4.27859
PTCRA pre T-cell antigen receptor alpha 4.27859
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 4.27859
TGM3 transglutaminase 3 4.27859
FITM1 fat storage-inducing transmembrane protein 1 4.27859
ADRA1B adrenoceptor alpha 1B 4.27859
BPIFC BPI fold containing family C 4.27859
TMEM156 transmembrane protein 156 4.27859
TMPRSS12 transmembrane (C-terminal) protease, serine 12 4.27859
ZNF534 zinc finger protein 534 4.27859
TEX35 testis expressed 35 4.27859
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 4.27859
GPR149 G protein-coupled receptor 149 4.27859
CCDC158 coiled-coil domain containing 158 4.23429
FZD2 frizzled class receptor 2 3.90066
NECAB2 N-terminal EF-hand calcium binding protein 2 3.89056
CDK17 cyclin-dependent kinase 17 3.43158
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 3.37428
LRRC3 leucine rich repeat containing 3 3.37428
SCARF1 scavenger receptor class F, member 1 3.37428
OR2H2 olfactory receptor, family 2, subfamily H, member 2 3.37428
GJA9 gap junction protein, alpha 9, 59kDa 3.37428
BCL2L10 BCL2-like 10 (apoptosis facilitator) 3.37428
TMEM102 transmembrane protein 102 3.37428
CRYGS crystallin, gamma S 3.37428
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 3.37428
SYF2 SYF2 pre-mRNA-splicing factor 2.96
TMEM100 transmembrane protein 100 2.94358
PLXNA4 plexin A4 2.93122
CFAP43 cilia and flagella associated protein 43 2.93122
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.93122
PAQR6 progestin and adipoQ receptor family member VI 2.93122
EGFL6 EGF-like-domain, multiple 6 2.90436
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.87025
CACUL1 CDK2-associated, cullin domain 1 2.76417
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.76115
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.74755
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.71467
BMP4 bone morphogenetic protein 4 2.70308
PDCD6IP programmed cell death 6 interacting protein 2.68196
RWDD3 RWD domain containing 3 2.68068
ATP5PD ATP synthase peripheral stalk subunit d 2.68068
FZD8 frizzled class receptor 8 2.61007
EML1 echinoderm microtubule associated protein like 1 2.53566
RNASEH2C ribonuclease H2, subunit C 2.53379
ATP9B ATPase, class II, type 9B 2.49981
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.491
ARGFX arginine-fifty homeobox 2.49071
ANKRD65 ankyrin repeat domain 65 2.49071
PLBD1 phospholipase B domain containing 1 2.44489
PEX10 peroxisomal biogenesis factor 10 2.43325
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 2.41099
GOLGA8A golgin A8 family, member A 2.40497
SCIN scinderin 2.36695
FOXA2 forkhead box A2 2.36695
USP47 ubiquitin specific peptidase 47 2.3507
UBE2Z ubiquitin-conjugating enzyme E2Z 2.34945
SLC35F2 solute carrier family 35, member F2 2.30262
ANKRD31 ankyrin repeat domain 31 2.27254
GRIK1 glutamate receptor, ionotropic, kainate 1 2.20768
PTRH2 peptidyl-tRNA hydrolase 2 2.20768
ARMCX1 armadillo repeat containing, X-linked 1 2.20768
RIMS3 regulating synaptic membrane exocytosis 3 2.20768
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.19362
SREK1 splicing regulatory glutamine/lysine-rich protein 1 2.18397
MAPK12 mitogen-activated protein kinase 12 2.18374
GUK1 guanylate kinase 1 2.18374
PTPRD protein tyrosine phosphatase, receptor type, D 2.16945
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.14827
E2F5 E2F transcription factor 5, p130-binding 2.14827
STRA6 stimulated by retinoic acid 6 2.14786
FAM184A family with sequence similarity 184, member A 2.14744
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 2.14744
MTF2 metal response element binding transcription factor 2 2.13835
SAMD4B sterile alpha motif domain containing 4B 2.13459
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.13333
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 2.13333
COP1 COP1 E3 ubiquitin ligase 2.12941
MARK1 MAP/microtubule affinity-regulating kinase 1 2.12028
TLN1 talin 1 2.11084
MED24 mediator complex subunit 24 2.09035
RHOT1 ras homolog family member T1 2.07653
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 2.07465
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 2.05669
AGGF1 angiogenic factor with G patch and FHA domains 1 2.05535
NDE1 nudE neurodevelopment protein 1 2.01773
LPL lipoprotein lipase 2.00979
CLK3 CDC-like kinase 3 2.00979
ZNF701 zinc finger protein 701 2.0059

decreased expression

Symbol Name Standardized Value
TSKS testis-specific serine kinase substrate -4.27859
KCNIP2 Kv channel interacting protein 2 -4.27859
TTLL13 tubulin tyrosine ligase like 13 -4.27859
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -4.00362
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -4.00362
SMIM31 small integral membrane protein 31 -4.00362
TICAM1 toll-like receptor adaptor molecule 1 -4.00362
SMTNL1 smoothelin-like 1 -4.00362
WDR64 WD repeat domain 64 -4.00362
MYCT1 myc target 1 -4.00362
FRMPD1 FERM and PDZ domain containing 1 -4.00362
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -4.00362
MMP28 matrix metallopeptidase 28 -4.00362
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -4.00362
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -4.00362
MRC1 mannose receptor, C type 1 -4.00362
MPL MPL proto-oncogene, thrombopoietin receptor -4.00362
MAMDC4 MAM domain containing 4 -4.00362
LTBP2 latent transforming growth factor beta binding protein 2 -4.00362
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -4.00362
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -4.00362
CCR6 chemokine (C-C motif) receptor 6 -4.00362
F2RL2 coagulation factor II (thrombin) receptor-like 2 -4.00362
IRF2-DT IRF2 divergent transcript -4.00362
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -4.00362
TSPAN8 tetraspanin 8 -4.00362
RASD1 RAS, dexamethasone-induced 1 -4.00362
ZNF99 zinc finger protein 99 -4.00362
STRIT1 small transmembrane regulator of ion transport 1 -4.00362
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -4.00362
H3C14 H3 clustered histone 14 -4.00362
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -4.00362
TMEM248 transmembrane protein 248 -3.99439
FBXL3 F-box and leucine-rich repeat protein 3 -3.86996
CCL2 chemokine (C-C motif) ligand 2 -3.86607
LCN2 lipocalin 2 -3.86607
RGS19 regulator of G-protein signaling 19 -3.63189
GOLT1B golgi transport 1B -3.3372
C4ORF33 chromosome 4 open reading frame 33 -3.27186
CLSTN2 calsyntenin 2 -3.2554
TMCO1 transmembrane and coiled-coil domains 1 -2.8955
PLAC8L1 PLAC8-like 1 -2.89043
MAOB monoamine oxidase B -2.88282
FBLN5 fibulin 5 -2.88282
NAGS N-acetylglutamate synthase -2.88282
HTRA3 HtrA serine peptidase 3 -2.81365
ATRAID all-trans retinoic acid-induced differentiation factor -2.76583
TTC21A tetratricopeptide repeat domain 21A -2.68068
ZNF446 zinc finger protein 446 -2.68068
TEDC1 tubulin epsilon and delta complex 1 -2.68068
KIF14 kinesin family member 14 -2.64544
DNAAF2 dynein, axonemal, assembly factor 2 -2.62105
PPP1R3B protein phosphatase 1, regulatory subunit 3B -2.46121
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.45004
GALK1 galactokinase 1 -2.38363
SPRYD4 SPRY domain containing 4 -2.38363
CATSPER2 cation channel, sperm associated 2 -2.38091
KLHL14 kelch-like family member 14 -2.37133
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.37023
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 -2.31656
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.30383
RWDD1 RWD domain containing 1 -2.30361
ZNF780B zinc finger protein 780B -2.30262
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.30205
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.29285
ZNF746 zinc finger protein 746 -2.28086
VMA22 vacuolar ATPase assembly factor VMA22 -2.27729
SCN9A sodium channel, voltage gated, type IX alpha subunit -2.27721
NUP62CL nucleoporin 62kDa C-terminal like -2.21274
TRIM54 tripartite motif containing 54 -2.20768
WFDC1 WAP four-disulfide core domain 1 -2.20768
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.20768
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.20768
RIPK4 receptor-interacting serine-threonine kinase 4 -2.20768
TFF3 trefoil factor 3 (intestinal) -2.20768
DNAAF8 dynein axonemal assembly factor 8 -2.20768
OTOGL otogelin-like -2.20768
LDLR low density lipoprotein receptor -2.20482
APH1A APH1A gamma secretase subunit -2.19329
DRAXIN dorsal inhibitory axon guidance protein -2.19329
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) -2.18374
NR4A1 nuclear receptor subfamily 4, group A, member 1 -2.16733
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.15695
METTL5 methyltransferase like 5 -2.15677
COQ10A coenzyme Q10 homolog A (S. cerevisiae) -2.15625
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.15216
BTBD1 BTB (POZ) domain containing 1 -2.14827
PRR14L proline rich 14-like -2.14786
BTBD2 BTB (POZ) domain containing 2 -2.14744
LDHD lactate dehydrogenase D -2.13333
PANX2 pannexin 2 -2.13333
MCM7 minichromosome maintenance complex component 7 -2.12029
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -2.12028
PAIP2 poly(A) binding protein interacting protein 2 -2.10754
STXBP6 syntaxin binding protein 6 (amisyn) -2.1046
CIBAR1 CBY1 interacting BAR domain containing 1 -2.09562
RHBDD2 rhomboid domain containing 2 -2.08132
TMEM154 transmembrane protein 154 -2.07465
TRIB2 tribbles pseudokinase 2 -2.04579
TMC1 transmembrane channel-like 1 -2.04265
WSCD1 WSC domain containing 1 -2.04265
TCEA2 transcription elongation factor A (SII), 2 -2.02527
MOV10 Mov10 RISC complex RNA helicase -2.02246
PLK1 polo-like kinase 1 -2.01185
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.00979
MPDZ multiple PDZ domain protein -2.00979
FADS2 fatty acid desaturase 2 -2.00612
ZNF419 zinc finger protein 419 -2.0059
PRRC1 proline-rich coiled-coil 1 -2.0059